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Figure 5


Fig. 5. The integrin {alpha}6β1 mediates cell spreading on endogenous Ln-332 when {alpha}3β1 is absent. MK{alpha}3+ and MK{alpha}3– cells were seeded on Ln-332 (A) or Col-1 (B), allowed to spread, and then incubated with {alpha}6-blocking antibody GoH3 (10 µg/ml). After 3 hours, the number of spread cells was scored and expressed as a percentage of the total number of cells. In each independent experiment, approximately 500 cells were counted for each condition. The graphs depict the averages of three experiments (*P<0.05, ***P<0.0005). Scale bar: 50 µm.





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