QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online February 18, 2009

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Virulence via fine-tuning of RhoG

Yersinia bacteria, which cause various human illnesses, use many different mechanisms to subvert host-cell responses and propagate disease. The Rho family of GTPases is commonly targeted by invading pathogens, as these proteins mediate many essential cellular functions (such as cytoskeletal organisation). For example, Yersinia outer proteins (Yops) have been shown to modulate the Rho GTPases RhoA, Rac1 and Cdc42. Martin Aepfelbacher and colleagues (p. 696) now show that RhoG (which acts upstream of Rac1) is differentially activated in host cells over the course of an infection with Yersinia enterocolitica. During invasion, before Yops are translocated into host cells, the triggering of host-cell β1-integrin activation by the Yersinia protein invasin causes RhoG activation, which facilitates bacterial entry. Thereafter, YopE specifically inhibits the activity of RhoG, which leads to downstream inhibition of Rac1 activity. The authors go on to show that YopE can also inhibit Rac1 and Cdc42 directly, and that its substrate specificity is determined by its localisation in the Golgi and ER. This work reveals that RhoG is targeted by Yersinia virulence mechanisms, and that its activity is modulated by the bacteria and depends on the stage of infection.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in JCS:

Yersinia enterocolitica differentially modulates RhoG activity in host cells

Bernhard Roppenser, Anja Röder, Moritz Hentschke, Klaus Ruckdeschel, and Martin Aepfelbacher
JCS 2009 122: 696-705. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?