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Figure 8


Fig. 8. Regulation of DLC1 by 14-3-3 proteins. Activation of PKC/PKD kinases leads to DLC1 phosphorylation on sites that include Ser327 and Ser431. This creates binding sites for 14-3-3 adaptor proteins, whereby DLC1 RhoGAP activity is inhibited, most likely by cytosolic sequestration. 14-3-3 binding furthermore masks a nuclear localization signal spanning residues 423-429, thus preventing DLC1 nucleocytoplasmic shuttling.





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