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Correction for Vicente-Manzanares et al., J Cell Sci 122 (2) 199-206.
First published online April 22, 2009
doi: 10.1242/10.1242/jcs.052894

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Integrins in cell migration - the actin connection

There was an error published in J. Cell Sci. 122, 199-206.

In the first paragraph of the section entitled `The integrin-actin linkage functions as a molecular clutch', the protrusion rate was inadvertently reported to increase rather than decrease. The correct paragraph is shown in full below.

The clutch hypothesis integrates adhesion, retrograde flow and actin polymerization. The retrograde flow of actin, generated by either myosin II contraction or membrane resistance to actin polymerization at the leading edge, counteracts the protrusive effect of polarized actin polymerization in protrusions. Thus, the net extension rate of a protrusion is the difference between the actin polymerization and the retrograde flow rates. Adhesions can modulate the protrusion mechanism by linking actin filaments to a fixed substratum, thereby creating traction points that inhibit actin retrograde flow (Alexandrova et al., 2008). This linkage would, therefore, increase the protrusion rate by shunting the forces that drive retrograde flow to the substratum and thereby inhibiting the retrograde flow (Fig. 3; supplementary material Movies 1 and 2). The weakening of such a substratum-integrin-actin linkage would increase the retrograde flow rate and decrease the protrusion rate, whereas decreasing the retrograde flow, by inhibiting myosin II, would increase the overall protrusion rate.

The authors apologise for this error and for any confusion caused.

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vicente-Manzanares, M. Articles by Horwitz, A. R. Search for Related Content PubMed Articles by Vicente-Manzanares, M. Articles by Horwitz, A. R. Social Bookmarking                         What's this?