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Figure 2


Fig. 2. β-catenin drives self-renewal in satellite cells. (a-i) Cultured myofibres were exposed to retrovirus and immunostained 48 hours later. Most proliferating satellite cells infected with (a) pMSCV–β-catenin–IRES–eGFP (β-catenin-RV) or (b) pMSCV–ST-β-catenin–IRES–eGFP (ST-β-catenin-RV) co-expressed eGFP (green) and Pax7 (red), which was in contrast to (c) pMSCV-IRES-eGFP-infected (Control-RV) cells. By contrast, there were fewer satellite cell progeny co-expressing wild-type or stabilised β-catenin (eGFP–green) with MyoD (red in d,e) and myogenin (red in g,h) compared with controls (f,i). Nuclei were counterstained with DAPI (blue). (j) Quantification of experiments shown in a-i. Values are the mean ± s.e.m. from three mice. *P<0.05, significantly different from control cultures.





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