The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail

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p23, a major COPI-vesicle membrane protein, constitutively cycles through the early secretory�pathway
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J. Dietrich, J. Kastrup, B. L. Nielsen, N. Odum, and C. Geisler
Regulation and Function of the CD3gamma DxxxLL Motif: A Binding Site for Adaptor Protein-1 and Adaptor Protein-2 in Vitro
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G. Odorizzi and I. S. Trowbridge
Structural Requirements for Major Histocompatibility Complex Class II Invariant Chain Trafficking in Polarized Madin-Darby Canine Kidney Cells
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V. Brachet, G. Raposo, S. Amigorena, and I. Mellman
Ii Chain Controls the Transport of Major Histocompatibility Complex Class II Molecules to and from Lysosomes
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M. Gedde-Dahl, I. Freisewinkel, M. Staschewski, K. Schenck, N. Koch, and O. Bakke
Exon 6Is Essential for Invariant Chain Trimerization and Induction of Large Endosomal Structures
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N. Barois, F. Forquet, and J. Davoust
Selective Modulation of the Major Histocompatibility Complex Class II Antigen Presentation Pathway following B Cell Receptor Ligation and Protein Kinase C Activation
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G. Zhong, P. Romagnoli, and R. N. Germain
Related Leucine-based Cytoplasmic Targeting Signals in Invariant Chain and Major Histocompatibility Complex Class II Molecules Control Endocytic Presentation of Distinct Determinants in a Single Protein
J. Exp. Med., February 3, 1997; 185(3): 429 - 438.
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S Martin, J. Rice, G. Gould, S. Keller, J. Slot, and D. James
The glucose transporter GLUT4 and the aminopeptidase vp165 colocalise in tubulo-vesicular elements in adipocytes and cardiomyocytes
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A Simonsen, E Stang, B Bremnes, M Roe, K Prydz, and O Bakke
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J. Salamero, R. Le Borgne, C. Saudrais, B. Goud, and B. Hoflack
Expression of Major Histocompatibility Complex Class II Molecules in HeLa Cells Promotes the Recruitment of AP-1 Golgi-specific Assembly Proteins on Golgi Membranes
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				R. S. Mitchell, R. Chaudhuri, O. W. Lindwasser, K. A. Tanaka, D. Lau, R. Murillo, J. S. Bonifacino, and J. C. Guatelli Competition Model for Upregulation of the Major Histocompatibility Complex Class II-Associated Invariant Chain by Human Immunodeficiency Virus Type 1 Nef J. Virol., August 15, 2008; 82(16): 7758 - 7767. [Abstract] [Full Text] [PDF]

				L. Ye, X. Liu, S. N. Rout, Z. Li, Y. Yan, L. Lu, T. Kamala, N. K. Nanda, W. Song, S. K. Samal, et al. The MHC Class II-Associated Invariant Chain Interacts with the Neonatal Fc{gamma} Receptor and Modulates Its Trafficking to Endosomal/Lysosomal Compartments J. Immunol., August 15, 2008; 181(4): 2572 - 2585. [Abstract] [Full Text] [PDF]

				E. Walseng, O. Bakke, and P. A. Roche Major Histocompatibility Complex Class II-Peptide Complexes Internalize Using a Clathrin- and Dynamin-independent Endocytosis Pathway J. Biol. Chem., May 23, 2008; 283(21): 14717 - 14727. [Abstract] [Full Text] [PDF]

				S. Becker-Herman, G. Arie, H. Medvedovsky, A. Kerem, and I. Shachar CD74 Is a Member of the Regulated Intramembrane Proteolysis-processed Protein Family Mol. Biol. Cell, November 1, 2005; 16(11): 5061 - 5069. [Abstract] [Full Text] [PDF]

				H. Khalil, A. Brunet, and J. Thibodeau A three-amino-acid-long HLA-DR{beta} cytoplasmic tail is sufficient to overcome ER retention of invariant-chain p35 J. Cell Sci., October 15, 2005; 118(20): 4679 - 4687. [Abstract] [Full Text] [PDF]

				G. A. Azar, R.-P. Sekaly, and J. Thibodeau A Defective Viral Superantigen-Presenting Phenotype in HLA-DR Transfectants Is Corrected by CIITA J. Immunol., June 15, 2005; 174(12): 7548 - 7557. [Abstract] [Full Text] [PDF]

				P. J. McCormick, J. A. Martina, and J. S. Bonifacino Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments PNAS, May 31, 2005; 102(22): 7910 - 7915. [Abstract] [Full Text] [PDF]

				M. Dugast, H. Toussaint, C. Dousset, and P. Benaroch AP2 Clathrin Adaptor Complex, but Not AP1, Controls the Access of the Major Histocompatibility Complex (MHC) Class II to Endosomes J. Biol. Chem., May 20, 2005; 280(20): 19656 - 19664. [Abstract] [Full Text] [PDF]

				L. M. Sevilla, S. S. Comstock, K. Swier, and J. Miller Endoplasmic Reticulum-Associated Degradation-Induced Dissociation of Class II Invariant Chain Complexes Containing a Glycosylation-Deficient Form of p41 J. Immunol., August 15, 2004; 173(4): 2586 - 2593. [Abstract] [Full Text] [PDF]

				A. Bonehill, C. Heirman, S. Tuyaerts, A. Michiels, K. Breckpot, F. Brasseur, Y. Zhang, P. van der Bruggen, and K. Thielemans Messenger RNA-Electroporated Dendritic Cells Presenting MAGE-A3 Simultaneously in HLA Class I and Class II Molecules J. Immunol., June 1, 2004; 172(11): 6649 - 6657. [Abstract] [Full Text] [PDF]

				L. A. Perrin-Cocon, C. L. Villiers, J. Salamero, F. Gabert, and P. N. Marche B Cell Receptors and Complement Receptors Target the Antigen to Distinct Intracellular Compartments J. Immunol., March 15, 2004; 172(6): 3564 - 3572. [Abstract] [Full Text] [PDF]

				T. F. Gregers, B. Fleckenstein, F. Vartdal, P. Roepstorff, O. Bakke, and I. Sandlie MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation Int. Immunol., November 1, 2003; 15(11): 1291 - 1299. [Abstract] [Full Text] [PDF]

				H. Khalil, A. Brunet, I. Saba, R. Terra, R. P. Sekaly, and J. Thibodeau The MHC class II {beta} chain cytoplasmic tail overcomes the invariant chain p35-encoded endoplasmic reticulum retention signal Int. Immunol., October 1, 2003; 15(10): 1249 - 1263. [Abstract] [Full Text] [PDF]

				T. W. Nordeng, T. F. Gregers, T. L. Kongsvik, S. Meresse, J.-P. Gorvel, F. Jourdan, A. Motta, and O. Bakke The Cytoplasmic Tail of Invariant Chain Regulates Endosome Fusion and Morphology Mol. Biol. Cell, June 1, 2002; 13(6): 1846 - 1856. [Abstract] [Full Text] [PDF]

				H. Katagiri, T. Asano, T. Yamada, T. Aoyama, Y. Fukushima, M. Kikuchi, T. Kodama, and Y. Oka Acyl-Coenzyme A Dehydrogenases Are Localized on GLUT4-Containing Vesicles via Association with Insulin-Regulated Aminopeptidase in a Manner Dependent on Its Dileucine Motif Mol. Endocrinol., May 1, 2002; 16(5): 1049 - 1059. [Abstract] [Full Text] [PDF]

				D. Matza, F. Lantner, Y. Bogoch, L. Flaishon, R. Hershkoviz, and I. Shachar Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity PNAS, February 20, 2002; (2002) 52703299. [Abstract] [Full Text] [PDF]

				I. Topilski, A. Harmelin, R. A. Flavell, Y. Levo, and I. Shachar Preferential Th1 Immune Response in Invariant Chain-Deficient Mice J. Immunol., February 15, 2002; 168(4): 1610 - 1617. [Abstract] [Full Text] [PDF]

				C. Lagaudriere-Gesbert, S. L. Newmyer, T. F. Gregers, O. Bakke, and H. L. Ploegh Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments PNAS, January 24, 2002; (2002) 42688099. [Abstract] [Full Text] [PDF]

				A. Engering and J. Pieters Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells Int. Immunol., February 1, 2001; 13(2): 127 - 134. [Abstract] [Full Text] [PDF]

				L. Zaliauskiene, S. Kang, C. G. Brouillette, J. Lebowitz, R. B. Arani, and J. F. Collawn Down-Regulation of Cell Surface Receptors Is Modulated by Polar Residues within the Transmembrane Domain Mol. Biol. Cell, August 1, 2000; 11(8): 2643 - 2655. [Abstract] [Full Text]

				L. Santambrogio, A. K. Sato, F. R. Fischer, M. E. Dorf, and L. J. Stern Abundant empty class II MHC molecules on the surface of immature dendritic cells PNAS, December 21, 1999; 96(26): 15050 - 15055. [Abstract] [Full Text] [PDF]

				M. W. Hofmann, S. Honing, D. Rodionov, B. Dobberstein, K. von Figura, and O. Bakke The Leucine-based Sorting Motifs in the Cytoplasmic Domain of the Invariant Chain Are Recognized by the Clathrin Adaptors AP1 and AP2 and their Medium Chains J. Biol. Chem., December 17, 1999; 274(51): 36153 - 36158. [Abstract] [Full Text] [PDF]

				R. L. Meighan-Mantha, D. K. W. Hsu, Y. Guo, S. A. N. Brown, S.-L. Y. Feng, K. A. Peifley, G. F. Alberts, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, et al. The Mitogen-inducible Fn14 Gene Encodes a Type I Transmembrane Protein that Modulates Fibroblast Adhesion and Migration J. Biol. Chem., November 12, 1999; 274(46): 33166 - 33176. [Abstract] [Full Text] [PDF]

				E. E. Eynon, C. Schlax, and J. Pieters A Secreted Form of the Major Histocompatibility Complex Class II-associated Invariant Chain Inhibiting T Cell Activation J. Biol. Chem., September 10, 1999; 274(37): 26266 - 26271. [Abstract] [Full Text] [PDF]

				J. B. Ashman and J. Miller A Role for the Transmembrane Domain in the Trimerization of the MHC Class II-Associated Invariant Chain J. Immunol., September 1, 1999; 163(5): 2704 - 2712. [Abstract] [Full Text] [PDF]

				L. Pond and C. Watts Functional Early Endosomes Are Required for Maturation of Major Histocompatibility Complex Class II Molecules in Human B Lymphoblastoid Cells J. Biol. Chem., June 18, 1999; 274(25): 18049 - 18054. [Abstract] [Full Text] [PDF]

				P. A. Calvo, D. W. Frank, B. M. Bieler, J. F. Berson, and M. S. Marks A Cytoplasmic Sequence in Human Tyrosinase Defines a Second Class of Di-leucine-based Sorting Signals for Late Endosomal and Lysosomal Delivery J. Biol. Chem., April 30, 1999; 274(18): 12780 - 12789. [Abstract] [Full Text] [PDF]

				F. Forquet, N. Barois, P. Machy, J. Trucy, V. S. Zimmermann, L. Leserman, and J. Davoust Presentation of Antigens Internalized Through the B Cell Receptor Requires Newly Synthesized MHC Class II Molecules J. Immunol., March 15, 1999; 162(6): 3408 - 3416. [Abstract] [Full Text] [PDF]

				A. Samaan, J. Thibodeau, W. Mahana, F. Castellino, P. A. Cazenave, and T. J. Kindt Cellular distribution of a mixed MHC class II heterodimer between DR{alpha} and a chimeric DO� chain Int. Immunol., January 1, 1999; 11(1): 99 - 111. [Abstract] [Full Text] [PDF]

				D. Maurer, E. Fiebiger, B. Reininger, C. Ebner, P. Petzelbauer, G.-P. Shi, H. A. Chapman, and G. Stingl Fc{epsilon} Receptor I on Dendritic Cells Delivers IgE-Bound Multivalent Antigens into a Cathepsin S-Dependent Pathway of MHC Class II Presentation J. Immunol., September 15, 1998; 161(6): 2731 - 2739. [Abstract] [Full Text] [PDF]