Getting integrins into shape: recent insights into how integrin activity is regulated by conformational changes

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Alemany, M., Concord, E., Garin, J., Vin\215on, M., Marguerie, G. and Gulino, D (1996). Sequence 274-368 in the3 subunit of the integrin IIb3 provides a ligand recognition and binding domain for the chain of fibrinogen that is independent of platelet activation. Blood 87, 592-601.[Abstract/Free Full Text]

Anderson, C. M., Zucker, F. H. and Steitz, T. A (1979). Space-filling models of kinase clefts and conformational changes. Comparison of the surface structures of kinase enzymes implicates closing clefts in their mechanism. Science 204, 375-380.[Abstract/Free Full Text]

Andrieux, A., Rabiet, M.-J., Chapel, A., Concord, E. and Marguerie, G (1991). A highly conserved region of the Arg-Gly-Asp-binding domain ofthe integrinsubunit is sensitive to stimulation. J. Biol. Chem 266, 14202-14207.[Abstract/Free Full Text]

Back, A. L., Kwok, W. W. and Hickstein, D. D (1992). Identification of two molecular defects in a child with leukocyte adherence deficiency. J. Biol. Chem 267, 5482-5487.[Abstract/Free Full Text]

Bajt, M. L., Loftus, J. C., Gawaz, M. P. and Ginsberg, M. H (1992). Characterization of a gain of function mutation of integrinIIb 3 (platelet glycoprotein IIb-IIIa). J. Biol. Chem 267, 22211-22216.[Abstract/Free Full Text]

Bajt, M. L., Goodman, T. and McGuire, S. L (1995). 2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 ( L2, CD11a/CD18) and Mac-1 ( M2, CD11b/CD18). J. Biol. Chem 270, 94-98.[Abstract/Free Full Text]

Bazzoni, G., Shih, D.-T., Buck, C. A. and Hemler, M. E (1995). Monoclonal antibody 9EG7 defines a novel1 integrin epitope induced by soluble ligand and manganese, but inhibited by calcium. J. Biol. Chem 270, 25570-25577.[Abstract/Free Full Text]

Bergelson, J. M. and Hemler, M. E (1995). Do integrins use a \324MIDAS touch' to grasp an Asp?. Curr. Biol 5, 615-617.[Medline]

Bilsland, C. A. G., Diamond, M. S. and Springer, T. A (1994). The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologoussubunit and localization of a ligand recognition site to the I domain. J. Immunol 152, 4582-4589.[Abstract]

Calvete, J. J., Mann, K., Alvarez, M. V., Lopez, M. V. and Gon\207lez-Rodr\222guez, J (1992). Proteolytic dissection of the isolated fibrinogen receptor, integrin GPIIb/IIIa. Localization of GPIIb and GPIIIa sequences putatively involved in the subunit interface and in intrasubunit and intrachain contacts. Biochem. J 282, 523-532.

Calvete, J. J (1994). Clues for understanding the structure and function of a prototypic human integrin: the platelet glycoprotein IIb/IIIa complex. Thromb. Haemost 72, 1-15.[Medline]

Calvete, J. J., Mann, K., Sch\212fer, W., Fernandez-Lafuente, R. and Guis\207n, J. M (1994). Proteolytic degradation of the RGD-binding and non-RGD binding conformers of human platelet integrin IIb/IIIa: clues for identification of regions involved in the receptor's activation. Biochem. J 298, 1-7.

Corbi, A. L., Miller, L. J., O'Connor, K., Larson, R. S. and Springer, T. A (1987). cDNA cloning and complete primary structure of thesubunit of a leukocyte adhesion protein. EMBO J 6, 4023-4028.[Medline]

Davis, G. E. and Camarillo, C. W (1993). Regulation of integrin-mediated myeloid cell adhesion to fibronectin: influence of disulfide reducing agents, divalent cations and phorbol ester. J. Immunol 151, 7138-7150.[Abstract]

Diamond, M. S. and Springer, T. A (1994). The dynamic regulation of integrin adhesiveness. Curr. Biol 4, 506-517.[Medline]

Dransfield, I., Cabanas, C., Craig, A. and Hogg, N (1992). Divalent cation regulation of the function of the leukocyte integrin LFA-1. J. Cell Biol 116, 219-226.[Abstract/Free Full Text]

D'Souza, S. E., Ginsberg, M. H., Burke, T. A., Lam, S. C. T. and Plow, E. F (1988). Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science 242, 91-93.[Abstract/Free Full Text]

D'Souza, S. E., Ginsberg, M. H., Burke, T. A. and Plow, E. F (1990). The ligand binding site of the platelet integrin receptor IIb/IIIa is proximal to the second calcium binding domain of itssubunit. J. Biol. Chem 265, 3440-3446.[Abstract/Free Full Text]

D'Souza, S. E., Haas, T. A., Piotrowicz, R. S., Byers-Ward, V., McGrath, D. E., Soule, H. R., Cierniewski, C., Plow, E. F. and Smith, J. W (1994). Ligand and cation binding are dual functions of a discrete segment of the integrin3 subunit: cation displacement is involved in ligand binding. Cell 79, 659-667.[Medline]

Faull, R. J. and Ginsberg, M. H (1995). Dynamic regulation of integrins. Stem Cells 13, 38-46.[Medline]

Hynes, R. O (1992). Integrins: versatility, modulation and signalling in cell adhesion. Cell 69, 11-25.[Medline]

Humphries, M. J (1990). The molecular basis and specificity of integrin-ligand interactions. J. Cell Sci 97, 585-592.[Free Full Text]

Irie, A., Kamata, T., Puzon-McLaughlin, W. and Takada, Y (1995). Critical amino acid residues for ligand binding are clustered around a predictedturn of the third N-terminal repeat in the integrin andsubunits. EMBO J 14, 5550-5556.[Medline]

Kamata, T. and Takada, Y (1994). Direct binding of collagen to the I domain of integrin(VLA-2, CD49b/CD29) in a divalent-cation independent manner. J. Biol. Chem 269, 26006-26010.[Abstract/Free Full Text]

Kamata, T., Puzon, W. and Takada, Y (1995). Identification of putativeligand-binding sites of integrin (VLA-4, CD49d/CD29). Biochem. J 305, 945-951.

Kouns, W. C., Hadvary, P., Haering, P. and Steiner, B (1992). Conformational modulation of purified glycoprotein (GP) IIb-IIIa allows proteolytic generaton of active fragments from either active or inactive GPIIb-IIIa. J. Biol. Chem 267, 18844-18851.[Abstract/Free Full Text]

Kouns, W. C., Steiner, B., Kunicki, T. J., Moog, S., Jutzi, J., Jennings, L. K., Cazenave, J.-P. and Lanza, F (1994). Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombasthenia. Blood 84, 1108-1115.[Abstract/Free Full Text]

Lanza, F., Stierle, A., Fournier D., Morales, M., Andre, G., Nurden, A. T. and Cazenave, J.-P (1992). A new variant of Glanzmann's thrombasthenia (Strasbourg I): Platelets with functionally defective GPIIb-IIIa complexes and a 214Arg214Trp mutation. J. Clin. Invest 89, 1995-2004.

Lee, O.-J., Rieu, P., Arnaout, M. A. and Liddington, R (1995). Crystal structure of the A-domain from thesubunit of the integrin CR3 (CD11a/CD18). Cell 80, 631-638.[Medline]

Lee, O.-J., Bankston, L. A., Arnaout, M. A. and Liddington, R (1995). Two conformations for the integrin A-domain (I-domain): a pathway for activation?. Structure 3, 1333-1340.[Medline]

Loftus, J. C., O'Toole, T. E., Plow, E. F., Glass, A., Frelinger, A. L. III and Ginsberg, M. H (1990). A3 integrin mutation abolishes ligand binding and alters a divalent-cation dependent conformation. Science 249, 915-918.[Abstract/Free Full Text]

Loftus, J. C., Halloran, C. E., Ginsberg, M. H., Feigen, L. P., Zablocki, J. A. and Smith J. W (1996). The amino-terminal one-third ofIIb defines the ligand specificity of integrin IIb3. J. Biol Chem 271, 2033-2039.[Abstract/Free Full Text]

Masumoto, A. and Hemler, M. E (1993). Mutation of putative divalent cation sites in the4subunit of the integrin VLA-4: distinct effects on adhesion to CS1/fibronectin, VCAM-1, and invasin. J. Cell Biol 123, 245-253.[Abstract/Free Full Text]

Michishita, M., Videm, V. and Arnaout, M. A (1993). A novel divalent-cation binding site in the A domain of the2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell 72, 857-867.[Medline]

Monod, J., Wyman, J. and Changeux, J.-P (1965). On the nature of allosteric transitions: a plausible model. J. Mol. Biol 12, 88-118.[Medline]

Mould, A. P., Akiyama, S. K. and Humphries, M. J (1995). Regulation of integrin-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+. J. Biol Chem 270, 26270-26277.[Abstract/Free Full Text]

Mould, A. P., Garratt, A. N., Askari, J. A., Akiyama, S. K. and Humphries, M. J (1995). Regulation of integrinfunction by anti-integrin antibodies and divalent cations. Biochem. Soc. Trans 23, 395-.

Mould, A. P., Akiyama, S. K. and Humphries, M. J (1996). The inhibitory anti-1 integrin monoclonal antibody 13 recognises an epitope that is attenuated by ligand occupancy: evidence for allosteric inhibition of integrin function. J. Biol. Chem 271, 20365-20374.[Abstract/Free Full Text]

Mu\226oz, M., Serrador, J., S\207nchez-Madrid, F. and Teixido, J (1996). A region of the integrin VLA4 subunit involved in homotypic cell aggregation and in fibronectin but not vascular cell adhesion molecule-1 binding. J. Biol. Chem 271, 2696-2702.[Abstract/Free Full Text]

Newham, P. and Humphries, M. J (1996). Integrin adhesion receptors: structure, function and implications for biomedicine. Mol. Med. Today 2, 304-313.[Medline]

Pasqualini, R., Koivunen, E. and Ruoslahti, E (1995). A peptide isolated from phage display libraries is a structural and functional mimic of an RGD binding site on integrins. J. Cell Biol 130, 1189-1196.[Abstract/Free Full Text]

Perutz, M. F (1989). Mechanisms of cooperativity and allosteric regulation of proteins. Quart. Rev. Biophys 22, 139-236.[Medline]

Qu, A. and Leahy, D. J (1995). Crystal structure of the I-domain from the CD11a/CD18 (LFA-1,L 2) integrin. Proc. Nat. Acad. Sci. USA 92, 10277-107281.[Abstract/Free Full Text]

Sastry, S. K. and Horwitz, A. F (1993). Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra-and intracellular initiated transmembrane signalling. Curr. Opin. Cell Biol 5, 819-831.[Medline]

Schiffer, S. G., Hemler, M. E., Lobb, R. R., Tizard, R. and Osborn, L (1995). Molecular mapping of functional antibody sites ofintegrin. J. Biol. Chem 270, 14270-14273.[Abstract/Free Full Text]

Schwartz, M. A., Schaller, M. D. and Ginsberg, M. H (1995). Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell Biol 11, 549-599.[Medline]

Smith, J. W. and Cheresh, D. A (1988). The Arg-Gly-Asp binding domain of the vitronectin receptor. Photoaffinity cross linking implicates amino acid residues 61-203 of thesubunit. J. Biol. Chem 263, 18726-18731.[Abstract/Free Full Text]

Smith, J. W. and Cheresh, D. A (1990). Integrin (V 3)-ligand interaction. Identification of a heterodimeric RGD binding site on the vitronectin receptor. J. Biol. Chem 265, 2168-2172.[Abstract/Free Full Text]

Strynadka, N. C. J. and James, M. N. G (1989). Crystal structures of the helix-loop-helix calcium binding proteins. Annu. Rev. Biochem 58, 951-998.[Medline]

Takada, Y., Ylanne, J., Mandelman, D., Puzon, W. and Ginsberg, M. H (1992). A point mutation in the integrinsubunit blocks binding of to fibronectin and invasin but not recruitment to adhesion plaques. J. Cell Biol 119, 913-921.[Abstract/Free Full Text]

Takada, Y. and Puzon, W (1993). Identification of a regulatory region of the integrin1 subunit using activating and inhibiting antibodies. J. Biol. Chem 268, 17597-17601.[Abstract/Free Full Text]

Yednock, T. A., Cannon, C., Vandevert, C., Goldbach, E. G., Shaw, G., Ellis, D. K., Liaw, C., Fritz, L. C. and Tanner, L. I (1995). integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand. J. Biol. Chem 270, 28740-28750.[Abstract/Free Full Text]

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				J. A. Askari, P. A. Buckley, A. P. Mould, and M. J. Humphries Linking integrin conformation to function J. Cell Sci., January 15, 2009; 122(2): 165 - 170. [Abstract] [Full Text] [PDF]

				S. M. Dallabrida, N. Ismail, J. R. Oberle, B. E. Himes, and M. A. Rupnick Angiopoietin-1 Promotes Cardiac and Skeletal Myocyte Survival Through Integrins Circ. Res., March 4, 2005; 96(4): e8 - e24. [Abstract] [Full Text] [PDF]

				K. Clark, R. Pankov, M. A. Travis, J. A. Askari, A. P. Mould, S. E. Craig, P. Newham, K. M. Yamada, and M. J. Humphries A specific {alpha}5{beta}1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation J. Cell Sci., January 15, 2005; 118(2): 291 - 300. [Abstract] [Full Text] [PDF]

				B.-H. Luo, K. Strokovich, T. Walz, T. A. Springer, and J. Takagi Allosteric {beta}1 Integrin Antibodies That Stabilize the Low Affinity State by Preventing the Swing-out of the Hybrid Domain J. Biol. Chem., June 25, 2004; 279(26): 27466 - 27471. [Abstract] [Full Text] [PDF]

				P. D. Arora, M. Glogauer, A. Kapus, D. J. Kwiatkowski, and C. A. McCulloch Gelsolin Mediates Collagen Phagocytosis through a Rac-dependent Step Mol. Biol. Cell, February 1, 2004; 15(2): 588 - 599. [Abstract] [Full Text] [PDF]

				M. Pires de Miranda, P. C. Reading, D. C. Tscharke, B. J. Murphy, and G. L. Smith The vaccinia virus kelch-like protein C2L affects calcium-independent adhesion to the extracellular matrix and inflammation in a murine intradermal model J. Gen. Virol., September 1, 2003; 84(9): 2459 - 2471. [Abstract] [Full Text] [PDF]

				M.-G. Yeh, B. L. Ziober, B. Liu, G. Lipkina, I. S. Vizirianakis, and R. H. Kramer The {beta}1 Cytoplasmic Domain Regulates the Laminin-binding Specificity of the {alpha}7X1 Integrin Mol. Biol. Cell, September 1, 2003; 14(9): 3507 - 3518. [Abstract] [Full Text] [PDF]

				K. A. Krivacic and A. D. Levine Extracellular Matrix Conditions T Cells for Adhesion to Tissue Interstitium J. Immunol., May 15, 2003; 170(10): 5034 - 5044. [Abstract] [Full Text] [PDF]

				A. P. Mould, S. J. Barton, J. A. Askari, P. A. McEwan, P. A. Buckley, S. E. Craig, and M. J. Humphries Conformational Changes in the Integrin beta A Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement J. Biol. Chem., May 2, 2003; 278(19): 17028 - 17035. [Abstract] [Full Text] [PDF]

				L. Kwong, M. A. Wozniak, A. S. Collins, S. D. Wilson, and P. J. Keely R-Ras Promotes Focal Adhesion Formation through Focal Adhesion Kinase and p130Cas by a Novel Mechanism That Differs from Integrins Mol. Cell. Biol., February 1, 2003; 23(3): 933 - 949. [Abstract] [Full Text]

				B. Gao, T. M. Saba, and M.-F. Tsan Role of alpha vbeta 3-integrin in TNF-alpha -induced endothelial cell migration Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1196 - C1205. [Abstract] [Full Text] [PDF]

				S. A. Cunningham, J. M. Rodriguez, M. P. Arrate, T. M. Tran, and T. A. Brock JAM2 Interacts with alpha 4beta 1. FACILITATION BY JAM3 J. Biol. Chem., July 26, 2002; 277(31): 27589 - 27592. [Abstract] [Full Text] [PDF]

				A. P. Mould, J. A. Askari, S. Barton, A. D. Kline, P. A. McEwan, S. E. Craig, and M. J. Humphries Integrin Activation Involves a Conformational Change in the alpha 1 Helix of the beta Subunit A-domain J. Biol. Chem., May 24, 2002; 277(22): 19800 - 19805. [Abstract] [Full Text] [PDF]

				R. F. Rotundo, T. M. Curtis, M. D. Shah, B. Gao, A. Mastrangelo, S. E. LaFlamme, and T. M. Saba TNF-alpha disruption of lung endothelial integrity: reduced integrin mediated adhesion to fibronectin Am J Physiol Lung Cell Mol Physiol, February 1, 2002; 282(2): L316 - L329. [Abstract] [Full Text] [PDF]

				L. Y. Koo, D. J. Irvine, A. M. Mayes, D. A. Lauffenburger, and L. G. Griffith Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus J. Cell Sci., January 4, 2002; 115(7): 1423 - 1433. [Abstract] [Full Text] [PDF]

				Y. Tanaka, Y. Minami, S. Mine, H. Hirano, C.-D. Hu, H. Fujimoto, K. Fujii, K. Saito, J. Tsukada, Y. van Kooyk, et al. H-Ras Signals to Cytoskeletal Machinery in Induction of Integrin-Mediated Adhesion of T Cells J. Immunol., December 1, 1999; 163(11): 6209 - 6216. [Abstract] [Full Text] [PDF]

				B Masson-Gadais, A Pierres, A. Benoliel, P Bongrand, and J. Lissitzky Integrin (alpha) and beta subunit contribution to the kinetic properties of (alpha)2beta1 collagen receptors on human keratinocytes analyzed under hydrodynamic conditions J. Cell Sci., January 7, 1999; 112(14): 2335 - 2345. [Abstract] [PDF]

				Y. Mou, H. Ni, and J. A. Wilkins The Selective Inhibition of {beta}1 and {beta}7 Integrin-Mediated Lymphocyte Adhesion by Bacitracin J. Immunol., December 1, 1998; 161(11): 6323 - 6329. [Abstract] [Full Text] [PDF]

				Z. Cao, K. Huang, and A. F. Horwitz Identification of a Domain on the Integrin alpha 5 Subunit Implicated in Cell Spreading and Signaling J. Biol. Chem., November 27, 1998; 273(48): 31670 - 31679. [Abstract] [Full Text] [PDF]

				C. Capo, S. Meconi, M.-V. Sanguedolce, N. Bardin, G. Flatau, P. Boquet, and J.-L. Mege Effect of Cytotoxic Necrotizing Factor-1 on Actin Cytoskeleton in Human Monocytes: Role in the Regulation of Integrin-Dependent Phagocytosis J. Immunol., October 15, 1998; 161(8): 4301 - 4308. [Abstract] [Full Text] [PDF]

				A. P. Mould, L. Burrows, and M. J. Humphries Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin alpha 5beta 1 J. Biol. Chem., October 2, 1998; 273(40): 25664 - 25672. [Abstract] [Full Text] [PDF]

				G. Flores-Delgado, P. Bringas, and D. Warburton Laminin 2�attachment selects myofibroblasts from fetal mouse lung Am J Physiol Lung Cell Mol Physiol, September 1, 1998; 275(3): L622 - L630. [Abstract] [Full Text] [PDF]

				Y. Tanaka, S. Mine, C. G. Figdor, A. Wake, H. Hirano, J. Tsukada, M. Aso, K. Fujii, K. Saito, Y. van Kooyk, et al. Constitutive Chemokine Production Results in Activation of Leukocyte Function-Associated Antigen-1 on Adult T-Cell Leukemia Cells Blood, May 15, 1998; 91(10): 3909 - 3919. [Abstract] [Full Text] [PDF]

				P. Newham, S. E. Craig, K. Clark, A. P. Mould, and M. J. Humphries Analysis of Ligand-Induced and Ligand-Attenuated Epitopes on the Leukocyte Integrin {alpha}4{beta}1: VCAM-1, Mucosal Addressin Cell Adhesion Molecule-1, and Fibronectin Induce Distinct Conformational Changes J. Immunol., May 1, 1998; 160(9): 4508 - 4517. [Abstract] [Full Text] [PDF]

				H. Ni, A. Li, N. Simonsen, and J. A. Wilkins Integrin Activation by Dithiothreitol or Mn2+ Induces a Ligand-occupied Conformation and Exposure of a Novel NH2-terminal Regulatory Site on the beta 1 Integrin Chain J. Biol. Chem., April 3, 1998; 273(14): 7981 - 7987. [Abstract] [Full Text] [PDF]

				D. Franco, W. H Lamers, and A. F.M Moorman Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model Cardiovasc Res, April 1, 1998; 38(1): 25 - 53. [Full Text] [PDF]

				A. M. Belkin, S. F. Retta, O. Y. Pletjushkina, F. Balzac, L. Silengo, R. Fassler, V. E. Koteliansky, K. Burridge, and G. Tarone Muscle {beta}1D Integrin Reinforces the Cytoskeleton-Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing J. Cell Biol., December 15, 1997; 139(6): 1583 - 1595. [Abstract] [Full Text] [PDF]

				J. L. Sechler, S. A. Corbett, and J. E. Schwarzbauer Modulatory Roles for Integrin Activation and the Synergy Site of Fibronectin during Matrix Assembly Mol. Biol. Cell, December 1, 1997; 8(12): 2563 - 2573. [Abstract] [Full Text]

				A. P. Mould, J. A. Askari, S.-i. Aota, K. M. Yamada, A. Irie, Y. Takada, H. J. Mardon, and M. J. Humphries Defining the Topology of Integrin alpha 5beta 1-Fibronectin Interactions Using Inhibitory Anti-alpha 5 and Anti-beta 1 Monoclonal Antibodies. EVIDENCE THAT THE SYNERGY SEQUENCE OF FIBRONECTIN IS RECOGNIZED BY THE AMINO-TERMINAL REPEATS OF THE alpha 5 SUBUNIT J. Biol. Chem., July 11, 1997; 272(28): 17283 - 17292. [Abstract] [Full Text] [PDF]

				M. Cruz, C. Dalgard, and M. Ignatius Functional partitioning of beta1 integrins revealed by activating and inhibitory mAbs J. Cell Sci., January 11, 1997; 110(21): 2647 - 2659. [Abstract] [PDF]