Proteinase-activated receptor-2: expression by human neutrophils

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Blackhart, B. D., Emilsson, K., Nguyen, D., Teng, W., Martelli, A. J., Nystedt, S., Sundelin, J. and Scarborough, R. M (1996). Ligand cross-reactivity within the protease-activated receptor family. J. Biol. Chem 271, 16466-16471.[Abstract/Free Full Text]

Bohm, S. K., Kong, W., Bromme, D., Smeekens, S. P., Anderson, D. C., Connolly, A., Kahn, M., Nelken, N. A., Coughlin, S. R., et al (1996). Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2. Biochem. J 314, 1009-1016.

Bohm, S. K., Khitin, L. M., Grady, E. F., Aponte, G., Payan, D. G. and Burnett, N. W (1996). Mechanisms of desensitization and resensitization of proteinase-activated receptor-2. J. Biol. Chem 271, 22003-22016.[Abstract/Free Full Text]

Brass, L. F., Pizarro, S., Ahuja, M., Belmonte, E., Blanchard, N., Stadel, J. M. and Hoxie, J. A (1994). Changes in the structure and function of the human thrombin receptor during receptor activation, internalization, and recycling. J. Biol. Chem 269, 2943-2952.[Abstract/Free Full Text]

Chao, B. H., Kalkunte, S., Maraganore, J. M. and Stone, S. R (1992). Essential groups in synthetic agonist peptides for activation of the platelet thrombin receptor. Biochemistry 31, 6175-6178.[Medline]

Coller, B. S., Ward, P., Ceruso, M., Scudder, L. E., Springer, K., Kutok, J. and Prestwich, G. D (1992). Thrombin receptor activating peptides: importance of the N-terminal serine and its ionization state as judged by pH dependence, nuclear magnetic resonance spectroscopy, and cleavage by aminopeptidase M. Biochemistry 31, 11713-11720.[Medline]

Connolly, A. J., Ishihara, H., Kahn, M. L., Farese, R. V. Jr and Coughlin, S. R (1996). Role of the thrombin receptor in development and evidence for a second receptor. Nature 381, 516-519.[Medline]

Edwards, S. W (1995). Cell signalling by integrins and immunoglobulin receptors in primed neutrophils. Trends Biochem. Sci 20, 362-367.[Medline]

Grand, R. J. A., Turnell, A. S. and Grabham, P. W (1996). Cellular consequences of thrombin-receptor activation. Biochem. J 313, 353-368.

Grynkiewicz, G., Poenie, M. and Tsien, R. Y (1985). A new generation of Ca2+indicators with greatly improved fluorescence properties. J. Biol. Chem 260, 3440-3450.[Abstract/Free Full Text]

Hickstein, D. D., Back, A. L. and Collins, S. J (1989). Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation. J. Biol. Chem 264, 21812-21817.[Abstract/Free Full Text]

Hollenberg, M. D., Saifeddine, M. and Alani, B (1996). Proteinase-activated receptor-2 in rat aorta \320 structural requirements for agonist activity of receptor-activating peptides. Mol. Pharmacol 49, 229-233.[Abstract]

Howells, G. L., Macey, M., Curtis, M. A. and Stone, S. R (1993). Peripheral blood lymphocytes express the platelet-type thrombin receptor. Br. J. Haematol 84, 156-160.[Medline]

Hoxie, J. A., Ahuja, M., Belmonte, E., Pizarro, S., Parton, R. and Brass, L. F (1993). Internalization and recycling of activated thrombin receptors. J. Biol. Chem 268, 13756-13763.[Abstract/Free Full Text]

Ishii, K., Chen, J., Ishii, M., Koch, W. J., Freedman, N. J., Lefkowitz, R. J. and Coughlin, S. R (1994). Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases. J. Biol. Chem 269, 1125-1130.[Abstract/Free Full Text]

Jenkins, A. L., Howells, G. L., Scott, E., Le Bonniec, B. F., Curtis, M. A. and Stone, S. R (1995). The response to thrombin of human neutrophils: evidence for two novel receptors. J. Cell Sci 108, 3059-3066.[Abstract]

Karnad, A. B., Hartshorn, K. L., Wright, J., Myers, J. B., Schwartz, J. H. and Tauber, A. I (1989). Priming of human neutrophils with N-formyl-methionyl-leucyl-phenylalanine by a calcium-independent, pertussis toxin-insensitive pathway. Blood 74, 2519-2526.[Abstract/Free Full Text]

Keller, H. U., Fedier, A. and Rohner, R (1995). Relationship between light scattering in flow cytometry and changes in shape, volume, and actin polymerization in human polymorphonuclear leukocytes. J. Leuk. Biol 58, 519-525.[Abstract]

Kenny, J (1993). Endopeptidase-24.11: putative substrates and possible roles. Biochem. Soc. Trans 21, 663-668.

Lalu, K., Lampelo, S. and Vanha-Perttula, T (1986). Characterization of three aminopeptidases purified from maternal serum. Biochim. Biophys. Acta 873, 190-197.[Medline]

Macey, M. G., Jiang, X. P., Veys, P., McCarthy, D. and Newland, A. C (1992). Expression of functional antigens on neutrophils. Effects of preparation. J. Immunol. Meth 149, 37-42.[Medline]

Macey, M. G., McCarthy, D. A. and Newland, A. C (1994). The ex vivo function and expression of function-associated antigens of peripheral blood neutrophils and monocytes. Exp. Hematol 22, 967-972.[Medline]

McCarthy, D. and Macey, M. G (1993). A simple flow cytometric procedure for the determination of surface antigens on unfixed leucocytes in whole blood. J. Immunol. Meth 163, 155-160.[Medline]

McCarthy, D. and Macey, M. G (1996). Novel anticoagulants for flow cytometric analysis of live leukocytes in whole-blood. Cytometry 23, 196-204.[Medline]

Mirza, H., Yatsula, V. and Bahou, W. F (1996). The proteinase activated receptor-2 (PAR-2) mediates mitogenic responses in human vascular endothelial-cells \320 molecular characterization and evidence for functional coupling to the thrombin receptor. J. Clin. Invest 97, 1705-1714.[Medline]

Nystedt, S., Emilsson, K., Wahlestedt, C. and Sundelin, J (1994). Molecular cloning of a potential proteinase activated receptor. Proc. Nat. Acad. Sci. USA 91, 9208-9212.[Abstract/Free Full Text]

Nystedt, S., Ramakrishnan, V. and Sundelin, J (1996). The proteinase-activated receptor 2 is induced by inflammatory mediators in human endothelial cells. J. Biol. Chem 271, 14910-14915.[Abstract/Free Full Text]

Posnett, D. N. and Tam, J. P (1989). Multiple antigenic peptide method for producing antipeptide site-specific antibodies. Meth. Enzymol 178, 739-746.[Medline]

Pyne, D. B (1994). Regulation of neutrophil function during exercise. Sports Medicine 17, 245-258.[Medline]

Santulli, R. J., Derian, C. K., Darrow, A. L., Tomko, K. A., Eckardt, A. J., Seiberg, M., Scarborough, R. M. and Andradegordon, P (1995). Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes. Proc. Nat. Acad. Sci. USA 92, 9151-9155.[Abstract/Free Full Text]

Socinski, M. A., Cannistra, S. A., Sullivan, R., Elias, A., Antman, K., Schnipper, L. and Griffin, J. D (1988). Granulocyte-macrophage colony-stimulating factor induces the expression of the CD11b surface adhesion molecule on human granulocytes in vivo. Blood 72, 691-697.[Abstract/Free Full Text]

Spycher, S. E., Nick, H. and Rickli, E. E (1986). Human complement component C1s. Partial sequence determination of the heavy chain and identification of the peptide bond cleaved during activation. Eur. J. Biochem 156, 49-57.[Medline]

Vu, T. K., Hung, D. T., Wheaton, V. I. and Coughlin, S. R (1991). Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64, 1057-1068.[Medline]

Walker, B. A. and Ward, P. A (1992). Priming and signal transduction in neutrophils. Biological Signals 1, 237-249.[Medline]

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				V. Shpacovitch, M. Feld, M. D. Hollenberg, T. A. Luger, and M. Steinhoff Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity J. Leukoc. Biol., June 1, 2008; 83(6): 1309 - 1322. [Abstract] [Full Text] [PDF]

				R. Jiang, A. Zatta, H. Kin, N. Wang, J. G. Reeves, J. Mykytenko, J. Deneve, Z.-Q. Zhao, R. A. Guyton, and J. Vinten-Johansen PAR-2 activation at the time of reperfusion salvages myocardium via an ERK1/2 pathway in in vivo rat hearts Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2845 - H2852. [Abstract] [Full Text] [PDF]

				L. Moussa, J. Apostolopoulos, P. Davenport, J. Tchongue, and P. G. Tipping Protease-Activated Receptor-2 Augments Experimental Crescentic Glomerulonephritis Am. J. Pathol., September 1, 2007; 171(3): 800 - 808. [Abstract] [Full Text] [PDF]

				Y. Kida, H. Inoue, T. Shimizu, and K. Kuwano Serratia marcescens Serralysin Induces Inflammatory Responses through Protease-Activated Receptor 2 Infect. Immun., January 1, 2007; 75(1): 164 - 174. [Abstract] [Full Text] [PDF]

				Q. Gu and L.-Y. Lee Hypersensitivity of pulmonary chemosensitive neurons induced by activation of protease-activated receptor-2 in rats J. Physiol., August 1, 2006; 574(3): 867 - 876. [Abstract] [Full Text] [PDF]

				M. Chignard and D. Pidard Neutrophil and Pathogen Proteinases versus Proteinase-Activated Receptor-2 Lung Epithelial Cells: More Terminators than Activators. Am. J. Respir. Cell Mol. Biol., April 1, 2006; 34(4): 394 - 398. [Abstract] [Full Text] [PDF]

				J. H. Cleator, W. Q. Zhu, D. E. Vaughan, and H. E. Hamm Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by protease-activated receptors and cAMP Blood, April 1, 2006; 107(7): 2736 - 2744. [Abstract] [Full Text] [PDF]

				U. Johansson, C. Lawson, M. Dabare, D. Syndercombe-Court, A. C. Newland, G. L. Howells, and M. G. Macey Human peripheral blood monocytes express protease receptor-2 and respond to receptor activation by production of IL-6, IL-8, and IL-1{beta} J. Leukoc. Biol., October 1, 2005; 78(4): 967 - 975. [Abstract] [Full Text] [PDF]

				X. Su, E. Camerer, J. R. Hamilton, S. R. Coughlin, and M. A. Matthay Protease-Activated Receptor-2 Activation Induces Acute Lung Inflammation by Neuropeptide-Dependent Mechanisms J. Immunol., August 15, 2005; 175(4): 2598 - 2605. [Abstract] [Full Text] [PDF]

				M. D. Morgan, L. Harper, X. Lu, G. Nash, J. Williams, and C. O. S. Savage Can neutrophils be manipulated in vivo? Rheumatology, May 1, 2005; 44(5): 597 - 601. [Full Text] [PDF]

				M. Steinhoff, J. Buddenkotte, V. Shpacovitch, A. Rattenholl, C. Moormann, N. Vergnolle, T. A. Luger, and M. D. Hollenberg Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response Endocr. Rev., February 1, 2005; 26(1): 1 - 43. [Abstract] [Full Text] [PDF]

				W. O. Chung, S. R. Hansen, D. Rao, and B. A. Dale Protease-Activated Receptor Signaling Increases Epithelial Antimicrobial Peptide Expression J. Immunol., October 15, 2004; 173(8): 5165 - 5170. [Abstract] [Full Text] [PDF]

				V. M. Shpacovitch, G. Varga, A. Strey, M. Gunzer, F. Mooren, J. Buddenkotte, N. Vergnolle, C. P. Sommerhoff, S. Grabbe, V. Gerke, et al. Agonists of proteinase-activated receptor-2 modulate human neutrophil cytokine secretion, expression of cell adhesion molecules, and migration within 3-D collagen lattices J. Leukoc. Biol., August 1, 2004; 76(2): 388 - 398. [Abstract] [Full Text] [PDF]

				H. S. Rosario, S. W. Waldo, S. A. Becker, and G. W. Schmid-Schonbein Pancreatic Trypsin Increases Matrix Metalloproteinase-9 Accumulation and Activation during Acute Intestinal Ischemia-Reperfusion in the Rat Am. J. Pathol., May 1, 2004; 164(5): 1707 - 1716. [Abstract] [Full Text] [PDF]

				V. S. OSSOVSKAYA and N. W. BUNNETT Protease-Activated Receptors: Contribution to Physiology and Disease Physiol Rev, April 1, 2004; 84(2): 579 - 621. [Abstract] [Full Text] [PDF]

				S. He, A. Aslam, M. D. A. Gaca, Y. He, M. G. Buckley, M. D. Hollenberg, and A. F. Walls Inhibitors of Tryptase as Mast Cell-Stabilizing Agents in the Human Airways: Effects of Tryptase and Other Agonists of Proteinase-Activated Receptor 2 on Histamine Release J. Pharmacol. Exp. Ther., April 1, 2004; 309(1): 119 - 126. [Abstract] [Full Text]

				S. SEELIGER, C. K. DERIAN, N. VERGNOLLE, N. W. BUNNETT, R. NAWROTH, M. SCHMELZ, P.-Y. VON DER WEID, J. BUDDENKOTTE, C. SUNDERKOTTER, D. METZE, et al. Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo FASEB J, October 1, 2003; 17(13): 1871 - 1885. [Abstract] [Full Text] [PDF]

				D. H. Sturn, N. C. Kaneider, C. Feistritzer, A. Djanani, K. Fukudome, and C. J. Wiedermann Expression and function of the endothelial protein C receptor in human neutrophils Blood, August 15, 2003; 102(4): 1499 - 1505. [Abstract] [Full Text] [PDF]

				S. J. Bolton, C. A. McNulty, R. J. Thomas, C. R. A. Hewitt, and A. J. Wardlaw Expression of and functional responses to protease-activated receptors on human eosinophils J. Leukoc. Biol., July 1, 2003; 74(1): 60 - 68. [Abstract] [Full Text] [PDF]

				V. Temkin, B. Kantor, V. Weg, M.-L. Hartman, and F. Levi-Schaffer Tryptase Activates the Mitogen-Activated Protein Kinase/Activator Protein-1 Pathway in Human Peripheral Blood Eosinophils, Causing Cytokine Production and Release J. Immunol., September 1, 2002; 169(5): 2662 - 2669. [Abstract] [Full Text] [PDF]

				Y. Wang, Y. Gu, and M. J. Lucas Expression of Thrombin Receptors in Endothelial Cells and Neutrophils from Normal and Preeclamptic Pregnancies J. Clin. Endocrinol. Metab., August 1, 2002; 87(8): 3728 - 3734. [Abstract] [Full Text] [PDF]

				N. Vergnolle, C. K. Derian, M. R. D'Andrea, M. Steinhoff, and P. Andrade-Gordon Characterization of Thrombin-Induced Leukocyte Rolling and Adherence: A Potential Proinflammatory Role for Proteinase-Activated Receptor-4 J. Immunol., August 1, 2002; 169(3): 1467 - 1473. [Abstract] [Full Text] [PDF]

				J. D. Moffatt, K. L. Jeffrey, and T. M. Cocks Protease-Activated Receptor-2 Activating Peptide SLIGRL Inhibits Bacterial Lipopolysaccharide-Induced Recruitment of Polymorphonuclear Leukocytes into the Airways of Mice Am. J. Respir. Cell Mol. Biol., June 1, 2002; 26(6): 680 - 684. [Abstract] [Full Text] [PDF]

				S. Miike, A. S. McWilliam, and H. Kita Trypsin Induces Activation and Inflammatory Mediator Release from Human Eosinophils Through Protease-Activated Receptor-2 J. Immunol., December 1, 2001; 167(11): 6615 - 6622. [Abstract] [Full Text] [PDF]

				M.M. Kelly, R. Leigh, S. Carruthers, P. Horsewood, G.J. Gleich, F.E. Hargreave, and G. Cox Increased detection of interleukin-;5 in sputum by addition of protease inhibitors Eur. Respir. J., October 1, 2001; 18(4): 685 - 691. [Abstract] [Full Text] [PDF]

				G. Sun, M. A. Stacey, M. Schmidt, L. Mori, and S. Mattoli Interaction of Mite Allergens Der P3 and Der P9 with Protease-Activated Receptor-2 Expressed by Lung Epithelial Cells J. Immunol., July 15, 2001; 167(2): 1014 - 1021. [Abstract] [Full Text] [PDF]

				T. Syrovets, M. Jendrach, A. Rohwedder, A. Schule, and T. Simmet Plasmin-induced expression of cytokines and tissue factor in human monocytes involves AP-1 and IKK{beta}-mediated NF-{kappa}B activation Blood, June 15, 2001; 97(12): 3941 - 3950. [Abstract] [Full Text] [PDF]

				S. R. Macfarlane, M. J. Seatter, T. Kanke, G. D. Hunter, and R. Plevin Proteinase-Activated Receptors Pharmacol. Rev., June 1, 2001; 53(2): 245 - 282. [Abstract] [Full Text] [PDF]

				H. Danahay, L. Withey, C. T. Poll, S. F. J. van de Graaf, and R. J. Bridges Protease-activated receptor-2-mediated inhibition of ion transport in human bronchial epithelial cells Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1455 - C1464. [Abstract] [Full Text] [PDF]

				C Chinni, M. de Niese, A. Jenkins, R. Pike, S. Bottomley, and E. Mackie Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts J. Cell Sci., January 12, 2000; 113(24): 4427 - 4433. [Abstract] [PDF]