Redox regulation of tyrosine phosphorylation in human spermatozoa and its role in the control of human sperm function

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Aitken, R. J.
	Articles by van Duin, M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Aitken, R. J.
	Articles by van Duin, M.

Acker, H., Dufau, E. Huber, J. and Sylvester, D (1989). Indications of an NADPH oxidase as a possible pO2sensor in the rat carotid body. FEBS. Lett 256, 75-78.[Medline]

Aitken, R. J. and Clarkson, J. S (1987). Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J. Reprod. Fertil 81, 459-469.[Abstract]

Aitken, R, J., Buckingham D. W. and West K. M (1992). Reactive oxygen species and human spermatozoa: analysis of the cellular mechanisms involved in luminol-and lucigenin-dependent chemiluminescence. J. Cell. Physiol 151, 466-477.[Medline]

Aitken, R. J., Buckingham, D. W. and Huang, G.-F (1993). Analysis of the responses of human spermatozoa to A23187 employing a novel technique to monitor the acrosome reaction. J. Androl 14, 132-141.[Abstract/Free Full Text]

Aitken, R. J., Harkiss, D. and Buckingham, D (1993). Relationship between iron-catalysed lipid peroxidation potential and human sperm function. J. Reprod. Fertil 31, 531-537.

Basci, A. and Shah, S. V (1987). Trypsin and chymotrypsin induced chemiluminescence by isolated rat glomeruli. Am. J. Physiol 252, 611-.

Bauskin, A. R., Alkalay, I. and Ben-Neriah, Y (1991). Redox regulation of a tyrosine kinase in the endoplasmic reticulum. Cell 56, 685-696.

Bize, I., Santander, G., Cabello, P., Driscoll, D. and Sharpe, C (1991). Hydrogen peroxide is involved in hamster sperm capacitation in vitro. Biol. Reprod 44, 398-403.[Abstract]

Borst, P (1962). The aerobic oxidation of the reduced diphosphopyridine nucleotide formed by glycolysis in Ehrlich ascites tumour cells. Biochim. Biophys. Acta 57, 270-282.[Medline]

Cross, A. R. and Jones, O. T. G (1991). Enzymic mechanisms of superoxide production. Biochim. Biophys. Acta 1057, 281-298.[Medline]

Deme, C., Virion, A., Ait Hammou, N. A. and Pommier, J (1985). NADPH-dependent generation of H2O2in a thyroid particulate fraction requires Ca2+. FEBS Lett 186, 107-110.[Medline]

Dupuy, C., Virion, A., Ait Hammou, N. A., Kaniewski, J., Deme, D. and Pommier, J (1986). Solubilization and characteristics of the thyroidNADPH-dependent H2O2 generating system. Biochem. Biophys. Res. Commun 141, 839-846.[Medline]

Fialkow, L., Chan, C. K., Grinstein, S. and Downey, G. P (1993). Regulation of tyrosine phosphorylation in neutrophils by the NADPH oxidase. J. Biol. Chem 268, 17131-17137.[Abstract/Free Full Text]

Finazzi-Agro, A., Menichelli, A., Persiani, M., Biancini, G. and Del Principe, D (1982). Hydrogen peroxide release from human platelets. Biochim. Biophys. Acta 718, 21-25.[Medline]

Grinstein, S., Furuya, W., Lu, D. J. and Mills, G. B (1990). Vanadate stimulates oxygen consumption and tyrosine phosphorylation in electropermeabilized human neutrophils. J. Biol. Chem 265, 318-327.[Abstract/Free Full Text]

Hecht, D. and Zick, Y (1992). Selective inhibition of protein tyrosine phosphatase activities by H2O2 and vanadate in vitro. Biochem. Biophys. Res. Commun 188, 773-779.[Medline]

Jeulin, C., Soufir, J. C., Weber, P., Laval-Martin, D. and Calvayrac, R (1989). Catalase activity in human spermatozoa and seminal plasma. Gamete Res 24, 185-96.[Medline]

Jeyendran, R. S., Van der Ven, H. H., Perez-Palaez, M., Crabo, B. G. and Zaneveld, L. J. D (1984). Development of an assay to assess the functional integrity of the human sperm membrane and its relationship to other semen characteristics,. J. Reprod. Fertil 70, 219-228.[Abstract]

Kalab, P., Visconti, P., Leclerc, P. and Kopf, G. S (1994). p95, the major phophotyrosine-containing protein inmouse spermatozoa, ia a hexakinase with unique properties. J. Biol. Chem 269, 3810-3817.[Abstract/Free Full Text]

Koshio, O., Akanuma, Y. and Kasuga, M (1988). Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells. Biochem. J 250, 95-101.[Medline]

Krausz, C., West, K., Buckingham, D. and Aitken, R. J (1992). Analysis of the interaction between N-formylmethionyl-leucyl-phenylalanine and human sperm suspensions: development of a technique for monitoring the contamination of human semen samples with leucocytes. Fertil. Steril 57, 1317-1325.[Medline]

Lessley, B. A. and Garner, D. L (1983). Isolation of motile spermatozoa by density gradient centrifugation in Percoll. Gamete Res 7, 49-61.

Leyton, L. and Saling, P. M (1989). Evidence that aggregation of mouse sperm receptors by ZP3 triggers the acrosome reaction. J. Cell Biol 108, 2163-2168.[Abstract/Free Full Text]

Leyton, L. and Saling, P. M (1989). 95kD sperm proteins bind ZP3 and serve as tyrosine kinase substrates in response to zona binding. Cell 57, 1123-1130.[Medline]

Leyton, L., LeGuen, P., Bunch, D. and Saling, P. M (1992). Regulation of mouse gamete interaction by a sperm tyrosine kinase. Proc. Nat. Acad. Sci. USA 89, 11692-11695.[Abstract/Free Full Text]

Meier, B., Radecke, H. H., Selle, S., Younes, M., Sies, H., Resch, K. and Habermehl, G. G (1989). Human fibroblasts release reactive oxygen species in response to interleukin 1 or tumour necrosis factor-. Biochem. J 263, 539-545.[Medline]

Mortimer, D., Curtis, E. F. and Miller, R. G (1987). Specific labelling bysperm agglutinin of the outer acrosomal membrane of the human spermatozoon. J. Reprod. Fertil 81, 127-135.[Abstract]

Mukherjee, S. P., Lane, R. H. and Lynn, W. S (1978). Endogenous hydrogen peroxide and peroxidative metabolism in adipocytes in response to insulin and sulfhydryl reagents. Biochem. Pharmacol 27, 2589-2594.[Medline]

Naz, R. K., Ahmed, K. and Kumar, R (1991). Role of membrane tyrosine proteins in human spermatozoal function. J. Cell Sci 99, 157-165.[Abstract/Free Full Text]

Ooi, B. S., MacCarthy, F. P., Hsu, A. and Ooi, Y. M (1983). Human mononuclear cell modulation of endothelial cell proliferation. J. Lab. Clin. Med 102, 428-433.[Medline]

O'Shea, J. J., McVicar, D. W., Bailey, T. L., Burns, C. and Smyth, M. J (1992). Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation. Proc. Nat. Acad. Sci. USA 89, 10306-10310.[Abstract/Free Full Text]

Sandhu, S. S., Band, A., Abavasekera, D. R. E., Rice-Evans, C. F. and Cooke, B. A (1989). A novel superoxide generating system. Biochem. Soc. Trans 17, 710-711.

Schieven, G. L., Kirihara, J. M., Burg, D. L., Geahlen, R. L. and Ledbetter, J. A (1993). p72syktyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phophorylation and Ca2+signals. J. Biol. Chem 268, 16688-16692.[Abstract/Free Full Text]

Shah, S. V. and Naum Bedigian, S (1981). Light emission by isolated rat glomeruli in response to phorbol myristate acetate. J. Lab. Clin. Med 98, 46-57.[Medline]

Taurog, A (1970). Thyroid peroxidase and thyroxine biosynthesis. Recent Prog. Horm. Res 26, 189-247.

Tesarik, J., Moos, J. and Mendoza, C (1993). Stimulation of protein tyrosine phophorylation by a progesterone receptor on the surface of human sperm. Endocrinology 133, 328-335.[Abstract]

van Duin, M., Polman, J. E. M., de Breet, I. T. M., van Ginneken, K., Bunschoten, H., Grootenhuis, A., Brindle, J. and Aitken, R. J (1994). Recombinant human zona pellucida protein ZP3 produced in Chinese hamster ovary cells induces the human sperm acrosome reaction and promotes sperm-egg fusion. Biol. Reprod 51, 607-617.[Abstract]

Volkman, D. J., Buescher, E. S., Gallin, J. I. and Fauci, A. S (1984). B cell lines as models for inherited phagocytic diseases: abnormal superoxide generation in chronic granulomatous disease and giant granules in Chadiak-Higashi syndrome. J. Immunol 133, 3006-3009.[Abstract]

Wassarman, P. M (1990). Profile of a mammalian sperm receptor. Development 108, 1-17.[Abstract]

Yanagimachi, R., Yanagimachi, H. and Rogers, B. J (1976). The use of zona free animal ova as a test system for the assessment of the fertilizing capacity of human spermatozoa. Biol. Reprod 15, 471-476.[Abstract]

This article has been cited by other articles:

C. Lawson, S. Goupil, and P. Leclerc
Increased Activity of the Human Sperm Tyrosine Kinase SRC by the cAMP-Dependent Pathway in the Presence of Calcium
Biol Reprod, October 1, 2008; 79(4): 657 - 666.
[Abstract] [Full Text] [PDF]

A. J. Koppers, G. N. De Iuliis, J. M. Finnie, E. A. McLaughlin, and R. J. Aitken
Significance of Mitochondrial Reactive Oxygen Species in the Generation of Oxidative Stress in Spermatozoa
J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3199 - 3207.
[Abstract] [Full Text] [PDF]

V. Kumar, V. Kota, and S. Shivaji
Hamster Sperm Capacitation: Role of Pyruvate Dehydrogenase A and Dihydrolipoamide Dehydrogenase
Biol Reprod, August 1, 2008; 79(2): 190 - 199.
[Abstract] [Full Text] [PDF]

K. Tremellen
Oxidative stress and male infertility--a clinical perspective
Hum. Reprod. Update, May 1, 2008; 14(3): 243 - 258.
[Abstract] [Full Text] [PDF]

L. A. Mitchell, B. Nixon, M. A. Baker, and R. J. Aitken
Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa
Mol. Hum. Reprod., April 1, 2008; 14(4): 235 - 243.
[Abstract] [Full Text] [PDF]

L.A. Mitchell, B. Nixon, and R.J. Aitken
Analysis of chaperone proteins associated with human spermatozoa during capacitation
Mol. Hum. Reprod., September 1, 2007; 13(9): 605 - 613.
[Abstract] [Full Text] [PDF]

K Sabeur and B A Ball
Characterization of NADPH oxidase 5 in equine testis and spermatozoa
Reproduction, August 1, 2007; 134(2): 263 - 270.
[Abstract] [Full Text] [PDF]

K. S. Athayde, M. Cocuzza, A. Agarwal, N. Krajcir, A. M. Lucon, M. Srougi, and J. Hallak
Development of Normal Reference Values for Seminal Reactive Oxygen Species and Their Correlation With Leukocytes and Semen Parameters in a Fertile Population
J Androl, July 1, 2007; 28(4): 613 - 620.
[Abstract] [Full Text] [PDF]

M. L. Vadnais and K. P. Roberts
Effects of Seminal Plasma on Cooling-Induced Capacitative Changes in Boar Sperm
J Androl, May 1, 2007; 28(3): 416 - 422.
[Abstract] [Full Text] [PDF]

P. Grasa, J. A. Cebrian-Perez, and T. Muino-Blanco
Signal transduction mechanisms involved in in vitro ram sperm capacitation.
Reproduction, November 1, 2006; 132(5): 721 - 732.
[Abstract] [Full Text] [PDF]

M. Lin, Y. H. Lee, W. Xu, M. A. Baker, and R. J. Aitken
Ontogeny of Tyrosine Phosphorylation-Signaling Pathways During Spermatogenesis and Epididymal Maturation in the Mouse
Biol Reprod, October 1, 2006; 75(4): 588 - 597.
[Abstract] [Full Text] [PDF]

M. A. Baker, L. Hetherington, and R. J. Aitken
Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa
J. Cell Sci., August 1, 2006; 119(15): 3182 - 3192.
[Abstract] [Full Text] [PDF]

J. Baumber and S. A. Meyers
Changes in Membrane Lipid Order With Capacitation in Rhesus Macaque (Macaca mulatta) Spermatozoa
J Androl, July 1, 2006; 27(4): 578 - 587.
[Abstract] [Full Text] [PDF]

L. Cotton, G. M. Gibbs, L. G. Sanchez-Partida, J. R. Morrison, D. M. de Kretser, and M. K. O'Bryan
FGFR-1 signaling is involved in spermiogenesis and sperm capacitation
J. Cell Sci., January 1, 2006; 119(1): 75 - 84.
[Abstract] [Full Text] [PDF]

B. Nixon, J. W. Paul, C. M. Spiller, A. G. Attwell-Heap, L. K. Ashman, and R. J. Aitken
Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa
J. Cell Sci., October 15, 2005; 118(20): 4865 - 4877.
[Abstract] [Full Text] [PDF]

J. Seligman, G. L. Newton, R. C. Fahey, R. Shalgi, and N. S. Kosower
Nonprotein Thiols and Disulfides in Rat Epididymal Spermatozoa and Epididymal Fluid: Role of {gamma}-Glutamyl-Transpeptidase in Sperm Maturation
J Androl, September 1, 2005; 26(5): 629 - 637.
[Abstract] [Full Text] [PDF]

H. Breitbart, G. Cohen, and S. Rubinstein
Role of actin cytoskeleton in mammalian sperm capacitation and the acrosome reaction
Reproduction, March 1, 2005; 129(3): 263 - 268.
[Abstract] [Full Text] [PDF]

K. L. Asquith, A. J. Harman, E. A. McLaughlin, B. Nixon, and R. J. Aitken
Localization and Significance of Molecular Chaperones, Heat Shock Protein 1, and Tumor Rejection Antigen gp96 in the Male Reproductive Tract and During Capacitation and Acrosome Reaction
Biol Reprod, February 1, 2005; 72(2): 328 - 337.
[Abstract] [Full Text] [PDF]

S. K. NagDas, V. P. Winfrey, and G. E. Olson
Tyrosine Phosphorylation Generates Multiple Isoforms of the Mitochondrial Capsule Protein, Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx), During Hamster Sperm Capacitation
Biol Reprod, January 1, 2005; 72(1): 164 - 171.
[Abstract] [Full Text] [PDF]

W.C.L. Ford
Regulation of sperm function by reactive oxygen species
Hum. Reprod. Update, September 1, 2004; 10(5): 387 - 399.
[Abstract] [Full Text] [PDF]

J. Seligman, Y. Zipser, and N. S. Kosower
Tyrosine Phosphorylation, Thiol Status, and Protein Tyrosine Phosphatase in Rat Epididymal Spermatozoa
Biol Reprod, September 1, 2004; 71(3): 1009 - 1015.
[Abstract] [Full Text] [PDF]

K. L. Asquith, R. M. Baleato, E. A. McLaughlin, B. Nixon, and R. J. Aitken
Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition
J. Cell Sci., July 15, 2004; 117(16): 3645 - 3657.
[Abstract] [Full Text] [PDF]

V. Nauc, E. De Lamirande, P. Leclerc, and C. Gagnon
Inhibitors of Phosphoinositide 3-Kinase, LY294002 and Wortmannin, Affect Sperm Capacitation and Associated Phosphorylation of Proteins Differently: Ca2+-Dependent Divergences
J Androl, July 1, 2004; 25(4): 573 - 585.
[Abstract] [Full Text] [PDF]

B. Willipinski-Stapelfeldt, J. Lubberstedt, S. Stelter, K. Vogt, A. K. Mukhopadhyay, and D. Muller
Comparative analysis between cyclic GMP and cyclic AMP signalling in human sperm
Mol. Hum. Reprod., July 1, 2004; 10(7): 543 - 552.
[Abstract] [Full Text] [PDF]

A. J. Travis, L. Tutuncu, C. J. Jorgez, T. S. Ord, B. H. Jones, G. S. Kopf, and C. J. Williams
Requirements for Glucose Beyond Sperm Capacitation During In Vitro Fertilization in the Mouse
Biol Reprod, July 1, 2004; 71(1): 139 - 145.
[Abstract] [Full Text] [PDF]

G. Balercia, S. Moretti, A. Vignini, M. Magagnini, F. Mantero, M. Boscaro, G. Ricciardo-Lamonica, and L. Mazzanti
Role of Nitric Oxide Concentrations on Human Sperm Motility
J Androl, March 1, 2004; 25(2): 245 - 249.
[Abstract] [Full Text] [PDF]

J. Rivlin, J. Mendel, S. Rubinstein, N. Etkovitz, and H. Breitbart
Role of Hydrogen Peroxide in Sperm Capacitation and Acrosome Reaction
Biol Reprod, February 1, 2004; 70(2): 518 - 522.
[Abstract] [Full Text] [PDF]

M. A. Baker, L. Hetherington, H. Ecroyd, S. D. Roman, and R. J. Aitken
Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation
J. Cell Sci., January 15, 2004; 117(2): 211 - 222.
[Abstract] [Full Text] [PDF]

S. C. Sikka
Role of Oxidative Stress and Antioxidants in Andrology and Assisted Reproductive Technology
J Androl, January 1, 2004; 25(1): 5 - 18.
[Full Text] [PDF]

R.J. Aitken, A.L. Ryan, B.J. Curry, and M.A. Baker
Multiple forms of redox activity in populations of human spermatozoa
Mol. Hum. Reprod., November 1, 2003; 9(11): 645 - 661.
[Abstract] [Full Text] [PDF]

J. Baumber, B. A. Ball, J. J. Linfor, and S. A. Meyers
Reactive Oxygen Species and Cryopreservation Promote DNA Fragmentation in Equine Spermatozoa
J Androl, July 1, 2003; 24(4): 621 - 628.
[Abstract] [Full Text] [PDF]

H. W. Ecroyd, R. C. Jones, and R. J. Aitken
Endogenous Redox Activity in Mouse Spermatozoa and Its Role in Regulating the Tyrosine Phosphorylation Events Associated with Sperm Capacitation
Biol Reprod, July 1, 2003; 69(1): 347 - 354.
[Abstract] [Full Text] [PDF]

A. C. Pommer, J. Rutllant, and S. A. Meyers
Phosphorylation of Protein Tyrosine Residues in Fresh and Cryopreserved Stallion Spermatozoa under Capacitating Conditions
Biol Reprod, April 1, 2003; 68(4): 1208 - 1214.
[Abstract] [Full Text] [PDF]

M. Furusawa, T. Taira, S. M. M. Iguchi-Ariga, and H. Ariga
AMY-1 Interacts with S-AKAP84 and AKAP95 in the Cytoplasm and the Nucleus, Respectively, and Inhibits cAMP-dependent Protein Kinase Activity by Preventing Binding of Its Catalytic Subunit to A-kinase-anchoring Protein (AKAP) Complex
J. Biol. Chem., December 20, 2002; 277(52): 50885 - 50892.
[Abstract] [Full Text] [PDF]

H. Yukitake, M. Furusawa, T. Taira, S. M. M. Iguchi-Ariga, and H. Ariga
AAT-1, a Novel Testis-specific AMY-1-binding Protein, Forms a Quaternary Complex with AMY-1, A-kinase Anchor Protein 84, and a Regulatory Subunit of cAMP-dependent Protein Kinase and Is Phosphorylated by Its Kinase
J. Biol. Chem., November 15, 2002; 277(47): 45480 - 45492.
[Abstract] [Full Text] [PDF]

R. A. Saleh and A. Agarwal
Oxidative Stress and Male Infertility: From Research Bench to Clinical Practice
J Androl, November 1, 2002; 23(6): 737 - 752.
[Full Text] [PDF]

V. Dorval, M. Dufour, and P. Leclerc
Regulation of the Phosphotyrosine Content of Human Sperm Proteins by Intracellular Ca2+: Role of Ca2+-Adenosine Triphosphatases
Biol Reprod, November 1, 2002; 67(5): 1538 - 1545.
[Abstract] [Full Text] [PDF]

J. A. Davis, X.-H. Wu, L. Wang, C. DeRossi, V. Westphal, R. Wu, G. Alton, G. Srikrishna, and H. H. Freeze
Molecular cloning, gene organization, and expression of mouse Mpi encoding phosphomannose isomerase
Glycobiology, July 1, 2002; 12(7): 435 - 442.
[Abstract] [Full Text] [PDF]

P. Leclerc and S. Goupil
Regulation of the Human Sperm Tyrosine Kinase c-yes. Activation by Cyclic Adenosine 3',5'-Monophosphate and Inhibition by Ca2+
Biol Reprod, July 1, 2002; 67(1): 301 - 307.
[Abstract] [Full Text] [PDF]

M. B. Herrero, E. de Lamirande, and C. Gagnon
Tyrosine nitration in human spermatozoa: a physiological function of peroxynitrite, the reaction product of nitric oxide and superoxide
Mol. Hum. Reprod., October 1, 2001; 7(10): 913 - 921.
[Abstract] [Full Text] [PDF]

S. Tardif, C. Dube, S. Chevalier, and J. L. Bailey
Capacitation Is Associated with Tyrosine Phosphorylation and Tyrosine Kinase-Like Activity of Pig Sperm Proteins
Biol Reprod, September 1, 2001; 65(3): 784 - 792.
[Abstract] [Full Text] [PDF]

F. Urner, G. Leppens-Luisier, and D. Sakkas
Protein Tyrosine Phosphorylation in Sperm During Gamete Interaction in the Mouse: The Influence of Glucose
Biol Reprod, May 1, 2001; 64(5): 1350 - 1357.
[Abstract] [Full Text]

B. Lewis and R. John Aitken
Impact of Epididymal Maturation on the Tyrosine Phosphorylation Patterns Exhibited by Rat Spermatozoa
Biol Reprod, May 1, 2001; 64(5): 1545 - 1556.
[Abstract] [Full Text]

S. C. Richer and W.C.L. Ford
A critical investigation of NADPH oxidase activity in human spermatozoa
Mol. Hum. Reprod., March 1, 2001; 7(3): 237 - 244.
[Abstract] [Full Text] [PDF]

J. Krzyzosiak, G. McMillan, P. Molan, and R. Vishwanath
Protein Tyrosine Phosphorylation During Prolonged In Vitro Incubation of Ejaculated Bovine Spermatozoa Is Regulated by the Oxidative State of the Medium
Biol Reprod, June 1, 2000; 62(6): 1615 - 1623.
[Abstract] [Full Text]

J. E. Osheroff, P. E. Visconti, J. P. Valenzuela, A. J. Travis, J. Alvarez, and G. S. Kopf
Regulation of human sperm capacitation by a cholesterol efflux-stimulated signal transduction pathway leading to protein kinase A-mediated up-regulation of protein tyrosine phosphorylation
Mol. Hum. Reprod., November 1, 1999; 5(11): 1017 - 1026.
[Abstract] [Full Text] [PDF]

M. C. Mahony and T. Gwathmey
Protein Tyrosine Phosphorylation during Hyperactivated Motility of Cynomolgus Monkey (Macaca fascicularis) Spermatozoa
Biol Reprod, May 1, 1999; 60(5): 1239 - 1243.
[Abstract] [Full Text]

F. Urner and D. Sakkas
Characterization of Glycolysis and Pentose Phosphate Pathway Activity during Sperm Entry into the Mouse Oocyte
Biol Reprod, April 1, 1999; 60(4): 973 - 978.
[Abstract] [Full Text]

F. Urner and D. Sakkas
A Possible Role for the Pentose Phosphate Pathway of Spermatozoa inGamete Fusion in the Mouse
Biol Reprod, March 1, 1999; 60(3): 733 - 739.
[Abstract] [Full Text]

R. J. Aitken, E. Gordon, D. Harkiss, J. P. Twigg, P. Milne, Z. Jennings, and D. S. Irvine
Relative Impact of Oxidative Stress on the Functional Competence and Genomic Integrity of Human Spermatozoa
Biol Reprod, November 1, 1998; 59(5): 1037 - 1046.
[Abstract] [Full Text]

P. E. Visconti and G. S. Kopf
Regulation of Protein Phosphorylation during Sperm Capacitation
Biol Reprod, July 1, 1998; 59(1): 1 - 6.
[Full Text]

R. Aitken, D Harkiss, W Knox, M Paterson, and D. Irvine
A novel signal transduction cascade in capacitating human spermatozoa characterised by a redox-regulated, cAMP-mediated induction of tyrosine phosphorylation
J. Cell Sci., January 3, 1998; 111(5): 645 - 656.
[Abstract] [PDF]

W. K. McCoubrey Jr., T. J. Huang, and M. D. Maines
Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis
J. Biol. Chem., May 9, 1997; 272(19): 12568 - 12574.
[Abstract] [Full Text] [PDF]

B. Banfi, G. Molnar, A. Maturana, K. Steger, B. Hegedus, N. Demaurex, and K.-H. Krause
A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes
J. Biol. Chem., September 28, 2001; 276(40): 37594 - 37601.
[Abstract] [Full Text] [PDF]

M. Furusawa, T. Ohnishi, T. Taira, S. M. M. Iguchi-Ariga, and H. Ariga
AMY-1, a c-Myc-binding Protein, Is Localized in the Mitochondria of Sperm by Association with S-AKAP84, an Anchor Protein of cAMP-dependent Protein Kinase
J. Biol. Chem., September 21, 2001; 276(39): 36647 - 36651.
[Abstract] [Full Text] [PDF]

This Article

				A. J. Koppers, G. N. De Iuliis, J. M. Finnie, E. A. McLaughlin, and R. J. Aitken Significance of Mitochondrial Reactive Oxygen Species in the Generation of Oxidative Stress in Spermatozoa J. Clin. Endocrinol. Metab., August 1, 2008; 93(8): 3199 - 3207. [Abstract] [Full Text] [PDF]

				V. Kumar, V. Kota, and S. Shivaji Hamster Sperm Capacitation: Role of Pyruvate Dehydrogenase A and Dihydrolipoamide Dehydrogenase Biol Reprod, August 1, 2008; 79(2): 190 - 199. [Abstract] [Full Text] [PDF]

				K. Tremellen Oxidative stress and male infertility--a clinical perspective Hum. Reprod. Update, May 1, 2008; 14(3): 243 - 258. [Abstract] [Full Text] [PDF]

				L. A. Mitchell, B. Nixon, M. A. Baker, and R. J. Aitken Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa Mol. Hum. Reprod., April 1, 2008; 14(4): 235 - 243. [Abstract] [Full Text] [PDF]

				L.A. Mitchell, B. Nixon, and R.J. Aitken Analysis of chaperone proteins associated with human spermatozoa during capacitation Mol. Hum. Reprod., September 1, 2007; 13(9): 605 - 613. [Abstract] [Full Text] [PDF]

				K Sabeur and B A Ball Characterization of NADPH oxidase 5 in equine testis and spermatozoa Reproduction, August 1, 2007; 134(2): 263 - 270. [Abstract] [Full Text] [PDF]

				K. S. Athayde, M. Cocuzza, A. Agarwal, N. Krajcir, A. M. Lucon, M. Srougi, and J. Hallak Development of Normal Reference Values for Seminal Reactive Oxygen Species and Their Correlation With Leukocytes and Semen Parameters in a Fertile Population J Androl, July 1, 2007; 28(4): 613 - 620. [Abstract] [Full Text] [PDF]

				M. L. Vadnais and K. P. Roberts Effects of Seminal Plasma on Cooling-Induced Capacitative Changes in Boar Sperm J Androl, May 1, 2007; 28(3): 416 - 422. [Abstract] [Full Text] [PDF]

				P. Grasa, J. A. Cebrian-Perez, and T. Muino-Blanco Signal transduction mechanisms involved in in vitro ram sperm capacitation. Reproduction, November 1, 2006; 132(5): 721 - 732. [Abstract] [Full Text] [PDF]

				M. Lin, Y. H. Lee, W. Xu, M. A. Baker, and R. J. Aitken Ontogeny of Tyrosine Phosphorylation-Signaling Pathways During Spermatogenesis and Epididymal Maturation in the Mouse Biol Reprod, October 1, 2006; 75(4): 588 - 597. [Abstract] [Full Text] [PDF]

				M. A. Baker, L. Hetherington, and R. J. Aitken Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa J. Cell Sci., August 1, 2006; 119(15): 3182 - 3192. [Abstract] [Full Text] [PDF]

				J. Baumber and S. A. Meyers Changes in Membrane Lipid Order With Capacitation in Rhesus Macaque (Macaca mulatta) Spermatozoa J Androl, July 1, 2006; 27(4): 578 - 587. [Abstract] [Full Text] [PDF]

				L. Cotton, G. M. Gibbs, L. G. Sanchez-Partida, J. R. Morrison, D. M. de Kretser, and M. K. O'Bryan FGFR-1 signaling is involved in spermiogenesis and sperm capacitation J. Cell Sci., January 1, 2006; 119(1): 75 - 84. [Abstract] [Full Text] [PDF]

				B. Nixon, J. W. Paul, C. M. Spiller, A. G. Attwell-Heap, L. K. Ashman, and R. J. Aitken Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa J. Cell Sci., October 15, 2005; 118(20): 4865 - 4877. [Abstract] [Full Text] [PDF]

				J. Seligman, G. L. Newton, R. C. Fahey, R. Shalgi, and N. S. Kosower Nonprotein Thiols and Disulfides in Rat Epididymal Spermatozoa and Epididymal Fluid: Role of {gamma}-Glutamyl-Transpeptidase in Sperm Maturation J Androl, September 1, 2005; 26(5): 629 - 637. [Abstract] [Full Text] [PDF]

				H. Breitbart, G. Cohen, and S. Rubinstein Role of actin cytoskeleton in mammalian sperm capacitation and the acrosome reaction Reproduction, March 1, 2005; 129(3): 263 - 268. [Abstract] [Full Text] [PDF]

				K. L. Asquith, A. J. Harman, E. A. McLaughlin, B. Nixon, and R. J. Aitken Localization and Significance of Molecular Chaperones, Heat Shock Protein 1, and Tumor Rejection Antigen gp96 in the Male Reproductive Tract and During Capacitation and Acrosome Reaction Biol Reprod, February 1, 2005; 72(2): 328 - 337. [Abstract] [Full Text] [PDF]

				S. K. NagDas, V. P. Winfrey, and G. E. Olson Tyrosine Phosphorylation Generates Multiple Isoforms of the Mitochondrial Capsule Protein, Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx), During Hamster Sperm Capacitation Biol Reprod, January 1, 2005; 72(1): 164 - 171. [Abstract] [Full Text] [PDF]

				W.C.L. Ford Regulation of sperm function by reactive oxygen species Hum. Reprod. Update, September 1, 2004; 10(5): 387 - 399. [Abstract] [Full Text] [PDF]

				J. Seligman, Y. Zipser, and N. S. Kosower Tyrosine Phosphorylation, Thiol Status, and Protein Tyrosine Phosphatase in Rat Epididymal Spermatozoa Biol Reprod, September 1, 2004; 71(3): 1009 - 1015. [Abstract] [Full Text] [PDF]

				K. L. Asquith, R. M. Baleato, E. A. McLaughlin, B. Nixon, and R. J. Aitken Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition J. Cell Sci., July 15, 2004; 117(16): 3645 - 3657. [Abstract] [Full Text] [PDF]

				V. Nauc, E. De Lamirande, P. Leclerc, and C. Gagnon Inhibitors of Phosphoinositide 3-Kinase, LY294002 and Wortmannin, Affect Sperm Capacitation and Associated Phosphorylation of Proteins Differently: Ca2+-Dependent Divergences J Androl, July 1, 2004; 25(4): 573 - 585. [Abstract] [Full Text] [PDF]

				B. Willipinski-Stapelfeldt, J. Lubberstedt, S. Stelter, K. Vogt, A. K. Mukhopadhyay, and D. Muller Comparative analysis between cyclic GMP and cyclic AMP signalling in human sperm Mol. Hum. Reprod., July 1, 2004; 10(7): 543 - 552. [Abstract] [Full Text] [PDF]

				A. J. Travis, L. Tutuncu, C. J. Jorgez, T. S. Ord, B. H. Jones, G. S. Kopf, and C. J. Williams Requirements for Glucose Beyond Sperm Capacitation During In Vitro Fertilization in the Mouse Biol Reprod, July 1, 2004; 71(1): 139 - 145. [Abstract] [Full Text] [PDF]

				G. Balercia, S. Moretti, A. Vignini, M. Magagnini, F. Mantero, M. Boscaro, G. Ricciardo-Lamonica, and L. Mazzanti Role of Nitric Oxide Concentrations on Human Sperm Motility J Androl, March 1, 2004; 25(2): 245 - 249. [Abstract] [Full Text] [PDF]

				J. Rivlin, J. Mendel, S. Rubinstein, N. Etkovitz, and H. Breitbart Role of Hydrogen Peroxide in Sperm Capacitation and Acrosome Reaction Biol Reprod, February 1, 2004; 70(2): 518 - 522. [Abstract] [Full Text] [PDF]

				M. A. Baker, L. Hetherington, H. Ecroyd, S. D. Roman, and R. J. Aitken Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation J. Cell Sci., January 15, 2004; 117(2): 211 - 222. [Abstract] [Full Text] [PDF]

				S. C. Sikka Role of Oxidative Stress and Antioxidants in Andrology and Assisted Reproductive Technology J Androl, January 1, 2004; 25(1): 5 - 18. [Full Text] [PDF]

				R.J. Aitken, A.L. Ryan, B.J. Curry, and M.A. Baker Multiple forms of redox activity in populations of human spermatozoa Mol. Hum. Reprod., November 1, 2003; 9(11): 645 - 661. [Abstract] [Full Text] [PDF]

				J. Baumber, B. A. Ball, J. J. Linfor, and S. A. Meyers Reactive Oxygen Species and Cryopreservation Promote DNA Fragmentation in Equine Spermatozoa J Androl, July 1, 2003; 24(4): 621 - 628. [Abstract] [Full Text] [PDF]