QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online June 3, 2009

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Social Bookmarking                         What's this?

Turning up the heat on stress granules

Eukaryotic cells form various mRNA-containing assemblies in response to environmental stress. These include stress granules (SGs), which contain the translation initiation factor eIF3 and small ribosomal subunits, and P-bodies, which share some components with SGs but specifically contain mRNA decapping and deadenylating complexes. The formation of SGs has primarily been studied in mammalian cells, but Jirí Hasek and colleagues (p. 2078) now investigate their formation in the budding yeast Saccharomyces cerevisiae. The authors subject yeast to robust heat shock, and report the energy-dependent formation of cytoplasmic accumulations (putative SGs) that contain several typical components of mammaliam SGs, including the initiation factor eIF3a and the small ribosomal subunit. The yeast SGs also colocalise with typical P-body proteins and, in contrast to mammalian SGs, they can form in the absence of eIF2 phosphorylation. Notably, heat-shock-induced SGs differ in their composition from SGs that have recently been reported to form in glucose-deprived S. cerevisiae [Buchan et al. (2008). J. Cell Biol. 183, 441-455], and the authors also show that different scaffolding proteins are required in heat-shock- and glucose-deprivation-induced SGs. Their results underscore the diverse composition of mRNA-containing assemblies in S. cerevisiae.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Robust heat shock induces eIF2-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae

Tomás Grousl, Pavel Ivanov, Ivana Frydlová, Pavla Vasicová, Filip Janda, Jana Vojtová, Katerina Malínská, Ivana Malcová, Lenka Nováková, Dana Janosková, Leos Valásek, and Jirí Hasek
JCS 2009 122: 2078-2088. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Social Bookmarking                         What's this?