NPXY motifs control the recruitment of the alpha5beta1 integrin in focal adhesions independently of the association of talin with the beta1 chain

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Vignoud, L.
	Articles by Block, M. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Vignoud, L.
	Articles by Block, M. R.

Albiges-Rizo C., Frachet, P. and Block, M. R (1995). Down regulation of talin alters cell adhesion and the processing of the5 1 integrin. J. Cell Sci 108, 3317-3329.[Abstract]

Backer, J. M., Shoelson, S. E., Weiss, M. A., Hua, Q. X., Cheatham, R. B., Haring, E., Cahill, D. C. and White, M. F (1992). The insulin receptor juxtamembrane region contains two independant tyrosine/-turn internalization signals. J. Cell Biol 118, 831-839.[Abstract/Free Full Text]

Balzac, F., Retta, S. F., Albini, A., Melchiorri, A., Koteliansky, V. E., Geuna,M., Silengo, L. and Tarone, G (1994). Expression of1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility. J. Cell Biol 127, 557-565.[Abstract/Free Full Text]

Bansal, K. and Gierash, L (1991). The NPXY internalization signal of the LDL receptor adopts a reverse-turn conformation. Cell 67, 1195-1201.[Medline]

Batzer, A. G., Blaikie, P., Nelson, K., Schlessinger, J. and Margolis B. ( (1995). The phosphotyrosine interaction domain of SHC binds an LYNPXY motif on the epidermal growth factor receptor. Mol. Cell. Biol 15, 4403-4409.[Abstract]

Bretscher, M. S (1989). Endocytosis and recycling of the fibronectin receptor in CHO cells. EMBO J 8, 1341-1348.[Medline]

Briesewitz, R., Kern, A. and Marcantonio, E. E (1993). Ligand-dependent and-independent integrin focal contact localization. The role of thechain cytoplasmic domain. Mol. Biol. Cell 4, 593-604.[Abstract]

Brown, P. J. and Juliano R. L (1985). Selective inhibition of fibronectin-mediated cell adhesion by monoclonal antibodies to a cell-surface glycoprotein. Science 228, 1448-1451.[Abstract/Free Full Text]

Campbell, K. S., Ogris, E., Burke, B., Su, W., Auger, K. R., Druker, B. J., Schaffhausen, B. S., Roberts, T. M. and Pallas, D. C (1994). Poloma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proc. Nat. Acad. Sci. USA 91, 6344-6348.[Abstract/Free Full Text]

Chan, B. M. C., Kassner, P. D., Schiro, J. A., Byers, H. R., Kupper, T. S. and Hemler, M. E (1992). Distinct cellular functions mediated by different VLA integrinsubunit cytoplasmic domains. Cell 68, 1051-1060.[Medline]

Chen, Y. P., O'Toole, T. E., Shipley, T., Forsyth, J., LaFlamme, S. E., Yamada, K. M., Shattil, S. J. and Ginsberg, M. H (1994). \324Inside-out' signal transduction inhibited by isolated integrin cytoplasmic domain. J. Biol. Chem 269, 18307-18310.[Abstract/Free Full Text]

Chen, W. J., Goldstein, J. L. and Brown, M. S (1990). NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J. Biol. Chem 265, 3116-3123.[Abstract/Free Full Text]

Clark, E. A. and Brugge, J. S (1995). Integrins and signal transduction pathways: the road taken. Science 268, 233-239.[Abstract/Free Full Text]

Craparo, A., O'Neill, T. J. and Gustafson, T. A (1995). Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif in the insulin-like growth factor I receptor. J. Biol. Chem 270, 15639-15643.[Abstract/Free Full Text]

Damsky, C. M. and Werb, Z (1992). Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr. Opin. Cell Biol 4, 772-781.[Medline]

Ellis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A. and Rutter, W. J (1986). Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose. Cell 45, 721-732.[Medline]

Engvall, E. and Ruoslahti, E (1977). Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. Int. J. Cancer 20, 1-5.[Medline]

Faull, R. J. and Ginsberg, M. H (1995). Dynamic regulation of integrins. Stem Cells 13, 38-46.[Abstract]

Filardo, E. J., Brooks, P. C., Deming, S. L., Damsky, C. and Cheresh, D. A (1995). Requirement of the NPXY motif in the3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. J. Cell Biol 130, 441-450.[Abstract/Free Full Text]

Giancotti, F. G. and Ruoslahti, E (1990). Elevated levels of the alpha5 beta1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 60, 849-859.[Medline]

Ginsberg, M. H., Du, X. and Plow, E. F (1992). Inside-out signaling. Curr. Opin. Cell Biol 4, 766-771.[Medline]

Goldmann, W. H., Bremer, A., H\212ner, M., Aebi, U. and Isenberg, G (1994). Native talin is a dumbbell-shaped homodimer when it interacts with actin. J. Struct. Biol 112, 3-10.[Medline]

Gustafson, T. A., He, W., Craparo, A., Schaub, C. D. and O'Neill, T. J (1995). Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol Cell. Biol 15, 2500-2508.[Abstract]

Hannigan, G. E., Leung-Hagesteijn, C., Fitz-Gibbon, L., Coppolino, M. G., Radeva, G., Filmus, J., Bell, J. C. and Dedhar, S (1996). Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379, 91-96.[Medline]

Hayashi, Y., Haimovich, B., Reszka, A., Boettiger, D. and Horwitz, A (1990). Expression and function of chicken integrin1 subunit and its cytoplasmic domain mutants in mouse NIH3T3 cells. J. Cell Biol 110, 175-184.[Abstract/Free Full Text]

Horwitz, A., Duggan, K., Burk, C., Beckerle, M. C. and Burridge, K (1986). Interaction of plasma membrane fibronectin receptor with talin \320 a transmembrane linkage. Nature 320, 531-533.[Medline]

Hughes, P. E., O'Toole, T. E., Yl\212nne, J., Shattil, S. J. and Ginsberg, M. H (1995). The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J. Biol. Chem 270, 12411-12417.[Abstract/Free Full Text]

Hunyady, L., Bor, M., Baukal, A. J., Balla, T. and Catt, K. J (1995). A conserved NPLFY sequence contributes to agonist binding and signal transduction but is not an internalization signal for type 1 angiotensin II receptor. J. Biol. Chem 270, 16602-16609.[Abstract/Free Full Text]

Hynes, R. O (1992). Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.[Medline]

Juliano, R. L. and Haskill, S (1993). Signal transduction from the extracellular matrix. J. Cell Biol 120, 577-585.[Free Full Text]

Kornberg, L., Earp, H. S., Parson, J. T., Schaller, M. and Juliano, R. L (1992). Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase. J. Biol. Chem 267, 23439-23442.[Abstract/Free Full Text]

Laemmli, U. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 1133-1142.[Medline]

LaFlamme, S. E., Akiyama, S. K. and Yamada, K. M (1992). Regulation of fibronectin receptor distribution. J. Cell Biol 117, 437-447.[Abstract/Free Full Text]

Lewis, J. M. and Schwartz, M. A (1995). Mapping in vivo associations of cytoplasmic proteins with integrin1 cytoplasmic domain mutants. Mol. Biol. Cell 6, 151-160.[Abstract]

Lukashev, M. E., Sheppard, D. and Pythela, R (1994). Disruption of integrin function and induction of tyrosin phosphorylation by the autonomously expressed1 integrin cytoplasmic domain. J. Biol. Chem 269, 18311-18314.[Abstract/Free Full Text]

Marcantonio, E. E., Guan, J. L., Trevithick, J. E. and Hynes, R. O (1990). Mapping of the functional determinants of the integrin1 cytoplasmic domain by site-directed mutagenesis. Cell Regul 1, 597-604.[Medline]

Miyamoto, S., Akiyama, S. T. and Yamada, K. M (1995). Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267, 883-885.[Abstract/Free Full Text]

Miyamoto, S., Teramoto, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K. and Yamada, K. M (1995). Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol 131, 791-805.[Abstract/Free Full Text]

Nojima Y., Morino, N., Mimura, T., Hamasaki, K., Furuya, H., Sakai, R., Sato, T., Tachibana, K., Morimoto, C., Yazaki, Y. and Hirai, H (1995). Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J. Biol. Chem 270, 15398-15402.[Abstract/Free Full Text]

Nuckolls, G. H., Romer, L. H. and Burridge, K (1992). Microinjection of antibodies against talin inhibits the spreading and migration of fibroblasts. J. Cell Sci 102, 753-762.[Abstract/Free Full Text]

O'Neill, T. J., Craparo, A. and Gustafson, T. A (1994). Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system. Mol. Cell. Biol 14, 6433-6442.[Abstract/Free Full Text]

O'Toole, T. E., Manselman, D., Forsyth, J., Shattil, S. J., Plow, E. F. and Ginsberg, M. H (1991). Modulation of the affinity of integrinIIb 3 (GPIIb-IIIa) by the cytoplasmic domain ofIIb. Science 254, 845-847.[Abstract/Free Full Text]

O'Toole, T. E., Ylanne, J. and Culley, B. M (1995). Regulation of integrin affinity states through an NPXY motif in thesubunit cytoplasmic domain. J. Biol. Chem 270, 8553-8558.[Abstract/Free Full Text]

Otey, C. A., Pavalko, F. M. and Burridge, K (1990). An interaction between-actinin and the 1 integrin subunit in vitro. J. Cell Biol 11, 721-729.

Otey, C. A., Vasquez, G. B., Burridge, K. and Erickson, B. W (1993). Mapping of the-actinin binding site within the 1 integrin cytoplasmic domain. J. Biol. Chem 268, 21193-21197.[Abstract/Free Full Text]

Parsons, J. T., Schaller, M. D., Hildebrand, J., Leu, T.-H. and Otey, C (1994). Focal adhesion kinase: structure and signalling. J. Cell Sci 18, 109-113.

Pavalko, F. M. and Burridge, K (1991). Disruption of the actin cytoskeleton after microinjection of proteolytic fragments of-actinin. J. Cell Biol 114, 481-491.[Abstract/Free Full Text]

Petch, L. A., Bockholt, S. M., Bouton, A., Parsons, J. T. and Burridge, K (1995). Adhesion-induced tyrosine phosphorylation of the p130 src substrate. J. Cell Sci 109, 1371-1379.

Rajagopalan, M., Neidigh, J. L. and McClain, D. A (1991). Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis. J. Biol. Chem 262, 11833-11840.[Abstract/Free Full Text]

Reszka, A. A., Hayashi, Y. and Horwitz, A. F (1992). Identification of amino acid sequences in the integrin1 cytoplasmic domain implicated in cytoskeletal association. J. Cell Biol 117, 1321-1330.[Abstract/Free Full Text]

Sastry, S. K. and Horwitz, A. F (1993). Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra-and intracellular initiated transmembrane signaling. Curr. Opin. Cell Biol 5, 819-831.[Medline]

Schaller, M. D., Borgman, C. A., Cobb, B. S., Vines, R. R., Reynolds, A. B. and Parsons, J. T (1992). pp125FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Nat. Acad. Sci. USA 89, 5192-5196.[Abstract/Free Full Text]

Schreiner, C. L., Bauer, J. S., Danilov, Y. N., Hussein, S., Sczekan, M. M. and Juliano R. L (1989). Isolation and characterization of Chinese hamster ovary cell variants deficient in the expression of fibronectin receptor. J. Cell Biol 109, 3157-3167.[Abstract/Free Full Text]

Schwartz, M. A., Schaller, M. D. and Ginsberg, M. H (1995). Integrins: emerging paradigms of signal transduction. Annu. Rev. Cell. Dev. Biol 11, 549-599.[Medline]

Sczekan, M. M. and Juliano, R. L (1990). Internalization of the fibronectin receptor is a constitutive process. J. Cell. Physiol 142, 574-580.[Medline]

Shattil, S. J., Ginsberg, M. H. and Brugge, J. S (1994). Adhesive signaling in platelets. Curr. Opin. Cell Biol 6, 695-706.[Medline]

Smyth, S. S. and Parise, L. V (1993). Regulation of ligand binding to glycoprotein IIb-IIIa (integrinIIb in isolated platelet membrane. Biochem. J 292, 749-758.

Southern, P. J. and Berg, P (1982). Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet 1, 327-341.[Medline]

Stuiver, I. and O'Toole, T. E (1995). Regulation of integrin function and cellular adhesion. Stem Cells 13, 250-262.[Abstract]

Takada, Y., Yl\212nne, J., Mandelman, D., Puzon, W. and Ginsberg, M. H (1992). A point mutation of integrin1 subunit blocks binding of 51 to fibronectin and invasin but not recruitment to adhesion plaques. J. Cell Biol 119, 913-921.[Abstract/Free Full Text]

Tapley, P., Horwitz, A. F., Buck, C., Duggan, K. and Rohrschneider, L (1989). Integrins isolated from rous virus-transformed chicken embryo fibroblasts. Oncogene 4, 325-333.[Medline]

Tranqui, L. and Block M. R (1995). Intracellular processing of talin occurs within focal adhesions. Exp. Cell Res 217, 149-156.[Medline]

Turner, C. E. and Burridge, K (1988). Detection of metavinculin in human platelets using a modified talin overlay assay. Eur. J. Cell Biol 49, 202-206.

Vignoud, L., Usson, Y., Balzac, F., Tarone, G. and Block, M. R (1994). Internalization of the5 1 integrin does not depend on \324NPXY' signals. Biochem. Biophys. Res. Commun 199, 603-611.[Medline]

Vuori, K. and Ruoslahti, E (1994). Association of insulin receptor substrate-1 with integrins. Science 266, 1576-1578.[Abstract/Free Full Text]

Vuori, K. and Ruoslahti, E (1995). Tyrosine phosphorylation of p130casand cortactin accompanies integrin-mediated cell adhesion to extracellular matrix. J. Biol. Chem 270, 22259-22262.[Abstract/Free Full Text]

Yl\212nne, J., Huuskonen, J., O'Toole, T. E., Ginsberg, M. H., Virtanen, I. and Gahmberg, C. G (1995). Mutation of the cytoplasmic domain of the3 subunit. J. Biol. Chem 270, 9550-9557.[Abstract/Free Full Text]

Yurochko, A. D., Liu, D. Y., Eierman, D. and Haskill, S (1992). Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction. Proc. Nat. Acad. Sci. USA 89, 9034-9038.[Abstract/Free Full Text]

This article has been cited by other articles:

G. Tanentzapf, M. D. Martin-Bermudo, M. S. Hicks, and N. H. Brown
Multiple factors contribute to integrin-talin interactions in vivo
J. Cell Sci., April 15, 2006; 119(8): 1632 - 1644.
[Abstract] [Full Text] [PDF]

A. Wiedemann, J. C. Patel, J. Lim, A. Tsun, Y. van Kooyk, and E. Caron
Two distinct cytoplasmic regions of the {beta}2 integrin chain regulate RhoA function during phagocytosis.
J. Cell Biol., March 27, 2006; 172(7): 1069 - 1079.
[Abstract] [Full Text] [PDF]

M. A. Rosenthal-Allieri, M. Ticchioni, J. P. Breittmayer, Y. Shimizu, and A. Bernard
Influence of {beta}1 Integrin Intracytoplasmic Domains in the Regulation of VLA-4-Mediated Adhesion of Human T Cells to VCAM-1 under Flow Conditions
J. Immunol., July 15, 2005; 175(2): 1214 - 1223.
[Abstract] [Full Text] [PDF]

D. Bouvard, L. Vignoud, S. Dupe-Manet, N. Abed, H.-N. Fournier, C. Vincent-Monegat, S. F. Retta, R. Fassler, and M. R. Block
Disruption of Focal Adhesions by Integrin Cytoplasmic Domain-associated Protein-1alpha
J. Biol. Chem., February 14, 2003; 278(8): 6567 - 6574.
[Abstract] [Full Text] [PDF]

L. Levy, S. Broad, D. Diekmann, R. D. Evans, and F. M. Watt
beta 1 Integrins Regulate Keratinocyte Adhesion and Differentiation by Distinct Mechanisms
Mol. Biol. Cell, February 1, 2000; 11(2): 453 - 466.
[Abstract] [Full Text]

M. J. Hewish, Y. Takada, and B. S. Coulson
Integrins alpha 2beta 1 and alpha 4beta 1 Can Mediate SA11 Rotavirus Attachment and Entry into Cells
J. Virol., January 1, 2000; 74(1): 228 - 236.
[Abstract] [Full Text]

D. S. Rice and T. Curran
Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS
Genes & Dev., November 1, 1999; 13(21): 2758 - 2773.
[Full Text]

S. Patil, A. Jedsadayanmata, J. D. Wencel-Drake, W. Wang, I. Knezevic, and S. C.-T. Lam
Identification of a Talin-binding Site in the Integrin beta 3 Subunit Distinct from the NPLY Regulatory Motif of Post-ligand Binding Functions. THE TALIN N-TERMINAL HEAD DOMAIN INTERACTS WITH THE MEMBRANE-PROXIMAL REGION OF THE beta 3 CYTOPLASMIC TAIL
J. Biol. Chem., October 1, 1999; 274(40): 28575 - 28583.
[Abstract] [Full Text] [PDF]

A. Gut, M. S. Balda, and K. Matter
The Cytoplasmic Domains of a beta 1 Integrin Mediate Polarization in Madin-Darby Canine Kidney Cells by Selective Basolateral Stabilization
J. Biol. Chem., November 6, 1998; 273(45): 29381 - 29388.
[Abstract] [Full Text] [PDF]

N. C. Romzek, E. S. Harris, C. L. Dell, J. Skronek, E. Hasse, P. J. Reynolds, S. W. Hunt III, and Y. Shimizu
Use of a beta 1 Integrin-deficient Human T Cell to Identify beta 1 Integrin Cytoplasmic Domain Sequences Critical for Integrin Function
Mol. Biol. Cell, October 1, 1998; 9(10): 2715 - 2727.
[Abstract] [Full Text]

J.-M. Heraud, C. Racaud-Sultan, D. Gironcel, C. Albiges-Rizo, T. Giacomini, S. Roques, V. Martel, M. Breton-Douillon, B. Perret, and H. Chap
Lipid Products of Phosphoinositide 3-Kinase and Phosphatidylinositol 4',5'-Bisphosphate Are Both Required for ADP-dependent Platelet Spreading
J. Biol. Chem., July 10, 1998; 273(28): 17817 - 17823.
[Abstract] [Full Text] [PDF]

E. Schaffner-Reckinger, V. Gouon, C. Melchior, S. Plancon, and N. Kieffer
Distinct Involvement of beta 3 Integrin Cytoplasmic Domain Tyrosine Residues 747�and 759�in Integrin-mediated Cytoskeletal Assembly and Phosphotyrosine Signaling
J. Biol. Chem., May 15, 1998; 273(20): 12623 - 12632.
[Abstract] [Full Text] [PDF]

T. Sakai, Q. Zhang, R. Fassler, and D. F. Mosher
Modulation of beta 1A Integrin Functions by Tyrosine Residues in the beta 1 Cytoplasmic Domain
J. Cell Biol., April 20, 1998; 141(2): 527 - 538.
[Abstract] [Full Text] [PDF]

V. Martel, C. Racaud-Sultan, S. Dupe, C. Marie, F. Paulhe, A. Galmiche, M. R. Block, and C. Albiges-Rizo
Conformation, Localization, and Integrin Binding of Talin Depend on Its Interaction with Phosphoinositides
J. Biol. Chem., June 8, 2001; 276(24): 21217 - 21227.
[Abstract] [Full Text] [PDF]

A. L. Jannuzi, T. A. Bunch, M. C. Brabant, S. W. Miller, L. Mukai, M. Zavortink, and D. L. Brower
Disruption of C-Terminal Cytoplasmic Domain of beta PS Integrin Subunit Has Dominant Negative Properties in Developing Drosophila
Mol. Biol. Cell, April 1, 2002; 13(4): 1352 - 1365.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Vignoud, L.

Articles by Block, M. R.

Search for Related Content

PubMed

PubMed Citation

Articles by Vignoud, L.

Articles by Block, M. R.

				A. Wiedemann, J. C. Patel, J. Lim, A. Tsun, Y. van Kooyk, and E. Caron Two distinct cytoplasmic regions of the {beta}2 integrin chain regulate RhoA function during phagocytosis. J. Cell Biol., March 27, 2006; 172(7): 1069 - 1079. [Abstract] [Full Text] [PDF]

				M. A. Rosenthal-Allieri, M. Ticchioni, J. P. Breittmayer, Y. Shimizu, and A. Bernard Influence of {beta}1 Integrin Intracytoplasmic Domains in the Regulation of VLA-4-Mediated Adhesion of Human T Cells to VCAM-1 under Flow Conditions J. Immunol., July 15, 2005; 175(2): 1214 - 1223. [Abstract] [Full Text] [PDF]

				D. Bouvard, L. Vignoud, S. Dupe-Manet, N. Abed, H.-N. Fournier, C. Vincent-Monegat, S. F. Retta, R. Fassler, and M. R. Block Disruption of Focal Adhesions by Integrin Cytoplasmic Domain-associated Protein-1alpha J. Biol. Chem., February 14, 2003; 278(8): 6567 - 6574. [Abstract] [Full Text] [PDF]

				L. Levy, S. Broad, D. Diekmann, R. D. Evans, and F. M. Watt beta 1 Integrins Regulate Keratinocyte Adhesion and Differentiation by Distinct Mechanisms Mol. Biol. Cell, February 1, 2000; 11(2): 453 - 466. [Abstract] [Full Text]

				M. J. Hewish, Y. Takada, and B. S. Coulson Integrins alpha 2beta 1 and alpha 4beta 1 Can Mediate SA11 Rotavirus Attachment and Entry into Cells J. Virol., January 1, 2000; 74(1): 228 - 236. [Abstract] [Full Text]

				D. S. Rice and T. Curran Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS Genes & Dev., November 1, 1999; 13(21): 2758 - 2773. [Full Text]

				S. Patil, A. Jedsadayanmata, J. D. Wencel-Drake, W. Wang, I. Knezevic, and S. C.-T. Lam Identification of a Talin-binding Site in the Integrin beta 3 Subunit Distinct from the NPLY Regulatory Motif of Post-ligand Binding Functions. THE TALIN N-TERMINAL HEAD DOMAIN INTERACTS WITH THE MEMBRANE-PROXIMAL REGION OF THE beta 3 CYTOPLASMIC TAIL J. Biol. Chem., October 1, 1999; 274(40): 28575 - 28583. [Abstract] [Full Text] [PDF]

				A. Gut, M. S. Balda, and K. Matter The Cytoplasmic Domains of a beta 1 Integrin Mediate Polarization in Madin-Darby Canine Kidney Cells by Selective Basolateral Stabilization J. Biol. Chem., November 6, 1998; 273(45): 29381 - 29388. [Abstract] [Full Text] [PDF]

				N. C. Romzek, E. S. Harris, C. L. Dell, J. Skronek, E. Hasse, P. J. Reynolds, S. W. Hunt III, and Y. Shimizu Use of a beta 1 Integrin-deficient Human T Cell to Identify beta 1 Integrin Cytoplasmic Domain Sequences Critical for Integrin Function Mol. Biol. Cell, October 1, 1998; 9(10): 2715 - 2727. [Abstract] [Full Text]

				J.-M. Heraud, C. Racaud-Sultan, D. Gironcel, C. Albiges-Rizo, T. Giacomini, S. Roques, V. Martel, M. Breton-Douillon, B. Perret, and H. Chap Lipid Products of Phosphoinositide 3-Kinase and Phosphatidylinositol 4',5'-Bisphosphate Are Both Required for ADP-dependent Platelet Spreading J. Biol. Chem., July 10, 1998; 273(28): 17817 - 17823. [Abstract] [Full Text] [PDF]

				E. Schaffner-Reckinger, V. Gouon, C. Melchior, S. Plancon, and N. Kieffer Distinct Involvement of beta 3 Integrin Cytoplasmic Domain Tyrosine Residues 747�and 759�in Integrin-mediated Cytoskeletal Assembly and Phosphotyrosine Signaling J. Biol. Chem., May 15, 1998; 273(20): 12623 - 12632. [Abstract] [Full Text] [PDF]

				T. Sakai, Q. Zhang, R. Fassler, and D. F. Mosher Modulation of beta 1A Integrin Functions by Tyrosine Residues in the beta 1 Cytoplasmic Domain J. Cell Biol., April 20, 1998; 141(2): 527 - 538. [Abstract] [Full Text] [PDF]

				V. Martel, C. Racaud-Sultan, S. Dupe, C. Marie, F. Paulhe, A. Galmiche, M. R. Block, and C. Albiges-Rizo Conformation, Localization, and Integrin Binding of Talin Depend on Its Interaction with Phosphoinositides J. Biol. Chem., June 8, 2001; 276(24): 21217 - 21227. [Abstract] [Full Text] [PDF]

				A. L. Jannuzi, T. A. Bunch, M. C. Brabant, S. W. Miller, L. Mukai, M. Zavortink, and D. L. Brower Disruption of C-Terminal Cytoplasmic Domain of beta PS Integrin Subunit Has Dominant Negative Properties in Developing Drosophila Mol. Biol. Cell, April 1, 2002; 13(4): 1352 - 1365. [Abstract] [Full Text] [PDF]