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First published online February 18, 2009

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Neuronal precursors do the Mash1

The proliferation of cerebellar granular neuronal precursors (CGNPs) during the development of the cerebellum is promoted by several signals, including the transcription factor MYCN, which promotes cell division by activating the cyclin D2 promoter. However, the differentiation of CGNPs into neurons requires cell-cycle exit, which can be triggered by exposure to various anti-mitotic stimuli. Murine Mash1 is a transcription factor that is reportedly involved in this process, but what is the molecular basis for its proneural function? Rubén Álvarez-Rodríguez and Sebastián Pons (p. 595) now show that Mash1 inhibits proliferation by binding to, and thereby repressing, pro-mitotic target genes that are activated by MYCN. Owing to the specificity of both Mash1 and MYCN for regulatory sequences known as E-box motifs, these transcription factors compete for binding of the cyclin D2 promoter, with repression by Mash1 acting dominantly over the inducing activity of MYCN. This work provides new insight into the molecular events that underlie neuronal proliferation and differentiation in mice.

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Related articles in JCS:

Expression of the proneural gene encoding Mash1 suppresses MYCN mitotic activity

Rubén Álvarez-Rodríguez and Sebastián Pons
JCS 2009 122: 595-599. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?