Proteinase-activated receptor-2: expression by human neutrophils

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Howells, G. L.
	Articles by Stone, S. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Howells, G. L.
	Articles by Stone, S. R.

Blackhart, B. D., Emilsson, K., Nguyen, D., Teng, W., Martelli, A. J., Nystedt, S., Sundelin, J. and Scarborough, R. M (1996). Ligand cross-reactivity within the protease-activated receptor family. J. Biol. Chem 271, 16466-16471.[Abstract/Free Full Text]

Bohm, S. K., Kong, W., Bromme, D., Smeekens, S. P., Anderson, D. C., Connolly, A., Kahn, M., Nelken, N. A., Coughlin, S. R., et al (1996). Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J 314, 1009-1016.

Bohm, S. K., Khitin, L. M., Grady, E. F., Aponte, G., Payan, D. G. and Burnett, N. W (1996). Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J. Biol. Chem 271, 22003-22016.[Abstract/Free Full Text]

Brass, L. F., Pizarro, S., Ahuja, M., Belmonte, E., Blanchard, N., Stadel, J. M. and Hoxie, J. A (1994). Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling. J. Biol. Chem 269, 2943-2952.[Abstract/Free Full Text]

Chao, B. H., Kalkunte, S., Maraganore, J. M. and Stone, S. R (1992). Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor. Biochemistry 31, 6175-6178.[Medline]

Coller, B. S., Ward, P., Ceruso, M., Scudder, L. E., Springer, K., Kutok, J. and Prestwich, G. D (1992). Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M. Biochemistry 31, 11713-11720.[Medline]

Connolly, A. J., Ishihara, H., Kahn, M. L., Farese, R. V. Jr and Coughlin, S. R (1996). Role of the thrombin receptor in development and evidence for a second receptor. Nature 381, 516-519.[Medline]

Edwards, S. W (1995). Cell signalling by integrins and immunoglobulin receptors in primed neutrophils. Trends Biochem. Sci 20, 362-367.[Medline]

Grand, R. J. A., Turnell, A. S. and Grabham, P. W (1996). Cellular consequences of thrombin-receptor activation. Biochem. J 313, 353-368.

Grynkiewicz, G., Poenie, M. and Tsien, R. Y (1985). A new generation of Ca2+indicators with greatly improved fluorescence properties. J. Biol. Chem 260, 3440-3450.[Abstract/Free Full Text]

Hickstein, D. D., Back, A. L. and Collins, S. J (1989). Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation. J. Biol. Chem 264, 21812-21817.[Abstract/Free Full Text]

Hollenberg, M. D., Saifeddine, M. and Alani, B (1996). Proteinase-activated receptor-2 in rat aorta \320 structural requirements for agonist activity of receptor-activating peptides. Mol. Pharmacol 49, 229-233.[Abstract]

Howells, G. L., Macey, M., Curtis, M. A. and Stone, S. R (1993). Peripheral blood lymphocytes express the platelet-type thrombin receptor. Br. J. Haematol 84, 156-160.[Medline]

Hoxie, J. A., Ahuja, M., Belmonte, E., Pizarro, S., Parton, R. and Brass, L. F (1993). Internalization and recycling of activated thrombin receptors. J. Biol. Chem 268, 13756-13763.[Abstract/Free Full Text]

Ishii, K., Chen, J., Ishii, M., Koch, W. J., Freedman, N. J., Lefkowitz, R. J. and Coughlin, S. R (1994). Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. J. Biol. Chem 269, 1125-1130.[Abstract/Free Full Text]

Jenkins, A. L., Howells, G. L., Scott, E., Le Bonniec, B. F., Curtis, M. A. and Stone, S. R (1995). The response to thrombin of human neutrophils: evidence for two novel receptors. J. Cell Sci 108, 3059-3066.[Abstract]

Karnad, A. B., Hartshorn, K. L., Wright, J., Myers, J. B., Schwartz, J. H. and Tauber, A. I (1989). Priming of human neutrophils with N-formyl-methionyl-leucyl-phenylalanine by a calcium-independent, pertussis toxin-insensitive pathway. Blood 74, 2519-2526.[Abstract/Free Full Text]

Keller, H. U., Fedier, A. and Rohner, R (1995). Relationship between light scattering in flow cytometry and changes in shape, volume, and actin polymerization in human polymorphonuclear leukocytes. J. Leuk. Biol 58, 519-525.[Abstract]

Kenny, J (1993). Endopeptidase-24.11: putative substrates and possible roles. Biochem. Soc. Trans 21, 663-668.

Lalu, K., Lampelo, S. and Vanha-Perttula, T (1986). Characterization of three aminopeptidases purified from maternal serum. Biochim. Biophys. Acta 873, 190-197.[Medline]

Macey, M. G., Jiang, X. P., Veys, P., McCarthy, D. and Newland, A. C (1992). Expression of functional antigens on neutrophils. Effects of preparation. J. Immunol. Meth 149, 37-42.[Medline]

Macey, M. G., McCarthy, D. A. and Newland, A. C (1994). The ex vivo function and expression of function-associated antigens of peripheral blood neutrophils and monocytes. Exp. Hematol 22, 967-972.[Medline]

McCarthy, D. and Macey, M. G (1993). A simple flow cytometric procedure for the determination of surface antigens on unfixed leucocytes in whole blood. J. Immunol. Meth 163, 155-160.[Medline]

McCarthy, D. and Macey, M. G (1996). Novel anticoagulants for flow cytometric analysis of live leukocytes in whole-blood. Cytometry 23, 196-204.[Medline]

Mirza, H., Yatsula, V. and Bahou, W. F (1996). The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial-cells \320 molecular characterization and evidence for functional coupling to the thrombin receptor. J. Clin. Invest 97, 1705-1714.[Medline]

Nystedt, S., Emilsson, K., Wahlestedt, C. and Sundelin, J (1994). Molecular cloning of a potential proteinase activated receptor. Proc. Nat. Acad. Sci. USA 91, 9208-9212.[Abstract/Free Full Text]

Nystedt, S., Ramakrishnan, V. and Sundelin, J (1996). The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. J. Biol. Chem 271, 14910-14915.[Abstract/Free Full Text]

Posnett, D. N. and Tam, J. P (1989). Multiple antigenic peptide method for producing antipeptide site-specific antibodies. Meth. Enzymol 178, 739-746.[Medline]

Pyne, D. B (1994). Regulation of neutrophil function during exercise. Sports Medicine 17, 245-258.[Medline]

Santulli, R. J., Derian, C. K., Darrow, A. L., Tomko, K. A., Eckardt, A. J., Seiberg, M., Scarborough, R. M. and Andradegordon, P (1995). Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. Proc. Nat. Acad. Sci. USA 92, 9151-9155.[Abstract/Free Full Text]

Socinski, M. A., Cannistra, S. A., Sullivan, R., Elias, A., Antman, K., Schnipper, L. and Griffin, J. D (1988). Granulocyte-macrophage colony-stimulating factor induces the expression of the CD11b surface adhesion molecule on human granulocytes in vivo. Blood 72, 691-697.[Abstract/Free Full Text]

Spycher, S. E., Nick, H. and Rickli, E. E (1986). Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation. Eur. J. Biochem 156, 49-57.[Medline]

Vu, T. K., Hung, D. T., Wheaton, V. I. and Coughlin, S. R (1991). Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64, 1057-1068.[Medline]

Walker, B. A. and Ward, P. A (1992). Priming and signal transduction in neutrophils. Biological Signals 1, 237-249.[Medline]

This article has been cited by other articles:

V. Shpacovitch, M. Feld, M. D. Hollenberg, T. A. Luger, and M. Steinhoff
Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity
J. Leukoc. Biol., June 1, 2008; 83(6): 1309 - 1322.
[Abstract] [Full Text] [PDF]

R. Jiang, A. Zatta, H. Kin, N. Wang, J. G. Reeves, J. Mykytenko, J. Deneve, Z.-Q. Zhao, R. A. Guyton, and J. Vinten-Johansen
PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2845 - H2852.
[Abstract] [Full Text] [PDF]

L. Moussa, J. Apostolopoulos, P. Davenport, J. Tchongue, and P. G. Tipping
Protease-Activated Receptor-2 Augments Experimental Crescentic Glomerulonephritis
Am. J. Pathol., September 1, 2007; 171(3): 800 - 808.
[Abstract] [Full Text] [PDF]

Y. Kida, H. Inoue, T. Shimizu, and K. Kuwano
Serratia marcescens Serralysin Induces Inflammatory Responses through Protease-Activated Receptor 2
Infect. Immun., January 1, 2007; 75(1): 164 - 174.
[Abstract] [Full Text] [PDF]

Q. Gu and L.-Y. Lee
Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease-activated receptor-2 in rats
J. Physiol., August 1, 2006; 574(3): 867 - 876.
[Abstract] [Full Text] [PDF]

M. Chignard and D. Pidard
Neutrophil and Pathogen Proteinases versus Proteinase-Activated Receptor-2 Lung Epithelial Cells: More Terminators than Activators.
Am. J. Respir. Cell Mol. Biol., April 1, 2006; 34(4): 394 - 398.
[Abstract] [Full Text] [PDF]

J. H. Cleator, W. Q. Zhu, D. E. Vaughan, and H. E. Hamm
Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP
Blood, April 1, 2006; 107(7): 2736 - 2744.
[Abstract] [Full Text] [PDF]

U. Johansson, C. Lawson, M. Dabare, D. Syndercombe-Court, A. C. Newland, G. L. Howells, and M. G. Macey
Human peripheral blood monocytes express protease receptor-2 and respond to receptor activation by production of IL-6, IL-8, and IL-1{beta}
J. Leukoc. Biol., October 1, 2005; 78(4): 967 - 975.
[Abstract] [Full Text] [PDF]

X. Su, E. Camerer, J. R. Hamilton, S. R. Coughlin, and M. A. Matthay
Protease-Activated Receptor-2 Activation Induces Acute Lung Inflammation by Neuropeptide-Dependent Mechanisms
J. Immunol., August 15, 2005; 175(4): 2598 - 2605.
[Abstract] [Full Text] [PDF]

M. D. Morgan, L. Harper, X. Lu, G. Nash, J. Williams, and C. O. S. Savage
Can neutrophils be manipulated in vivo?
Rheumatology, May 1, 2005; 44(5): 597 - 601.
[Full Text] [PDF]

M. Steinhoff, J. Buddenkotte, V. Shpacovitch, A. Rattenholl, C. Moormann, N. Vergnolle, T. A. Luger, and M. D. Hollenberg
Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response
Endocr. Rev., February 1, 2005; 26(1): 1 - 43.
[Abstract] [Full Text] [PDF]

W. O. Chung, S. R. Hansen, D. Rao, and B. A. Dale
Protease-Activated Receptor Signaling Increases Epithelial Antimicrobial Peptide Expression
J. Immunol., October 15, 2004; 173(8): 5165 - 5170.
[Abstract] [Full Text] [PDF]

V. M. Shpacovitch, G. Varga, A. Strey, M. Gunzer, F. Mooren, J. Buddenkotte, N. Vergnolle, C. P. Sommerhoff, S. Grabbe, V. Gerke, et al.
Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices
J. Leukoc. Biol., August 1, 2004; 76(2): 388 - 398.
[Abstract] [Full Text] [PDF]

H. S. Rosario, S. W. Waldo, S. A. Becker, and G. W. Schmid-Schonbein
Pancreatic Trypsin Increases Matrix Metalloproteinase-9 Accumulation and Activation during Acute Intestinal Ischemia-Reperfusion in the Rat
Am. J. Pathol., May 1, 2004; 164(5): 1707 - 1716.
[Abstract] [Full Text] [PDF]

V. S. OSSOVSKAYA and N. W. BUNNETT
Protease-Activated Receptors: Contribution to Physiology and Disease
Physiol Rev, April 1, 2004; 84(2): 579 - 621.
[Abstract] [Full Text] [PDF]

S. He, A. Aslam, M. D. A. Gaca, Y. He, M. G. Buckley, M. D. Hollenberg, and A. F. Walls
Inhibitors of Tryptase as Mast Cell-Stabilizing Agents in the Human Airways: Effects of Tryptase and Other Agonists of Proteinase-Activated Receptor 2 on Histamine Release
J. Pharmacol. Exp. Ther., April 1, 2004; 309(1): 119 - 126.
[Abstract] [Full Text]

S. SEELIGER, C. K. DERIAN, N. VERGNOLLE, N. W. BUNNETT, R. NAWROTH, M. SCHMELZ, P.-Y. VON DER WEID, J. BUDDENKOTTE, C. SUNDERKOTTER, D. METZE, et al.
Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo
FASEB J, October 1, 2003; 17(13): 1871 - 1885.
[Abstract] [Full Text] [PDF]

D. H. Sturn, N. C. Kaneider, C. Feistritzer, A. Djanani, K. Fukudome, and C. J. Wiedermann
Expression and function of the endothelial protein C receptor in human neutrophils
Blood, August 15, 2003; 102(4): 1499 - 1505.
[Abstract] [Full Text] [PDF]

S. J. Bolton, C. A. McNulty, R. J. Thomas, C. R. A. Hewitt, and A. J. Wardlaw
Expression of and functional responses to protease-activated receptors on human eosinophils
J. Leukoc. Biol., July 1, 2003; 74(1): 60 - 68.
[Abstract] [Full Text] [PDF]

V. Temkin, B. Kantor, V. Weg, M.-L. Hartman, and F. Levi-Schaffer
Tryptase Activates the Mitogen-Activated Protein Kinase/Activator Protein-1 Pathway in Human Peripheral Blood Eosinophils, Causing Cytokine Production and Release
J. Immunol., September 1, 2002; 169(5): 2662 - 2669.
[Abstract] [Full Text] [PDF]

Y. Wang, Y. Gu, and M. J. Lucas
Expression of Thrombin Receptors in Endothelial Cells and Neutrophils from Normal and Preeclamptic Pregnancies
J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3728 - 3734.
[Abstract] [Full Text] [PDF]

N. Vergnolle, C. K. Derian, M. R. D'Andrea, M. Steinhoff, and P. Andrade-Gordon
Characterization of Thrombin-Induced Leukocyte Rolling and Adherence: A Potential Proinflammatory Role for Proteinase-Activated Receptor-4
J. Immunol., August 1, 2002; 169(3): 1467 - 1473.
[Abstract] [Full Text] [PDF]

J. D. Moffatt, K. L. Jeffrey, and T. M. Cocks
Protease-Activated Receptor-2 Activating Peptide SLIGRL Inhibits Bacterial Lipopolysaccharide-Induced Recruitment of Polymorphonuclear Leukocytes into the Airways of Mice
Am. J. Respir. Cell Mol. Biol., June 1, 2002; 26(6): 680 - 684.
[Abstract] [Full Text] [PDF]

S. Miike, A. S. McWilliam, and H. Kita
Trypsin Induces Activation and Inflammatory Mediator Release from Human Eosinophils Through Protease-Activated Receptor-2
J. Immunol., December 1, 2001; 167(11): 6615 - 6622.
[Abstract] [Full Text] [PDF]

M.M. Kelly, R. Leigh, S. Carruthers, P. Horsewood, G.J. Gleich, F.E. Hargreave, and G. Cox
Increased detection of interleukin-;5 in sputum by addition of protease inhibitors
Eur. Respir. J., October 1, 2001; 18(4): 685 - 691.
[Abstract] [Full Text] [PDF]

G. Sun, M. A. Stacey, M. Schmidt, L. Mori, and S. Mattoli
Interaction of Mite Allergens Der P3 and Der P9 with Protease-Activated Receptor-2 Expressed by Lung Epithelial Cells
J. Immunol., July 15, 2001; 167(2): 1014 - 1021.
[Abstract] [Full Text] [PDF]

T. Syrovets, M. Jendrach, A. Rohwedder, A. Schule, and T. Simmet
Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKK{beta}-mediated NF-{kappa}B activation
Blood, June 15, 2001; 97(12): 3941 - 3950.
[Abstract] [Full Text] [PDF]

S. R. Macfarlane, M. J. Seatter, T. Kanke, G. D. Hunter, and R. Plevin
Proteinase-Activated Receptors
Pharmacol. Rev., June 1, 2001; 53(2): 245 - 282.
[Abstract] [Full Text] [PDF]

H. Danahay, L. Withey, C. T. Poll, S. F. J. van de Graaf, and R. J. Bridges
Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells
Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1455 - C1464.
[Abstract] [Full Text] [PDF]

C Chinni, M. de Niese, A. Jenkins, R. Pike, S. Bottomley, and E. Mackie
Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts
J. Cell Sci., January 12, 2000; 113(24): 4427 - 4433.
[Abstract] [PDF]

N. Vergnolle
Proteinase-Activated Receptor-2-Activating Peptides Induce Leukocyte Rolling, Adhesion, and Extravasation In Vivo
J. Immunol., November 1, 1999; 163(9): 5064 - 5069.
[Abstract] [Full Text] [PDF]

C. Cicala, A. Pinto, M. Bucci, R. Sorrentino, B. Walker, P. Harriot, A. Cruchley, S. Kapas, G. L. Howells, and G. Cirino
Protease-Activated Receptor-2 Involvement in Hypotension in Normal and Endotoxemic Rats In Vivo
Circulation, May 18, 1999; 99(19): 2590 - 2597.
[Abstract] [Full Text] [PDF]

O. Dery, C. U. Corvera, M. Steinhoff, and N. W. Bunnett
Proteinase-activated receptors: novel mechanisms of signaling by serine proteases
Am J Physiol Cell Physiol, June 1, 1998; 274(6): C1429 - C1452.
[Abstract] [Full Text] [PDF]

S. J. Compton, J. A. Cairns, K.-J. Palmer, B. Al-Ani, M. D. Hollenberg, and A. F. Walls
A Polymorphic Protease-activated Receptor 2 (PAR2) Displaying Reduced Sensitivity to Trypsin and Differential Responses to PAR Agonists
J. Biol. Chem., December 8, 2000; 275(50): 39207 - 39212.
[Abstract] [Full Text] [PDF]

C. Huang, G. T. De Sanctis, P. J. O'Brien, J. P. Mizgerd, D. S. Friend, J. M. Drazen, L. F. Brass, and R. L. Stevens
Evaluation of the Substrate Specificity of Human Mast Cell Tryptase beta I and Demonstration of Its Importance in Bacterial Infections of the Lung
J. Biol. Chem., July 6, 2001; 276(28): 26276 - 26284.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Howells, G. L.

Articles by Stone, S. R.

Search for Related Content

PubMed

PubMed Citation

Articles by Howells, G. L.

Articles by Stone, S. R.

				R. Jiang, A. Zatta, H. Kin, N. Wang, J. G. Reeves, J. Mykytenko, J. Deneve, Z.-Q. Zhao, R. A. Guyton, and J. Vinten-Johansen PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2845 - H2852. [Abstract] [Full Text] [PDF]

				L. Moussa, J. Apostolopoulos, P. Davenport, J. Tchongue, and P. G. Tipping Protease-Activated Receptor-2 Augments Experimental Crescentic Glomerulonephritis Am. J. Pathol., September 1, 2007; 171(3): 800 - 808. [Abstract] [Full Text] [PDF]

				Y. Kida, H. Inoue, T. Shimizu, and K. Kuwano Serratia marcescens Serralysin Induces Inflammatory Responses through Protease-Activated Receptor 2 Infect. Immun., January 1, 2007; 75(1): 164 - 174. [Abstract] [Full Text] [PDF]

				Q. Gu and L.-Y. Lee Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease-activated receptor-2 in rats J. Physiol., August 1, 2006; 574(3): 867 - 876. [Abstract] [Full Text] [PDF]

				M. Chignard and D. Pidard Neutrophil and Pathogen Proteinases versus Proteinase-Activated Receptor-2 Lung Epithelial Cells: More Terminators than Activators. Am. J. Respir. Cell Mol. Biol., April 1, 2006; 34(4): 394 - 398. [Abstract] [Full Text] [PDF]

				J. H. Cleator, W. Q. Zhu, D. E. Vaughan, and H. E. Hamm Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP Blood, April 1, 2006; 107(7): 2736 - 2744. [Abstract] [Full Text] [PDF]

				U. Johansson, C. Lawson, M. Dabare, D. Syndercombe-Court, A. C. Newland, G. L. Howells, and M. G. Macey Human peripheral blood monocytes express protease receptor-2 and respond to receptor activation by production of IL-6, IL-8, and IL-1{beta} J. Leukoc. Biol., October 1, 2005; 78(4): 967 - 975. [Abstract] [Full Text] [PDF]

				X. Su, E. Camerer, J. R. Hamilton, S. R. Coughlin, and M. A. Matthay Protease-Activated Receptor-2 Activation Induces Acute Lung Inflammation by Neuropeptide-Dependent Mechanisms J. Immunol., August 15, 2005; 175(4): 2598 - 2605. [Abstract] [Full Text] [PDF]

				M. D. Morgan, L. Harper, X. Lu, G. Nash, J. Williams, and C. O. S. Savage Can neutrophils be manipulated in vivo? Rheumatology, May 1, 2005; 44(5): 597 - 601. [Full Text] [PDF]

				M. Steinhoff, J. Buddenkotte, V. Shpacovitch, A. Rattenholl, C. Moormann, N. Vergnolle, T. A. Luger, and M. D. Hollenberg Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response Endocr. Rev., February 1, 2005; 26(1): 1 - 43. [Abstract] [Full Text] [PDF]

				W. O. Chung, S. R. Hansen, D. Rao, and B. A. Dale Protease-Activated Receptor Signaling Increases Epithelial Antimicrobial Peptide Expression J. Immunol., October 15, 2004; 173(8): 5165 - 5170. [Abstract] [Full Text] [PDF]

				V. M. Shpacovitch, G. Varga, A. Strey, M. Gunzer, F. Mooren, J. Buddenkotte, N. Vergnolle, C. P. Sommerhoff, S. Grabbe, V. Gerke, et al. Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices J. Leukoc. Biol., August 1, 2004; 76(2): 388 - 398. [Abstract] [Full Text] [PDF]

				H. S. Rosario, S. W. Waldo, S. A. Becker, and G. W. Schmid-Schonbein Pancreatic Trypsin Increases Matrix Metalloproteinase-9 Accumulation and Activation during Acute Intestinal Ischemia-Reperfusion in the Rat Am. J. Pathol., May 1, 2004; 164(5): 1707 - 1716. [Abstract] [Full Text] [PDF]

				V. S. OSSOVSKAYA and N. W. BUNNETT Protease-Activated Receptors: Contribution to Physiology and Disease Physiol Rev, April 1, 2004; 84(2): 579 - 621. [Abstract] [Full Text] [PDF]

				S. He, A. Aslam, M. D. A. Gaca, Y. He, M. G. Buckley, M. D. Hollenberg, and A. F. Walls Inhibitors of Tryptase as Mast Cell-Stabilizing Agents in the Human Airways: Effects of Tryptase and Other Agonists of Proteinase-Activated Receptor 2 on Histamine Release J. Pharmacol. Exp. Ther., April 1, 2004; 309(1): 119 - 126. [Abstract] [Full Text]

				S. SEELIGER, C. K. DERIAN, N. VERGNOLLE, N. W. BUNNETT, R. NAWROTH, M. SCHMELZ, P.-Y. VON DER WEID, J. BUDDENKOTTE, C. SUNDERKOTTER, D. METZE, et al. Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo FASEB J, October 1, 2003; 17(13): 1871 - 1885. [Abstract] [Full Text] [PDF]

				D. H. Sturn, N. C. Kaneider, C. Feistritzer, A. Djanani, K. Fukudome, and C. J. Wiedermann Expression and function of the endothelial protein C receptor in human neutrophils Blood, August 15, 2003; 102(4): 1499 - 1505. [Abstract] [Full Text] [PDF]

				S. J. Bolton, C. A. McNulty, R. J. Thomas, C. R. A. Hewitt, and A. J. Wardlaw Expression of and functional responses to protease-activated receptors on human eosinophils J. Leukoc. Biol., July 1, 2003; 74(1): 60 - 68. [Abstract] [Full Text] [PDF]

				V. Temkin, B. Kantor, V. Weg, M.-L. Hartman, and F. Levi-Schaffer Tryptase Activates the Mitogen-Activated Protein Kinase/Activator Protein-1 Pathway in Human Peripheral Blood Eosinophils, Causing Cytokine Production and Release J. Immunol., September 1, 2002; 169(5): 2662 - 2669. [Abstract] [Full Text] [PDF]

				Y. Wang, Y. Gu, and M. J. Lucas Expression of Thrombin Receptors in Endothelial Cells and Neutrophils from Normal and Preeclamptic Pregnancies J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3728 - 3734. [Abstract] [Full Text] [PDF]

				N. Vergnolle, C. K. Derian, M. R. D'Andrea, M. Steinhoff, and P. Andrade-Gordon Characterization of Thrombin-Induced Leukocyte Rolling and Adherence: A Potential Proinflammatory Role for Proteinase-Activated Receptor-4 J. Immunol., August 1, 2002; 169(3): 1467 - 1473. [Abstract] [Full Text] [PDF]

				J. D. Moffatt, K. L. Jeffrey, and T. M. Cocks Protease-Activated Receptor-2 Activating Peptide SLIGRL Inhibits Bacterial Lipopolysaccharide-Induced Recruitment of Polymorphonuclear Leukocytes into the Airways of Mice Am. J. Respir. Cell Mol. Biol., June 1, 2002; 26(6): 680 - 684. [Abstract] [Full Text] [PDF]

				S. Miike, A. S. McWilliam, and H. Kita Trypsin Induces Activation and Inflammatory Mediator Release from Human Eosinophils Through Protease-Activated Receptor-2 J. Immunol., December 1, 2001; 167(11): 6615 - 6622. [Abstract] [Full Text] [PDF]

				M.M. Kelly, R. Leigh, S. Carruthers, P. Horsewood, G.J. Gleich, F.E. Hargreave, and G. Cox Increased detection of interleukin-;5 in sputum by addition of protease inhibitors Eur. Respir. J., October 1, 2001; 18(4): 685 - 691. [Abstract] [Full Text] [PDF]

				G. Sun, M. A. Stacey, M. Schmidt, L. Mori, and S. Mattoli Interaction of Mite Allergens Der P3 and Der P9 with Protease-Activated Receptor-2 Expressed by Lung Epithelial Cells J. Immunol., July 15, 2001; 167(2): 1014 - 1021. [Abstract] [Full Text] [PDF]

				T. Syrovets, M. Jendrach, A. Rohwedder, A. Schule, and T. Simmet Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKK{beta}-mediated NF-{kappa}B activation Blood, June 15, 2001; 97(12): 3941 - 3950. [Abstract] [Full Text] [PDF]

				S. R. Macfarlane, M. J. Seatter, T. Kanke, G. D. Hunter, and R. Plevin Proteinase-Activated Receptors Pharmacol. Rev., June 1, 2001; 53(2): 245 - 282. [Abstract] [Full Text] [PDF]

				H. Danahay, L. Withey, C. T. Poll, S. F. J. van de Graaf, and R. J. Bridges Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1455 - C1464. [Abstract] [Full Text] [PDF]

				C Chinni, M. de Niese, A. Jenkins, R. Pike, S. Bottomley, and E. Mackie Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts J. Cell Sci., January 12, 2000; 113(24): 4427 - 4433. [Abstract] [PDF]

				N. Vergnolle Proteinase-Activated Receptor-2-Activating Peptides Induce Leukocyte Rolling, Adhesion, and Extravasation In Vivo J. Immunol., November 1, 1999; 163(9): 5064 - 5069. [Abstract] [Full Text] [PDF]