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First published online March 18, 2009

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VEGF branches out with PLCβ3

The binding of vascular endothelial growth factor (VEGF) to its receptors (VEGFR1 and VEGFR2) on endothelial cells can induce many effects, including proliferation, migration and angiogenesis, through the activation of several intracellular signalling pathways. For example, Debabrata Mukhopadhyay and colleagues showed in a previous study that VEGF induces the lipase activity of phospholipase C1 (PLC1) and PLCβ3. Whereas PLC1 activation is known to have a role in VEGF-induced DNA synthesis, the role of PLCβ3 downstream of VEGF has been unclear. Now, Mukhopadhyay and colleagues (p. 1025) use RNA-interference techniques to show that PLCβ3 promotes directional migration and inhibits proliferation downstream of VEGFR2 in endothelial cells. They show that the pro-migratory function of PLCβ3 involves its effects on actin reorganisation and its capacity to activate the small GTPase Cdc42, and that PLCβ3 inhibits proliferation through effects on the cell cycle. Therefore, the authors conclude that PLCβ3 is important in the context of angiogenesis by promoting a pro-migratory and anti-proliferative phenotype in endothelial cells.

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Distinct role of PLCβ3 in VEGF-mediated directional migration and vascular sprouting

Resham Bhattacharya, Junhye Kwon, Xiujuan Li, Enfeng Wang, Sujata Patra, John Paul Bida, Zeljko Bajzer, Lena Claesson-Welsh, and Debabrata Mukhopadhyay
JCS 2009 122: 1025-1034. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in JCS Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?