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Figure 3


Fig. 3. Ability of P2-receptor agonists to induce translocation of PKC{alpha}-EGFP. Because, in addition to activating P2X7, BzATP activates other P2 receptors, we investigated the effects of other P2-receptor agonists. UTP (150 µM, which activates P2Y2 receptors) or ATP (10 µM, which activates P2X4 and P2Y2 receptors) did not induce translocation of PKC{alpha}-EGFP. By contrast, ATP (3 mM) or BzATP (150 µM), both of which activate P2X7 receptors, caused significant translocation. Brilliant Blue G (BBG, 10 µM, which blocks P2X7 receptors) inhibited the translocation of PKC that was induced by BzATP. Data are means ± s.e.m. for at least three independent experiments. *P<0.05 compared with control as assessed by one-way ANOVA followed by Bonferroni post hoc test.





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