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Figure 6


Fig. 6. EGFP-UAP56 K95N was present in higher concentrations in regions outside of the RNA-splicing domains, compared with EGFP-UAP56 wt. HeLa cells were transfected with either EGFP-UAP56 wt or EGFP-UAP56 K95N. At 24 hours after transfection, the cells were fixed, permeabilized and immunostained for endogenous UAP56. Compared with UAP56 wt, UAP56 K95N was less constrained to speckled domains and a higher fraction was present in regions outside the RNA-splicing speckled domains compared with cells expressing UAP56 wt. When stained for endogenous UAP56 protein using affinity purified anti-UAP56 antibody, both proteins localized to RNA-splicing speckled domains along with endogenous UAP56 proteins. Scale bars: 10 µm.





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