Intracellular acidification induces apoptosis by stimulating ICE-like protease activity

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Baffy, G., Miyashita, T., Williamson, J. R. and Reed, J. C (1993). Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production. J. Biol. Chem 268, 6511-6519.[Abstract/Free Full Text]

Barry, M. A. and Eastman, A (1993). Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch. Biochem. Biophys 300, 440-450.[Medline]

Barry, M. A., Reynolds, J. E. and Eastman, A (1993). Etoposide induced apoptosis in human HL60 cells is associated with intracellular acidification. Cancer Res 53, 2349-2357.[Abstract/Free Full Text]

Bassnett, S., Reinisch, L. and Beebe, D. C (1990). Intracellular pH measurement using single excitation-dual emission fluorescence ratios. Am. J. Physiol 258, 171-178.

Bernardi, P., Veronese, P. and Petronilli, V (1993). Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore,. J. Biol. Chem 268, 1005-1010.[Abstract/Free Full Text]

Boldin, M., Goncharov, T., Goltsev, Y. and Wallach, D (1996). Involvement of MACH, a novel MORT1/FADD-interacting protease in Fas/APO-1-and TNF receptor-induced cell death. Cell 85, 803-815.[Medline]

Caceres-Cortes, J., Rajotte, D., Dumouchel, J., Haddad, P. and Hoang, T (1994). Product of the steel locus suppresses apoptosis in hemopoietic cells. Comparison with pathways activated by granulocyte macrophage colony-stimulating factor. J. Biol. Chem 269, 12084-12091.[Abstract/Free Full Text]

Casciola-Rosen, L. A., Miller, D. K., Anhalt, G. J. and Rosen, A (1994). Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J. Biol. Chem 269, 30757-30760.[Abstract/Free Full Text]

Chinnaiyan, A. M., Orth, K., O'Rourke, K., Duan, H., Poirier, G. G. and Dixit, V. M (1996). Molecular ordering of the cell death pathway: Bcl-2 and Bcl-XLfunction upstream of the CED-3-like apoptotic proteases. J. Biol. Chem 271, 4573-4576.[Abstract/Free Full Text]

Collins, M. K., Marvel, J., Malde, P. and Lopez-Rivas, A (1992). Interleukin 3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J. Exp. Med 176, 1043-1051.[Abstract/Free Full Text]

Collins, M. K. L., Furlong, I. J., Malde, P., Ascaso, R., Oliver, F. J. and Lopez-Rivas, A (1996). An apoptotic endonuclease that can be activated by either decreasing pH or addition of calcium. J. Cell Sci 109, 2393-2399.[Abstract]

Duan, H., Orth, K., Chinnaiyan, Poirier, G., Froelich, C., He, W.-W. and Dixit, V (1996). ICE-LAP6, a novel member of the ICE/Ced-3 gene family is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem 271, 16720-16724.[Abstract/Free Full Text]

Enari, M., Talanian, R. V., Wong, W. W. and Nagata, S (1996). Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380, 723-726.[Medline]

Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z. and Hancock, D. C (1992). Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119-128.[Medline]

Fearnhead, H., Dinsdale, D. and Cohen, G (1995). An interleukin-1beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes. FEBS Lett 375, 283-288.[Medline]

Fernandes-Alnemri, T., Takahashi, A., Armstrong, R., Krebs, J., Fritz, L., Tomaselli, K. J., Wang, L., Yu, Z., Croce, C. M., Salveson, G., Earnshaw, W. C., Litwack, G. and Alnemri, E. S (1995). Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res 55, 6045-6052.[Abstract/Free Full Text]

Fletcher, D., Agarwal, L., Chapman, K., Chin, J., Egger, L., Limjuco, G., Luell, S., MacIntyre, D., Peterson, E., Thornberry, N. and Kostura, M (1995). A synthetic inhibitor of interleukin-1beta converting enzyme prevents endotoxin-induced interleukin-1beta production in vitro and in vivo. J. Interferon Cytokine Res 15, 243-248.[Medline]

Gottlieb, R. A., Giesing, H. A., Engler, R. L. and Babior, B. M (1995). The acid deoxyribonuclease of neutrophils: a possible participant in apoptosis-associated genome destruction. Blood 86, 2414-2418.[Abstract/Free Full Text]

Gottlieb, R. A., Giesing, H. A., Zhu, J. Y., Engler, R. L. and Babior, B. M (1995). Cell acidification in apoptosis: GCSF delays programed cell death in neutrophils by up-regulating the vacuolar H+-ATPase. Proc. Nat. Acad. Sci. USA 92, 5965-5968.[Abstract/Free Full Text]

Gottlieb, R. A. and Dosanjh, A (1996). Mutant cystic fibrosis transmembrane conductance regulator inhibits acidification and apoptosis in C127 cells: Possible relevance to cystic fibrosis. Proc. Nat. Acad. Sci. USA 93, 3587-3591.[Abstract/Free Full Text]

Gottlieb, R. A., Nordberg, J., Skowronski, E. and Babior, B. M (1996). Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification,. Proc. Nat. Acad. Sci. USA 93, 654-658.[Abstract/Free Full Text]

Gu, Y., Sarnecki, C., Aldape, R. A., Livingston, D. J. and Su, M (1995). Cleavage of poly(ADP-ribose) polymerase by interleukin-1beta converting enzyme and its homologs TX and Nedd-2. J. Biol. Chem 270, 18715-18718.[Abstract/Free Full Text]

Herrmann, M., Lorenz, H. M., Voll, R., Grunke, M., Woith, W. and Kalden, J. R (1994). A rapid and simple method for the isolation of apoptotic DNA fragments. Nucl. Acids Res 22, 5506-5507.[Free Full Text]

Kaufmann, S. H., Desnoyers, S., Ottaviano, Y., Davidson, N. E. and Poirier, G. G (1993). Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 53, 3976-3985.[Abstract/Free Full Text]

Korsmeyer, S. J (1995). Regulators of cell death. Trends Genet 11, 101-105.[Medline]

Krajewski, S., Tanaka, S., Takayama, S., Schibler, M. J., Fenton, W. and Reed, J. C (1993). Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 53, 4701-4714.[Abstract/Free Full Text]

Kumar, S. and Harvey, N (1995). Role of multiple cellular proteases in the execution of programmed cell death. FEBS Lett 375, 169-173.[Medline]

Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. and Earnshaw, W. C (1994). Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347.[Medline]

Lazebnik, Y. A., Takahashi, A., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H. and Earnshaw, W. C (1995). Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc. Nat. Acad. Sci. USA 92, 9042-9046.[Abstract/Free Full Text]

Li, J. and Eastman, A (1995). Apoptosis in an interleukin-2-dependent cytotoxic T lymphocyte cell line is associated with intracellular acidification. Role of the Na(+)/H(+)-antiport. J. Biol. Chem 270, 3203-3211.[Abstract/Free Full Text]

Marvel, J., Perkins, G. R., Lopez-Rivas, A. and Collins, M. K. L (1993). Bcl-2 over-expression in murine bone marrow cells induces refractoriness to interleukin-3 stimulation of proliferation. Oncogene 9, 1117-1122.

Mashima, T., Naito, M., Fujita, N., Noguchi, K. and Tsuruo, T (1995). Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis. Biochem. Biophys. Res. Commun 217, 1185-1192.[Medline]

Meisenholder, G., Martin, S., Green, D., Nordberg, J., Babior, B. and Gottlieb, R (1996). Events in apoptosis: intracellular acidification is downstream of protease activation and Bcl-2 protection. J. Biol. Chem 271, 16260-16262.[Abstract/Free Full Text]

Moolenaar, W (1986). Effects of growth factors on intracellular pH regulation. Annu. Rev. Physiol 48, 363-376.[Medline]

Muzio, M., Chinnaiyan, A., Kischkel, F., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J., Zhang, M., Gentz, R., Mann, M., Krammer, P., Peter, M. and Dixit, V (1996). FLICE, a novel FADD-homologous ICE/Ced3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85, 817-827.[Medline]

Na, S., Chuang, T., Cunningham, A., Turi, T., Hanke, J., Bokoch, G. and Danley, D (1996). D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J. Biol. Chem 271, 11209-11213.[Abstract/Free Full Text]

Nicholson, D. W., Ali, A., Thornberry, N. A., Vaillancourt, J. P., Ding, C. K., Gallant, M., Gareau, Y., Griffin, P. R., Labelle, M., Lazebnik, Y. A., et al (1995). Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37-43.[Medline]

Palacios, R. and Steinmetz, M (1985). IL3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration and generate B lymphocytes in vivo. Cell 41, 727-734.[Medline]

Qin, X., Livingston, D., Kaelin, W. and Adams, P (1994). Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Nat. Acad. Sci. USA 91, 10918-10922.[Abstract/Free Full Text]

Raff, M. C (1992). Social controls on cell survival and cell death. Nature 356, 397-400.[Medline]

Rajotte, D., Haddad, P., Haman, A., Cragoe, E. J. and Hoang, T (1992). Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by GMCSF and IL3. J. Biol. Chem 267, 9980-9987.[Abstract/Free Full Text]

Rebollo, A., Gomez, J., Martinez, A., Lastres, P., Silva, A. and Perez-Sala, D (1995). Apoptosis induced by IL-2 withdrawal is associated with an intracellular acidification. Exp. Cell Res 218, 581-585.[Medline]

Reynolds, J. E., Li, J., Craig, R. W. and Eastman, A (1996). BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine. Exp. Cell Res 225, 430-436.[Medline]

Rodriguez-Tarduchy, G., Collins, M. and Lopez-Rivas, A (1990). Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores. EMBO J 9, 2997-3002.[Medline]

Seksek, O., Henry, T. N., Sureau, F. and Bolard, J (1991). SNARF-1 as an intracellular pH indicator in laser microspectrofluorometry: a critical assessment. Anal. Biochem 193, 49-54.[Medline]

Song, Q., Lees-Miller, S., Kumar, S., Zhang, N., Chan, D., Smith, G., Jackson, S., Alnemri, E., Litwack, G., Khanna, K. and Lavin, M (1996). DNA-dependent protein kinase catalytic subunit as a target for an ICE-like protease in apoptosis. EMBO J 15, 3238-3246.[Medline]

Tewari, M., Beidler, D. R. and Dixit, V. M (1995). CrmA-inhibitable cleavage of the 70-kDa protein component of the U1 small nuclearribonucleoprotein during Fas-and tumor necrosis factor-induced apoptosis. J. Biol. Chem 270, 18738-18741.[Abstract/Free Full Text]

Tewari, M. and Dixit, V. M (1995). Fas-and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J. Biol. Chem 270, 3255-3260.[Abstract/Free Full Text]

Tewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S. and Dixit, V. M (1995). Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81, 801-809.[Medline]

Voelkel, J. C., Entingh, A. J., Wold, W. S., Gooding, L. R. and Laster, S. M (1995). Activation of intracellular proteases is an early event in TNF-induced apoptosis. J. Immunol 154, 1707-1716.[Abstract]

Xue, D. and Horvitz, H (1995). Inhibition of the C. elegans cell-death proteaseCED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature 377, 248-251.[Medline]

Yuan, J., Shaham, S., Ledoux, S., Ellis, H. M. and Horvitz, H. R (1993). The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1-converting enzyme. Cell 75, 641-652.[Medline]

Zamzami, N., Susin, S., Marchetti, P., Hirsch, T., Gomez-Monterrey, I., Castedo, M. and Kroemer, G (1996). Mitochondrial control of nuclear apoptosis. J. Exp. Med 183, 1533-1544.[Abstract/Free Full Text]

Zoratti, M. and Szabo, I (1995). The mitochondrial permeability transition. Biochim. Biophys. Acta 1241, 139-176.[Medline]

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				S.-Z. Ding, Y. Minohara, X. J. Fan, J. Wang, V. E. Reyes, J. Patel, B. Dirden-Kramer, I. Boldogh, P. B. Ernst, and S. E. Crowe Helicobacter pylori Infection Induces Oxidative Stress and Programmed Cell Death in Human Gastric Epithelial Cells Infect. Immun., August 1, 2007; 75(8): 4030 - 4039. [Abstract] [Full Text] [PDF]

				L. Padron-Barthe, C. Lepretre, E. Martin, M.-F. Counis, and A. Torriglia Conformational Modification of Serpins Transforms Leukocyte Elastase Inhibitor into an Endonuclease Involved in Apoptosis Mol. Cell. Biol., June 1, 2007; 27(11): 4028 - 4036. [Abstract] [Full Text] [PDF]

				P. Bouyer, H. Sakai, T. Itokawa, T. Kawano, C. M. Fulton, W. F. Boron, and K. L. Insogna Colony-Stimulating Factor-1 Increases Osteoclast Intracellular pH and Promotes Survival via the Electroneutral Na/HCO3 Cotransporter NBCn1 Endocrinology, February 1, 2007; 148(2): 831 - 840. [Abstract] [Full Text] [PDF]

				X. Lu, W. Qin, J. Li, N. Tan, D. Pan, H. Zhang, L. Xie, G. Yao, H. Shu, M. Yao, et al. The Growth and Metastasis of Human Hepatocellular Carcinoma Xenografts Are Inhibited by Small Interfering RNA Targeting to the Subunit ATP6L of Proton Pump Cancer Res., August 1, 2005; 65(15): 6843 - 6849. [Abstract] [Full Text] [PDF]

				J. R. Beckley, B. U. Pauli, and R. C. Elble Re-expression of Detachment-inducible Chloride Channel mCLCA5 Suppresses Growth of Metastatic Breast Cancer Cells J. Biol. Chem., October 1, 2004; 279(40): 41634 - 41641. [Abstract] [Full Text] [PDF]

				E. Beem, L. S. Holliday, and M. S. Segal The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation Am J Physiol Cell Physiol, September 1, 2004; 287(3): C664 - C672. [Abstract] [Full Text] [PDF]

				C. Terminella, K. Tollefson, J. Kroczynski, J. Pelli, and M. Cutaia Inhibition of apoptosis in pulmonary endothelial cells by altered pH, mitochondrial function, and ATP supply Am J Physiol Lung Cell Mol Physiol, December 1, 2002; 283(6): L1291 - L1302. [Abstract] [Full Text] [PDF]

				R. J. Sleiman and B. W. Stewart Early Caspase Activation in Leukemic Cells Subject to Etoposide-induced G2-M Arrest: Evidence of Commitment to Apoptosis Rather Than Mitotic Cell Death Clin. Cancer Res., September 1, 2000; 6(9): 3756 - 3765. [Abstract] [Full Text]

				D. Liu, G. Martino, M. Thangaraju, M. Sharma, F. Halwani, S.-H. Shen, Y. C. Patel, and C. B. Srikant Caspase-8-mediated Intracellular Acidification Precedes Mitochondrial Dysfunction in Somatostatin-induced Apoptosis J. Biol. Chem., March 24, 2000; 275(13): 9244 - 9250. [Abstract] [Full Text] [PDF]

				J. Pawlowski and A. S. Kraft Bax-induced apoptotic cell death PNAS, January 18, 2000; 97(2): 529 - 531. [Full Text] [PDF]

				A. R. Khaled, K. Kim, R. Hofmeister, K. Muegge, and S. K. Durum From the Cover: Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH PNAS, December 7, 1999; 96(25): 14476 - 14481. [Abstract] [Full Text] [PDF]

				M. Thangaraju, K. Sharma, B. Leber, D. W. Andrews, S.-H. Shen, and C. B. Srikant Regulation of Acidification and Apoptosis by SHP-1 and Bcl-2 J. Biol. Chem., October 8, 1999; 274(41): 29549 - 29557. [Abstract] [Full Text] [PDF]

				M. L. Anthony, M. Zhao, and K. M. Brindle Inhibition of Phosphatidylcholine Biosynthesis following Induction of Apoptosis in HL-60 Cells J. Biol. Chem., July 9, 1999; 274(28): 19686 - 19692. [Abstract] [Full Text] [PDF]

				R. Benson, C Dive, and A. Watson Cytoplasmic acidification is not an effector mechanism of VP16 or DEX-induced apoptosis in CEM T leukaemia cells J. Cell Sci., January 6, 1999; 112(11): 1755 - 1760. [Abstract] [PDF]

				J. G. Pryde, A. Walker, A. G. Rossi, S. Hannah, and C. Haslett Temperature-dependent Arrest of Neutrophil Apoptosis. FAILURE OF Bax INSERTION INTO MITOCHONDRIA AT 15 {degrees}C PREVENTS THE RELEASE OF CYTOCHROME c J. Biol. Chem., October 20, 2000; 275(43): 33574 - 33584. [Abstract] [Full Text] [PDF]

				J. L. Hirpara, M.-V. Clement, and S. Pervaiz Intracellular Acidification Triggered by Mitochondrial-derived Hydrogen Peroxide Is an Effector Mechanism for Drug-induced Apoptosis in Tumor Cells J. Biol. Chem., January 5, 2001; 276(1): 514 - 521. [Abstract] [Full Text] [PDF]

				R. Marches, E. S. Vitetta, and J. W. Uhr A role for intracellular pH in membrane IgM-mediated cell death of human B lymphomas PNAS, March 13, 2001; 98(6): 3434 - 3439. [Abstract] [Full Text] [PDF]

				S. Roy, C. I. Bayly, Y. Gareau, V. M. Houtzager, S. Kargman, S. L. C. Keen, K. Rowland, I. M. Seiden, N. A. Thornberry, and D. W. Nicholson Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide PNAS, May 22, 2001; 98(11): 6132 - 6137. [Abstract] [Full Text] [PDF]