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Journal of Cell Science is pleased to present a collection of articles that focus on the endosomal sorting complex required for transport (ESCRT) machinery. These complexes were initially identified on the basis of their important function in the sorting of ubiquitylated receptors into multivesicular bodies. Since this discovery, cell biologists have made significant progress in understanding the structure of the ESCRT machinery at the molecular level, and it is now clear that its function extends to many other topologically equivalent cellular processes that involve a membrane-scission event. Our Minifocus on the ESCRT machinery contains three articles that bring these new ideas together:
The ESCRT machinery at a glance
Wollert, T., Yang, D., Ren, X., Lee, H. H., Im, Y. J. and Hurley, J. H.
No strings attached: the ESCRT machinery in viral budding and cytokinesis
McDonald, B. and Martin-Serrano, J.
How do ESCRT proteins control autophagy?
Rusten, T. E. and Stenmark, H.
Akiko Mukai, Emi Mizuno, Kaoru Kobayashi, Masaki Matsumoto, Keiichi I. Nakayama, Naomi Kitamura, and Masayuki Komada
Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis
J Cell Sci 2008 121: 1325-1333.
Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor β-chain
J Cell Sci 2008 121: 1727-1738
Cinzia Progida, Lene Malerød, Susanne Stuffers, Andreas Brech, Cecilia Bucci, and Harald Stenmark
RILP is required for the proper morphology and function of late endosomes
J Cell Sci 2007 120: 3729-3737.
Elizabeth Kirk, Lih-Shen Chin, and Lian Li
GRIF1 binds Hrs and is a new regulator of endosomal trafficking
J Cell Sci 2006 119: 4689-4701
Yuki Ohsaki, Yuko Sugimoto, Michitaka Suzuki, Hiroshi Hosokawa, Tamotsu Yoshimori, Joanna P. Davies, Yiannis A. Ioannou, Marie T. Vanier, Kousaku Ohno, and Haruaki Ninomiya
Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4
J Cell Sci 2006 119: 2643-2653
C. Raiborg, J. Wesche, L. Malerød, and H. Stenmark
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains
J Cell Sci 2006 119: 2414-2424
Aurelie Doyotte, Matthew R. G. Russell, Colin R. Hopkins, and Philip G. Woodman
Depletion of TSG101 forms a mammalian `Class E' compartment: a multicisternal early endosome with multiple sorting defects
J Cell Sci 2005 118: 3003-3017.
Alicia Cabezas, Kristi G. Bache, Andreas Brech, and Harald Stenmark
Alix regulates cortical actin and the spatial distribution of endosomes
J Cell Sci 2005 118: 2625-2635
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