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Figure 5


Fig. 5. Quantitative evaluations of ultrastructural data. (A) A quantitative evaluation of CPD labeling density in irradiated cells either 10 minutes (n=10) or 1 hour (n=10) following irradiation in condensed chromatin domains (orange bars) and the perichromatin region (blue bars). Values were corrected for residual labeling in non-irradiated cells (n=20). The values represent the average gold-grain number per µm2 nuclear surface area ± s.e.m. (B,C) A quantitative evaluation of EGFP-XPA (blue bars) and XPC-EGFP (orange bars) labeling density (gold particles per µm2 nuclear area) in the perichromatin region (B) or in condensed chromatin domains (C). The labeling density was determined in non-irradiated cells (n=20 for XPC and XPA; NoDa), and in nuclei 10 minutes (n=15 for XPC and XPA) and 1 hour (n=15 for XPC and XPA) following irradiation. Values represent the average ± s.e.m. (D) A quantitative evaluation of the fraction of the nucleus occupied by condensed chromatin domains (%) before (n=29; NoDa) and after global UV irradiation at 60 J.m–2 determined 10 minutes (n=15) or 1 hour (n=15) following UV exposure. The values represent the mean ± s.e.m. NoDa, no UV irradiation; GloDa, after global UV irradiation.





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