Focal adhesion kinase: at the crossroads of signal transduction

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Indomethacin Delays Gastric Restitution: Association with the Inhibition of Focal Adhesion Kinase and Tensin Phosphorylation and Reduced Actin Stress Fibers
Experimental Biology and Medicine, June 1, 2002; 227(6): 412 - 424.
[Abstract] [Full Text] [PDF]

D. Huang, A. T. Cheung, J. T. Parsons, and M. Bryer-Ash
Focal Adhesion Kinase (FAK) Regulates Insulin-stimulated Glycogen Synthesis in Hepatocytes
J. Biol. Chem., May 10, 2002; 277(20): 18151 - 18160.
[Abstract] [Full Text] [PDF]

Y. Lim, I. Han, H. J. Kwon, and E.-S. Oh
Trichostatin A-induced Detransformation Correlates with Decreased Focal Adhesion Kinase Phosphorylation at Tyrosine 861 in ras-transformed Fibroblasts
J. Biol. Chem., April 5, 2002; 277(15): 12735 - 12740.
[Abstract] [Full Text] [PDF]

P. J. Bruce-Staskal, C. L. Weidow, J. J. Gibson, and A. H. Bouton
Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake
J. Cell Sci., January 7, 2002; 115(13): 2689 - 2700.
[Abstract] [Full Text] [PDF]

G. W. McLean, K. Brown, M. I. Arbuckle, A. W. Wyke, T. Pikkarainen, E. Ruoslahti, and M. C. Frame
Decreased Focal Adhesion Kinase Suppresses Papilloma Formation during Experimental Mouse Skin Carcinogenesis
Cancer Res., December 1, 2001; 61(23): 8385 - 8389.
[Abstract] [Full Text] [PDF]

W. Thomas, G. D. Pullinger, A. J. Lax, and E. Rozengurt
Escherichia coli Cytotoxic Necrotizing Factor and Pasteurella multocida Toxin Induce Focal Adhesion Kinase Autophosphorylation and Src Association
Infect. Immun., September 1, 2001; 69(9): 5931 - 5935.
[Abstract] [Full Text] [PDF]

W. T. Gerthoffer and S. J. Gunst
Signal Transduction in Smooth Muscle: Invited Review: Focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscle
J Appl Physiol, August 1, 2001; 91(2): 963 - 972.
[Abstract] [Full Text] [PDF]

J. M. Weinberg, M. A. Venkatachalam, N. F. Roeser, R. A. Senter, and I. Nissim
Energetic Determinants of Tyrosine Phosphorylation of Focal Adhesion Proteins during Hypoxia/Reoxygenation of Kidney Proximal Tubules
Am. J. Pathol., June 1, 2001; 158(6): 2153 - 2164.
[Abstract] [Full Text] [PDF]

Y. Tu, Y. Huang, Y. Zhang, Y. Hua, and C. Wu
A New Focal Adhesion Protein that Interacts with Integrin-linked Kinase and Regulates Cell Adhesion and Spreading
J. Cell Biol., April 30, 2001; 153(3): 585 - 598.
[Abstract] [Full Text] [PDF]

E. O. Harrington, A. Smeglin, J. Newton, G. Ballard, and S. Rounds
Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosis
Am J Physiol Lung Cell Mol Physiol, February 1, 2001; 280(2): L342 - L353.
[Abstract] [Full Text] [PDF]

D. J. Mulholland, S. Dedhar, and A. Wayne Vogl
Rat Seminiferous Epithelium Contains a Unique Junction (Ectoplasmic Specialization) with Signaling Properties Both of Cell/Cell and Cell/Matrix Junctions
Biol Reprod, January 1, 2001; 64(1): 396 - 407.
[Abstract] [Full Text]

M. A. Reddy, C. A. Wass, K. S. Kim, D. D. Schlaepfer, and N. V. Prasadarao
Involvement of Focal Adhesion Kinase in Escherichia coli Invasion of Human Brain Microvascular Endothelial Cells
Infect. Immun., November 1, 2000; 68(11): 6423 - 6430.
[Abstract] [Full Text] [PDF]

Z.-s. Zhao, E. Manser, T.-H. Loo, and L. Lim
Coupling of PAK-Interacting Exchange Factor PIX to GIT1 Promotes Focal Complex Disassembly
Mol. Cell. Biol., September 1, 2000; 20(17): 6354 - 6363.
[Abstract] [Full Text]

L.-M. Chen, D. Bailey, and C. Fernandez-Valle
Association of beta 1 Integrin with Focal Adhesion Kinase and Paxillin in Differentiating Schwann Cells
J. Neurosci., May 15, 2000; 20(10): 3776 - 3784.
[Abstract] [Full Text] [PDF]

K. K. Kaulsay, H. C. Mertani, K.-O. Lee, and P. E. Lobie
Autocrine Human Growth Hormone Enhancement of Human Mammary Carcinoma Cell Spreading Is Jak2 Dependent
Endocrinology, April 1, 2000; 141(4): 1571 - 1584.
[Abstract] [Full Text] [PDF]

L. A. Sabourin, P. Seale, J. Wagner, and M. A. Rudnicki
Caspase 3 Cleavage of the Ste20-Related Kinase SLK Releases and Activates an Apoptosis-Inducing Kinase Domain and an Actin-Disassembling Region
Mol. Cell. Biol., January 15, 2000; 20(2): 684 - 696.
[Abstract] [Full Text]

P Schedin, R Strange, T Mitrenga, P Wolfe, and M Kaeck
Fibronectin fragments induce MMP activity in mouse mammary epithelial cells: evidence for a role in mammary tissue remodeling
J. Cell Sci., January 3, 2000; 113(5): 795 - 806.
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M. Tamura, J. Gu, H. Tran, and K. M. Yamada
PTEN Gene and Integrin Signaling in Cancer
J Natl Cancer Inst, November 3, 1999; 91(21): 1820 - 1828.
[Abstract] [Full Text] [PDF]

E. P. Salazar and E. Rozengurt
Bombesin and Platelet-derived Growth Factor Induce Association of Endogenous Focal Adhesion Kinase with Src in Intact Swiss 3T3 Cells
J. Biol. Chem., October 1, 1999; 274(40): 28371 - 28378.
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				X. Peng, X. Wu, J. E. Druso, H. Wei, A. Y.-J. Park, M. S. Kraus, A. Alcaraz, J. Chen, S. Chien, R. A. Cerione, et al. Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice PNAS, May 6, 2008; 105(18): 6638 - 6643. [Abstract] [Full Text] [PDF]

				P. Liu, C. Zhang, J. B. Feng, Y. X. Zhao, X. P. Wang, J. M. Yang, M. X. Zhang, X. L. Wang, and Y. Zhang Cross Talk Among Smad, MAPK, and Integrin Signaling Pathways Enhances Adventitial Fibroblast Functions Activated by Transforming Growth Factor-{beta}1 and Inhibited by Gax Arterioscler. Thromb. Vasc. Biol., April 1, 2008; 28(4): 725 - 731. [Abstract] [Full Text] [PDF]

				M. Grove, N. H. Komiyama, K.-A. Nave, S. G. Grant, D. L. Sherman, and P. J. Brophy FAK is required for axonal sorting by Schwann cells J. Cell Biol., January 29, 2007; 176(3): 277 - 282. [Abstract] [Full Text] [PDF]

				M. J. Bouchard, L. Wang, and R. J. Schneider Activation of Focal Adhesion Kinase by Hepatitis B Virus HBx Protein: Multiple Functions in Viral Replication J. Virol., May 1, 2006; 80(9): 4406 - 4414. [Abstract] [Full Text] [PDF]

				R. S. Fan, R. O. Jacamo, X. Jiang, J. Sinnett-Smith, and E. Rozengurt G Protein-coupled Receptor Activation Rapidly Stimulates Focal Adhesion Kinase Phosphorylation at Ser-843: MEDIATION BY Ca2+, CALMODULIN, AND Ca2+/CALMODULIN-DEPENDENT KINASE II J. Biol. Chem., June 24, 2005; 280(25): 24212 - 24220. [Abstract] [Full Text] [PDF]

				S. L. Yancy, E. A. Shelden, R. R. Gilmont, and M. J. Welsh Sodium Arsenite Exposure Alters Cell Migration, Focal Adhesion Localization and Decreases Tyrosine Phosphorylation of Focal Adhesion Kinase in H9C2 Myoblasts Toxicol. Sci., April 1, 2005; 84(2): 278 - 286. [Abstract] [Full Text] [PDF]

				J. H. Lieman, L. A. Worley, and J. W. Harbour Loss of Rb-E2F Repression Results in Caspase-8-mediated Apoptosis through Inactivation of Focal Adhesion Kinase J. Biol. Chem., March 18, 2005; 280(11): 10484 - 10490. [Abstract] [Full Text] [PDF]

				L. A. Cohen and J.-L. Guan Residues within the First Subdomain of the FERM-like Domain in Focal Adhesion Kinase Are Important in Its Regulation J. Biol. Chem., March 4, 2005; 280(9): 8197 - 8207. [Abstract] [Full Text] [PDF]

				G. W. McLean, N. H. Komiyama, B. Serrels, H. Asano, L. Reynolds, F. Conti, K. Hodivala-Dilke, D. Metzger, P. Chambon, S. G.N. Grant, et al. Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression Genes & Dev., December 15, 2004; 18(24): 2998 - 3003. [Abstract] [Full Text] [PDF]

				A. KUMAR, R. MURPHY, P. ROBINSON, L. WEI, and A. M. BORIEK Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-{kappa}B transcription factor FASEB J, October 1, 2004; 18(13): 1524 - 1535. [Abstract] [Full Text] [PDF]

				E. Bae, T. Sakai, and D. F. Mosher Assembly of Exogenous Fibronectin by Fibronectin-null Cells Is Dependent on the Adhesive Substrate J. Biol. Chem., August 20, 2004; 279(34): 35749 - 35759. [Abstract] [Full Text] [PDF]

				M. K.Y. Siu and C. Y. Cheng Extracellular Matrix: Recent Advances on Its Role in Junction Dynamics in the Seminiferous Epithelium During Spermatogenesis Biol Reprod, August 1, 2004; 71(2): 375 - 391. [Abstract] [Full Text] [PDF]

				L. A. Cooper, T.-L. Shen, and J.-L. Guan Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction Mol. Cell. Biol., November 15, 2003; 23(22): 8030 - 8041. [Abstract] [Full Text] [PDF]

				L. Rosano, F. Spinella, V. Di Castro, M. R. Nicotra, A. Albini, P. G. Natali, and A. Bagnato Endothelin Receptor Blockade Inhibits Molecular Effectors of Kaposi's Sarcoma Cell Invasion and Tumor Growth in Vivo Am. J. Pathol., August 1, 2003; 163(2): 753 - 762. [Abstract] [Full Text] [PDF]

				M. Funakoshi-Tago, Y. Sonoda, S. Tanaka, K. Hashimoto, K. Tago, S.-i. Tominaga, and T. Kasahara Tumor Necrosis Factor-induced Nuclear Factor {kappa}B Activation Is Impaired in Focal Adhesion Kinase-deficient Fibroblasts J. Biol. Chem., August 1, 2003; 278(31): 29359 - 29365. [Abstract] [Full Text] [PDF]

				L. Neff, M. Zeisel, V. Druet, K. Takeda, J.-P. Klein, J. Sibilia, and D. Wachsmann ERK 1/2- and JNKs-dependent Synthesis of Interleukins 6 and 8 by Fibroblast-like Synoviocytes Stimulated with Protein I/II, a Modulin from Oral Streptococci, Requires Focal Adhesion Kinase J. Biol. Chem., July 18, 2003; 278(30): 27721 - 27728. [Abstract] [Full Text] [PDF]

				I. Hunger-Glaser, E. P. Salazar, J. Sinnett-Smith, and E. Rozengurt Bombesin, Lysophosphatidic Acid, and Epidermal Growth Factor Rapidly Stimulate Focal Adhesion Kinase Phosphorylation at Ser-910: REQUIREMENT FOR ERK ACTIVATION J. Biol. Chem., June 13, 2003; 278(25): 22631 - 22643. [Abstract] [Full Text] [PDF]

				D. M. McKean, L. Sisbarro, D. Ilic, N. Kaplan-Alburquerque, R. Nemenoff, M. Weiser-Evans, M. J. Kern, and P. L. Jones FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration J. Cell Biol., April 28, 2003; 161(2): 393 - 402. [Abstract] [Full Text] [PDF]

				C. A. Lipinski, N. L. Tran, C. Bay, J. Kloss, W. S. McDonough, C. Beaudry, M. E. Berens, and J. C. Loftus Differential Role of Proline-Rich Tyrosine Kinase 2 and Focal Adhesion Kinase in Determining Glioblastoma Migration and Proliferation Mol. Cancer Res., March 1, 2003; 1(5): 323 - 332. [Abstract] [Full Text] [PDF]

				D. Sinha, Z. Wang, V. R. Price, J. H. Schwartz, and W. Lieberthal Chemical anoxia of tubular cells induces activation of c-Src and its translocation to the zonula adherens Am J Physiol Renal Physiol, March 1, 2003; 284(3): F488 - F497. [Abstract] [Full Text] [PDF]

				W.-J. Wang, J.-C. Kuo, C.-C. Yao, and R.-H. Chen DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals J. Cell Biol., October 14, 2002; 159(1): 169 - 179. [Abstract] [Full Text] [PDF]

				V. Golubovskaya, L. Beviglia, L.-H. Xu, H. S. Earp III, R. Craven, and W. Cance Dual Inhibition of Focal Adhesion Kinase and Epidermal Growth Factor Receptor Pathways Cooperatively Induces Death Receptor-mediated Apoptosis in Human Breast Cancer Cells J. Biol. Chem., October 4, 2002; 277(41): 38978 - 38987. [Abstract] [Full Text] [PDF]

				C. Y. Cheng and D. D. Mruk Cell Junction Dynamics in the Testis: Sertoli-Germ Cell Interactions and Male Contraceptive Development Physiol Rev, October 1, 2002; 82(4): 825 - 874. [Abstract] [Full Text] [PDF]

				S. Wagner, T. A. Flood, P. O'Reilly, K. Hume, and L. A. Sabourin Association of the Ste20-like Kinase (SLK) with the Microtubule. ROLE IN Rac1-MEDIATED REGULATION OF ACTIN DYNAMICS DURING CELL ADHESION AND SPREADING J. Biol. Chem., September 27, 2002; 277(40): 37685 - 37692. [Abstract] [Full Text] [PDF]

				T.-L. Shen, D. C. Han, and J.-L. Guan Association of Grb7 with Phosphoinositides and Its Role in the Regulation of Cell Migration J. Biol. Chem., August 2, 2002; 277(32): 29069 - 29077. [Abstract] [Full Text] [PDF]

				M. C. Rebsamen, J. Sun, A. W. Norman, and J. K. Liao 1{alpha},25-Dihydroxyvitamin D3 Induces Vascular Smooth Muscle Cell Migration via Activation of Phosphatidylinositol 3-Kinase Circ. Res., July 12, 2002; 91(1): 17 - 24. [Abstract] [Full Text] [PDF]

				L. Zhang, M. Bewick, and R. M. Lafrenie Role of Raf-1 and FAK in cell density-dependent regulation of integrin-dependent activation of MAP kinase Carcinogenesis, July 1, 2002; 23(7): 1251 - 1258. [Abstract] [Full Text] [PDF]

				I. L. Szabo, R. Pai, M. K. Jones, G. R. Ehring, H. Kawanaka, and A. S. Tarnawski Indomethacin Delays Gastric Restitution: Association with the Inhibition of Focal Adhesion Kinase and Tensin Phosphorylation and Reduced Actin Stress Fibers Experimental Biology and Medicine, June 1, 2002; 227(6): 412 - 424. [Abstract] [Full Text] [PDF]

				D. Huang, A. T. Cheung, J. T. Parsons, and M. Bryer-Ash Focal Adhesion Kinase (FAK) Regulates Insulin-stimulated Glycogen Synthesis in Hepatocytes J. Biol. Chem., May 10, 2002; 277(20): 18151 - 18160. [Abstract] [Full Text] [PDF]

				Y. Lim, I. Han, H. J. Kwon, and E.-S. Oh Trichostatin A-induced Detransformation Correlates with Decreased Focal Adhesion Kinase Phosphorylation at Tyrosine 861 in ras-transformed Fibroblasts J. Biol. Chem., April 5, 2002; 277(15): 12735 - 12740. [Abstract] [Full Text] [PDF]