Characterization of a 5.4 kb cDNA fragment from the Z-line region of rabbit cardiac titin reveals phosphorylation sites for proline-directed kinases

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Sebestyen, M. G.
	Articles by Greaser, M. L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Sebestyen, M. G.
	Articles by Greaser, M. L.

Alessandrini, A., Crews, C. M. and Erikson, R. L (1992). Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the ERK-1 gene product. Proc. Nat. Acad. Sci. USA 89, 8200-8204.[Abstract/Free Full Text]

Behr, T., Fischer, P., Muller-Felber, W., Schmidt, A. M. and Pongratz, D (1994). Myofibrillogenesis in primary tissue cultures of adult human skeletal muscle: expression of desmin, titin and nebulin. Clin. Invest 72, 150-155.[Medline]

Bork, P., Holm, L. and Sander, C (1994). The immunoglobulin fold. Structural classification, sequence patterns and common core. J. Mol. Biol 242, 309-320.[Medline]

Chou, P. Y. and Fasman, G. D (1978). Prediction of the secondary structure of proteins from their amino acid sequence. Advan. Enzymol 47, 45-147.[Medline]

Devereux, J., Haeberli, P. and Smithies, O (1984). A comprehensive set of sequence analysis programs for the VAX. Nucl. Acids Res 12, 387-395.

Erickson, H. P (1994). Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin. Proc. Nat. Acad. Sci. USA 91, 10114-10118.[Abstract/Free Full Text]

Fritz, J. D., Greaser, M. L. and Wolff, J. A (1991). A novel 3extension technique using random primers in RNA-PCR. Nucl. Acids Res 19, 3747-.[Free Full Text]

Fritz, J. D., Wolff, J. A. and Greaser, M. L (1993). Partial titin cDNA sequence isolated from rabbit cardiac muscle RNA. J. Muscle Res. Cell Motil 14, 347-350.[Medline]

Fritz, J. D., Wolff, J. A. and Greaser, M. L (1993). Characterization of a partial cDNA clone encoding porcine skeletal muscle titin: comparison with rabbit and mouse skeletal muscle titin sequences. Comp. Biochem. Physiol 105, 357-360.

Furst, D. O., Osborn, M., Nave, R. and Weber, K (1988). The organization of titin filaments in the half-sarcomere revealed by monoclonal antibodies in immunoelectron microscopy: a map of ten nonrepetitive epitopes starting at Z line extends close to the M line. J. Cell Biol 106, 1563-1572.[Abstract/Free Full Text]

Furst, D. O., Nave, R., Osborn, M. and Weber, K (1989). Repetitive titin epitopes with a 42 nm spacing coincide in relative position with known A band striation also identified by major myosin-associated proteins. J. Cell Sci 94, 119-125.[Abstract/Free Full Text]

Gautel, M., Lakey, A., Barlow, D. P., Holmes, Z., Scales, S., Leonard, K., Labeit, S., Mygland, A., Gilhus, N. E. and Aarli, J.A (1993). Titin antibodies in myasthenia gravis: identification of a major immunogenic region of titin. Neurology 43, 1581-1585.[Abstract/Free Full Text]

Gautel, M., Leonard, K. and Labeit, S (1993). Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts. EMBO J 12, 3827-3834.[Medline]

Gonzalez, F. A., Raden, D. L. and Davis, R. J (1993). Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J. Biol. Chem 266, 22159-22163.[Abstract/Free Full Text]

Granzier, H. and Irving, T. C (1995). Passive tension in cardiac muscle: contribution of collagen, titin, microtubules and intermediate filaments. Biophys. J 68, 1029-1044.

Handel, S. E., Greaser, M. L., Schultz, E., Wang, S.-M., Bulinski, J. C., Lin, J. J.-C. and Lessard, J. L (1991). Chicken cardiac myofibrillogenesis studied with antibodies specific for titin and the muscle and nonmuscle isoform of actin and tropomyosin. Cell Tissue Res 263, 419-430.[Medline]

Harpaz, Y. and Chothia, C (1994). Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains. J. Mol. Biol 238, 528-539.[Medline]

Holden, H. M., Ito, M., Hartshorne, D. J. and Rayment, I (1992). X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 \201 resolution. J. Mol. Biol 227, 840-851.[Medline]

Horowits, R. and Podolsky, R. J (1987). The positional stability of thick filaments in activated skeletal muscle sarcomere length: evidence for the role of titin filaments. J. Cell Biol 105, 2217-2223.[Abstract/Free Full Text]

Horowits, R (1992). Passive force generation and titin isoforms in mammalian skeletal muscle. Biophys. J 61, 392-398.[Abstract/Free Full Text]

Isaacs, W. B., Kim, I. S., Struve, A. and Fulton, A. B (1992). Association of titin and myosin heavy chain in developing skeletal muscle. Proc. Nat. Acad. Sci. USA 89, 7496-7500.[Abstract/Free Full Text]

Itoh, Y., Suzuki, T., Kimura, S., Ohashi, K., Higuchi, H., Sawada, H., Shimizu, T., Shibata, M. and Maruyama, K (1988). Extensible and less-extensible domains of connectin filaments in stretched vertebrate skeletal muscle sarcomeres as detected by immunofluorescence and immunoelectron microscopy using monoclonal antibodies. J. Biochem 104, 504-508.

Kurzban, G. P. and Wang, K (1988). Giant polypeptides of skeletal muscle titin: sedimentation equilibrium in guanidine hydrochloride. Biochem. Biophys. Res. Commun 150, 1155-1161.[Medline]

Labeit, S., Barlow, D. P., Gautel, M., Gibson, T., Holt, J., Hsieh, C.-L., Francke, U., Leonard, K., Wardale, J., Whiting, A. and Trinick, J (1990). A regular pattern of two types of 100-residue motif in the sequence of titin. Nature 345, 273-276.[Medline]

Labeit, S., Gautel, M., Lakey, A. and Trinick, J (1992). Towards a molecular understanding of titin. EMBO J 11, 1711-1716.[Medline]

Langan, T. A., Gautier, J., Lohka, M., Hollingsworth, R., Moreno, S., Nurse, P., Maller, J. and Sclafani, R. A (1989). Mammalian growth-associated H1 histone kinase: a homology of cdc2+/cdc28 protein kinases controlling mitotic entry in yeast and frog cells. Mol. Cell. Biol 9, 3860-3868.[Abstract/Free Full Text]

Maruyama, K., Kimura, S., Yoshidomi, H., Sawada, H. and Kikuchi, M (1984). Molecular size and shape of-connectin, an elastic protein of striated muscle. J. Biochem 95, 1424-1433.

Maruyama, K., Endo, T., Kume, H., Kawamura, Y., Kanzawa, N., Nakauchi, Y., Kimura, S., Kawashima, S. and Maruyama, K (1993). A novel domain sequence of connectin localized at the I band of skeletal muscle sarcomeres: homology to neurofilament subunits. Biochem. Biophys. Res. Commun 194, 1288-1291.[Medline]

Maruyama, K., Endo, T., Kume, H., Kawamura, Y., Kanzawa, N.,Kimura, S., Kawashima, S. and Maruyama, K (1994). A partial connectin cDNA encoding a novel type of RSP motifs isolated from chicken embryonic skeletal muscle. J. Biochem 115, 147-149.

Musco, G., Tziatzios, C., Schuck, P. and Pastore, A (1995). Dissecting titin into its structural motifs: identification of an-helix motif near the titin N-terminus. Biochemistry 34, 553-561.[Medline]

Neville, D. M (1971). Molecular weight determination of protein-dodecyl sulfate complexes by gel electrophoresis in a discontinuous buffer system. J. Biol. Chem 246, 6328-6334.[Abstract/Free Full Text]

Noonan, K. E. and Roninson, I. B (1988). mRNA phenotyping by enzymatic amplification of randomly primed cDNA. Nucl. Acids Res 16, 10366-.[Free Full Text]

Pan, K.-M., Roelke, D. L. and Greaser, M. L (1986). Isolation and characterization of a new 40-kilodalton protein from bovine cardiac muscle. J. Biol. Chem 26, 9922-9928.

Pierobon-Bormioli, S., Betto, R. and Salviati, G (1989). The organization of titin (connectin) and nebulin in the sarcomeres: an immunocytolocalization study. J. Muscle Res. Cell Motil 10, 446-456.[Medline]

Politou, A. S., Gautel, M., Labeit, S. and Pastore, A (1994). Immunoglobulin-type domains of titin: same fold, different stability?. Biochemistry 33, 4730-4737.[Medline]

Rhee, D., Sanger, J. M. and Sanger, J. W (1994). The premyofibril: evidence for its role in myofibrillogenesis. Cell Motil. Cytoskel 28, 1-24.[Medline]

Soteriou, A., Clarke, A., Martin, S. and Trinick, J (1993). Titin folding energy and elasticity. Proc. R. Soc. Lond. B 254, 83-86.[Medline]

Tan, K. O., Sater, G. R., Myers, A. M., Robson, R. M. and Huiatt, T. W (1993). Molecular characterization of avian muscle titin. J. Biol. Chem 268, 22900-22907.[Abstract/Free Full Text]

Trombit\207s, K., Pollack, G. H., Wright, J. and Wang, K (1993). Elastic properties of titin filaments demonstrated using a \324freeze-break' technique. Cell Motil. Cytoskel 24, 274-283.[Medline]

Trombit\207s, K. and Pollack, G. H (1993). Elastic properties of the titin filament in the Z-line region of vertebrate striated muscle. J. Muscle Res. Cell Motil 14, 416-422.[Medline]

Wang, K., McCarter, R., Wright, J., Beverly, J. and Ramirez-Mitchell, R (1991). Regulation of skeletal muscle stiffness and elasticity by titin isoforms: a test of the segmental extension model of resting tension. Proc. Nat. Acad. Sci. USA 88, 7101-7105.[Abstract/Free Full Text]

Wang, S.-M. and Greaser, M. L (1985). Immunocytochemical studies using a monoclonal antibody to bovine cardiac titin on intact and extracted myofibrils. J. Muscle Res. Cell Motil 6, 293-312.[Medline]

Whiting, A., Wardale, J. and Trinick, J (1989). Does titin regulate the length of muscle thick filaments?. J. Mol. Biol 205, 263-268.[Medline]

This article has been cited by other articles:

A. Nagy, L. Grama, T. Huber, P. Bianco, K. Trombitas, H. L. Granzier, and M. S. Z. Kellermayer
Hierarchical Extensibility in the PEVK Domain of Skeletal-Muscle Titin
Biophys. J., July 1, 2005; 89(1): 329 - 336.
[Abstract] [Full Text] [PDF]

K. Trombitas, Y. Wu, M. McNabb, M. Greaser, M. S. Z. Kellermayer, S. Labeit, and H. Granzier
Molecular Basis of Passive Stress Relaxation in Human Soleus Fibers: Assessment of the Role of Immunoglobulin-Like Domain Unfolding
Biophys. J., November 1, 2003; 85(5): 3142 - 3153.
[Abstract] [Full Text] [PDF]

R. Yamasaki, Y. Wu, M. McNabb, M. Greaser, S. Labeit, and H. Granzier
Protein Kinase A Phosphorylates Titin's Cardiac-Specific N2B Domain and Reduces Passive Tension in Rat Cardiac Myocytes
Circ. Res., June 14, 2002; 90(11): 1181 - 1188.
[Abstract] [Full Text] [PDF]

K. Trombitas, Y. Wu, D. Labeit, S. Labeit, and H. Granzier
Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently
Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1793 - H1799.
[Abstract] [Full Text] [PDF]

P. van der Ven, J. Bartsch, M Gautel, H Jockusch, and D. Furst
A functional knock-out of titin results in defective myofibril assembly
J. Cell Sci., January 4, 2000; 113(8): 1405 - 1414.
[Abstract] [PDF]

K Ojima, Z. Lin, Z. Zhang, T Hijikata, S Holtzer, S Labeit, H. Sweeney, and H Holtzer
Initiation and maturation of I-Z-I bodies in the growth tips of transfected myotubes
J. Cell Sci., January 11, 1999; 112(22): 4101 - 4112.
[Abstract] [PDF]

C. Machado, C. E. Sunkel, and D. J. Andrew
Human Autoantibodies Reveal Titin as a Chromosomal Protein
J. Cell Biol., April 20, 1998; 141(2): 321 - 333.
[Abstract] [Full Text] [PDF]

K. Trombitas, M. Greaser, S. Labeit, J.-P. Jin, M. Kellermayer, M. Helmes, and H. Granzier
Titin Extensibility In Situ: Entropic Elasticity of Permanently Folded and Permanently Unfolded Molecular Segments
J. Cell Biol., February 23, 1998; 140(4): 853 - 859.
[Abstract] [Full Text] [PDF]

S. Labeit, B. Kolmerer, and W. A. Linke
The Giant Protein Titin: Emerging Roles in Physiology and Pathophysiology
Circ. Res., February 1, 1997; 80(2): 290 - 294.
[Abstract] [Full Text]

M Gautel, D Goulding, B Bullard, K Weber, and D. Furst
The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers
J. Cell Sci., January 11, 1996; 109(11): 2747 - 2754.
[Abstract] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Sebestyen, M. G.

Articles by Greaser, M. L.

Search for Related Content

PubMed

PubMed Citation

Articles by Sebestyen, M. G.

Articles by Greaser, M. L.

				K. Trombitas, Y. Wu, M. McNabb, M. Greaser, M. S. Z. Kellermayer, S. Labeit, and H. Granzier Molecular Basis of Passive Stress Relaxation in Human Soleus Fibers: Assessment of the Role of Immunoglobulin-Like Domain Unfolding Biophys. J., November 1, 2003; 85(5): 3142 - 3153. [Abstract] [Full Text] [PDF]

				R. Yamasaki, Y. Wu, M. McNabb, M. Greaser, S. Labeit, and H. Granzier Protein Kinase A Phosphorylates Titin's Cardiac-Specific N2B Domain and Reduces Passive Tension in Rat Cardiac Myocytes Circ. Res., June 14, 2002; 90(11): 1181 - 1188. [Abstract] [Full Text] [PDF]

				K. Trombitas, Y. Wu, D. Labeit, S. Labeit, and H. Granzier Cardiac titin isoforms are coexpressed in the half-sarcomere and extend independently Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1793 - H1799. [Abstract] [Full Text] [PDF]

				P. van der Ven, J. Bartsch, M Gautel, H Jockusch, and D. Furst A functional knock-out of titin results in defective myofibril assembly J. Cell Sci., January 4, 2000; 113(8): 1405 - 1414. [Abstract] [PDF]

				K Ojima, Z. Lin, Z. Zhang, T Hijikata, S Holtzer, S Labeit, H. Sweeney, and H Holtzer Initiation and maturation of I-Z-I bodies in the growth tips of transfected myotubes J. Cell Sci., January 11, 1999; 112(22): 4101 - 4112. [Abstract] [PDF]

				C. Machado, C. E. Sunkel, and D. J. Andrew Human Autoantibodies Reveal Titin as a Chromosomal Protein J. Cell Biol., April 20, 1998; 141(2): 321 - 333. [Abstract] [Full Text] [PDF]

				K. Trombitas, M. Greaser, S. Labeit, J.-P. Jin, M. Kellermayer, M. Helmes, and H. Granzier Titin Extensibility In Situ: Entropic Elasticity of Permanently Folded and Permanently Unfolded Molecular Segments J. Cell Biol., February 23, 1998; 140(4): 853 - 859. [Abstract] [Full Text] [PDF]

				S. Labeit, B. Kolmerer, and W. A. Linke The Giant Protein Titin: Emerging Roles in Physiology and Pathophysiology Circ. Res., February 1, 1997; 80(2): 290 - 294. [Abstract] [Full Text]

				M Gautel, D Goulding, B Bullard, K Weber, and D. Furst The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers J. Cell Sci., January 11, 1996; 109(11): 2747 - 2754. [Abstract] [PDF]