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Figure 6


Fig. 6. L-type Ca2+ channels mediate DCV exocytosis in hippocampal neurons. Release probabilities in the neuronal soma in response to 90 mM K+ were determined after treatment with the indicated Ca2+-channel inhibitors. Verapamil at 100 µM (specific for L-type Ca2+ channels) completely blocked evoked DCV exocytosis [total number of analyzed vesicles (n)=803], whereas 10 µM {omega}-conotoxin MVIIC (N- and Q-type specific, n=734) and 200 nM {omega}-agatoxin TK (P-type specific, n=712) were without effect (P>0.5 by t-test).





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