Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage

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Amon, A., Tyers, M., Futcher, B. and Nasmyth, K (1993). Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins. Cell 74, 993-1007.[Medline]

Bernhard, E. J., McKenna, W. G. and Muschel, R. J (1994). Cyclin expression and G2 phase delay after irradiation. Radiat. Res 138, 64-.

Broek, D., Bartlett, R., Crawford, K. and Nurse, P (1991). Involvement of p34 cdc2 in establishing the dependency of S phase on mitosis. Nature 349, 388-394.[Medline]

Chow, K. C. and Ross, W. E (1987). Topoisomerase-specific drug sensitivity in relation to cell cycle progression. Mol. Cell. Biol 7, 3119-3123.[Abstract/Free Full Text]

Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L. and Wyllie, A. H (1993). Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362, 849-852.[Medline]

Cowan, W. M., Fawcett, J. W., O'Leary, D. D. M. and Stanfield, B. B (1984). Regressive events in neurogenesis. Science 225, 1258-1265.[Abstract/Free Full Text]

D'Arpa, P., Beardmore, C. and Liu, L. F (1990). Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res 50, 6919-6924.[Abstract/Free Full Text]

DelBino, G., Skierski, J. S. and Darzynkiewicz, Z (1991). The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells. Exp. Cell Res 195, 485-491.[Medline]

Draetta, G., Luca, F., Westendorf, J., Brizuela, L., Ruderman, J. and Beach, D (1989). Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 56, 829-838.[Medline]

Eastman, A (1990). Activation of programmed cell death by anticancer agents: cisplatin as a model system. Cancer Cells 2, 275-280.[Medline]

Freeman, R. S., Estus, S. and Johnson, E. M (1994). Analysis of cell cycle-related gene-expression in postmitotic neurons- selective induction of cyclin D1 during programmed cell-death. Neuron 12, 343-355.[Medline]

Gautier, J., Norbury, C., Lohka, M., Nurse, P. and Maller, J (1988). Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. Cell 54, 433-9.[Medline]

Girard, F., Strausfeld, U., Fernandez, A. and Lamb, N. J. C (1991). Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67, 1169-1179.[Medline]

Glab, N., Labidi, B., Qin, L. X., Trehin, C., Bergounioux, C. and Meijer, L (1994). Olomoucine, an inhibitor of the cdc2/cdk2 kinases activity, blocks plant-cells at the G1-S and G2-M cell-cycle transitions. FEBS Lett 353, 207-211.[Medline]

Glucksmann, A (1951). Cell deaths in normal vertebrate ontogeny. Biol. Rev 26, 289-300.

Gorczyca, W., Gong, J. P., Ardelt, B., Traganos, F. and Darzynkiewicz, Z (1993). The cell-cycle related differences in susceptibility of hl-60-cells to apoptosis induced by various antitumor agents. Cancer Res 53, 3186-3192.[Abstract/Free Full Text]

Hagan, I., Hayles, J. and Nurse, P (1988). Cloning and sequencing of the cyclin-related cdc13+ gene and a cytological study of its role in fission yeast mitosis. J. Cell Sci 91, 587-595.[Abstract/Free Full Text]

Hamaguchi, J. R., Tobey, R. A., Pines, J., Crissman, H. A., Hunter, T. and Bradbury, E. M (1992). Requirement for p34 cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210. J. Cell Biol 117, 1041-1053.[Abstract/Free Full Text]

Hayles, J., Fisher, D., Woollard, A. and Nurse, P (1994). Temporal-order of S-phase and mitosis in fission yeast is determined by the state of the p34 cdc2 mitotic B-cyclin complex. Cell 78, 813-822.[Medline]

Hickman, J. A (1992). Apoptosis induced by anticancer drugs. Cancer Metast. Rev 11, 121-139.[Medline]

Hotz, M. A., Gong, J. P., Traganos, F. and Darzynkiewicz, Z (1994). Flow cytometric detection of apoptosis- comparison of the assays of in-situ DNA-degradation and chromatin changes. Cytometry 15, 237-244.[Medline]

Kaufmann, S (1989). Induction of endonucleolytic DNA cleavage in human acute myelogenous leukaemia cells by etoposide, camptothecin and other cytotoxic anticancer drugs: a cautionary note. Cancer Res 49, 5870-5878.[Abstract/Free Full Text]

Kerr, J. F. R (1971). Shrinkage necrosis: a distinct mode of cell death. J. Pathol 105, 13-20.[Medline]

Kitagawa, M., Okabe, T., Ogino, H., Matsumoto, H., Suzukitakahashi, I., Kokubo, T., Higashi, H., Saitoh, S., Taya, Y. and Yasuda, H (1993). Butyrolactone-I, a selective inhibitor of cdk2 and cdc2 kinase. Oncogene 8, 2425-2432.[Medline]

Knoblich, J. A. and Lehner, C. F (1993). Synergistic action of Drosophila cyclins A and B during the G2-M transition. EMBO J 12, 65-74.[Medline]

Labbe, J. C., Capony, J. P., Caput, D., Cavadore, J. C., Derancourt, M. K., Lelias, J. M., Picard, A. and Doree, M (1989). MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and one molecule of cyclin B. EMBO J 8, 3053-3058.[Medline]

Lazebnik, Y. A., Cole, S., Cooke, C. A., Nelson, W. G. and Earnshaw, W. C (1993). Nuclear events of apoptosis in vitro in cell-free mitotic extracts- a model system for analysis of the active phase of apoptosis. J. Cell Biol 123, 7-22.[Abstract/Free Full Text]

Lee, M. G. and Nurse, P (1987). Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature 327, 31-35.[Medline]

Levine, A. J., Momand, J. and Finlay, C. A (1991). The p53 tumour suppressor gene. Nature 351, 453-456.[Medline]

Lock, R. B. and Ross, W. E (1990). Possible role for p34 cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells. Cancer Res 50, 3767-3771.[Abstract/Free Full Text]

Lock, R. B (1992). Inhibition of p34 cdc2 kinase activation, p34 cdc2 tyrosine dephosphorylation, and mitotic progression in Chinese-hamster ovary cells exposed to etoposide. Cancer Res 52, 1817-1822.[Abstract/Free Full Text]

Lock, R. B. and Keeling, P. K (1993). Responses of HeLa and Chinese hamster ovary p34 cdc2 /cyclin-B kinase in relation to cell-cycle perturbations induced by etoposide. Int. J. Oncol 3, 33-42.

MacDonald, H. R. and Lees, R. K (1990). Programmed death of autoreactive thymocytes. Nature 343, 642-644.[Medline]

Marraccino, R. L., Firpo, E. J. and Roberts, J. M (1992). Activation of the p34 cdc2 protein-kinase at the start of S-phase in the human cell-cycle. Mol. Biol. Cell 3, 389-401.[Abstract]

MacNeill, S. A. and Nurse, P (1993). Genetic-analysis of human p34 cdc2 function in fission yeast. Mol. Gen. Genet 240, 315-322.[Medline]

Meikrantz, W., Gisselbrecht, S., Tam, S. W. and Schlegel, R (1994). Activation of cyclin A-dependent protein-kinases during apoptosis. Proc. Nat. Acad. Sci. USA 91, 3754-3758.[Abstract/Free Full Text]

Mineo, C., Murakami, Y., Ishimi, Y., Hanaoka, F. and Yamada, M (1986). Isolation and analysis of a mammalian temperature-sensitive mutant defective in G2 functions. Exp. Cell Res 167, 53-62.[Medline]

Minshull, J., Blow, J. J. and Hunt, T (1989). Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis. Cell 56, 947-956.[Medline]

Minshull, J., Golsteyn, R., Hill, C. S. and Hunt, T (1990). The A-and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle. EMBO J 9, 2865-75.[Medline]

Murray, A. W. and Kirschner, M. W (1989). Cyclin synthesis drives the early embryonic cell cycle. Nature 339, 275-280.[Medline]

Muschel, R. J., Zhang, H. B. and McKenna, W. G (1993). Differential effect of ionizing-radiation on the expression of cyclin-A and cyclin-B in HeLa-cells. Cancer Res 53, 1128-1135.[Abstract/Free Full Text]

Norbury, C. J. and Nurse, P (1992). Animal cell cycles and their control. Annu. Rev. Biochem 61, 441-470.[Medline]

Norbury, C., MacFarlane, M., Fearnhead, H. and Cohen, G. M (1994). Cdc2 activation is not required for thymocyte apoptosis. Biochem. Biophys. Res. Commun 202, 1400-1406.[Medline]

Nurse, P. and Bissett, Y (1981). Gene required in Gl for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature 292, 558-560.[Medline]

Nurse, P. and Thuriaux, P (1980). Regulatory genes controlling mitosis in the fission yeast Schizosaccharomyces pombe. Genetics 96, 627-637.[Abstract/Free Full Text]

Nurse, P (1990). Universal control mechanism regulating onset of M-phase. Nature 344, 503-508.[Medline]

Obara-Ishihara, T. and Okayama, H (1994). A B-type cyclin negatively regulates conjugation via interacting with cell-cycle start genes in fission yeast. EMBO J 13, 1863-1872.[Medline]

Oberhammer, F. A., Hochegger, K. and Froschl, G (1994). Chromatin condensation during apoptosis is accompanied by degradation of lamin A and B, without enhanced activation of cdc2 kinase. J. Cell Biol 126, 827-837.[Abstract/Free Full Text]

O'Connor, P. M., Ferris, D. K., Pagano, M., Draetta, G., Pines, J., Hunter, T., Longo, D. L. and Kohn, K. W (1993). G2 delay induced by nitrogen-mustard in human-cells affects cyclin A/cdk2 and cyclin-B1/cdc2-kinase complexes differently. J. Biol. Chem 268, 8298-8308.[Abstract/Free Full Text]

Pagano, M., Pepperkok, R., Verde, F., Ansorge, W. and Draetta, G (1992). Cyclin A is required at two points in the human cell cycle. EMBO J 11, 961-971.[Medline]

Sen, S., Takahashi, R., Rani, S., Freireich, E. J. and Stass, S. A (1993). Expression of differentially phosphorylated Rb and mutant p53 proteins in myeloid leukemia cell lines. Leukemia Res 17, 639-647.[Medline]

Sherr, C. J (1993). Mammalian G1 cyclins. Cell 73, 1059-1065.[Medline]

Shi, L., Nishioka, W. K., Th'ng, J., Bradbury, E. M., Litchfield, D. W. and Greenberg, A. H (1994). Premature p34 cdc2 activation required for apoptosis. Science 263, 1143-1145.[Abstract/Free Full Text]

Shimizu, T., O'Connor, P. M., Kohn, K. W. and Pommier, Y (1995). Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL-60 cells undergoing apoptosis induced by DNA damage. Cancer Res 55, 228-231.[Abstract/Free Full Text]

Solary, E., Bertrand, R. and Pommier, Y (1994). Apoptosis induced by DNA topoisomerase-I and topoisomerase-II inhibitors in human leukemic HL-60 cells. Leuk. Lymphoma 15, 21-32.[Medline]

Th'ng, J. P., Wright, P. S., Hamaguchi, J., Lee, M. G., Norbury, C. J., Nurse, P. and Bradbury, E. M (1990). The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC 2 gene product. Cell 63, 313-24.[Medline]

Thiebaut, F., Enns, R. and Howell, S. B (1994). Cisplatin sensitivity correlates with its ability to cause cell-cycle arrest via a wee1 kinase-dependent pathway in Schizosaccharomyces pombe. J. Cell Physiol 159, 506-514.[Medline]

Ucker, D. S (1991). Death by suicide: one way to go in mammalian cellular development?. New Biol 3, 103-109.[Medline]

Ucker, D. S., Obermiller, P. S., Eckhart, W., Apgar, J. R., Berger, N. A. and Myers, J (1992). Genome digestion is a dispensible consequence of physiological cell death mediated by cytotoxic T lymphocytes. Mol. Cell. Biol 12, 3060-3069.[Abstract/Free Full Text]

Vandenheuvel, S. and Harlow, E (1993). Distinct roles for cyclin-dependent kinases in cell-cycle control. Science 262, 2050-2054.[Abstract/Free Full Text]

Walker, P. R., Smith, C., Youdale, T., Leblanc, J., Whitfield, J. F. and Sikorska, M (1990). Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes. Cancer Res 51, 1078-1085.[Abstract/Free Full Text]

Walker, D. H. and Maller, J. L (1991). Role for cyclin A in the dependence of mitosis on completion of DNA replication. Nature 354, 314-317.[Medline]

Wyllie, A. H., Kerr, J. F. H. and Currie, A. R (1980). Cell death: the significance of apoptosis. Int. Rev. Cytol 68, 251-306.[Medline]

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				M. J. Hendzel, W. K. Nishioka, Y. Raymond, C. D. Allis, D. P. Bazett-Jones, and J. P.�H. Th'ng Chromatin Condensation Is Not Associated with Apoptosis J. Biol. Chem., September 18, 1998; 273(38): 24470 - 24478. [Abstract] [Full Text] [PDF]

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