QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online May 20, 2009

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Cell division – a need for NudE

Kinetochores, which attach chromosomes to the spindle apparatus during cell division, are associated with molecular machinery that recruits and regulates the function of dynein. Dynein at kinetochores moves chromosomes towards spindle poles, and is involved in the `shedding' of proteins from kinetochores and onto the microtubules to which they are attached. Previous studies have shown that NudE physically associates with dynein, but the function of NudE in cell division has been unclear. Now, Michael Goldberg and colleagues (p. 1747) establish a new role for this protein in regulating dynein function at the kinetochore. They show that NudE is essential in Drosophila, as flies expressing a null nudE allele die at the third-instar larval or pupal stage. Examination of larval cells from the mutant flies shows that many are arrested at prometaphase or metaphase because of the activation of the spindle assembly checkpoint (SAC). Although the SAC is activated normally in nudE-null flies, protein `shedding' from kinetochores is disrupted, which the authors propose might lead to persistent SAC signalling and cause mitotic arrest. In line with these observations, the mutant cells also have defects in spindle morphology, chromosome congression and centrosome migration during mitosis and meiosis. This work clarifies the role of NudE in cell division.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Roles of the Drosophila NudE protein in kinetochore function and centrosome migration

Alan Wainman, Jacklyn Creque, Byron Williams, Erika V. Williams, Silvia Bonaccorsi, Maurizio Gatti, and Michael L. Goldberg
JCS 2009 122: 1747-1758. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?