Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

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				C. R. Burton, J. E. Meredith, D. M. Barten, M. E. Goldstein, C. M. Krause, C. J. Kieras, L. Sisk, L. G. Iben, C. Polson, M. W. Thompson, et al. The Amyloid-{beta} Rise and {gamma}-Secretase Inhibitor Potency Depend on the Level of Substrate Expression J. Biol. Chem., August 22, 2008; 283(34): 22992 - 23003. [Abstract] [Full Text] [PDF]

				J. Lee, C. Retamal, L. Cuitino, A. Caruano-Yzermans, J.-E. Shin, P. van Kerkhof, M.-P. Marzolo, and G. Bu Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes J. Biol. Chem., April 25, 2008; 283(17): 11501 - 11508. [Abstract] [Full Text] [PDF]

				A. Schneider, L. Rajendran, M. Honsho, M. Gralle, G. Donnert, F. Wouters, S. W. Hell, and M. Simons Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons J. Neurosci., March 12, 2008; 28(11): 2874 - 2882. [Abstract] [Full Text] [PDF]

				I.-S. Yoon, E. Chen, T. Busse, E. Repetto, M. K. Lakshmana, E. H. Koo, and D. E. Kang Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway FASEB J, September 1, 2007; 21(11): 2742 - 2752. [Abstract] [Full Text] [PDF]

				D. Tampellini, J. Magrane, R. H. Takahashi, F. Li, M. T. Lin, C. G. Almeida, and G. K. Gouras Internalized Antibodies to the Abeta Domain of APP Reduce Neuronal Abeta and Protect against Synaptic Alterations J. Biol. Chem., June 29, 2007; 282(26): 18895 - 18906. [Abstract] [Full Text] [PDF]

				N. N. Dewji, D. Mukhopadhyay, and S. J. Singer An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures PNAS, January 31, 2006; 103(5): 1540 - 1545. [Abstract] [Full Text] [PDF]

				R. Spoelgen, C. A. F. von Arnim, A. V. Thomas, I. D. Peltan, M. Koker, A. Deng, M. C. Irizarry, O. M. Andersen, T. E. Willnow, and B. T. Hyman Interaction of the Cytosolic Domains of sorLA/LR11 with the Amyloid Precursor Protein (APP) and beta-Secretase beta-Site APP-Cleaving Enzyme J. Neurosci., January 11, 2006; 26(2): 418 - 428. [Abstract] [Full Text] [PDF]

				S. Ye, Y. Huang, K. Mullendorff, L. Dong, G. Giedt, E. C. Meng, F. E. Cohen, I. D. Kuntz, K. H. Weisgraber, and R. W. Mahley Apolipoprotein (apo) E4 enhances amyloid {beta} peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target PNAS, December 20, 2005; 102(51): 18700 - 18705. [Abstract] [Full Text] [PDF]

				I. Y. Tamboli, K. Prager, E. Barth, M. Heneka, K. Sandhoff, and J. Walter Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the {beta}-Amyloid Precursor Protein and Amyloid {beta}-Peptide J. Biol. Chem., July 29, 2005; 280(30): 28110 - 28117. [Abstract] [Full Text] [PDF]

				I.-S. Yoon, C. U. Pietrzik, D. E. Kang, and E. H. Koo Sequences from the Low Density Lipoprotein Receptor-related Protein (LRP) Cytoplasmic Domain Enhance Amyloid {beta} Protein Production via the {beta}-Secretase Pathway without Altering Amyloid Precursor Protein/LRP Nuclear Signaling J. Biol. Chem., May 20, 2005; 280(20): 20140 - 20147. [Abstract] [Full Text] [PDF]

				J. A. Cam, C. V. Zerbinatti, Y. Li, and G. Bu Rapid Endocytosis of the Low Density Lipoprotein Receptor-related Protein Modulates Cell Surface Distribution and Processing of the {beta}-Amyloid Precursor Protein J. Biol. Chem., April 15, 2005; 280(15): 15464 - 15470. [Abstract] [Full Text] [PDF]

				J. H. Chyung, D. M. Raper, and D. J. Selkoe {gamma}-Secretase Exists on the Plasma Membrane as an Intact Complex That Accepts Substrates and Effects Intramembrane Cleavage J. Biol. Chem., February 11, 2005; 280(6): 4383 - 4392. [Abstract] [Full Text] [PDF]

				D. Langui, N. Girardot, K. H. El Hachimi, B. Allinquant, V. Blanchard, L. Pradier, and C. Duyckaerts Subcellular Topography of Neuronal A{beta} Peptide in APPxPS1 Transgenic Mice Am. J. Pathol., November 1, 2004; 165(5): 1465 - 1477. [Abstract] [Full Text] [PDF]

				C. A. F. von Arnim, M. M. Tangredi, I. D. Peltan, B. M. Lee, M. C. Irizarry, A. Kinoshita, and B. T. Hyman Demonstration of BACE ({beta}-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy J. Cell Sci., October 15, 2004; 117(22): 5437 - 5445. [Abstract] [Full Text] [PDF]

				J. A. Cam, C. V. Zerbinatti, J. M. Knisely, S. Hecimovic, Y. Li, and G. Bu The Low Density Lipoprotein Receptor-related Protein 1B Retains {beta}-Amyloid Precursor Protein at the Cell Surface and Reduces Amyloid-{beta} Peptide Production J. Biol. Chem., July 9, 2004; 279(28): 29639 - 29646. [Abstract] [Full Text] [PDF]

				C. U. Pietrzik, I.-S. Yoon, S. Jaeger, T. Busse, S. Weggen, and E. H. Koo FE65 Constitutes the Functional Link between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein J. Neurosci., April 28, 2004; 24(17): 4259 - 4265. [Abstract] [Full Text] [PDF]

				S. H. Pasternak, R. D. Bagshaw, M. Guiral, S. Zhang, C. A. Ackerley, B. J. Pak, J. W. Callahan, and D. J. Mahuran Presenilin-1, Nicastrin, Amyloid Precursor Protein, and {gamma}-Secretase Activity Are Co-localized in the Lysosomal Membrane J. Biol. Chem., July 11, 2003; 278(29): 26687 - 26694. [Abstract] [Full Text] [PDF]

				C. S. Ho, V. Marinescu, M. L. Steinhilb, J. R. Gaut, R. S. Turner, and E. L. Stuenkel Synergistic Effects of Munc18a and X11 Proteins on Amyloid Precursor Protein Metabolism J. Biol. Chem., July 19, 2002; 277(30): 27021 - 27028. [Abstract] [Full Text] [PDF]

				M. Marella, S. Lehmann, J. Grassi, and J. Chabry Filipin Prevents Pathological Prion Protein Accumulation by Reducing Endocytosis and Inducing Cellular PrP Release J. Biol. Chem., July 5, 2002; 277(28): 25457 - 25464. [Abstract] [Full Text] [PDF]

				M. M. Verbeek, I. Otte-Holler, J. A.M. Fransen, and R. M.W. de Waal Accumulation of the Amyloid-{beta} Precursor Protein in Multivesicular Body-like Organelles J. Histochem. Cytochem., May 1, 2002; 50(5): 681 - 690. [Abstract] [Full Text] [PDF]

				S.-R. Ji, Y. Wu, and S.-f. Sui Cholesterol Is an Important Factor Affecting the Membrane Insertion of beta -Amyloid Peptide (Abeta 1-40), Which May Potentially Inhibit the Fibril Formation J. Biol. Chem., February 15, 2002; 277(8): 6273 - 6279. [Abstract] [Full Text] [PDF]

				W. Xia, W. J. Ray, B. L. Ostaszewski, T. Rahmati, W. T. Kimberly, M. S. Wolfe, J. Zhang, A. M. Goate, and D. J. Selkoe Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta -protein generation PNAS, August 1, 2000; 97(16): 9299 - 9304. [Abstract] [Full Text] [PDF]

				P. G. Ulery, J. Beers, I. Mikhailenko, R. E. Tanzi, G. W. Rebeck, B. T. Hyman, and D. K. Strickland Modulation of beta -Amyloid Precursor Protein Processing by the Low Density Lipoprotein Receptor-related Protein (LRP). EVIDENCE THAT LRP CONTRIBUTES TO THE PATHOGENESIS OF ALZHEIMER'S DISEASE J. Biol. Chem., March 15, 2000; 275(10): 7410 - 7415. [Abstract] [Full Text] [PDF]

				B De Strooper and W Annaert Proteolytic processing and cell biological functions of the amyloid precursor protein J. Cell Sci., January 6, 2000; 113(11): 1857 - 1870. [Abstract] [PDF]

				S. Soriano, A. S. C. Chyung, X. Chen, G. B. Stokin, V. M.-Y. Lee, and E. H. Koo Expression of beta -Amyloid Precursor Protein-CD3gamma Chimeras to Demonstrate the Selective Generation of Amyloid beta 1-40 and Amyloid beta 1-42 Peptides within Secretory and Endocytic Compartments J. Biol. Chem., November 5, 1999; 274(45): 32295 - 32300. [Abstract] [Full Text] [PDF]

				L. Torroja, M. Packard, M. Gorczyca, K. White, and V. Budnik The Drosophila beta -Amyloid Precursor Protein Homolog Promotes Synapse Differentiation at the Neuromuscular Junction J. Neurosci., September 15, 1999; 19(18): 7793 - 7803. [Abstract] [Full Text] [PDF]

				R. G. Perez, S. Soriano, J. D. Hayes, B. Ostaszewski, W. Xia, D. J. Selkoe, X. Chen, G. B. Stokin, and E. H. Koo Mutagenesis Identifies New Signals for beta -Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Abeta 42 J. Biol. Chem., July 2, 1999; 274(27): 18851 - 18856. [Abstract] [Full Text] [PDF]

				S. L. Sabo, L. M. Lanier, A. F. Ikin, O. Khorkova, S. Sahasrabudhe, P. Greengard, and J. D. Buxbaum Regulation of beta -Amyloid Secretion by FE65, an Amyloid Protein Precursor-binding Protein J. Biol. Chem., March 19, 1999; 274(12): 7952 - 7957. [Abstract] [Full Text] [PDF]

				L.-W. Jin, M. G. Hearn, C. E. Ogburn, N. Dang, D. Nochlin, W. C. Ladiges, and G. M. Martin Transgenic Mice Over-Expressing the C-99 Fragment of �PP with an {alpha}-Secretase Site Mutation Develop a Myopathy Similar to Human Inclusion Body Myositis Am. J. Pathol., December 1, 1998; 153(6): 1679 - 1686. [Abstract] [Full Text] [PDF]

				D. S. Howland, S. P. Trusko, M. J. Savage, A. G. Reaume, D. M. Lang, J. D. Hirsch, N. Maeda, R. Siman, B. D. Greenberg, R. W. Scott, et al. Modulation of Secreted beta -Amyloid Precursor Protein and Amyloid beta -Peptide in Brain by Cholesterol J. Biol. Chem., June 26, 1998; 273(26): 16576 - 16582. [Abstract] [Full Text] [PDF]