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Figure 1


Fig. 1. Alignment of β-integrin-tail sequences. β-integrin tails from several species were aligned manually. The divergent sequences of human β4 integrin and β8 integrin were not included. Residues that are normally buried in the membrane but that might become available for adaptor binding upon integrin activation are depicted in green. The conserved NxxY motifs and HDR[R/K] motif are highlighted in bold. Residues that might be phosphorylated to regulate adaptor binding are highlighted in red. Residues are numbered according to the National Center for Biotechnology Information (NCBI) sequence.





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