An LI and ML motif in the cytoplasmic tail of the MHC-associated invariant chain mediate rapid internalization

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				R. S. Mitchell, R. Chaudhuri, O. W. Lindwasser, K. A. Tanaka, D. Lau, R. Murillo, J. S. Bonifacino, and J. C. Guatelli Competition Model for Upregulation of the Major Histocompatibility Complex Class II-Associated Invariant Chain by Human Immunodeficiency Virus Type 1 Nef J. Virol., August 15, 2008; 82(16): 7758 - 7767. [Abstract] [Full Text] [PDF]

				A. M. Keller, T. A. Groothuis, E. A. M. Veraar, M. Marsman, L. M. de Buy Wenniger, H. Janssen, J. Neefjes, and J. Borst Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules PNAS, April 3, 2007; 104(14): 5989 - 5994. [Abstract] [Full Text] [PDF]

				J. Neumann and N. Koch A novel domain on HLA-DR{beta} chain regulates the chaperone role of the invariant chain J. Cell Sci., October 15, 2006; 119(20): 4207 - 4214. [Abstract] [Full Text] [PDF]

				M. Dugast, H. Toussaint, C. Dousset, and P. Benaroch AP2 Clathrin Adaptor Complex, but Not AP1, Controls the Access of the Major Histocompatibility Complex (MHC) Class II to Endosomes J. Biol. Chem., May 20, 2005; 280(20): 19656 - 19664. [Abstract] [Full Text] [PDF]

				C. Scott, M. E. Higgins, J. P. Davies, and Y. A. Ioannou Targeting of NPC1 to Late Endosomes Involves Multiple Signals, Including One Residing within the Putative Sterol-sensing Domain J. Biol. Chem., November 12, 2004; 279(46): 48214 - 48223. [Abstract] [Full Text] [PDF]

				L. M. Sevilla, S. S. Comstock, K. Swier, and J. Miller Endoplasmic Reticulum-Associated Degradation-Induced Dissociation of Class II Invariant Chain Complexes Containing a Glycosylation-Deficient Form of p41 J. Immunol., August 15, 2004; 173(4): 2586 - 2593. [Abstract] [Full Text] [PDF]

				T. F. Gregers, B. Fleckenstein, F. Vartdal, P. Roepstorff, O. Bakke, and I. Sandlie MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation Int. Immunol., November 1, 2003; 15(11): 1291 - 1299. [Abstract] [Full Text] [PDF]

				D. G. Rodionov, S. Honing, A. Silye, T. L. Kongsvik, K. von Figura, and O. Bakke Structural Requirements for Interactions between Leucine-sorting Signals and Clathrin-associated Adaptor Protein Complex AP3 J. Biol. Chem., November 27, 2002; 277(49): 47436 - 47443. [Abstract] [Full Text] [PDF]

				T. W. Nordeng, T. F. Gregers, T. L. Kongsvik, S. Meresse, J.-P. Gorvel, F. Jourdan, A. Motta, and O. Bakke The Cytoplasmic Tail of Invariant Chain Regulates Endosome Fusion and Morphology Mol. Biol. Cell, June 1, 2002; 13(6): 1846 - 1856. [Abstract] [Full Text] [PDF]

				T. L. Kongsvik, S. Honing, O. Bakke, and D. G. Rodionov Mechanism of Interaction between Leucine-based Sorting Signals from the Invariant Chain and Clathrin-associated Adaptor Protein Complexes AP1 and AP2 J. Biol. Chem., May 3, 2002; 277(19): 16484 - 16488. [Abstract] [Full Text] [PDF]

				B. A. Syed, N. J. Beaumont, A. Patel, C. E. Naylor, H. K. Bayele, C. L. Joannou, P. S.N. Rowe, R. W. Evans, and S. K. S. Srai Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin Protein Eng. Des. Sel., March 1, 2002; 15(3): 205 - 214. [Abstract] [Full Text] [PDF]

				L. Zaliauskiene, S. Kang, C. G. Brouillette, J. Lebowitz, R. B. Arani, and J. F. Collawn Down-Regulation of Cell Surface Receptors Is Modulated by Polar Residues within the Transmembrane Domain Mol. Biol. Cell, August 1, 2000; 11(8): 2643 - 2655. [Abstract] [Full Text]

				M. W. Hofmann, S. Honing, D. Rodionov, B. Dobberstein, K. von Figura, and O. Bakke The Leucine-based Sorting Motifs in the Cytoplasmic Domain of the Invariant Chain Are Recognized by the Clathrin Adaptors AP1 and AP2 and their Medium Chains J. Biol. Chem., December 17, 1999; 274(51): 36153 - 36158. [Abstract] [Full Text] [PDF]

				A. D. Blagoveshchenskaya, E. W. Hewitt, and D. F. Cutler Di-Leucine Signals Mediate Targeting of Tyrosinase and Synaptotagmin to Synaptic-like Microvesicles within PC12 Cells Mol. Biol. Cell, November 1, 1999; 10(11): 3979 - 3990. [Abstract] [Full Text]

				A. Simonsen, K. W. Pedersen, T. W. Nordeng, A. von der Lippe, E. Stang, E. O. Long, and O. Bakke Polarized Transport of MHC Class II Molecules in Madin-Darby Canine Kidney Cells Is Directed by a Leucine-Based Signal in the Cytoplasmic Tail of the {beta}-Chain J. Immunol., September 1, 1999; 163(5): 2540 - 2548. [Abstract] [Full Text] [PDF]

				T. W. Nordeng and O. Bakke Overexpression of Proteins Containing Tyrosine- or Leucine-based Sorting Signals Affects Transferrin Receptor Trafficking J. Biol. Chem., July 23, 1999; 274(30): 21139 - 21148. [Abstract] [Full Text] [PDF]

				N. Sharma, A. Crane, J. P. Clement IV, G. Gonzalez, A. P. Babenko, J. Bryan, and L. Aguilar-Bryan The C Terminus of SUR1 Is Required for Trafficking of KATP Channels J. Biol. Chem., July 16, 1999; 274(29): 20628 - 20632. [Abstract] [Full Text] [PDF]

				C. Pitcher, S. Höning, A. Fingerhut, K. Bowers, and M. Marsh Cluster of Differentiation Antigen 4�() Endocytosis and Adaptor Complex Binding Require Activation of the Endocytosis Signal by Serine Phosphorylation Mol. Biol. Cell, March 1, 1999; 10(3): 677 - 691. [Abstract] [Full Text]

				D. Maurer, E. Fiebiger, B. Reininger, C. Ebner, P. Petzelbauer, G.-P. Shi, H. A. Chapman, and G. Stingl Fc{epsilon} Receptor I on Dendritic Cells Delivers IgE-Bound Multivalent Antigens into a Cathepsin S-Dependent Pathway of MHC Class II Presentation J. Immunol., September 15, 1998; 161(6): 2731 - 2739. [Abstract] [Full Text] [PDF]

				C. Geisler, J. Dietrich, B. L. Nielsen, J. Kastrup, J. P. H. Lauritsen, N. Odum, and M. D. Christensen Leucine-based Receptor Sorting Motifs Are Dependent on the Spacing Relative to the Plasma Membrane J. Biol. Chem., August 14, 1998; 273(33): 21316 - 21323. [Abstract] [Full Text] [PDF]

				S. Kang, L. Liang, C. D. Parker, and J. F. Collawn Structural Requirements for Major Histocompatibility Complex Class II Invariant Chain Endocytosis and Lysosomal Targeting J. Biol. Chem., August 7, 1998; 273(32): 20644 - 20652. [Abstract] [Full Text] [PDF]

				P. K. Tan, C. Waites, Y. Liu, D. E. Krantz, and R. H. Edwards A Leucine-based Motif Mediates the Endocytosis of Vesicular Monoamine and Acetylcholine Transporters J. Biol. Chem., July 10, 1998; 273(28): 17351 - 17360. [Abstract] [Full Text] [PDF]

				S. White, S. R. Hatton, M. A. Siddiqui, C. D. Parker, I. S. Trowbridge, and J. F. Collawn Analysis of the Structural Requirements for Lysosomal Membrane Targeting Using Transferrin Receptor Chimeras J. Biol. Chem., June 5, 1998; 273(23): 14355 - 14362. [Abstract] [Full Text] [PDF]

				H. A. Anderson and P. A. Roche Phosphorylation Regulates the Delivery of MHC Class II Invariant Chain Complexes to Antigen Processing Compartments J. Immunol., May 15, 1998; 160(10): 4850 - 4858. [Abstract] [Full Text] [PDF]

				T. Bremnes, V. Lauvrak, B. Lindqvist, and O. Bakke A Region from the Medium Chain Adaptor Subunit (�) Recognizes Leucine- and Tyrosine-based Sorting Signals J. Biol. Chem., April 10, 1998; 273(15): 8638 - 8645. [Abstract] [Full Text] [PDF]

				C. R. Haft, M. de La Luz Sierra, I. Hamer, J.-L. Carpentier, and S. I. Taylor Analysis of the Juxtamembrane Dileucine Motif in the Insulin Receptor Endocrinology, April 1, 1998; 139(4): 1618 - 1629. [Abstract] [Full Text] [PDF]

				C. Saudrais, D. Spehner, H. de la Salle, A. Bohbot, J.-P. Cazenave, B. Goud, D. Hanau, and J. Salamero Intracellular Pathway for the Generation of Functional MHC Class II Peptide Complexes in Immature Human Dendritic Cells J. Immunol., March 15, 1998; 160(6): 2597 - 2607. [Abstract] [Full Text] [PDF]

				D. G. Rodionov and O. Bakke Medium Chains of Adaptor Complexes AP-1 and AP-2 Recognize Leucine-based Sorting Signals from the Invariant Chain J. Biol. Chem., March 13, 1998; 273(11): 6005 - 6008. [Abstract] [Full Text] [PDF]

				J. K. Olson and C. Grose Complex Formation Facilitates Endocytosis of the Varicella-Zoster Virus gE:gI Fc Receptor J. Virol., February 1, 1998; 72(2): 1542 - 1551. [Abstract] [Full Text] [PDF]

				A. D. Blagoveshchenskaya, J. P. Norcott, and D. F. Cutler Lysosomal Targeting of P-selectin Is Mediated by a Novel Sequence within Its Cytoplasmic Tail J. Biol. Chem., January 30, 1998; 273(5): 2729 - 2737. [Abstract] [Full Text] [PDF]