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Figure 5


Fig. 5. Integration of SNX9 and dynamin function with actin remodeling during vesicular release. The figure shows a model that is outlined in the text. SNX9 recruits dynamin to the neck of a highly invaginated clathrin-coated pit. Ordered assembly of the proteins on the membrane surface leads to the formation of a narrow tubule that, through SNX9-assisted GTP hydrolysis by dynamin, becomes destabilized. Recruitment and activation of N-WASP by SNX9 triggers a burst of actin polymerization, which might aid in the final release of the vesicle.





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