Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Midgley, C. A.
	Articles by Hall, P. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Midgley, C. A.
	Articles by Hall, P. A.

Ansari, B., Coates, P. J., Greenstein, B. and Hall, P. A (1993). In situ end labelling detects DNA strand breaks in apoptosis and other physiological and pathological states. J. Pathol 170, 1-8.[Medline]

Caelles, C., Helmberg, A. and Karin, M (1994). p53-dependent apoptosis in the abscence of transcriptional activation of p53 target genes. Nature 370, 220-224.[Medline]

Campbell, C., Quinn, A. G., Angus, B., Farr, P. M. and Rees, J. L (1993). Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation. Cancer Res 53, 2697-9.[Abstract/Free Full Text]

Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, L. and Wyllie, A. H (1993). Thymocyte apoptosis is induced by p53-dependent and independent pathways. Nature 362, 849-852.[Medline]

Clarke, A. R., Gledhill, S., Hooper, M. L., Bird, C. C. and Wyllie, A. H (1994). p53 dependence of early apoptotic and proliferative responses within the mouse small intestinal epithelium followingirradiation. Oncogene 9, 1767-1773.[Medline]

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S. and Bradley, A (1992). Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356, 215-221.[Medline]

El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W. and Vogelstein, B (1993). WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817-825.[Medline]

Fritsche, M., Haessler, C. and Brandner, G (1993). Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 8, 307-18.[Medline]

Gannon, J. V., Greaves, R., Iggo, R. and Lane, D. P (1990). Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J 9, 1595-1602.[Medline]

Gannon, J. V. and Lane, D. P (1991). Protein synthesis required to anchor a mutant p53 protein which is temperature-sensitive for nuclear transport. Nature 349, 802-806.[Medline]

Greenblatt, M., Bennett, W., Hollstein, M. and Harris, C (1994). Mutations in the p53 tumour suppressor gene: clues to cancer aetiology and cancer pathogenesis. Cancer Res 54, 4855-4878.[Free Full Text]

Hall, P. A., McKee, P. H., Menage, H. d., Dover, R. and Lane, D. P (1993). High levels of p53 protein in UV irradiated human skin. Oncogene 8, 203-208.[Medline]

Hall, P. A. and Lane, D. P (1994). Genetics of growth arrest and cell death: key determinants of tissue homeostasis. Eur. J. Cancer 13, 2001-2012.

Harlow, E., Crawford, L. V., Pim, D. C. and Williamson, N. M (1981). Monoclonal antibodies specific for simian virus 40 tumor antigens. J. Virol 39, 861-869.[Abstract/Free Full Text]

Harvey, M., McArthur, M. J., Montgomery, C. A., Butel, J. S., Bradley, A. and Donehower, L. A (1993). Spontaneous and carcinogen induced tumorigenesis in p53-deficient mice. Nature Genet 5, 225-229.[Medline]

Jenkins, J. R., Rudge, K. and Currie, G. A (1984). Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53. Nature 312, 651-654.[Medline]

Kastan, M. B., Onyekwere, P., Sidransky, D., Vogelstein, B. and Craig, R. W (1991). Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51, 6304-6311.[Medline]

Kastan, M. B., Zhan, Q., el, D. W., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B. and Fornace, A. J (1992). A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71, 587-597.[Medline]

Kemp, C. J., Donehower, L. A., Bradley, A. and Balmain, A (1993). Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74, 813-822.[Medline]

Kern, S. E., Kinzler, K. W., Bruskin, A., Jarosz, D., Friedman, P., Proves, C. and Vogelstein, B (1991). Identification of p53 as a sequence-specific DNA-binding protein. Science 252, 1708-1711.[Abstract/Free Full Text]

Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V. and Kastan, M. B (1992). Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Nat. Acad. Sci. USA 89, 7491-7495.[Abstract/Free Full Text]

Lane, D. P (1992). p53, guardian of the genome. Nature 358, 15-16.[Medline]

Lane, D. P (1993). A death in the life of p53. Nature 362, 786-787.[Medline]

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A. and Jacks, T (1993). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-9.[Medline]

Lu, X. and Lane, D. P (1993). Differential induction of transcriptionally active p53 following UV or ionising radiation; defects in chromosome instability syndromes. Cell 75, 765-778.[Medline]

Maltzman, W. and Czyzyk, L (1984). UV irradiation stimulates levels of p53 cellular tumor anitgen in nontransformed mouse cells. Mol. Cell. Biol 4, 1689-1694.[Abstract/Free Full Text]

Merritt, A. J., Potten, C. S., Kemp, C. J., Hickman, J. A., Balmain, A., Lane, D. P. and Hall, P. A (1994). The role of p53 in spontaneous and radiation-induced apoptosis in the gastrintestinal tract of normal and p53 deficient mice. Cancer Res 54, 614-617.[Abstract/Free Full Text]

Midgley, C. A., Fisher, C. J., Bartek, J., Vojtesek, B., Lane, D. P. and Barnes, D. M (1992). Analysis of p53 expression in human tumours: an antibody raised against human p53 expressed in E. coli. J. Cell Sci 101, 183-189.[Abstract/Free Full Text]

Milner, J., Chan, Y. S., Medcalf, E. A., Wang, Y. and Eckhart, W (1993). Partially transformed T3T3 cells express high levels of mutant p53 in the \324wild-type' immunoreactive form with defective oligomerization. Oncogene 8, 2001-8.[Medline]

Shivji, M. K. K., Kenny, M. K. and Wood, R. D (1992). Proliferating cell nuclear antigen is required for DNA excision repair. Cell 69, 367-374.[Medline]

Symonds, H., Krail, L., Remmington, L., Saenz-Robles, M., Lowe, S., Jacks, T. and VanDyke, T (1994). p53 dependent apoptosis suppresses tumor growth and progression in vivo. Cell 78, 703-712.[Medline]

Tabor, S. and Richardson, C. C (1985). A bacteriophage T7 polymerase/promoter system for controlled exclusive expression of specific genes. Proc. Nat. Acad. Sci. USA 82, 1074-1078.[Abstract/Free Full Text]

Wang, L., Miura, M., Bergeron, L., Zhu, H., Yuan, J (1994). Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78, 739-750.[Medline]

Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. and Horwitz, H. R (1993). The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1-converting enzyme. Cell 75, 641-652.[Medline]

This article has been cited by other articles:

S. Lu, K. A. Becker, M. J. Hagen, H. Yan, A. L. Roberts, L. A. Mathews, S. S. Schneider, H. T. Siegelmann, K. J. MacBeth, S. M. Tirrell, et al.
Transcriptional Responses to Estrogen and Progesterone in Mammary Gland Identify Networks Regulating p53 Activity
Endocrinology, October 1, 2008; 149(10): 4809 - 4820.
[Abstract] [Full Text] [PDF]

C. Hogan, C. Hutchison, L. Marcar, D. Milne, M. Saville, J. Goodlad, N. Kernohan, and D. Meek
Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma
J. Biol. Chem., June 27, 2008; 283(26): 18012 - 18023.
[Abstract] [Full Text] [PDF]

K. A. Boehme, R. Kulikov, and C. Blattner
p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK
PNAS, June 3, 2008; 105(22): 7785 - 7790.
[Abstract] [Full Text] [PDF]

A. Petitjean, C. Ruptier, V. Tribollet, A. Hautefeuille, F. Chardon, C. Cavard, A. Puisieux, P. Hainaut, and C. Caron de Fromentel
Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with {Delta}Np73
Carcinogenesis, February 1, 2008; 29(2): 273 - 281.
[Abstract] [Full Text] [PDF]

S. Y. Nam, M. K. Lee, and K. Sabapathy
The tumour-suppressor p53 is not required for pancreatic cell death during diabetes and upon irradiation
J. Physiol., January 15, 2008; 586(2): 407 - 417.
[Abstract] [Full Text] [PDF]

K. E. Gurley and C. J. Kemp
Ataxia-Telangiectasia Mutated Is Not Required for p53 Induction and Apoptosis in Irradiated Epithelial Tissues
Mol. Cancer Res., December 1, 2007; 5(12): 1312 - 1318.
[Abstract] [Full Text] [PDF]

A. Meiller, S. Alvarez, P. Drane, C. Lallemand, B. Blanchard, M. Tovey, and E. May
p53-dependent stimulation of redox-related genes in the lymphoid organs of {gamma}-irradiated mice identification of Haeme-oxygenase 1 as a direct p53 target gene
Nucleic Acids Res., November 29, 2007; 35(20): 6924 - 6934.
[Abstract] [Full Text] [PDF]

S. Cassie, I. Koturbash, D. Hudson, M. Baker, Y. Ilnytskyy, R. Rodriguez-Juarez, E. Weber, and O. Kovalchuk
Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo
Carcinogenesis, March 1, 2006; 27(3): 465 - 474.
[Abstract] [Full Text] [PDF]

P. Kramata, Y.-P. Lu, Y.-R. Lou, R. N. Singh, S. M. Kwon, and A. H. Conney
Patches of Mutant p53-Immunoreactive Epidermal Cells Induced by Chronic UVB Irradiation Harbor the Same p53 Mutations as Squamous Cell Carcinomas in the Skin of Hairless SKH-1 Mice
Cancer Res., May 1, 2005; 65(9): 3577 - 3585.
[Abstract] [Full Text] [PDF]

M. K. Saville, A. Sparks, D. P. Xirodimas, J. Wardrop, L. F. Stevenson, J.-C. Bourdon, Y. L. Woods, and D. P. Lane
Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo
J. Biol. Chem., October 1, 2004; 279(40): 42169 - 42181.
[Abstract] [Full Text] [PDF]

H Ashktorab, S Frank, A R Khaled, S K Durum, B Kifle, and D T Smoot
Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori
Gut, June 1, 2004; 53(6): 805 - 813.
[Abstract] [Full Text] [PDF]

M. E. Perry
Mdm2 in the Response to Radiation
Mol. Cancer Res., January 1, 2004; 2(1): 9 - 19.
[Abstract] [Full Text] [PDF]

B. Shan, J. Xu, Y. Zhuo, C. A. Morris, and G. F. Morris
Induction of p53-dependent Activation of the Human Proliferating Cell Nuclear Antigen Gene in Chromatin by Ionizing Radiation
J. Biol. Chem., November 7, 2003; 278(45): 44009 - 44017.
[Abstract] [Full Text] [PDF]

L. M. Minter, E. S. Dickinson, S. P. Naber, and D. J. Jerry
Epithelial cell cycling predicts p53 responsiveness to {gamma}-irradiation during post-natal mammary gland development
Development, March 8, 2003; 129(12): 2997 - 3008.
[Abstract] [Full Text] [PDF]

S. M. Mendrysa, M. K. McElwee, J. Michalowski, K. A. O'Leary, K. M. Young, and M. E. Perry
mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation
Mol. Cell. Biol., January 15, 2003; 23(2): 462 - 472.
[Abstract] [Full Text] [PDF]

P. Fei, E. J. Bernhard, and W. S. El-Deiry
Tissue-specific Induction of p53 Targets in Vivo
Cancer Res., December 15, 2002; 62(24): 7316 - 7327.
[Abstract] [Full Text] [PDF]

L. Musallam, C. Ethier, P. S. Haddad, F. Denizeau, and M. Bilodeau
Resistance to Fas-induced apoptosis in hepatocytes: role of GSH depletion by cell isolation and culture
Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G709 - G718.
[Abstract] [Full Text] [PDF]

J. C. Fanzo, S. K. Reaves, L. Cui, L. Zhu, and K. Y. Lei
p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells
Am J Physiol Cell Physiol, August 1, 2002; 283(2): C631 - C638.
[Abstract] [Full Text] [PDF]

M. A. Wani, G. Wani, J. Yao, Q. Zhu, and A. A. Wani
Human cells deficient in p53 regulated p21waf1/cip1 expression exhibit normal nucleotide excision repair of UV-induced DNA damage
Carcinogenesis, March 1, 2002; 23(3): 403 - 410.
[Abstract] [Full Text] [PDF]

P A Hall, A C Woodman, S J Campbell, and N A Shepherd
Expression of the p53 homologue p63{alpha} and {Delta}Np63{alpha} in the neoplastic sequence of Barrett's oesophagus: correlation with morphology and p53 protein
Gut, November 1, 2001; 49(5): 618 - 623.
[Abstract] [Full Text] [PDF]

A. Seluanov, V. Gorbunova, A. Falcovitz, A. Sigal, M. Milyavsky, I. Zurer, G. Shohat, N. Goldfinger, and V. Rotter
Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53
Mol. Cell. Biol., March 1, 2001; 21(5): 1552 - 1564.
[Abstract] [Full Text]

M. Ljungman
Individual Variation in p53 Responsiveness
J Natl Cancer Inst, January 17, 2001; 93(2): 82 - 83.
[Full Text] [PDF]

F. Ponten, H. Lindman, A. Bostrom, B. Berne, and J. Bergh
Induction of p53 Expression in Skin by Radiotherapy and UV Radiation: a Randomized Study
J Natl Cancer Inst, January 17, 2001; 93(2): 128 - 133.
[Abstract] [Full Text] [PDF]

Y.-P. Lu, Y.-R. Lou, X. H. Li, J. G. Xie, D. Brash, M.-T. Huang, and A. H. Conney
Stimulatory Effect of Oral Administration of Green Tea or Caffeine on Ultraviolet Light-induced Increases in Epidermal Wild-Type p53, p21(WAF1/CIP1), and Apoptotic Sunburn Cells in SKH-1 Mice
Cancer Res., September 1, 2000; 60(17): 4785 - 4791.
[Abstract] [Full Text]

M. E. Hegi, M. A. Klein, D. Ruedi, P. Chene, M.-F. Hamou, and A. Aguzzi
p53 Transdominance But No Gain of Function in Mouse Brain Tumor Model
Cancer Res., June 1, 2000; 60(11): 3019 - 3024.
[Abstract] [Full Text] [PDF]

D. C. Dey, R. P. Bronson, J. Dahl, J. P. Carroll, and T. L. Benjamin
Accelerated Development of Polyoma Tumors and Embryonic Lethality: Different Effects of p53 Loss on Related Mouse Backgrounds
Cell Growth Differ., May 1, 2000; 11(5): 231 - 237.
[Abstract] [Full Text]

C. Kuperwasser, J. Pinkas, G. D. Hurlbut, S. P. Naber, and D. J. Jerry
Cytoplasmic Sequestration and Functional Repression of p53 in the Mammary Epithelium Is Reversed by Hormonal Treatment
Cancer Res., May 1, 2000; 60(10): 2723 - 2729.
[Abstract] [Full Text]

S. M. Mendrysa and M. E. Perry
The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress
Mol. Cell. Biol., March 15, 2000; 20(6): 2023 - 2030.
[Abstract] [Full Text]

M. E. Perry, S. M. Mendrysa, L. J. Saucedo, P. Tannous, and M. Holubar
p76MDM2 Inhibits the Ability of p90MDM2 to Destabilize p53
J. Biol. Chem., February 25, 2000; 275(8): 5733 - 5738.
[Abstract] [Full Text] [PDF]

P. A. Hall, S. J. Campbell, M. O'neill, D. J. Royston, K. Nylander, F. A. Carey, and N. M. Kernohan
Expression of the p53 homologue p63{alpha} and {Delta}Np63{alpha} in normal and neoplasticcells
Carcinogenesis, February 1, 2000; 21(2): 153 - 160.
[Abstract] [Full Text] [PDF]

S. Song and P. F. Lambert
Different Responses of Epidermal and Hair Follicular Cells to Radiation Correlate with Distinct Patterns of p53 and p21 Induction
Am. J. Pathol., October 1, 1999; 155(4): 1121 - 1127.
[Abstract] [Full Text] [PDF]

R. Serpi, J. Piispala, M. Jarvilehto, and K. Vahakangas
Thapsigargin has similar effect on p53 protein response to benzo[a]pyrene�DNA adducts as TPA in mouse skin
Carcinogenesis, September 1, 1999; 20(9): 1755 - 1760.
[Abstract] [Full Text] [PDF]

Y.-P. Lu, Y.-R. Lou, P. Yen, D. Mitchell, M.-T. Huang, and A. H. Conney
Time Course for Early Adaptive Responses to Ultraviolet B Light in the Epidermis of SKH-1 Mice
Cancer Res., September 1, 1999; 59(18): 4591 - 4602.
[Abstract] [Full Text] [PDF]

V. A. Tron, M. J. Trotter, L. Tang, M. Krajewska, J. C. Reed, V. C. Ho, and G. Li
p53-Regulated Apoptosis Is Differentiation Dependent in Ultraviolet B-Irradiated Mouse Keratinocytes
Am. J. Pathol., August 1, 1998; 153(2): 579 - 585.
[Abstract] [Full Text] [PDF]

S. E. Bray, C. Schorl, and P. A. Hall
The Challenge of p53: Linking Biochemistry, Biology, and Patient Management
Stem Cells, July 1, 1998; 16(4): 248 - 260.
[Abstract] [Full Text]

M. A. O'Reilly, R. J. Staversky, B. R. Stripp, and J. N. Finkelstein
Exposure to Hyperoxia Induces p53 Expression in Mouse Lung Epithelium
Am. J. Respir. Cell Mol. Biol., January 1, 1998; 18(1): 43 - 50.
[Abstract] [Full Text]

A. Tomkinson, J. Reeve, R. W. Shaw, and B. S. Noble
The Death of Osteocytes via Apoptosis Accompanies Estrogen Withdrawal in Human Bone
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 3128 - 3135.
[Abstract] [Full Text] [PDF]

H. Xiang, D. W. Hochman, H. Saya, T. Fujiwara, P. A. Schwartzkroin, and R. S. Morrison
Evidence for p53-Mediated Modulation of Neuronal Viability
J. Neurosci., November 1, 1996; 16(21): 6753 - 6765.
[Abstract] [Full Text] [PDF]

L J Ko and C Prives
p53: puzzle and paradigm.
Genes & Dev., May 1, 1996; 10(9): 1054 - 1072.
[PDF]

T. R. Hupp and D. P. Lane
Two Distinct Signaling Pathways Activate the Latent DNA Binding Function of p53 in a Casein Kinase II-independent Manner
J. Biol. Chem., July 28, 1995; 270(30): 18165 - 18174.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Midgley, C. A.

Articles by Hall, P. A.

Search for Related Content

PubMed

PubMed Citation

Articles by Midgley, C. A.

Articles by Hall, P. A.

				C. Hogan, C. Hutchison, L. Marcar, D. Milne, M. Saville, J. Goodlad, N. Kernohan, and D. Meek Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma J. Biol. Chem., June 27, 2008; 283(26): 18012 - 18023. [Abstract] [Full Text] [PDF]

				K. A. Boehme, R. Kulikov, and C. Blattner p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK PNAS, June 3, 2008; 105(22): 7785 - 7790. [Abstract] [Full Text] [PDF]

				A. Petitjean, C. Ruptier, V. Tribollet, A. Hautefeuille, F. Chardon, C. Cavard, A. Puisieux, P. Hainaut, and C. Caron de Fromentel Properties of the six isoforms of p63: p53-like regulation in response to genotoxic stress and cross talk with {Delta}Np73 Carcinogenesis, February 1, 2008; 29(2): 273 - 281. [Abstract] [Full Text] [PDF]

				S. Y. Nam, M. K. Lee, and K. Sabapathy The tumour-suppressor p53 is not required for pancreatic cell death during diabetes and upon irradiation J. Physiol., January 15, 2008; 586(2): 407 - 417. [Abstract] [Full Text] [PDF]

				K. E. Gurley and C. J. Kemp Ataxia-Telangiectasia Mutated Is Not Required for p53 Induction and Apoptosis in Irradiated Epithelial Tissues Mol. Cancer Res., December 1, 2007; 5(12): 1312 - 1318. [Abstract] [Full Text] [PDF]

				A. Meiller, S. Alvarez, P. Drane, C. Lallemand, B. Blanchard, M. Tovey, and E. May p53-dependent stimulation of redox-related genes in the lymphoid organs of {gamma}-irradiated mice identification of Haeme-oxygenase 1 as a direct p53 target gene Nucleic Acids Res., November 29, 2007; 35(20): 6924 - 6934. [Abstract] [Full Text] [PDF]

				S. Cassie, I. Koturbash, D. Hudson, M. Baker, Y. Ilnytskyy, R. Rodriguez-Juarez, E. Weber, and O. Kovalchuk Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo Carcinogenesis, March 1, 2006; 27(3): 465 - 474. [Abstract] [Full Text] [PDF]

				P. Kramata, Y.-P. Lu, Y.-R. Lou, R. N. Singh, S. M. Kwon, and A. H. Conney Patches of Mutant p53-Immunoreactive Epidermal Cells Induced by Chronic UVB Irradiation Harbor the Same p53 Mutations as Squamous Cell Carcinomas in the Skin of Hairless SKH-1 Mice Cancer Res., May 1, 2005; 65(9): 3577 - 3585. [Abstract] [Full Text] [PDF]

				M. K. Saville, A. Sparks, D. P. Xirodimas, J. Wardrop, L. F. Stevenson, J.-C. Bourdon, Y. L. Woods, and D. P. Lane Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo J. Biol. Chem., October 1, 2004; 279(40): 42169 - 42181. [Abstract] [Full Text] [PDF]

				H Ashktorab, S Frank, A R Khaled, S K Durum, B Kifle, and D T Smoot Bax translocation and mitochondrial fragmentation induced by Helicobacter pylori Gut, June 1, 2004; 53(6): 805 - 813. [Abstract] [Full Text] [PDF]

				M. E. Perry Mdm2 in the Response to Radiation Mol. Cancer Res., January 1, 2004; 2(1): 9 - 19. [Abstract] [Full Text] [PDF]

				B. Shan, J. Xu, Y. Zhuo, C. A. Morris, and G. F. Morris Induction of p53-dependent Activation of the Human Proliferating Cell Nuclear Antigen Gene in Chromatin by Ionizing Radiation J. Biol. Chem., November 7, 2003; 278(45): 44009 - 44017. [Abstract] [Full Text] [PDF]

				L. M. Minter, E. S. Dickinson, S. P. Naber, and D. J. Jerry Epithelial cell cycling predicts p53 responsiveness to {gamma}-irradiation during post-natal mammary gland development Development, March 8, 2003; 129(12): 2997 - 3008. [Abstract] [Full Text] [PDF]

				S. M. Mendrysa, M. K. McElwee, J. Michalowski, K. A. O'Leary, K. M. Young, and M. E. Perry mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation Mol. Cell. Biol., January 15, 2003; 23(2): 462 - 472. [Abstract] [Full Text] [PDF]

				P. Fei, E. J. Bernhard, and W. S. El-Deiry Tissue-specific Induction of p53 Targets in Vivo Cancer Res., December 15, 2002; 62(24): 7316 - 7327. [Abstract] [Full Text] [PDF]

				L. Musallam, C. Ethier, P. S. Haddad, F. Denizeau, and M. Bilodeau Resistance to Fas-induced apoptosis in hepatocytes: role of GSH depletion by cell isolation and culture Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G709 - G718. [Abstract] [Full Text] [PDF]

				J. C. Fanzo, S. K. Reaves, L. Cui, L. Zhu, and K. Y. Lei p53 protein and p21 mRNA levels and caspase-3 activity are altered by zinc status in aortic endothelial cells Am J Physiol Cell Physiol, August 1, 2002; 283(2): C631 - C638. [Abstract] [Full Text] [PDF]

				M. A. Wani, G. Wani, J. Yao, Q. Zhu, and A. A. Wani Human cells deficient in p53 regulated p21waf1/cip1 expression exhibit normal nucleotide excision repair of UV-induced DNA damage Carcinogenesis, March 1, 2002; 23(3): 403 - 410. [Abstract] [Full Text] [PDF]

				P A Hall, A C Woodman, S J Campbell, and N A Shepherd Expression of the p53 homologue p63{alpha} and {Delta}Np63{alpha} in the neoplastic sequence of Barrett's oesophagus: correlation with morphology and p53 protein Gut, November 1, 2001; 49(5): 618 - 623. [Abstract] [Full Text] [PDF]

				A. Seluanov, V. Gorbunova, A. Falcovitz, A. Sigal, M. Milyavsky, I. Zurer, G. Shohat, N. Goldfinger, and V. Rotter Change of the Death Pathway in Senescent Human Fibroblasts in Response to DNA Damage Is Caused by an Inability To Stabilize p53 Mol. Cell. Biol., March 1, 2001; 21(5): 1552 - 1564. [Abstract] [Full Text]

				M. Ljungman Individual Variation in p53 Responsiveness J Natl Cancer Inst, January 17, 2001; 93(2): 82 - 83. [Full Text] [PDF]

				F. Ponten, H. Lindman, A. Bostrom, B. Berne, and J. Bergh Induction of p53 Expression in Skin by Radiotherapy and UV Radiation: a Randomized Study J Natl Cancer Inst, January 17, 2001; 93(2): 128 - 133. [Abstract] [Full Text] [PDF]

				Y.-P. Lu, Y.-R. Lou, X. H. Li, J. G. Xie, D. Brash, M.-T. Huang, and A. H. Conney Stimulatory Effect of Oral Administration of Green Tea or Caffeine on Ultraviolet Light-induced Increases in Epidermal Wild-Type p53, p21(WAF1/CIP1), and Apoptotic Sunburn Cells in SKH-1 Mice Cancer Res., September 1, 2000; 60(17): 4785 - 4791. [Abstract] [Full Text]

				M. E. Hegi, M. A. Klein, D. Ruedi, P. Chene, M.-F. Hamou, and A. Aguzzi p53 Transdominance But No Gain of Function in Mouse Brain Tumor Model Cancer Res., June 1, 2000; 60(11): 3019 - 3024. [Abstract] [Full Text] [PDF]

				D. C. Dey, R. P. Bronson, J. Dahl, J. P. Carroll, and T. L. Benjamin Accelerated Development of Polyoma Tumors and Embryonic Lethality: Different Effects of p53 Loss on Related Mouse Backgrounds Cell Growth Differ., May 1, 2000; 11(5): 231 - 237. [Abstract] [Full Text]

				C. Kuperwasser, J. Pinkas, G. D. Hurlbut, S. P. Naber, and D. J. Jerry Cytoplasmic Sequestration and Functional Repression of p53 in the Mammary Epithelium Is Reversed by Hormonal Treatment Cancer Res., May 1, 2000; 60(10): 2723 - 2729. [Abstract] [Full Text]

				S. M. Mendrysa and M. E. Perry The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress Mol. Cell. Biol., March 15, 2000; 20(6): 2023 - 2030. [Abstract] [Full Text]

				M. E. Perry, S. M. Mendrysa, L. J. Saucedo, P. Tannous, and M. Holubar p76MDM2 Inhibits the Ability of p90MDM2 to Destabilize p53 J. Biol. Chem., February 25, 2000; 275(8): 5733 - 5738. [Abstract] [Full Text] [PDF]

				P. A. Hall, S. J. Campbell, M. O'neill, D. J. Royston, K. Nylander, F. A. Carey, and N. M. Kernohan Expression of the p53 homologue p63{alpha} and {Delta}Np63{alpha} in normal and neoplasticcells Carcinogenesis, February 1, 2000; 21(2): 153 - 160. [Abstract] [Full Text] [PDF]

				S. Song and P. F. Lambert Different Responses of Epidermal and Hair Follicular Cells to Radiation Correlate with Distinct Patterns of p53 and p21 Induction Am. J. Pathol., October 1, 1999; 155(4): 1121 - 1127. [Abstract] [Full Text] [PDF]