Differential effects of temperature blockade on the proteolytic processing of three secretory granule-associated proteins

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Milgram, S. L.
	Articles by Mains, R. E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Milgram, S. L.
	Articles by Mains, R. E.


Social Bookmarking

	What's this?

Bailyes, E. M., Shennan, K. I. J., Seal, A. J., Smeekens, S. P., Steiner, D. F., Hutton, J. C. and Docherty, K (1992). A member of the eukaryoticsubtilisin family (PC3) has the enzymic properties of the type 1 proinsulin-converting endopeptidase. Biochem. J 285, 391-394.

Baeuerle, P. A. and Huttner, W. B (1987). Tyrosine sulfation is a trans- Golgi-specific protein modification. J. Cell Biol 105, 2655-2664.[Abstract/Free Full Text]

Benjannet, S., Reudelhuber T., Mercure, C., Rodeau, N., Chretien, M. and Seidah, N. G (1992). Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. J. Biol. Chem 267, 11417-11423.[Abstract/Free Full Text]

Bourbonnais, Y., Germain, D., Latchinian-Sadek, L., Boileau, G. and Thomas, D. Y (1991). Prohormone processing by yeast proteases. Enzyme 45, 244-256.[Medline]

Bourdais, J., Devilliers, G., Girard, R., Morel, A., Benedetti, L. and Cohen, P (1990). Prosomatostatin II processing is initiated in the trans -Golgi network of anglerfish pancreatic cells. Biochem. Biophys. Res. Commun 170, 1263-1272.[Medline]

Bresnahan, P. A., Leduc, R., Thomas, L., Thorner, J., Gibson, H. L., Brake, A. J., Barr, P. J. and Thomas, G (1990). Human furin gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J. Cell Biol 111, 2851-2859.[Abstract/Free Full Text]

Chanat, E. and Huttner, W. B (1991). Milieu-induced selective aggregation of regulated secretory proteins in the trans- Golgi network. J. Cell Biol 115, 1505-1520.[Abstract/Free Full Text]

Davidson, H. W., Rhodes, C. J. and Hutton, J. C (1988). Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic B-cell via two distinct site-specific endopeptidases. Nature 333, 93-96.[Medline]

Day, R. M., Schafer, M. K. H., Watson, S. J., Chretien, M. and Seidah, N. G (1992). Distribution and regulation of PC1 and PC2 in the rat pituitary. Mol. Endocrinol 6, 485-497.[Abstract/Free Full Text]

Eipper, B. A., Park, L. P., Dickerson, I. M., Keutmann, H. T., Thiele, E. A., Rodriguez, H., Schofield, P. R. and Mains, R. E (1987). Structure of the precursor to an enzyme mediating COOH-terminal amidation. Mol. Endocrinol 1, 777-790.[Abstract/Free Full Text]

Eipper, B. A., Bloomquist, B. T., Husten, E. J., Milgram, S. L. and Mains, R. E (1993). Peptidylglycine-amidating monooxygenase and other processing enzymes in the neurointermediate pituitary: the melanotropic peptides. Ann. NY Acad. Sci 680, 147-160.[Medline]

Eipper, B. A., Milgram, S. L., Husten, E. J., Yun, H.-Y. and Mains, R. E (1993). Peptidylglycine-amidating monooxygenase: A multifunctional protein with catalytic, processing, and routing domains. Protein Sci 2, 489-497.[Medline]

Fiedorek, F. T. Jr and Parkinson, D (1992). Carboxypeptidase H processing and secretion in rat clonal-cell lines. Endocrinology 131, 1054-1062.[Abstract/Free Full Text]

Fricker, L. D., Das, B. and Hogue Angeletti, R (1990). Identification of the pH-dependent membrane anchor of carboxypeptidase E (EC 3.4.17.10). J. Biol. Chem 265, 2476-2482.[Abstract/Free Full Text]

Greene, D., Das, B. and Fricker, L (1992). Regulation of carboxypeptidase E. Biochem. J 285, 613-618.

Griffiths, G., Pfeiffer, S., Simons, K. and Matlin, K (1985). Exit of newly synthesized membrane proteins from the trans cisterna of the Golgi complex to the plasma membrane. J. Cell Biol 101, 949-964.[Abstract/Free Full Text]

Griffiths, G. and Simons, K (1986). The trans- Golgi network: sorting at the exit site of the Golgi complex. Science 234, 438-443.[Abstract/Free Full Text]

Guest, P. C., Ravazzola, M., Davidson, H. W., Orci, L. and Hutton, J. C (1991). Molecular heterogeneity and cellular localization of carboxypeptidase H in the islets of Langerhans. Endocrinology 129, 734-740.[Abstract/Free Full Text]

Guest, P. C., Arden, S. D., Bennett, D. L., Clark, A., Rutherford, N. G. and Hutton J. C (1992). The post-translational processing and intracellular sorting of PC2 in the islets of Langerhans. J. Biol. Chem 267, 22401-22406.[Abstract/Free Full Text]

Hong, W. and Tang, B. L (1993). Protein trafficking along the exocytotic pathway. BioEssays 15, 231-238.[Medline]

Jean, F., Basak, A., Rondeau, N., Benjannet, S., Hendy, G. N., Seidah, N. G., Chretien, M. and Lazure, C (1993). Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells. Biochem. J 292, 891-900.

Jung, L. J., Kreiner, T. and Scheller, R. H (1993). Expression of mutant ELH prohormones in AtT-20 cells: the relationship between prohormone processing and sorting. J. Cell Biol 121, 11-21.[Abstract/Free Full Text]

Klein, R. S. and Fricker, L. D (1993). Differential effects of a phorbol esteron carboxypeptidase E in cultured astrocytes and AtT-20 cells. J. Neurochem 60, 1615-1625.[Medline]

Kuliawat, R. and Arvan, P (1992). Protein targeting via the \324constitutive-like' secretory pathway in isolated pancreatic islets: passive sorting in the immature granule compartment. J. Cell Biol 118, 521-529.[Abstract/Free Full Text]

Leduc, R., Molloy S. S., Thorne, B. A. and Thomas G (1992). Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage. J. Biol. Chem 267, 14304-14308.[Abstract/Free Full Text]

Lepage-Lezin, A., Joseph-Bravo, P., Devilliers, G., Benedetti, L., Launay, J. M., Gomez, S. and Cohen, P (1991). Prosomatostatin is processed in the Golgi apparatus of rat neural cells. J. Biol. Chem 266, 1679-1688.[Abstract/Free Full Text]

Lodish, H. F., Kong, N., Snider, M. and Strous, G. J. A. M (1983). Hepatoma secretory proteins migrate from rough endoplasmic reticulum to Golgi at characteristic rates. Nature 304, 80-83.[Medline]

Mains, R. E. and Eipper, B. A (1984). Secretion and regulation of two biosynthetic enzyme activities, peptidyl-glycine-amidating monooxygenase and a carboxypeptidase, by mouse pituitary corticotropic tumor cells. Endocrinology 115, 1683-1690.[Abstract/Free Full Text]

Mains, R. E., Dickerson, I. M., May, V., Stoffers, D. A., Perkins, S. N., Ouafik, L' H., Husten, E. J. and Eipper, B. A (1990). Cellular and molecular aspects of peptide hormone biosynthesis. Front. Neuroendocrinol 11, 52-89.

Matsuuchi, L. and Kelly, R. B (1991). Constitutive and basal secretion from the endocrine cell line, AtT-20. J. Cell Biol 112, 843-852.[Abstract/Free Full Text]

Mellman, I. and Simons, K (1992). The Golgi complex: in vitro veritas?. Cell 68, 829-840.[Medline]

Milgram, S. L., Johnson, R. C. and Mains, R. E (1992). Expression of individual forms of peptidylglycine-amidating monooxygenase in AtT-20 cells: endoproteolytic processing and routing to secretory granules. J. Cell Biol 117, 717-728.[Abstract/Free Full Text]

Milgram, S. L., Mains, R. E. and Eipper, B. A (1993). COOH-terminal signals mediate the trafficking of a peptide processing enzyme in endocrine cells. J. Cell Biol 121, 23-36.[Abstract/Free Full Text]

Molloy, S. S., Bresnahan, P. A., Leppla, S. H., Klimpel, K. R. and Gary T (1992). Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J. Biol. Chem 267, 16396-16402.[Abstract/Free Full Text]

Nillni, E. A., Sevarino, K. A. and Jackson, I. M. D (1993). Processing of proTRH to its intermediate products occurs before the packing into secretory granules of transfected AtT20 cells. Endocrinology 132, 1271-1277.[Abstract/Free Full Text]

Noel, G. and Mains, R. E (1991). The ordered secretion of bioactive peptides: oldest or newest first?. Mol. Endocrinol 5, 787-794.[Abstract/Free Full Text]

Orci, L., Ravazzola, M., Storch, M.-J., Anderson, R. G. W., Vassalli, J.-D. and Perrelet A (1987). Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles. Cell 49, 865-868.[Medline]

Rhodes, C. J., Thorne, B. A., Lincoln, B., Nielsen, E., Hutton, J. C. and Thoms, G (1993). Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases. J. Biol. Chem 268, 4267-4275.[Abstract/Free Full Text]

Saraste, J. and Kuismanen, E (1984). Pre-and post-Golgi vacuoles operate in the transport of Semliki forest virus membrane glycoproteins to the cell surface. Cell 38, 535-549.[Medline]

Schnabel, E., Mains, R. E. and Farquhar M. G (1989). Proteolytic processing of Pro-ACTH/endorphin begins in the Golgi complex of pituitary corticotropes and AtT-20 cells. Mol. Endocrinol 3, 1223-1235.[Abstract/Free Full Text]

Smeekens, S. P., Montag, A. G., Thomas, G., Albiges-Rizo, C., Carroll, R., Benig, M., Phillips, L. A., Martin, S., Ohagi, S., Gardner, P., Swift, H. H. and Steiner, D. F (1992). Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Proc. Nat. Acad. Sci. USA 89, 8822-8826.[Abstract/Free Full Text]

Smeekens, S. P (1993). Processing of protein precursors by a novel family of subtilisin-related mammalian endoproteases. Biotechnology 11, 182-186.[Medline]

Steiner, D. F., Michael, J., Houghten, R., Mathieu, M., Gardner, P. R., Ravazzola, M. and Orci, L (1987). Use of a synthetic peptide antigen to generate antisera reactive with a proteolytic processing site in native human proinsulin: demonstration of cleavage within clathrin-coated (pro)secretory vesicles. Proc. Nat. Acad. Sci. USA 84, 6184-6188.[Abstract/Free Full Text]

Steiner, D. F., Smeekens, S. P., Ohagi, S. and Chan, S. J (1992). The new enzymology of precursor processing endoproteases. J. Biol. Chem 267, 23435-23438.[Free Full Text]

Tausk, F. A., Milgram, S. L., Mains, R. E. and Eipper, B. A (1992). Expression of a peptide processing enzyme in cultured cells: truncation mutants reveal a routing domain. Mol. Endocrinol 6, 2185-2196.[Abstract/Free Full Text]

Tooze, J., Hollinshead, M., Frank, R. and Burke, B (1987). An antibody specific for an endoproteolytic cleavage site provides evidence that proopiomelanocortin is packaged into secretory granules in AtT-20 cells before its cleavage. J. Cell Biol 105, 155-162.[Abstract/Free Full Text]

Tooze, S. A (1991). Biogenesis of secretory granules. FEBS Lett 285, 220-224.[Medline]

Uhler, M. and Herbert, E (1983). Complete amino acid sequence of mouse proopiomelanocortin derived from the nucleotide sequence of cDNA. J. Biol. Chem 258, 257-261.[Abstract/Free Full Text]

Vindrola, O. and Lindberg, I (1992). Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells. Mol. Endocrinol 6, 1088-1094.[Abstract/Free Full Text]

Vuillez, P., Rene, F., Plante, M., Hindelang, C., Klein, M. J., Felix, J. M. and Stoeckel, M. E (1992). Differentiation of the melanotropic cells of rat pituitary primordium in organotypic culture in defined medium. Cell Tissue Res 267, 169-183.[Medline]

Watanabe, T., Nakagawa, T., Ikemizu, J., Nagahama, M., Murakami, K. and Nakayama, K (1992). Sequence requirements for precursor cleavage within the constitutive secretory pathway. J. Biol. Chem 267, 8270-8274.[Abstract/Free Full Text]

Zhou, A., Bloomquist, B. T. and Mains, R. E (1993). The prohormone convertases PC1 and PC2 mediate distinct endoproteolytic cleavages in astrict temporal order during proopiomelanocortin biosynthetic processing. J. Biol. Chem 268, 1763-1769.[Abstract/Free Full Text]

Zhou, Y. and Lindberg, I (1993). Purification and characterization of the prohormone convertase PC1 (PC3). J. Biol. Chem._Fb_268 , 5615-5623.After submission of this work, two relevant papers have appeared. Benjannet et al. ( Biochem. J._Fb_294 , 735-743 (1993)) have expressed PC1 in GH4C1 cells and have also reported that the initial cleavage of PC1 is resistant to blockade at 15degC. Xu and Shields (. J. Cell Biol 122, 1169-1184.[Abstract/Free Full Text]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

L. E. Pritchard and A. White
Neuropeptide Processing and Its Impact on Melanocortin Pathways
Endocrinology, September 1, 2007; 148(9): 4201 - 4207.
[Abstract] [Full Text] [PDF]

S.-N. Lee, J. R. Hwang, and I. Lindberg
Neuroendocrine Protein 7B2 Can Be Inactivated by Phosphorylation within the Secretory Pathway
J. Biol. Chem., February 10, 2006; 281(6): 3312 - 3320.
[Abstract] [Full Text] [PDF]

A. Claperon, C. Rose, P. Gane, E. Collec, O. Bertrand, and T. Ouimet
The Kell Protein of the Common K2 Phenotype Is a Catalytically Active Metalloprotease, whereas the Rare Kell K1 Antigen Is Inactive: IDENTIFICATION OF NOVEL SUBSTRATES FOR THE KELL PROTEIN
J. Biol. Chem., June 3, 2005; 280(22): 21272 - 21283.
[Abstract] [Full Text] [PDF]

M. Marti, Y. Li, E. M. Schraner, P. Wild, P. Kohler, and A. B. Hehl
The Secretory Apparatus of an Ancient Eukaryote: Protein Sorting to Separate Export Pathways Occurs Before Formation of Transient Golgi-like Compartments
Mol. Biol. Cell, April 1, 2003; 14(4): 1433 - 1447.
[Abstract] [Full Text] [PDF]

O. Garmendia, M. P. Rodriguez, M. A. Burrell, and A. C. Villaro
Immunocytochemical Finding of the Amidating Enzymes in Mouse Pancreatic A-, B-, and D-cells: A Comparison with Human and Rat
J. Histochem. Cytochem., October 1, 2002; 50(10): 1401 - 1416.
[Abstract] [Full Text] [PDF]

T. C. Steveson, G. C. Zhao, H. T. Keutmann, R. E. Mains, and B. A. Eipper
Access of a Membrane Protein to Secretory Granules Is Facilitated by Phosphorylation
J. Biol. Chem., October 19, 2001; 276(43): 40326 - 40337.
[Abstract] [Full Text] [PDF]

M. R. Alam, T. C. Steveson, R. C. Johnson, N. Back, B. Abraham, R. E. Mains, and B. A. Eipper
Signaling Mediated by the Cytosolic Domain of Peptidylglycine {alpha}-Amidating Monooxygenase
Mol. Biol. Cell, March 1, 2001; 12(3): 629 - 644.
[Abstract] [Full Text]

R. El Meskini, L. Jin, R. Marx, A. Bruzzaniti, J. Lee, R. B. Emeson, and R. E. Mains
A Signal Sequence Is Sufficient for Green Fluorescent Protein to Be Routed to Regulated Secretory Granules
Endocrinology, February 1, 2001; 142(2): 864 - 873.
[Abstract] [Full Text] [PDF]

O Varlamov, E Kalinina, F. Che, and L. Fricker
Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-trans-Golgi network trafficking
J. Cell Sci., January 1, 2001; 114(2): 311 - 322.
[Abstract] [PDF]

E. A. Nillni and K. A. Sevarino
The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides
Endocr. Rev., October 1, 1999; 20(5): 599 - 648.
[Abstract] [Full Text]

A. Bruzzaniti, R. Marx, and R. E. Mains
Activation and Routing of Membrane-tethered Prohormone Convertases 1 and 2
J. Biol. Chem., August 27, 1999; 274(35): 24703 - 24713.
[Abstract] [Full Text] [PDF]

T. C. Steveson, H. T. Keutmann, R. E. Mains, and B. A. Eipper
Phosphorylation of Cytosolic Domain Ser937 Affects Both Biosynthetic and Endocytic Trafficking of Peptidylglycine alpha -Amidating Monooxygenase
J. Biol. Chem., July 23, 1999; 274(30): 21128 - 21138.
[Abstract] [Full Text] [PDF]

O. Varlamov, F. J. Eng, E. G. Novikova, and L. D. Fricker
Localization of Metallocarboxypeptidase D in AtT-20 Cells. POTENTIAL ROLE IN PROHORMONE PROCESSING
J. Biol. Chem., May 21, 1999; 274(21): 14759 - 14767.
[Abstract] [Full Text] [PDF]

C. Rovere, J. Luis, J.-C. Lissitzky, A. Basak, J. Marvaldi, M. Chretien, and N. G. Seidah
The RGD Motif and the C-terminal Segment of Proprotein Convertase 1�Are Critical for Its Cellular Trafficking but Not for Its Intracellular Binding to Integrin alpha 5beta 1
J. Biol. Chem., April 30, 1999; 274(18): 12461 - 12467.
[Abstract] [Full Text] [PDF]

A. Zhou, S. Martin, G. Lipkind, J. LaMendola, and D. F. Steiner
Regulatory Roles of the P Domain of the Subtilisin-like Prohormone Convertases
J. Biol. Chem., May 1, 1998; 273(18): 11107 - 11114.
[Abstract] [Full Text] [PDF]

R. Marx and R. E. Mains
Adenovirally Encoded Prohormone Convertase-1 Functions in Atrial Myocyte Large Dense Core Vesicles
Endocrinology, December 1, 1997; 138(12): 5108 - 5118.
[Abstract] [Full Text] [PDF]

C. J. Fernandez, M. Haugwitz, B. Eaton, and H.-P. H. Moore
Distinct Molecular Events during Secretory Granule Biogenesis Revealed by Sensitivities to Brefeldin A
Mol. Biol. Cell, November 1, 1997; 8(11): 2171 - 2185.
[Abstract] [Full Text]

S. Milgram, S. Kho, G. Martin, R. Mains, and B. Eipper
Localization of integral membrane peptidylglycine alpha-amidating monooxygenase in neuroendocrine cells
J. Cell Sci., January 3, 1997; 110(6): 695 - 706.
[Abstract] [PDF]

K. Johanning, J. P. Mathis, and I. Lindberg
Processing Site Blockade Results in More Efficient Conversion of Proenkephalin to Active Opioid Peptides
J. Biol. Chem., November 1, 1996; 271(44): 27871 - 27878.
[Abstract] [Full Text] [PDF]

I. P. d. l. Cruz and E. A. Nillni
Intracellular Sites of Prothyrotropin-releasing Hormone Processing
J. Biol. Chem., September 13, 1996; 271(37): 22736 - 22745.
[Abstract] [Full Text] [PDF]

S. L. Milgram, R. E. Mains, and B. A. Eipper
Identification of Routing Determinants in the Cytosolic Domain of a Secretory Granule-associated Integral Membrane Protein
J. Biol. Chem., July 19, 1996; 271(29): 17526 - 17535.
[Abstract] [Full Text] [PDF]

M. R. Schiller, R. E. Mains, and B. A. Eipper
A Neuroendocrine-specific Protein Localized to the Endoplasmic Reticulum by Distal Degradation
J. Biol. Chem., November 3, 1995; 270(44): 26129 - 26138.
[Abstract] [Full Text] [PDF]

Y. Zhou, C. Rovere, P. Kitabgi, and I. Lindberg
Mutational Analysis of PC1 (SPC3) in PC12 Cells
J. Biol. Chem., October 20, 1995; 270(42): 24702 - 24706.
[Abstract] [Full Text] [PDF]

A. Zhou, L. Paquet, and R. E. Mains
Structural Elements That Direct Specific Processing of Different Mammalian Subtilisin-like Prohormone Convertases
J. Biol. Chem., September 15, 1995; 270(37): 21509 - 21516.
[Abstract] [Full Text] [PDF]

H.-Y. Yun and B. A. Eipper
Addition of an Endoplasmic Reticulum Retention/Retrieval Signal Does Not Block Maturation of Enzymatically Active Peptidylglycine [IMAGE]-Amidating Monooxygenase
J. Biol. Chem., June 23, 1995; 270(25): 15412 - 15416.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Milgram, S. L.

Articles by Mains, R. E.

Search for Related Content

PubMed

PubMed Citation

Articles by Milgram, S. L.

Articles by Mains, R. E.

Social Bookmarking

What's this?

				S.-N. Lee, J. R. Hwang, and I. Lindberg Neuroendocrine Protein 7B2 Can Be Inactivated by Phosphorylation within the Secretory Pathway J. Biol. Chem., February 10, 2006; 281(6): 3312 - 3320. [Abstract] [Full Text] [PDF]

				A. Claperon, C. Rose, P. Gane, E. Collec, O. Bertrand, and T. Ouimet The Kell Protein of the Common K2 Phenotype Is a Catalytically Active Metalloprotease, whereas the Rare Kell K1 Antigen Is Inactive: IDENTIFICATION OF NOVEL SUBSTRATES FOR THE KELL PROTEIN J. Biol. Chem., June 3, 2005; 280(22): 21272 - 21283. [Abstract] [Full Text] [PDF]

				M. Marti, Y. Li, E. M. Schraner, P. Wild, P. Kohler, and A. B. Hehl The Secretory Apparatus of an Ancient Eukaryote: Protein Sorting to Separate Export Pathways Occurs Before Formation of Transient Golgi-like Compartments Mol. Biol. Cell, April 1, 2003; 14(4): 1433 - 1447. [Abstract] [Full Text] [PDF]

				O. Garmendia, M. P. Rodriguez, M. A. Burrell, and A. C. Villaro Immunocytochemical Finding of the Amidating Enzymes in Mouse Pancreatic A-, B-, and D-cells: A Comparison with Human and Rat J. Histochem. Cytochem., October 1, 2002; 50(10): 1401 - 1416. [Abstract] [Full Text] [PDF]

				T. C. Steveson, G. C. Zhao, H. T. Keutmann, R. E. Mains, and B. A. Eipper Access of a Membrane Protein to Secretory Granules Is Facilitated by Phosphorylation J. Biol. Chem., October 19, 2001; 276(43): 40326 - 40337. [Abstract] [Full Text] [PDF]

				M. R. Alam, T. C. Steveson, R. C. Johnson, N. Back, B. Abraham, R. E. Mains, and B. A. Eipper Signaling Mediated by the Cytosolic Domain of Peptidylglycine {alpha}-Amidating Monooxygenase Mol. Biol. Cell, March 1, 2001; 12(3): 629 - 644. [Abstract] [Full Text]

				R. El Meskini, L. Jin, R. Marx, A. Bruzzaniti, J. Lee, R. B. Emeson, and R. E. Mains A Signal Sequence Is Sufficient for Green Fluorescent Protein to Be Routed to Regulated Secretory Granules Endocrinology, February 1, 2001; 142(2): 864 - 873. [Abstract] [Full Text] [PDF]

				O Varlamov, E Kalinina, F. Che, and L. Fricker Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-trans-Golgi network trafficking J. Cell Sci., January 1, 2001; 114(2): 311 - 322. [Abstract] [PDF]

				E. A. Nillni and K. A. Sevarino The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides Endocr. Rev., October 1, 1999; 20(5): 599 - 648. [Abstract] [Full Text]

				A. Bruzzaniti, R. Marx, and R. E. Mains Activation and Routing of Membrane-tethered Prohormone Convertases 1 and 2 J. Biol. Chem., August 27, 1999; 274(35): 24703 - 24713. [Abstract] [Full Text] [PDF]

				T. C. Steveson, H. T. Keutmann, R. E. Mains, and B. A. Eipper Phosphorylation of Cytosolic Domain Ser937 Affects Both Biosynthetic and Endocytic Trafficking of Peptidylglycine alpha -Amidating Monooxygenase J. Biol. Chem., July 23, 1999; 274(30): 21128 - 21138. [Abstract] [Full Text] [PDF]

				O. Varlamov, F. J. Eng, E. G. Novikova, and L. D. Fricker Localization of Metallocarboxypeptidase D in AtT-20 Cells. POTENTIAL ROLE IN PROHORMONE PROCESSING J. Biol. Chem., May 21, 1999; 274(21): 14759 - 14767. [Abstract] [Full Text] [PDF]

				C. Rovere, J. Luis, J.-C. Lissitzky, A. Basak, J. Marvaldi, M. Chretien, and N. G. Seidah The RGD Motif and the C-terminal Segment of Proprotein Convertase 1�Are Critical for Its Cellular Trafficking but Not for Its Intracellular Binding to Integrin alpha 5beta 1 J. Biol. Chem., April 30, 1999; 274(18): 12461 - 12467. [Abstract] [Full Text] [PDF]

				A. Zhou, S. Martin, G. Lipkind, J. LaMendola, and D. F. Steiner Regulatory Roles of the P Domain of the Subtilisin-like Prohormone Convertases J. Biol. Chem., May 1, 1998; 273(18): 11107 - 11114. [Abstract] [Full Text] [PDF]

				R. Marx and R. E. Mains Adenovirally Encoded Prohormone Convertase-1 Functions in Atrial Myocyte Large Dense Core Vesicles Endocrinology, December 1, 1997; 138(12): 5108 - 5118. [Abstract] [Full Text] [PDF]

				C. J. Fernandez, M. Haugwitz, B. Eaton, and H.-P. H. Moore Distinct Molecular Events during Secretory Granule Biogenesis Revealed by Sensitivities to Brefeldin A Mol. Biol. Cell, November 1, 1997; 8(11): 2171 - 2185. [Abstract] [Full Text]

				S. Milgram, S. Kho, G. Martin, R. Mains, and B. Eipper Localization of integral membrane peptidylglycine alpha-amidating monooxygenase in neuroendocrine cells J. Cell Sci., January 3, 1997; 110(6): 695 - 706. [Abstract] [PDF]

				K. Johanning, J. P. Mathis, and I. Lindberg Processing Site Blockade Results in More Efficient Conversion of Proenkephalin to Active Opioid Peptides J. Biol. Chem., November 1, 1996; 271(44): 27871 - 27878. [Abstract] [Full Text] [PDF]

				I. P. d. l. Cruz and E. A. Nillni Intracellular Sites of Prothyrotropin-releasing Hormone Processing J. Biol. Chem., September 13, 1996; 271(37): 22736 - 22745. [Abstract] [Full Text] [PDF]

				S. L. Milgram, R. E. Mains, and B. A. Eipper Identification of Routing Determinants in the Cytosolic Domain of a Secretory Granule-associated Integral Membrane Protein J. Biol. Chem., July 19, 1996; 271(29): 17526 - 17535. [Abstract] [Full Text] [PDF]

				M. R. Schiller, R. E. Mains, and B. A. Eipper A Neuroendocrine-specific Protein Localized to the Endoplasmic Reticulum by Distal Degradation J. Biol. Chem., November 3, 1995; 270(44): 26129 - 26138. [Abstract] [Full Text] [PDF]

				Y. Zhou, C. Rovere, P. Kitabgi, and I. Lindberg Mutational Analysis of PC1 (SPC3) in PC12 Cells J. Biol. Chem., October 20, 1995; 270(42): 24702 - 24706. [Abstract] [Full Text] [PDF]

				A. Zhou, L. Paquet, and R. E. Mains Structural Elements That Direct Specific Processing of Different Mammalian Subtilisin-like Prohormone Convertases J. Biol. Chem., September 15, 1995; 270(37): 21509 - 21516. [Abstract] [Full Text] [PDF]

				H.-Y. Yun and B. A. Eipper Addition of an Endoplasmic Reticulum Retention/Retrieval Signal Does Not Block Maturation of Enzymatically Active Peptidylglycine [IMAGE]-Amidating Monooxygenase J. Biol. Chem., June 23, 1995; 270(25): 15412 - 15416. [Abstract] [Full Text] [PDF]