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First published online January 17, 2009

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Integrin 3β1 runs interference

Wound healing in the skin requires migration and hyperproliferation of keratinocytes. Integrin 3β1, among other members of the integrin family, mediates the attachment of basal epidermal keratinocytes to the basement membrane, so its role in adult skin and wound healing is of interest. Complicating such studies, however, are 3-integrin-null mice, which die during the neonatal period. Controversially, integrin 3β1 has also been independently reported to promote and inhibit keratinocyte migration in vitro. Arnoud Sonnenberg and colleagues (p. 278) now generate epidermis-specific 3-integrin-knockout mice to investigate the function of integrin 3β1 in wound re-epithelialisation. These mice are viable, but display local inflammation, hair loss, basement-membrane duplication and microblistering at the dermal-epidermal junction; hemidesmosome assembly and keratinocyte differentiation are not impaired. In the absence of integrin 3β1 there is no change in keratinocyte proliferation, the distribution of other integrins and the deposition of basement-membrane proteins in the wound bed, but wound healing is faster, suggesting accelerated keratinocyte migration. Supporting in vitro evidence shows that 3-integrin-deficient keratinocytes migrate with increased velocity and persistence. The authors' results support a role for 3β1 integrin in inhibiting the directional migration of keratinocytes in vitro and wound re-epithelialisation in vivo.

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Related articles in JCS:

Integrin 3β1 inhibits directional migration and wound re-epithelialization in the skin

Coert Margadant, Karine Raymond, Maaike Kreft, Norman Sachs, Hans Janssen, and Arnoud Sonnenberg
JCS 2009 122: 278-288. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?