Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1

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Baldwin, H. S., Shen, H. M., Yan, H.-C., DeLisser, H. M., Chong, A., Mickanin, C., Trask, T., Kirschbaum, N. E., Newman, P. J., Albelda, S. M. and Buck, C. A (1994). Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development. Development 120, 2539-2553.[Abstract/Free Full Text]

Berendt A. R., McDowall, A., Craig A. G., Bates, P. A., Sternberg, M. J. E., Marsh, K., Newbold, C. I. and Hogg, N (1992). The binding site on ICAM-1 for Plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1binding site. Cell 68, 71-81.[Medline]

Bergelson, J. M. and Hemler, M. E (1995). Do integrins use a \324MIDAS touch' to grasp an Asp?. Curr. Biol 5, 615-617.[Medline]

Berman, M. E. and Muller, W. A (1995). Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM/CD31) on monocytes and neutrophils increases the binding capacity of leukocyte CR3 (CD11b/CD18). J. Immunol 154, 299-307.[Abstract]

Bird, I. N., Spragg, J. H., Ager, A. and Matthews, N (1993). Studies of lymphocyte transendothelial migration: analysis of migrated cell phenotypes with regard to CD31 (PECAM-1), CD45RA and CD45RO. Immunology 80, 553-560.[Medline]

Blystone, S. D., Lindberg, F. P., LaFlamme, S. E. and Brown, E. J (1995). Integrin3 cytoplasmic tail is necessary and sufficient for regulation of 51 phagocytosis by v3 and integrin-associated protein. J. Cell Biol 130, 745-754.[Abstract/Free Full Text]

Bogen, S., Pak, J., Garifallou, M., Deng, X. and Muller, W. A (1994). Monolclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo. J. Exp. Med 179, 1059-1064.[Abstract/Free Full Text]

Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G. and Cherish, D. A (1994). Integrinv 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.[Medline]

Cepek, K. L., Shaw, S. K., Parker, C. M., Russell, G. J., Morrow, J. S., Rimm, D. L. and Brenner, M. B (1994). Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and theE 7 integrin. Nature 372, 190-193.[Medline]

Chan, B. M. C and Hemler, M. E (1993). Multiple functional forms of the integrin VLA-2 can be derived from a single2 cDNA clone: Interconversion of forms induced by an anti- 1 antibody. J. Cell Biol 120, 537-543.[Abstract/Free Full Text]

Charo I, F., Nannizzi, L., Smith J. W. and Cherish, D. A (1990). The vitronectin receptorv 3 binds fibronectin and acts in concert with5 1 in promoting cellular attachment and spreading on fibronectin. J. Cell Biol 111, 2795-2800.[Abstract/Free Full Text]

Chen, W., Knapp, W., Majdic, O., Stockinger, H., Bohmig, G. and Zlabinger, G. J (1994). Co-ligation of CD31 and FcRII induces cytokine production in human monocytes. J. Immunol 152, 3991-3997.[Abstract]

DeLisser, H. M., Yan, H. C., Newman, P. J., Muller, W. A., Buck, C. A. and Albelda, S. M (1993). Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. J. Biol. Chem 268, 16037-16046.[Abstract/Free Full Text]

DeLisser, H. M., Chilkowtowsky, J., Yan, H. C., Daise, M. L., Buck, C. A. and Albelda, S. M (1994). Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) result in changes in ligand binding properties. J. Cell Biol 124, 195-203.[Abstract/Free Full Text]

DeLisser, H. M., Newman, P. J. and Albelda, S. M (1994). Molecular and functional aspects of PECAM-1/CD31. Immunol. Today 15, 490-495.[Medline]

Fawcett, J., Holness, C. L. L., Needham, L. A., Turley, H., Gatter, K. C. Mason, D. Y. and Simmons, D. L (1992). Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. Nature 360, 481-484.[Medline]

Fawcett, J., Buckley, C., Holness, C. L, Bird, I. N., Spragg, J. H., Saunders, J., Harris, A. and Simmons, D. L (1995). Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of inter endothelial cell contacts. J. Cell Biol 128, 1229-1241.[Abstract/Free Full Text]

Goldberger, A., Middleton, K. A., Oliver, J. A., Paddock, C., Yan, H.-C., DeLisser, H. M., Albelda, S. M and Newman, P. J (1994). Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form. J. Biol. Chem 269, 17183-17191.[Abstract/Free Full Text]

Holness, C. L. and Simmons, D. L (1994). Structural motifs for recognition and adhesion in members of the immunoglobulin superfamily. J. Cell Sci 107, 2065-2070.[Medline]

Holness, C. L., Bates P. A., Littler, A. J., Buckley, C. D., McDowall, A., Bossy, D., Hogg, N. and Simmons, D. L (1995). Analysis of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function associated antigen 1. J. Biol. Chem 220, 877-884.

Jones, E. Y., Harlos, K., Bottomley, M. J., Robinson, R. C., Driscoll, P. C., Edwards, R. M., Clements, J. M., Dudgeon, T. J. and Stuart, D. I (1995). Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1. 8\201 resolution. Nature 373, 539-544.[Medline]

Karecla, P. I., Bowden, S. J., Green, S. J. and Kilshaw, P. J (1995). Recognition of E-cadherin on epithelial cells by the mucosal T cell integrinM290 7(E 7). Eur. J. Immunol 25, 852-856.[Medline]

Kirschbaum, N. E., Gumina, R. J. and Newman, P. J (1994). , Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain. Blood 84, 4028-4037.[Abstract/Free Full Text]

Koch, A. E., Halloran, M. M., Haskell, C. J., Shah, M. R. and Polverini, P. J (1995). Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature 376, 517-519.[Medline]

Landis, R. C., McDowall, A., Holness, C. L. L., Littler, A. J., Simmons, D. L. and Hogg. N (1994). Involvement of the \324I' domain of LFA-1 in the selective binding to ligands ICAM-1 and ICAM-3. J. Cell Biol 126, 529-537.[Abstract/Free Full Text]

Leavesley, D. I., Oliver, J. M., Swart, B. W., Berndt, M. C., Haylock, D. N. and Simmons, P. J (1994). Signals from platelet/endothelial cell adhesion molecule enhance the adhesive of the very late antigen-4 integrin of human CD34+haematopoietic progenitor cells. J. Immunol 153, 4673-4683.[Abstract]

Loftus, J. C., Smith, J. W. and Ginsberg, M. H (1994). Integrin-mediated cell adhesion: the extracellular face. J. Biol. Chem 269, 25235-25238.[Free Full Text]

Muller, W. A., Ratti, C. M., McDonnell, S. L. and Cohn, Z. A (1989). A human endothelial cell-restricted externally disposed plasmalemmal protein enriched in intercellular junctions. J. Exp. Med 170, 399-414.[Abstract/Free Full Text]

Muller, W. A., Berman, M. E., Newman, P. J., DeLisser, H. M. and Albelda, S. M (1992). A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31). J. Exp. Med 175, 1401-1404.[Abstract/Free Full Text]

Muller, W. A., Weigl, S. A., Deng, X. and Philips, D. M (1993). PECAM-1 is required for transendothelial migration of leukocytes. J. Exp. Med 178, 449-460.[Abstract/Free Full Text]

Neugebauer, K. M and Reichardt, L. F (1991). Cell surface regulation of1-integrin activity on developing retinal neurons. Nature 350, 68-71.[Medline]

Newman, P. J., Berndt, M. C., Gorski, J., White II, G. C., Lyman, S., Paddock, C. and Muller, W. A (1990). PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin superfamily. Science 247, 1219-1221.[Abstract/Free Full Text]

Newman, P. J., Hillery, C. A., Albrecht, R., Parise, L. V., Berndt, M. C., Mazurov, A. V. Dunlop, L. C., Zhang, J and Rittenhouse, S. E (1992). Activation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution. J. Cell Biol 119, 239-246.[Abstract/Free Full Text]

Piali, L., Albelda, S. M, Baldwin, H. S., Hammel, P., Gisler, R. H. and Imhof B. A (1993). Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates2 integrins on lymphokine-activated killer cells. Eur. J. Immunol 23, 2464-2471.[Medline]

Piali, L., Hemmel, P., Uherek, C., Bachmann, F., Gisler, R. H., Dunon D. and Ihmof, B. A (1995). CD31/ PECAM-1 is a ligand forv 3integrin involved in adhesion of leukocytes to endothelium. J. Cell Biol 130, 451-460.[Abstract/Free Full Text]

Romer, L. H., McLean, N. V., Yan, H.-C., Daise, M., Sun, J. and DeLisser, H. M (1995). INF-gamma and TNF-alpha induce redistribution of PECAM-1 (CD31) on human endothelial cells. J. Immunol 154, 6582-6592.[Abstract]

Ruiz, P., Dunon, D., Sonnenberg, A. and Ihmof, B. A (1993). Suppression of mouse melanoma metastasis by EA-1, a monoclonal antibody specific for6 integrins. Cell Adhes. Commun 1, 67-81.[Medline]

Schimmenti, L. A., Yan, H. C., Madri, J. A. and Albelda S. M (1992). Platelet endothelial cell adhesion molecule, PECAM-1 modulates cell migration. J. Cell. Physiol 153, 417-428.[Medline]

Simmons, D. L., Walker, C., Power, C and Pigott. R (1990). Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen. J. Exp. Med 171, 2147-2151.[Abstract/Free Full Text]

Stockinger, H., Gadd, S. J., Eher, R., Majdic, O., Schreiber, W., Kasinrerk, W. Strass, B., Schnabl, E. and Knapp, W (1990). Molecular characterisation and functional analysis of the leukocyte surface protein CD31. J. Immunol 145, 3889-3897.[Abstract]

Tanaka, Y., Albelda, S. M., Horgan, K. J., van Seventer, G. A., Shimizu, Y., Newman, W., Hallam, J., Newman, P. J., Buck, C. A. and Shaw. S (1992). CD31 expressed on distinctive T cell subsets is a preferential amplifier of1 integrin-mediated adhesion. J. Exp. Med 176, 245-253.[Abstract/Free Full Text]

Van Kooyk, Y., Van de Wiel van Kemenade, E., Weder, P., Huijbens, J. F. and Figdor, C. G (1993). Lymphocyte function-associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium. J. Exp. Med 177, 185-190.[Abstract/Free Full Text]

Vaporciyan, A. A., DeLisser, H. M., Yan, H. C., Mendiguren, I. I., Thorn, S. R., Jones, M. L., Ward, P. A. and Albelda S. M (1993). Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science 262, 1580-1582.[Abstract/Free Full Text]

Watt, S. M., Williamson, J., Genevier, H., Fawcett, J., Simmons, D. L, Hatzfeld, A., Nesbitt, S. A. and Coombe, D. R (1993). The heparin binding PECAM-1 adhesion molecule is expressed by CD34+ hematopoietic precursor cells with early myeloid and B-lymphoid cell phenotypes. Blood 82, 2649-2663.[Abstract/Free Full Text]

Yan, H.-C., Pilewski, J. M., DeLisser, H. M., Romer, L and Albelda S. M (1995). Localization of multiple functional domains on human PECAM-1 (CD31) by monoclonal antibody epitope mapping. Cell Adhes. Commun 3, 45-66.[Medline]

Zehnder, J. L., Hirai, K., Shatsky, M., McGregor, J. L., Levitt, L. J. and Leung, L. L. K (1992). The cell adhesion molecule CD31 is phosphorylated after cell activation. J. Biol. Chem 267, 5243-5249.[Abstract/Free Full Text]

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Mol. Biol. Cell, April 1, 1998; 9(4): 701 - 713.
[Abstract] [Full Text]

D. Varon, D. E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, and P. J. Newman
Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets
Blood, January 15, 1998; 91(2): 500 - 507.
[Abstract] [Full Text] [PDF]

P Boissy, I Machuca, M Pfaff, D Ficheux, and P Jurdic
Aggregation of mononucleated precursors triggers cell surface expression of alphavbeta3 integrin, essential to formation of osteoclast-like multinucleated cells
J. Cell Sci., January 9, 1998; 111(17): 2563 - 2574.
[Abstract] [PDF]

S. Deaglio, M. Morra, R. Mallone, C. M. Ausiello, E. Prager, G. Garbarino, U. Dianzani, H. Stockinger, and F. Malavasi
Human CD38 (ADP-Ribosyl Cyclase) Is a Counter-Receptor of CD31, an Ig Superfamily Member
J. Immunol., January 1, 1998; 160(1): 395 - 402.
[Abstract] [Full Text] [PDF]

J. Famiglietti, J. Sun, H. M. DeLisser, and S. M. Albelda
Tyrosine Residue in Exon 14�of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity
J. Cell Biol., September 22, 1997; 138(6): 1425 - 1435.
[Abstract] [Full Text] [PDF]

J. P. Newton, C. D. Buckley, E. Y. Jones, and D. L. Simmons
Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31
J. Biol. Chem., August 15, 1997; 272(33): 20555 - 20563.
[Abstract] [Full Text] [PDF]

F. Liao, J. Ali, T. Greene, and W. A. Muller
Soluble Domain 1�of Platelet-Endothelial Cell Adhesion Molecule (PECAM) Is Sufficient to Block Transendothelial Migration In Vitro and In Vivo
J. Exp. Med., April 7, 1997; 185(7): 1349 - 1358.
[Abstract] [Full Text] [PDF]

D. E. Jackson, C. M. Ward, R. Wang, and P. J. Newman
The Protein-tyrosine Phosphatase SHP-2 Binds Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Forms a Distinct Signaling Complex during Platelet Aggregation. EVIDENCE FOR A MECHANISTIC LINK BETWEEN PECAM-1- AND INTEGRIN-MEDIATED CELLULAR SIGNALING
J. Biol. Chem., March 14, 1997; 272(11): 6986 - 6993.
[Abstract] [Full Text] [PDF]

P. Martin and J. Sanes
Integrins mediate adhesion to agrin and modulate agrin signaling
Development, January 10, 1997; 124(19): 3909 - 3917.
[Abstract] [PDF]

J. Sun, J. Williams, H.-C. Yan, K. M. Amin, S. M. Albelda, and H. M. DeLisser
Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) Homophilic Adhesion Is Mediated by Immunoglobulin-like Domains 1and 2and Depends on the Cytoplasmic Domain and the Level of Surface Expression
J. Biol. Chem., August 2, 1996; 271(31): 18561 - 18570.
[Abstract] [Full Text] [PDF]

S. A. Cunningham, M. P. Arrate, J. M. Rodriguez, R. J. Bjercke, P. Vanderslice, A. P. Morris, and T. A. Brock
A Novel Protein with Homology to the Junctional Adhesion Molecule. CHARACTERIZATION OF LEUKOCYTE INTERACTIONS
J. Biol. Chem., October 27, 2000; 275(44): 34750 - 34756.
[Abstract] [Full Text] [PDF]

				E. F. Vernon-Wilson, F. Aurade, L. Tian, I. C. M. Rowe, M. J. Shipston, J. Savill, and S. B. Brown CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells J. Leukoc. Biol., November 1, 2007; 82(5): 1278 - 1288. [Abstract] [Full Text] [PDF]

				J. H. Chidlow Jr., D. Shukla, M. B. Grisham, and C. G. Kevil Pathogenic angiogenesis in IBD and experimental colitis: new ideas and therapeutic avenues Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G5 - G18. [Abstract] [Full Text] [PDF]

				S. Kondo, E. A. Scheef, N. Sheibani, and C. M. Sorenson PECAM-1 isoform-specific regulation of kidney endothelial cell migration and capillary morphogenesis Am J Physiol Cell Physiol, June 1, 2007; 292(6): C2070 - C2083. [Abstract] [Full Text] [PDF]

				E. F. Vernon-Wilson, F. Aurade, and S. B. Brown CD31 promotes {beta}1 integrin-dependent engulfment of apoptotic Jurkat T lymphocytes opsonized for phagocytosis by fibronectin J. Leukoc. Biol., June 1, 2006; 79(6): 1260 - 1267. [Abstract] [Full Text] [PDF]

				E. A. Eugenin, R. Gamss, C. Buckner, D. Buono, R. S. Klein, E. E. Schoenbaum, T. M. Calderon, and J. W. Berman Shedding of PECAM-1 during HIV infection: a potential role for soluble PECAM-1 in the pathogenesis of NeuroAIDS. J. Leukoc. Biol., March 1, 2006; 79(3): 444 - 452. [Abstract] [Full Text] [PDF]

				S. Falati, S. Patil, P. L. Gross, M. Stapleton, G. Merrill-Skoloff, N. E. Barrett, K. L. Pixton, H. Weiler, B. Cooley, D. K. Newman, et al. Platelet PECAM-1 inhibits thrombus formation in vivo Blood, January 15, 2006; 107(2): 535 - 541. [Abstract] [Full Text] [PDF]

				D. Mehta and A. B. Malik Signaling Mechanisms Regulating Endothelial Permeability Physiol Rev, January 1, 2006; 86(1): 279 - 367. [Abstract] [Full Text] [PDF]

				J. M. Gibbins Platelet adhesion signalling and the regulation of thrombus formation J. Cell Sci., July 15, 2004; 117(16): 3415 - 3425. [Abstract] [Full Text] [PDF]

				L. Righi, S. Deaglio, C. Pecchioni, A. Gregorini, A. L. Horenstein, G. Bussolati, A. Sapino, and F. Malavasi Role of CD31/Platelet Endothelial Cell Adhesion Molecule-1 Expression in in Vitro and in Vivo Growth and Differentiation of Human Breast Cancer Cells Am. J. Pathol., April 1, 2003; 162(4): 1163 - 1174. [Abstract] [Full Text] [PDF]

				Y. Wang, X. Su, C. M. Sorenson, and N. Sheibani Tissue-specific distributions of alternatively spliced human PECAM-1 isoforms Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H1008 - H1017. [Abstract] [Full Text] [PDF]

				L. S. Davis, M. Sackler, R. I. Brezinschek, E. Lightfoot, J. L. Bailey, N. Oppenheimer-Marks, and P. E. Lipsky Inflammation, Immune Reactivity, and Angiogenesis in a Severe Combined Immunodeficiency Model of Rheumatoid Arthritis Am. J. Pathol., January 1, 2002; 160(1): 357 - 367. [Abstract] [Full Text] [PDF]

				M. Cicmil, J. M. Thomas, M. Leduc, C. Bon, and J. M. Gibbins Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets Blood, January 1, 2002; 99(1): 137 - 144. [Abstract] [Full Text] [PDF]

				E. B. Voura, R. A. Ramjeesingh, A. M.P. Montgomery, and C.-H. Siu Involvement of Integrin alpha vbeta 3 and Cell Adhesion Molecule L1 in Transendothelial Migration of Melanoma Cells Mol. Biol. Cell, September 1, 2001; 12(9): 2699 - 2710. [Abstract] [Full Text] [PDF]

				F. A. Spring, S. F. Parsons, S. Ortlepp, M. L. Olsson, R. Sessions, R. L. Brady, and D. J. Anstee Intercellular adhesion molecule-4 binds {alpha}4{beta}1 and {alpha}V-family integrins through novel integrin-binding mechanisms Blood, July 15, 2001; 98(2): 458 - 466. [Abstract] [Full Text] [PDF]

				R. D. Thompson, K. E. Noble, K. Y. Larbi, A. Dewar, G. S. Duncan, T. W. Mak, and S. Nourshargh Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane Blood, March 15, 2001; 97(6): 1854 - 1860. [Abstract] [Full Text] [PDF]

				E. Prager, G. Staffler, O. Majdic, M. D. Saemann, S. Godar, G. J. Zlabinger, and H. Stockinger Induction of Hyporesponsiveness and Impaired T Lymphocyte Activation by the CD31 Receptor:Ligand Pathway in T Cells J. Immunol., February 15, 2001; 166(4): 2364 - 2371. [Abstract] [Full Text] [PDF]

				T. Zhao and P. J. Newman Integrin Activation by Regulated Dimerization and Oligomerization of Platelet Endothelial Cell Adhesion Molecule (PECAM)-1 from Within the Cell J. Cell Biol., January 8, 2001; 152(1): 65 - 74. [Abstract] [Full Text] [PDF]

				K. Zibara, E. Chignier, C. Covacho, R. Poston, G. Canard, P. Hardy, and J. McGregor Modulation of Expression of Endothelial Intercellular Adhesion Molecule-1, Platelet-Endothelial Cell Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Aortic Arch Lesions of Apolipoprotein E-Deficient Compared With Wild-Type Mice Arterioscler. Thromb. Vasc. Biol., October 1, 2000; 20(10): 2288 - 2296. [Abstract] [Full Text] [PDF]

				C. W.Y. Wong, G. Wiedle, C. Ballestrem, B. Wehrle-Haller, S. Etteldorf, M. Bruckner, B. Engelhardt, R. H. Gisler, and B. A. Imhof PECAM-1/CD31 Trans-homophilic Binding at the Intercellular Junctions Is Independent of Its Cytoplasmic Domain; Evidence for Heterophilic Interaction with Integrin alpha vbeta 3 in Cis Mol. Biol. Cell, September 1, 2000; 11(9): 3109 - 3121. [Abstract] [Full Text]

				S. Mahooti, D. Graesser, S. Patil, P. Newman, G. Duncan, T. Mak, and J. A. Madri PECAM-1 (CD31) Expression Modulates Bleeding Time in Vivo Am. J. Pathol., July 1, 2000; 157(1): 75 - 81. [Abstract] [Full Text] [PDF]

				R. D. Thompson, M. W. Wakelin, K. Y. Larbi, A. Dewar, G. Asimakopoulos, M. A. Horton, M. T. Nakada, and S. Nourshargh Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and {beta}3 Integrin Blockade on Leukocyte Transmigration In Vivo J. Immunol., July 1, 2000; 165(1): 426 - 434. [Abstract] [Full Text] [PDF]

				L. M. Botella, A. Puig-Kroger, N. Almendro, T. Sanchez-Elsner, E. Munoz, A. Corbi, and C. Bernabeu Identification of a Functional NF-{kappa}B Site in the Platelet Endothelial Cell Adhesion Molecule-1 Promoter J. Immunol., February 1, 2000; 164(3): 1372 - 1378. [Abstract] [Full Text] [PDF]

				C Johnson-Leger, M Aurrand-Lions, and B. Imhof The parting of the endothelium: miracle, or simply a junctional affair? J. Cell Sci., January 3, 2000; 113(6): 921 - 933. [Abstract] [PDF]

				M. T. Nakada, K. Amin, M. Christofidou-Solomidou, C. D. O'Brien, J. Sun, I. Gurubhagavatula, G. A. Heavner, A. H. Taylor, C. Paddock, Q.-H. Sun, et al. Antibodies Against the First Ig-Like Domain of Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Inhibit PECAM-1-Dependent Homophilic Adhesion Block In Vivo Neutrophil Recruitment J. Immunol., January 1, 2000; 164(1): 452 - 462. [Abstract] [Full Text] [PDF]

				G. Wiedle, C. Johnson-Leger, and B. A. Imhof A Chimeric Cell Adhesion Molecule Mediates Homing of Lymphocytes to Vascularized Tumors Cancer Res., October 1, 1999; 59(20): 5255 - 5263. [Abstract] [Full Text] [PDF]

				R. Chiba, N. Nakagawa, K. Kurasawa, Y. Tanaka, Y. Saito, and I. Iwamoto Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of alpha vbeta 3 Integrin and Enhances beta 1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells Blood, August 15, 1999; 94(4): 1319 - 1329. [Abstract] [Full Text] [PDF]

				V. M. Morales, A. Christ, S. M. Watt, H. S. Kim, K. W. Johnson, N. Utku, A. M. Texieira, A. Mizoguchi, E. Mizoguchi, G. J. Russell, et al. Regulation of Human Intestinal Intraepithelial Lymphocyte Cytolytic Function by Biliary Glycoprotein (CD66a) J. Immunol., August 1, 1999; 163(3): 1363 - 1370. [Abstract] [Full Text] [PDF]

				T. Schneider, T. B. Issekutz, and A. C. Issekutz The Role of alpha 4 (CD49d) and beta 2 (CD18) Integrins in Eosinophil and Neutrophil Migration to Allergic Lung Inflammation in the Brown Norway Rat Am. J. Respir. Cell Mol. Biol., March 1, 1999; 20(3): 448 - 457. [Abstract] [Full Text]

				S. Quarmby, P. Kumar, J. Wang, J. A. Macro, J. J. Hutchinson, R. D. Hunter, and S. Kumar Irradiation Induces Upregulation of CD31 in Human Endothelial Cells Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 588 - 597. [Abstract] [Full Text] [PDF]

				G. E. Rainger, C. D. Buckley, D. L. Simmons, and G. B. Nash Neutrophils sense flow-generated stress and direct their migration through alpha Vbeta 3-integrin Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H858 - H864. [Abstract] [Full Text] [PDF]