Deregulation of cyclins D1 and E and suppression of cdk2 and cdk4 in senescent human fibroblasts

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Lucibello, F. C.
	Articles by Muller, R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Lucibello, F. C.
	Articles by Muller, R.


Social Bookmarking

	What's this?

Arcari, P., Martinelli, R. and Salvatore, F (1984). The complete sequence of a full length cDNA for human liver glyceraldehyde-3-phosphate dehydrogenase: Evidence for multiple mRNA species. Nucl. Acids Res 12, 9179-9189.[Abstract/Free Full Text]

Bell, E., Marek, L. F., Levinstone, D. S., Merrill, C., Sher, S., Young, I. T. and Eden, M (1978). Loss of division potential in vitro: aging or differentiation?. Science 202, 1158-1163.[Abstract/Free Full Text]

Chirgwin, J. M., Przybyla, A. E. MacDonald, R.I. and Rutter, W. J (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294-5299.[Medline]

Dulic, V., Lees, E. and Reed, S. I (1992). Association of human cyclin E with a periodic G1 -S phase kinase. Science 257, 1958-1961.[Abstract/Free Full Text]

Faha, B., Ewen, M. E., Tsai, L.-H., Livingston, D. M. and Harlow, E (1992). Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science 255, 87-90.[Abstract/Free Full Text]

Fureal, P. A. and Barrett, C (1991). Failure of senescent cells to phosphorylate the RB protein. Oncogene 6, 1109-1113.[Medline]

Girard, F., Strausfeld, U., Fernandez, A. and Lamb, N. J. C (1991). Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67, 1169-1179.[Medline]

Goldstein, S (1990). Replicative senescence: the human fibroblast comes of age. Science 249, 1129-1133.[Abstract/Free Full Text]

Hayflick, L (1965). The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res 37, 614-636.[Medline]

Hayflick, L. and Moorhead, P. S (1961). The serial cultivation of human diploid cell strains. Exp. Cell Res 25, 585-621.

Hinds, P. W., Mittnacht, S., Dulic, V., Arnold, A., Reed, S. I. and Weinberg R. A (1992). Regulation of the retinoblastoma protein functions by ectopic expression of human cyclins. Cell 70, 993-1006.[Medline]

Hunter, T. and Pines, J (1991). Cyclins and cancer. Cell 66, 1071-1074.[Medline]

Koff, A., Cross, F., Fisher, A., Schumacher, J., Leguellec, K., Philippe, M. and Roberts, J. M (1991). Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family. Cell 66, 1217-1228.[Medline]

Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper J. W., Elledge, S., Nishimoto, T., Morgan, D. O., Franza, B. R. and Roberts, J. M (1992). Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257, 1689-1694.[Abstract/Free Full Text]

Lammie, G. A., Fantl, V., Smith, R., Schuuring, E., Brookes, S., Michalides, R., Dickson, C., Arnold, A. and Peters, G (1991). D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to bcl-1. Oncogene 6, 439-444.[Medline]

Lee, M. G. and Nurse, P (1987). Complementation used to clone a human homologue of the fission yeast cell cyle gene cdc2. Nature 327, 31-35.[Medline]

Lew, D. J., Dulic, V. and Reed, S. I (1991). Isolation of three novel human cyclins by rescue of G1 cyclin Cln function in yeast. Cell 66, 1197-1206.[Medline]

Matsushime, H., Roussel, M. F., Ashmun, R. A. and Sherr, C. J (1991). Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65, 701-713.[Medline]

Matsushime, H., Ewen, M. E., Strom, D. K., Kato, J.-Y., Hanks, S. K., Roussel, M. F. and Sherr, C. J (1992). Identification and properties of an atypical catalytic subunit (p34PSK-J3 /cdk4) for mammalian D type G1 cyclins. Cell 71, 323-334.[Medline]

McCormick, A. and Campisi, J (1991). Cellular aging and senescence. Curr. Biol 3, 230-234.

Meyerson, M., Enders, G. H., Wu, C.-L., Su, L.-K., Gorka, C., Nelson, C., Harlow, E. and Tsai, L.-H (1992). A family of human cdc2-related protein kinases. EMBO J 11, 2909-2919.[Medline]

Motokura, T., Bloom, T., Goo Kim, H., Juppner, H., Ruderman, J. V., Kronenberg, H. M. and Arnold, A (1991). A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350, 512-515.[Medline]

Mumberg, D., Lucibello, F. C., Schuermann, M. and Muller, R (1991). Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functinally antagonistic proteins. Genes Dev 5, 1212-1223.[Abstract/Free Full Text]

Nasmyth, K (1990). FAR-reaching discoveries about the regulation of START. Cell 63, 1117-1120.[Medline]

Pagano, M., Draetta, G. and Jansen-Durr, P (1992). Association of cdk2 kinase with the transcription factor E2F during S phase. Science 255, 1144-1147.[Abstract/Free Full Text]

Pagano, M., Pepperkok, R., Verde, F., Ansorge, W. and Draetta, G (1992). Cyclin A is required at two points in the human cell cycle. EMBO J 11, 961-971.[Medline]

Pines, J. and Hunter, T (1989). Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and interaction with p34cdc2. Cell 58, 833-846.[Medline]

Pines, J. and Hunter, T (1990). Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature 346, 760-763.[Medline]

Pines, J. and Hunter, T (1990). p34cdc2 : the S and M kinase?. New Biol 2, 389-401.[Medline]

Riabowol, K., Schiff, J. and Gilman, M. Z (1992). Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging. Proc. Nat. Acad. Sci. USA 89, 157-161.[Abstract/Free Full Text]

Rosenblatt, J., Gu, Y. and Morgan, D. O (1992). Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc. Nat. Acad. Sci. USA 89, 2824-2921.[Abstract/Free Full Text]

Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Russell, H., Horn, G. T., Mullis, K. B. and Erlich, H. A (1988). Primer directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239, 487-491.[Abstract/Free Full Text]

Seshadri, T. and Campisi, J (1990). Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts. Science 247, 205-209.[Abstract/Free Full Text]

Sewing, A., Burger, C., Brusselbach, S., Schalk, C., Lucibello, F. L. and Muller, R (1993). Human cyclin D1 encodes a labile nuclear protein whose synthesis is directly induced by growth factors and suppressed by cyclic AMP. J. Cell Sci 104, 545-554.[Abstract]

Stein, G. H., Beeson, M. and Gordon, L (1990). Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 249, 666-669.[Abstract/Free Full Text]

Stein, G. H., Drullinger, L. F., Robetorye, R. S., Pereira-Smith, O. M. and Smith, J. R (1991). Senescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation. Proc. Nat. Acad. Sci. USA 88, 11012-11016.[Abstract/Free Full Text]

Thomas, P. S (1980). Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc. Nat. Acad. Sci. USA 77, 5201-5205.[Abstract/Free Full Text]

Tsai, L. H., Harlow, E. and Meyerson, M (1991). Isolation of the human cdk2 gene that encodes the cyclin A-and adenovirus E1A-associated p33 kinase. Nature 353, 174-177.[Medline]

Walker, D. H. and Maller, J. L (1991). Role for cyclin A in the dependence of mitosis on completion of DNA replication. Nature 354, 314-317.[Medline]

Wang, J., Chenivesse, X., Henglein, B. and Brechot, C (1990). Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 343, 555-557.[Medline]

Won, K.-A., Xiong, Y., Beach, D. and Gilman, M. Z (1992). Growth-regulated expression of D-type cyclins in human diploid fibroblasts. Proc. Nat. Acad. Sci. USA 89, 9910-9914.[Abstract/Free Full Text]

Xiong, Y., Connolly, T., Futcher, B. and Beach, D (1991). Human D-type cyclin. Cell 65, 691-699.[Medline]

Xiong, Y., Zhang, H. and Beach, D (1992). D type cyclins associate with multiple protein kinases and the DNA replication and rapair factor PCNA. Cell 71, 505-514.[Medline]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

K. E. Morris, L. M. Schang, and D. N. Brindley
Lipid Phosphate Phosphatase-2 Activity Regulates S-phase Entry of the Cell Cycle in Rat2 Fibroblasts
J. Biol. Chem., April 7, 2006; 281(14): 9297 - 9306.
[Abstract] [Full Text] [PDF]

H. Harada, H. Nakagawa, K. Oyama, M. Takaoka, C. D. Andl, B. Jacobmeier, A. von Werder, G. H. Enders, O. G. Opitz, and A. K. Rustgi
Telomerase Induces Immortalization of Human Esophageal Keratinocytes Without p16INK4a Inactivation
Mol. Cancer Res., August 1, 2003; 1(10): 729 - 738.
[Abstract] [Full Text] [PDF]

R. Haq, J. D. Brenton, M. Takahashi, D. Finan, R. Rottapel, and B. Zanke
Constitutive p38HOG Mitogen-activated Protein Kinase Activation Induces Permanent Cell Cycle Arrest and Senescence
Cancer Res., September 1, 2002; 62(17): 5076 - 5082.
[Abstract] [Full Text] [PDF]

R. Marcotte and E. Wang
Replicative Senescence Revisited
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2002; 57(7): B257 - 269.
[Abstract] [Full Text]

M. M. Awad and P. A. Gruppuso
Cell Cycle Control during Liver Development in the Rat: Evidence Indicating a Role for Cyclin D1 Posttranscriptional Regulation
Cell Growth Differ., June 1, 2000; 11(6): 325 - 334.
[Abstract] [Full Text]

C. Sandhu, D. M. Peehl, and J. Slingerland
p16INK4A Mediates Cyclin Dependent Kinase 4 and 6 Inhibition in Senescent Prostatic Epithelial Cells
Cancer Res., May 1, 2000; 60(10): 2616 - 2622.
[Abstract] [Full Text]

R. A. Quadri, A. Arbogast, M.-A. Phelouzat, S. Boutet, O. Plastre, and J. J. Proust
Age-Associated Decline in cdk1 Activity Delays Cell Cycle Progression of Human T Lymphocytes
J. Immunol., November 15, 1998; 161(10): 5203 - 5209.
[Abstract] [Full Text] [PDF]

M. Meyyappan, H. Wong, C. Hull, and K. T. Riabowol
Increased Expression of Cyclin D2 during Multiple States of Growth Arrest in Primary and Established Cells
Mol. Cell. Biol., June 1, 1998; 18(6): 3163 - 3172.
[Abstract] [Full Text]

C. Asiedu, J. Biggs, and A. S. Kraft
Complex Regulation of CDK2 During Phorbol Ester-Induced Hematopoietic Differentiation
Blood, November 1, 1997; 90(9): 3430 - 3437.
[Abstract] [Full Text] [PDF]

J. Kikuchi, Y. Furukawa, S. Iwase, Y. Terui, M. Nakamura, S. Kitagawa, M. Kitagawa, N. Komatsu, and Y. Miura
Polyploidization and Functional Maturation Are Two Distinct Processes During Megakaryocytic Differentiation: Involvement of Cyclin-Dependent Kinase Inhibitor p21 in Polyploidization
Blood, June 1, 1997; 89(11): 3980 - 3990.
[Abstract] [Full Text] [PDF]

D.�A. Alcorta, Y. Xiong, D. Phelps, G. Hannon, D. Beach, and J.�C. Barrett
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human�fibroblasts
PNAS, November 26, 1996; 93(24): 13742 - 13747.
[Abstract] [Full Text] [PDF]

C. Burger, M. Wick, and R. Muller
Lineage-specific regulation of cell cycle gene expression in differentiating myeloid cells
J. Cell Sci., July 1, 1994; 107(7): 2047 - 2054.
[Abstract] [PDF]

S Adolph, S Brusselbach, and R Muller
Inhibition of transcription blocks cell cycle progression of NIH3T3 fibroblasts specifically in G1
J. Cell Sci., January 5, 1993; 105(1): 113 - 122.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Lucibello, F. C.

Articles by Muller, R.

Search for Related Content

PubMed

PubMed Citation

Articles by Lucibello, F. C.

Articles by Muller, R.

Social Bookmarking

What's this?

				H. Harada, H. Nakagawa, K. Oyama, M. Takaoka, C. D. Andl, B. Jacobmeier, A. von Werder, G. H. Enders, O. G. Opitz, and A. K. Rustgi Telomerase Induces Immortalization of Human Esophageal Keratinocytes Without p16INK4a Inactivation Mol. Cancer Res., August 1, 2003; 1(10): 729 - 738. [Abstract] [Full Text] [PDF]

				R. Haq, J. D. Brenton, M. Takahashi, D. Finan, R. Rottapel, and B. Zanke Constitutive p38HOG Mitogen-activated Protein Kinase Activation Induces Permanent Cell Cycle Arrest and Senescence Cancer Res., September 1, 2002; 62(17): 5076 - 5082. [Abstract] [Full Text] [PDF]

				R. Marcotte and E. Wang Replicative Senescence Revisited J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2002; 57(7): B257 - 269. [Abstract] [Full Text]

				M. M. Awad and P. A. Gruppuso Cell Cycle Control during Liver Development in the Rat: Evidence Indicating a Role for Cyclin D1 Posttranscriptional Regulation Cell Growth Differ., June 1, 2000; 11(6): 325 - 334. [Abstract] [Full Text]

				C. Sandhu, D. M. Peehl, and J. Slingerland p16INK4A Mediates Cyclin Dependent Kinase 4 and 6 Inhibition in Senescent Prostatic Epithelial Cells Cancer Res., May 1, 2000; 60(10): 2616 - 2622. [Abstract] [Full Text]

				R. A. Quadri, A. Arbogast, M.-A. Phelouzat, S. Boutet, O. Plastre, and J. J. Proust Age-Associated Decline in cdk1 Activity Delays Cell Cycle Progression of Human T Lymphocytes J. Immunol., November 15, 1998; 161(10): 5203 - 5209. [Abstract] [Full Text] [PDF]

				M. Meyyappan, H. Wong, C. Hull, and K. T. Riabowol Increased Expression of Cyclin D2 during Multiple States of Growth Arrest in Primary and Established Cells Mol. Cell. Biol., June 1, 1998; 18(6): 3163 - 3172. [Abstract] [Full Text]

				C. Asiedu, J. Biggs, and A. S. Kraft Complex Regulation of CDK2 During Phorbol Ester-Induced Hematopoietic Differentiation Blood, November 1, 1997; 90(9): 3430 - 3437. [Abstract] [Full Text] [PDF]

				J. Kikuchi, Y. Furukawa, S. Iwase, Y. Terui, M. Nakamura, S. Kitagawa, M. Kitagawa, N. Komatsu, and Y. Miura Polyploidization and Functional Maturation Are Two Distinct Processes During Megakaryocytic Differentiation: Involvement of Cyclin-Dependent Kinase Inhibitor p21 in Polyploidization Blood, June 1, 1997; 89(11): 3980 - 3990. [Abstract] [Full Text] [PDF]

				D.�A. Alcorta, Y. Xiong, D. Phelps, G. Hannon, D. Beach, and J.�C. Barrett Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human�fibroblasts PNAS, November 26, 1996; 93(24): 13742 - 13747. [Abstract] [Full Text] [PDF]

				C. Burger, M. Wick, and R. Muller Lineage-specific regulation of cell cycle gene expression in differentiating myeloid cells J. Cell Sci., July 1, 1994; 107(7): 2047 - 2054. [Abstract] [PDF]

				S Adolph, S Brusselbach, and R Muller Inhibition of transcription blocks cell cycle progression of NIH3T3 fibroblasts specifically in G1 J. Cell Sci., January 5, 1993; 105(1): 113 - 122. [Abstract] [PDF]