Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages

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Boocock, C. A., Jones, G. E., Stanley, E. R. and Pollard, J. W (1989). Colony stimulating factor-1 induces rapid behavioural responses in the mouse macrophage cell lines, Bac1. J. Cell Sci 93, 447-456.[Abstract/Free Full Text]

Burridge, K., Fath, K., Kelly, T., Nuckolls, G. and Turner, C (1988). Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol 4, 487-525.

Choi, K., Kennedy, M. and Keller, G (1993). Expression of a gene encoding a unique protein-tyrosine kinase within specific fetal-and adult-derived hematopoietic lineages. Proc. Nat. Acad. Sci. USA 90, 5747-5751.[Abstract/Free Full Text]

Chrzanowska-Wodnicka, M. and Burridge, K (1996). Rho-stimulated contractility drives the formation of stress fibres and focal adhesions. J. Cell Biol 133, 1403-1415.[Abstract/Free Full Text]

de Nichilo, M. O. and Burns, G. F (1993). Granulocyte-macrophage and macrophage colony-stimulating factors differentially regulatev integrin expression on cultured human macrophages. Proc. Nat. Acad. Sci. USA 90, 2517-2521.[Abstract/Free Full Text]

de Nichilo, M. O. and Yamada, K. M (1996). Integrinv 5-dependent serine phosphorylation of paxillin in cultured human macrophages adherent to vitronectin. J. Biol. Chem 271, 11016-11022.[Abstract/Free Full Text]

Downey, G. P (1994). Mechanisms of leukocyte motility and chemotaxis. Curr. Opin. Immunol 6, 113-124.[Medline]

Dutartre, H., Davoust, J., Gorvel, J.-P. and Chavrier, P (1996). Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs. J. Cell Sci 109, 367-377.[Abstract]

Flinn, H. M. and Ridley, A. J (1996). Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin. J. Cell Sci 109, 1133-1141.[Abstract]

Hall, A. and Self, A. J (1986). The effect of Mg2+on the guanine nucleotide exchange rate of p21 N-ras. J. Biol. Chem 261, 10963-10965.[Abstract/Free Full Text]

Hall, A (1994). Small GTP-binding proteins and the regulation of the actin cytoskeleton. Annu. Rev. Cell Biol 10, 31-54.

Hartwig, J. H., Bokoch, G. M., Carpenter, C. L., Janmey, P. A., Taylor, L. A., Toker, A. and Stossel, T. P (1995). Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82, 643-653.[Medline]

Hotchin, N. A. and Hall, A (1995). The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol 131, 1857-1865.[Abstract/Free Full Text]

Huttenlocher, A., Sandborg, R. R. and Horwitz, A. F (1995). Adhesion in cell migration. Curr. Opin. Cell Biol 7, 697-706.[Medline]

Jalink, K., van Corven, E. J., Hengeveld, T., Morii, N., Narumiya, S. and Moolenaar, W. H (1994). Inhibition of lysophosphatidate-and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J. Cell Biol 126, 801-810.[Abstract/Free Full Text]

Jockush, B. M., Bubeck, P., Giehl, K., Kroemker, M., Moschner, J., Rothkegel, M., Rudiger, M., Schluter, K., Stanke, G. and Winkler, J (1995). The molecular architecture of focal adhesions. Annu. Rev. Cell Dev. Biol 11, 379-416.[Medline]

Kharbanda, S., Saleem, A., Yuan, Z., Emoto, Y., Prasad, E. V. S. and Kufe, D (1995). Stimulation of human monocytes with macrophage colony-stimulating factor induces a Grb2-mediated association of the focal adhesion kinase pp125FAKand dynamin. Proc. Nat. Acad. Sci. USA 92, 6132-6136.[Abstract/Free Full Text]

Kimura, K., Ito, M., Amano, K., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A. and Kaibuchi, K (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248.[Abstract]

Kozma, R., Ahmed, S., Best, A. and Lim, L (1995). The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell. Biol 15, 1942-1952.[Abstract]

Lauffenburger, D. A. and Horwitz, A. F (1996). Cell migration: a physically integrated molecular process. Cell 84, 359-369.[Medline]

Leung, T., Chen, X.-Q., Manser, E. and Lim, L (1996). The p160 RhoA-binding kinase ROKa is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol. Cell. Biol 16, 5313-5327.[Abstract]

Lin, T. H., Yurochko, A., Kornberg, L., Morris, J., Walker, J. J., Haskill, S. and Juliano, R. L (1994). The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes. J. Cell Biol 126, 1585-1593.[Abstract/Free Full Text]

Lin, T. H., Rosales, C., Mondal, K., Bolen, J. B., Haskill, S. and Juliano, R. L (1995). Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. J. Biol. Chem 270, 16189-16197.[Abstract/Free Full Text]

Matsui, T., Amano, M., Yamamoto, T., Chihara, K., Nakafuku, M., Ito, M., Nakano, T., Okawa, K., Iwamatsu, A. and Kaibuchi, K (1996). Rho-associated kinase, a novel serine/threonine kinase, as a putative target for the small GTP binding protein Rho. EMBO J 15, 2208-2216.[Medline]

Mitchison, T. J. and Cramer, L. P (1996). Actin-based cell motility and cell locomotion. Cell 84, 371-379.[Medline]

Miyamoto, S., Teramoto, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K. and Yamada, K. M (1995). Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J. Cell Biol 131, 791-805.[Abstract/Free Full Text]

Morgan, C., Pollard, J. W. and Stanley, E. R (1987). Isolation and characterization of a cloned growth factor dependent macrophage cell line, Bac1. J. Cell. Physiol 130, 420-427.[Medline]

Morii, N., Teru-uchi, T., Tominaga, T, Kumagai, N., Kozaki, S., Ushikubi, F. and Narumiya S (1992). A rho gene product in human blood platelets. II. Effects of the ADP-ribosylation by Botulinum C3 ADP-ribosyltransferase on platelet aggregation. J. Biol. Chem 267, 20921-20926.[Abstract/Free Full Text]

Nishiyama, T., Sasaki, T., Takaishi, K., Kato, M., Yaku, H., Araki, K., Matsuura, Y. and Takai, Y (1994). rac p21 is involved in insulin-induced membrane ruffling and rho p21 is involved in hepatocyte growth factor-and 12- 0 -tetradecanoylphorbol-13-acetate (TPA)-induced membrane ruffling in KB cells. Mol. Cell. Biol 14, 2447-2456.[Abstract/Free Full Text]

Nobes, C. D. and Hall, A (1995). Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.[Medline]

Postma, F. R., Jalink, K., Hengeveld, T. and Moolenaar, W. H (1996). Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. EMBO J 15, 2388-2395.[Medline]

Ridley, A. J. and Hall, A (1992). The small GTP-binding protein Rho regulates the assembly of focal adhesions and stress fibres in response to growth factors. Cell 70, 389-399.[Medline]

Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A (1992). The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.[Medline]

Ridley, A. J (1995). Rho-related proteins: actin cytoskeleton and cell cycle. Curr. Opin. Genet. Dev 5, 24-30.[Medline]

Ridley, A. J (1995). Rac and Bcr regulate phagocytic phoxes. Curr. Biol 5, 710-712.[Medline]

Ridley, A. J., Comoglio, P. M. and Hall, A (1995). Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac and Rho proteins in MDCK cells. Mol. Cell. Biol 15, 1110-1122.[Abstract]

Ridley, A. J (1996). Rho: theme and variations. Curr. Biol 6, 1256-1264.[Medline]

Rosen, A., Keenan, K. F., Thelen, M., Nairn, A. C. and Aderem, A (1990). Activation of protein kinase C results in the displacement of its myristoylated, alanine-rich substrate from punctate structures in macrophage filopodia. J. Exp. Med 172, 1211-1215.[Abstract/Free Full Text]

Self, A. J. and Hall, A (1995). Purification of recombinant Rho/Rac/G25K from Escherichia coli. Meth. Enzymol 256, 3-10.[Medline]

Symons, M., Derry, J. M. J., Karlak, B., Jiang, S., Lemahieu, V., McCormick, F., Francke, U. and Abo, A (1996). Wiskott-Aldrich Syndrome protein, a novel effector for the GTPase Cdc42Hs, is implicated in actin polymerization. Cell 84, 723-734.[Medline]

Tan, J. L., Ravid, S. and Spudich, J. A (1992). Control of nonmuscle myosins by phosphorylation. Annu. Rev. Biochem 61, 721-759.[Medline]

Tominaga, T., Sugie, K., Hirata, M., Morii, N., Fukata, J., Uchida, A., Imura, H. and Narumiya, S (1993). Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP-ribosylation of the small molecular weight GTP-binding protein, Rho. J. Cell Biol 111, 2097-2108.[Abstract/Free Full Text]

van Aelst, L., Joneson, T. and Bar-Sagi, D (1996). Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO J 15, 3778-3786.[Medline]

von Eichel-Streiber, C., Boquet, P., Sauerborn, M. and Thelestam, M (1996). Large clostridial cytotoxins \320 a family of glycosyltransferases modifying small GTP-binding proteins. Trends Microbiol 4, 375-382.[Medline]

Webb, S. E., Pollard, J. W. and Jones, G. E (1996). Direct observation and quantification of macrophage chemoattraction to the growth factor CSF-1. J. Cell. Sci 109, 793-803.[Abstract]

Wojciak-Stothard, B., Curtis, A., Monaghan, W., MacDonald, K. and Wilkinson, C (1996). Guidance and activation of murine macrophages by nanometric scale topography. Exp. Cell Res 223, 426-435.[Medline]

Zhang, D., Udagawa, N., Nakamura, I., Murakami, H., Saito, S., Yamasaki, K., Shibasaki, Y., Morii, N., Narumiya, S., Takahashi, N. and Suda, T (1995). The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts. J. Cell Sci 108, 2285-2292.[Abstract]

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[Abstract] [Full Text] [PDF]

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Fibronectin Fragments Promote Human Retinal Endothelial Cell Adhesion and Proliferation and ERK Activation through {alpha}5{beta}1 Integrin and PI 3-Kinase
Invest. Ophthalmol. Vis. Sci., April 1, 2003; 44(4): 1704 - 1715.
[Abstract] [Full Text] [PDF]

B. Butler, M. P. Williams, and S. D. Blystone
Ligand-dependent Activation of Integrin alpha vbeta 3
J. Biol. Chem., February 7, 2003; 278(7): 5264 - 5270.
[Abstract] [Full Text] [PDF]

N. Mori, R. Suzuki, T. Furuno, D. M. McKay, M. Wada, R. Teshima, J. Bienenstock, and M. Nakanishi
Nerve-mast cell (RBL) interaction: RBL membrane ruffling occurs at the contact site with an activated neurite
Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1738 - C1744.
[Abstract] [Full Text] [PDF]

G. O. C. Cory, R. Garg, R. Cramer, and A. J. Ridley
Phosphorylation of Tyrosine 291 Enhances the Ability of WASp to Stimulate Actin Polymerization and Filopodium Formation
J. Biol. Chem., November 15, 2002; 277(47): 45115 - 45121.
[Abstract] [Full Text] [PDF]

				W. Abou-Kheir, B. Isaac, H. Yamaguchi, and D. Cox Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2 J. Cell Sci., February 1, 2008; 121(3): 379 - 390. [Abstract] [Full Text] [PDF]

				K. A. Owen, F. J. Pixley, K. S. Thomas, M. Vicente-Manzanares, B. J. Ray, A. F. Horwitz, J. T. Parsons, H. E. Beggs, E. R. Stanley, and A. H. Bouton Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase J. Cell Biol., December 17, 2007; 179(6): 1275 - 1287. [Abstract] [Full Text] [PDF]

				J. Sturge, S. K. Todd, G. Kogianni, A. McCarthy, and C. M. Isacke Mannose receptor regulation of macrophage cell migration J. Leukoc. Biol., September 1, 2007; 82(3): 585 - 593. [Abstract] [Full Text] [PDF]

				A. Woods, G. Wang, H. Dupuis, Z. Shao, and F. Beier Rac1 Signaling Stimulates N-cadherin Expression, Mesenchymal Condensation, and Chondrogenesis J. Biol. Chem., August 10, 2007; 282(32): 23500 - 23508. [Abstract] [Full Text] [PDF]

				Z. Su, L. Cao, Y. Zhu, X. Liu, Z. Huang, A. Huang, and C. He Nogo enhances the adhesion of olfactory ensheathing cells and inhibits their migration J. Cell Sci., June 1, 2007; 120(11): 1877 - 1887. [Abstract] [Full Text] [PDF]

				Y. J. Cho, J. M. Cunnick, S.-J. Yi, V. Kaartinen, J. Groffen, and N. Heisterkamp Abr and Bcr, Two Homologous Rac GTPase-Activating Proteins, Control Multiple Cellular Functions of Murine Macrophages Mol. Cell. Biol., February 1, 2007; 27(3): 899 - 911. [Abstract] [Full Text] [PDF]

				N. A. Luckashenak, R. L. Ryszkiewicz, K. D. Ramsey, and J. L. Clements The Src Homology 2 Domain-Containing Leukocyte Protein of 76-kDa Adaptor Links Integrin Ligation with p44/42 MAPK Phosphorylation and Podosome Distribution in Murine Dendritic Cells J. Immunol., October 15, 2006; 177(8): 5177 - 5185. [Abstract] [Full Text] [PDF]

				R. Chapados, K. Abe, K. Ihida-Stansbury, D. McKean, A. T. Gates, M. Kern, S. Merklinger, J. Elliott, A. Plant, H. Shimokawa, et al. ROCK Controls Matrix Synthesis in Vascular Smooth Muscle Cells: Coupling Vasoconstriction to Vascular Remodeling Circ. Res., October 13, 2006; 99(8): 837 - 844. [Abstract] [Full Text] [PDF]

				A. Aziz, L. Vanhille, P. Mohideen, L. M. Kelly, C. Otto, Y. Bakri, N. Mossadegh, S. Sarrazin, and M. H. Sieweke Development of Macrophages with Altered Actin Organization in the Absence of MafB. Mol. Cell. Biol., September 1, 2006; 26(18): 6808 - 6818. [Abstract] [Full Text] [PDF]

				A. Lemarie, C. Morzadec, E. Bourdonnay, O. Fardel, and L. Vernhet Human macrophages constitute targets for immunotoxic inorganic arsenic. J. Immunol., September 1, 2006; 177(5): 3019 - 3027. [Abstract] [Full Text] [PDF]

				S. Saraswathy, G. Wu, and N. A. Rao Retinal microglial activation and chemotaxis by docosahexaenoic Acid hydroperoxide. Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3656 - 3663. [Abstract] [Full Text] [PDF]

				F. Guo, M. Debidda, L. Yang, D. A. Williams, and Y. Zheng Genetic Deletion of Rac1 GTPase Reveals Its Critical Role in Actin Stress Fiber Formation and Focal Adhesion Complex Assembly J. Biol. Chem., July 7, 2006; 281(27): 18652 - 18659. [Abstract] [Full Text] [PDF]

				A. P. Wheeler, C. M. Wells, S. D. Smith, F. M. Vega, R. B. Henderson, V. L. Tybulewicz, and A. J. Ridley Rac1 and Rac2 regulate macrophage morphology but are not essential for migration J. Cell Sci., July 1, 2006; 119(13): 2749 - 2757. [Abstract] [Full Text] [PDF]

				Z. Li, C. Wang, X. Jiao, Y. Lu, M. Fu, A. A. Quong, C. Dye, J. Yang, M. Dai, X. Ju, et al. Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling. Mol. Cell. Biol., June 1, 2006; 26(11): 4240 - 4256. [Abstract] [Full Text] [PDF]

				E. Cernuda-Morollon and A. J. Ridley Rho GTPases and Leukocyte Adhesion Receptor Expression and Function in Endothelial Cells Circ. Res., March 31, 2006; 98(6): 757 - 767. [Abstract] [Full Text] [PDF]

				I. O. Gordon and R. S. Freedman Defective Antitumor Function of Monocyte-Derived Macrophages from Epithelial Ovarian Cancer Patients Clin. Cancer Res., March 1, 2006; 12(5): 1515 - 1524. [Abstract] [Full Text] [PDF]

				C. Qin, T. Nagao, I. Grosheva, F. R. Maxfield, and L. M. Pierini Elevated Plasma Membrane Cholesterol Content Alters Macrophage Signaling and Function Arterioscler. Thromb. Vasc. Biol., February 1, 2006; 26(2): 372 - 378. [Abstract] [Full Text] [PDF]

				H. Fan, V. A. Patel, A. Longacre, and J. S. Levine Abnormal regulation of the cytoskeletal regulator Rho typifies macrophages of the major murine models of spontaneous autoimmunity J. Leukoc. Biol., January 1, 2006; 79(1): 155 - 165. [Abstract] [Full Text] [PDF]

				R. F. Wu, Y. C. Xu, Z. Ma, F. E. Nwariaku, G. A. Sarosi Jr., and L. S. Terada Subcellular targeting of oxidants during endothelial cell migration J. Cell Biol., December 5, 2005; 171(5): 893 - 904. [Abstract] [Full Text] [PDF]

				S. Bagchi, Z. Liao, F. A. Gonzalez, N. E. Chorna, C. I. Seye, G. A. Weisman, and L. Erb The P2Y2 Nucleotide Receptor Interacts with {alpha}v Integrins to Activate Go and Induce Cell Migration J. Biol. Chem., November 25, 2005; 280(47): 39050 - 39057. [Abstract] [Full Text] [PDF]

				W. Abou Kheir, J.-C. Gevrey, H. Yamaguchi, B. Isaac, and D. Cox A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages J. Cell Sci., November 15, 2005; 118(22): 5369 - 5379. [Abstract] [Full Text] [PDF]

				U. K. Misra, T. Sharma, and S. V. Pizzo Ligation of Cell Surface-Associated Glucose-Regulated Protein 78 by Receptor-Recognized Forms of {alpha}2-Macroglobulin: Activation of p21-Activated Protein Kinase-2-Dependent Signaling in Murine Peritoneal Macrophages J. Immunol., August 15, 2005; 175(4): 2525 - 2533. [Abstract] [Full Text] [PDF]

				D. D. Tang, W. Zhang, and S. J. Gunst The Adapter Protein CrkII Regulates Neuronal Wiskott-Aldrich Syndrome Protein, Actin Polymerization, and Tension Development during Contractile Stimulation of Smooth Muscle J. Biol. Chem., June 17, 2005; 280(24): 23380 - 23389. [Abstract] [Full Text] [PDF]

				F. J. Pixley, Y. Xiong, R. Y.-L. Yu, E. A. Sahai, E. R. Stanley, and B. H. Ye BCL6 suppresses RhoA activity to alter macrophage morphology and motility J. Cell Sci., May 1, 2005; 118(9): 1873 - 1883. [Abstract] [Full Text] [PDF]

				G. V. Shurin, I. L. Tourkova, G. S. Chatta, G. Schmidt, S. Wei, J. Y. Djeu, and M. R. Shurin Small Rho GTPases Regulate Antigen Presentation in Dendritic Cells J. Immunol., March 15, 2005; 174(6): 3394 - 3400. [Abstract] [Full Text] [PDF]

				M. Jansen, F.-C. Yang, J. A. Cancelas, J. R. Bailey, and D. A. Williams Rac2-Deficient Hematopoietic Stem Cells Show Defective Interaction with the Hematopoietic Microenvironment and Long-Term Engraftment Failure Stem Cells, March 1, 2005; 23(3): 335 - 346. [Abstract] [Full Text] [PDF]

				C. B. Pollock, S. Shirasawa, T. Sasazuki, W. Kolch, and A. S. Dhillon Oncogenic K-RAS Is Required to Maintain Changes in Cytoskeletal Organization, Adhesion, and Motility in Colon Cancer Cells Cancer Res., February 15, 2005; 65(4): 1244 - 1250. [Abstract] [Full Text] [PDF]

				Y. Gu, A. C. Jasti, M. Jansen, and J. E. Siefring RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells Blood, February 15, 2005; 105(4): 1467 - 1475. [Abstract] [Full Text] [PDF]

				M. Paladi and U. Tepass Function of Rho GTPases in embryonic blood cell migration in Drosophila J. Cell Sci., December 15, 2004; 117(26): 6313 - 6326. [Abstract] [Full Text] [PDF]

				G. Gadea, L. Roger, C. Anguille, M. de Toledo, V. Gire, and P. Roux TNF{alpha} induces sequential activation of Cdc42- and p38/p53-dependent pathways that antagonistically regulate filopodia formation J. Cell Sci., December 15, 2004; 117(26): 6355 - 6364. [Abstract] [Full Text] [PDF]