Regulation of Cdc2/cyclin B activation by Ran, a Ras-related GTPase

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Al-Khodairy, F. and Carr, A. M (1992). DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe. EMBO J 11, 1343-1350.[Medline]

Bischoff, F. R., Maier, G., Tilz, G. and Ponstingl, H (1990). A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1 , a gene implicated in onset of chromosome condensation. Proc. Nat. Acad. Sci. USA 87, 8617-8621.[Abstract/Free Full Text]

Bischoff, F. R. and Ponstingl, H (1991). Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 354, 80-82.[Medline]

Bischoff, F. R. and Ponstingl, H (1991). Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide. Proc Nat. Acad. Sci. USA 88, 10830-10834.[Abstract/Free Full Text]

Bischoff, F. R., Klebe, C., Kretschmer, J., Wittinghofer, A. and Ponstingl, H (1994). Ran-GAP1 induces GTPase activity of nuclear Ras-related Ran. Proc. Nat. Acad. Sci. USA 91, 2587-2591.[Abstract/Free Full Text]

Blow, J. J. and Laskey, R. A (1986). Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs. Cell 47, 577-587.[Medline]

Clarke, P. R., Leiss, D., Pagano, M. and Karsenti, E (1992). Cyclin A-and cyclin B-dependent protein kinases are regulated by different mechanisms in Xenopus egg extracts. EMBO J 11, 1751-1761.[Medline]

Clarke, P. R., Hoffmann, I., Draetta, G. and Karsenti, E (1993). Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts. Mol. Biol. Cell 4, 397-411.[Abstract]

Coutavas, E., Ren, M., Oppenheim, J. D., D'Eustachio, P. and Rush, M. G (1993). Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. Nature 366, 585-587.[Medline]

Dasso, M. and Newport, J. W (1990). Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus. Cell 61, 811-823.[Medline]

Dasso, M., Nishitani, H., Kornbluth, S., Nishimoto, T. and Newport, J. W (1992). RCC1, a regulator of mitosis, is essential for DNA replication. Mol. Cell. Biol 12, 3337-3345.[Abstract/Free Full Text]

Drivas, G. T., Shih, A., Coutavas, E., Rush, M. G. and D'Eustachio, P (1990). Characterization of four novel ras -like genes expressed in a human teratocarcinoma cell line. Mol. Cell. Biol 10, 1793-1798.[Abstract/Free Full Text]

Enoch, T. and Nurse, P (1991). Coupling M phase and S phase: controls maintaining the dependence of mitosis on chromosome replication. Cell 65, 921-923.[Medline]

Enoch, T., Carr, A. M. and Nurse, P (1992). Fission yeast genes involved in coupling mitosis to completion of DNA replication. Genes Dev 6, 2035-2046.[Abstract/Free Full Text]

Farnsworth, C. L. and Feig, L. A (1991). Dominant inhibitory mutations in the Mg2+-binding site of RasHprevent its activation by GTP. Mol. Cell. Biol 11, 4822-4829.[Abstract/Free Full Text]

Feig, L. A. and Cooper, G. M (1988). Inhibition of NIH 3T3 cell proliferation by a mutant ras protein with preferential affinity for GDP. Mol. Cell. Biol 8, 3235-3243.[Abstract/Free Full Text]

Glotzer, M., Murray, A. W. and Kirschner, M. W (1991). Cyclin is degraded by the ubiquitin pathway. Nature 349, 132-138.[Medline]

Gould, K. L. and Nurse, P (1989). Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis. Nature 342, 39-45.[Medline]

Gurdon, J. B (1976). Injected nuclei in frog oocytes: Fate, enlargement, and chromatin dispersal. J. Embryol. Exp. Morph 36, 523-540.[Medline]

Hartwell, L. H. and Weinert, T. A (1989). Checkpoints: controls that ensure the order of cell cycle events. Science 246, 629-634.[Abstract/Free Full Text]

Hunt, T (1991). Cyclins and their partners: from a simple idea to complicated reality. Semin. Cell Biol 2, 213-222.[Medline]

Hutchison, C. J., Cox, R., Drepaul, R. S., Gomperts, M. and Ford, C. C (1987). Periodic DNA synthesis in cell-free extracts of Xenopus eggs. EMBO J 6, 2003-2010.[Medline]

John, J., Sohman, R., Feuerstein, J., Linke, R., Wittinghofer, A. and Goody, R (1990). Kinetics of interaction of nucleotides with nucleotide-free H-ras p21. Biochemistry 29, 6058-6065.[Medline]

John, J., Rensland, H., Schlichting, i., Vetter, I., Borasio, G. D., Goody, R. S. and Wittinghofer, A (1993). Kinetic and structural analysis of the Mg2+-binding site of the guanine nucleotide binding protein p21H-ras. J. Biol. Chem 268, 923-929.[Abstract/Free Full Text]

Kharbanda, S., Saleem, A., Datta, R., Yuan, Z.-M., Weichselbaum, R. and Kufe, D (1994). Ionizing radiation induces rapid tyrosine phosphorylation of p34cdc2. Cancer Res 54, 1412-1414.[Abstract/Free Full Text]

Kinoshita, N., Yamano, H., Niwa, H., Yoshida, T. and Yanagida, M (1993). Negative regulation of mitosis by the fission yeast protein phosphatase ppa2. Genes Dev 7, 1059-1071.[Abstract/Free Full Text]

Klebe, C., Nishimoto, T. and Wittinghofer, F (1993). Functional expression in Escherichia coli of the mitotic regulator proteins p24ranand p45rcc1and fluorescence measurements of their interaction. Biochemistry 32, 11923-11928.[Medline]

Kornbluth, S., Dasso, M. and Newport, J (1994). Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression. J. Cell Biol 125, 705-719.[Abstract/Free Full Text]

Kornbluth, S., Sebastian, B., Hunter, T. and Newport, J (1994). Membrane localization of the kinase which phosphorylates p34cdc2on threonine 14. Mol. Biol. Cell 5, 273-282.[Abstract]

Kumagai, A. and Dunphy, W. G (1991). The cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system. Cell 64, 903-914.[Medline]

Kumagai, A. and Dunphy, W. G (1992). Regulation of the cdc25 protein during the cell cycle in Xenopus extracts. Cell 70, 139-151.[Medline]

Lock, R. B (1992). Inhibition of p34 cdc2 kinase activation, p34 cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese hamster ovary cells exposed to etoposide. Cancer Res 52, 1817-22.[Abstract/Free Full Text]

Lounsbury, K. M., Beddow, A. L. and Macara, I. G (1994). A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation. J. Biol. Chem 269, 11285-11290.[Abstract/Free Full Text]

Matsumoto, T. and Beach, D (1991). Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase. Cell 66, 347-360.[Medline]

Mechali, M. and Harland, R. M (1982). DNA synthesis in a cell-free system from Xenopus eggs: priming and elongation on single-stranded DNA in vitro. Cell 30, 93-101.[Medline]

Melchior, F., Paschal, B., Evans, J. and Gerace, L (1993). Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor. J. Cell Biol 123, 1649-1659.[Abstract/Free Full Text]

Moore, M. S. and Blobel, G (1993). The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. Nature 365, 661-663.[Medline]

Murray, A. W. and Kirschner, M. W (1989). Cyclin synthesis drives the early embryonic cell cycle. Nature 339, 275-280.[Medline]

Murray, A. W (1992). Creative blocks: cell-cycle checkpoints and feedback controls. Nature 359, 599-604.[Medline]

Nasmyth, K. and Hunt, T (1993). Dams and sluices. Nature 366, 634-635.[Medline]

Newport, J (1987). Nuclear reconstitution in vitro: Stages of assembly around protein-free DNA. Cell 48, 205-217.[Medline]

Nishitani, H., Ohtsubo, M., Yamashita, K., Iida, H., Pines, J., Yasudo, H., Shibata, Y., Hunter, T. and Nishimoto, T (1991). Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis. EMBO J 10, 1555-1564.[Medline]

Nurse, P (1990). Universal control mechanism regulating onset of M-phase. Nature 344, 503-508.[Medline]

O'Connor, P. M., Ferris, D. K., Pagano, M., Draetta, G., Pines, J., Hunter, T., Longo, D. L. and Kohn, K. W (1993). G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J. Biol. Chem 268, 8298-8308.[Abstract/Free Full Text]

Ohtsubo, M., Okazaki, H. and Nishimoto, T (1989). The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA. J. Cell Biol 109, 1389-1397.[Abstract/Free Full Text]

Pai, F. E., Kabsch, W., Krengel, U., Holmes, K. C., John, J. and Wittinghofer, A (1989). Structure of the guanine-nucleotide binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. Nature 341, 209-214.[Medline]

Pines, J (1993). Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem. Sci 18, 195-197.[Medline]

Polakis, P. and McCormick, F (1993). Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target. J. Biol. Chem 268, 9157-9160.[Abstract/Free Full Text]

Ren, M., Drivas, G., D'Eustachio, P. and Rush, M. G (1993). Ran/TC4: asmall nuclear GTP-binding protein that regulates DNA synthesis. J. Cell Biol 120, 313-323.[Abstract/Free Full Text]

Ren, M., Coutavas, E., D'Eustachio, P. and Rush, M. G (1994). Effects of mutant Ran/TC4 proteins on cell cycle progression. Mol. Cell. Biol 14, 4216-4224.[Abstract/Free Full Text]

Sazer, S. and Nurse, P (1994). A fission yeast RCC1-related protein is required for the mitosis to interphase transition. EMBO J 13, 606-615.[Medline]

Schweighofer, F., Cai, H., Chevallier-Multon, M. C., Fath, I., Cooper, G. and Tocque, B (1993). The Saccharomyces cerevisiae SDC25 C-domain gene product overcomes the dominant inhibitory activity of Ha-Ras Asn-17. Mol. Cell. Biol 13, 39-43.[Abstract/Free Full Text]

Sheehan, M. A., Mills, A. D., Sleeman, A. M., Laskey, R. A. and Blow, J. J (1988). Steps in the assembly of replication competent nuclei in a cell-free system from Xenopus eggs. J. Cell Biol 106, 1-12.[Abstract/Free Full Text]

Smythe, C. and Newport, J. W (1992). Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2. Cell 68, 787-797.[Medline]

Solomon, M. J., Glotzer, M., Lee, T. H., Philippe, M. and Kirschner, M. W (1990). Cyclin activation of p34cdc2. Cell 63, 1013-1024.[Medline]

Tang, Z., Coleman, T. R. and Dunphy, W. G (1993). Two distinct mechanisms for the negative regulation of the wee1 protein kinase. EMBO J 12, 3427-3436.[Medline]

Tsao, Y. P., D'Arpa, P. and Liu, L. F (1992). The involvement of active DNA synthesis in camptothecin-induced G2 arrest: altered regulation of p34cdc2/cyclin B. Cancer Res 52, 1823-1829.[Abstract/Free Full Text]

Weinert, T. and Lydall, D (1993). Cell cycle checkpoints, genetic instability and cancer. Semin. Cancer Biol 4, 129-140.[Medline]

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				C. Zhang and P. R. Clarke Chromatin-Independent Nuclear Envelope Assembly Induced by Ran GTPase in Xenopus Egg Extracts Science, May 26, 2000; 288(5470): 1429 - 1432. [Abstract] [Full Text]

				S Sazer and M Dasso The ran decathlon: multiple roles of Ran J. Cell Sci., January 4, 2000; 113(7): 1111 - 1118. [Abstract] [PDF]

				M Hughes, C Zhang, J. Avis, C. Hutchison, and P. Clarke The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants J. Cell Sci., January 10, 1998; 111(20): 3017 - 3026. [Abstract] [PDF]

				Y. Liu, S. A. Bohn, and J. L. Sherley Inosine-5'-Monophosphate Dehydrogenase Is a Rate-determining Factor for p53-dependent Growth Regulation Mol. Biol. Cell, January 1, 1998; 9(1): 15 - 28. [Abstract] [Full Text]

				R. T. Pu and M. Dasso The Balance of RanBP1 and RCC1 Is Critical for Nuclear Assembly and Nuclear Transport Mol. Biol. Cell, October 1, 1997; 8(10): 1955 - 1970. [Abstract] [Full Text]

				H. Saitoh, R. Pu, M. Cavenagh, and M. Dasso RanBP2 associates with Ubc9p and a modified form�of�RanGAP1 PNAS, April 15, 1997; 94(8): 3736 - 3741. [Abstract] [Full Text] [PDF]

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				A Battistoni, G Guarguaglini, F Degrassi, C Pittoggi, A Palena, G Di Matteo, C Pisano, E Cundari, and P Lavia Deregulated expression of the RanBP1 gene alters cell cycle progression in murine fibroblasts J. Cell Sci., January 10, 1997; 110(19): 2345 - 2357. [Abstract] [PDF]

				T. Ohba, T. Seki, Y. Azuma, and T. Nishimoto Premature Chromatin Condensation Induced by Loss of RCC1 Is Inhibited by GTP- and GTPgamma S-Ran, but Not GDP-Ran J. Biol. Chem., June 21, 1996; 271(25): 14665 - 14667. [Abstract] [Full Text] [PDF]

				H Bastians and H Ponstingl The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation J. Cell Sci., January 12, 1996; 109(12): 2865 - 2874. [Abstract] [PDF]

				J. Avis and P. Clarke Ran, a GTPase involved in nuclear processes: its regulators and effectors J. Cell Sci., January 10, 1996; 109(10): 2423 - 2427. [Abstract] [PDF]