Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein

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Andre, E. and Becker-Andre, M (1993). Expression of an N-terminally truncated form of human focal adhesion kinase in brain. Biochem. Biophysic. Res. Comm 190, 140-147.[Medline]

Astier, A., Avraham, H., Manie, S. N., Groopman, J., Canty, T., Avraham, S. and Freedman, A. S (1997). The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after1-integrin stimulation in B cells and binds to p130cas. J. Biol. Chem 272, 228-232.[Abstract/Free Full Text]

Avraham, S., London, R., Fu, Y., Ota, S., Hiregowdara, D., Li, J., Jiang, S., Pasztor, L. M., White, R. A., Groopman, J. E. and Avraham, H (1995). Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J. Biol. Chem 270, 27742-27751.[Abstract/Free Full Text]

Bellis, S. L., Miller, J. T. and Turner, C. E (1995). Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J. Biol. Chem 270, 17437-17441.[Abstract/Free Full Text]

Berg, N. N. and Ostergaard, H. L (1997). T cell receptor engagement induces tyrosine phosphorylation of FAK and PYK2 and their association with Lck. J. Immunol 159, 1753-1757.[Abstract]

Burgaya, F., Toutant, M., Studler, J. M., Costa, A., Bert, M. L., Gelman, M. and Girault, J. A (1997). Alternatively spliced focal adhesion kinase in rat brain with increased autophosphorylation activity. J. Biol. Chem 272, 28720-28725.[Abstract/Free Full Text]

Burridge, K. and Chrzanowska-Wodnicka, M (1996). Focal adhesions, contractility and signaling. Annu. Rev. Cell Dev. Biol 12, 463-519.[Medline]

Chen, H.-C. and Guan, J. L (1994). Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc. Nat. Acad. Sci. USA 91, 10148-10152.[Abstract/Free Full Text]

Chen, H.-C., Appedda, P. A., Parsons, J. T., Hidebrand, J. O., Schaller, M. D. and Guan, J. L (1995). Interaction of focal adhesion kinase with cytoskeletal protein talin. J. Biol. Chem 270, 16995-16999.[Abstract/Free Full Text]

Cobb, B. S., Schaller, M. D., Leu, T. H. and Parsons, J. T (1994). Stable association of pp60srcand pp59fynwith the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol. Cell Biol 14, 147-155.[Abstract/Free Full Text]

Collinge, M., Matrisian, P. E., Zimmer, W. E., Shattuck, R. L., Lukas, T. J., Van Eldik, L. J. and Watterson, D. M (1992). Structure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase gene. Mol. Cell. Biol 12, 2359-2371.[Abstract/Free Full Text]

Derkinderen, P., Toutant, M., Burgaya, F., Bert, M. L., Siciliano, J. C., Franciscis, V. d., Gelman, M. and Girault, J.-A (1996). Regulation of neuronal form of focal adhesion kinase by anandamide. Science 273, 1719-1722.[Abstract/Free Full Text]

Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S. A. and Schlessinger, J (1996). A role for Pyk2 and Src in Linking G-protein-coupled receptors with MAP kinase activation. Nature 383, 547-550.[Medline]

Evan, G. I., Lewis, G. K., Ramsay, G. and Bishop, J. M (1985). Isolation of mono-clonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell Biol 5, 3610-3616.[Abstract/Free Full Text]

Frisch, S. M., Vuori, K., Ruoslahti, E. and Chan-Hui, P. Y (1996). Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol 134, 793-799.[Abstract/Free Full Text]

Grant, S. G., Karl, K. A., Kiebler, M. A. and Kandel, E. R (1995). Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice. Genes Dev 9, 1909-1921.[Abstract/Free Full Text]

Guan, J. L. and Shalloway, D (1992). Regulation of pp125FAKboth bycellular adhesion and by oncogenic transformation. Nature 358, 690-692.[Medline]

Guinebault, C., Payratre, B., Racaud-Sultan, C., Mazarguil, H., Breton, M., Mauco, G., Plantavid, M. and Chap, H (1995). Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrmbin-activated platelets involves specific interactions of p85a with actin filaments and focal adhesion kinase. J. Cell Biol 129, 831-842.[Abstract/Free Full Text]

Harte, M. T., Hildebrand, J. D., Burnham, M. R., Bouton, A. H. and Parsons, J. T (1996). p130cas, a substrate associated with v-Src and c-Crk, localizes to focal adhesions and binds to focal adhesion kinase. J. Biol. Chem 271, 13649-13655.[Abstract/Free Full Text]

Hildebrand, J. D., Schaller, M. D. and Parsons, J. T (1993). Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAKto cellular focal adhesions. J. Cell Biol 123, 993-1005.[Abstract/Free Full Text]

Hildebrand, J. D., Schaller, M. D. and Parsons, J. T (1995). Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Mol. Biol. Cell 6, 637-647.[Abstract]

Hildebrand, J. D., Taylor, J. M. and Parsons, J. T (1996). An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Mol. Cell. Biol 16, 3169-3178.[Abstract]

Hiregowdara, D., Avraham, H., Fu, Y., London, R. and Avraham, S (1997). Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin. J. Biol. Chem 272, 10804-10810.[Abstract/Free Full Text]

Ho, S. N., Hunt, H. D., Horton, R. M., Pullen, J. K. and Pease, L. R (1989). Site-directed mutagenesis by overlap extension using polymerase chain reaction. Gene 7, 51-59.

Hungerford, J. E., Campton, M. T., Matter, M. L., Hoffstrom, B. G. and Otey, C. A (1996). Inhibition of pp125FAKin cultured fibroblasts results in apoptosis. J. Cell Biol 135, 1383-1390.[Abstract/Free Full Text]

Li, X. and Earp, H. S (1997). Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells. J. Biol. Chem 272, 14341-14348.[Abstract/Free Full Text]

Manie, S. N., Beck, A. R. P., Astier, A., Law, S., Canty, T., Hirai, H., Druker, B. J., Avraham, H., Haghayeghi, N., Sattler, M., et al (1997). Involvement of p130casand p105HEF1, a novel cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. J. Biol. Chem 272, 4-.

Means, A. R., Cruzalegui, F., Lemagueresse, B., Needleman, D. S., Slaughter, G. R. and Ono, T (1991). A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene. Mol. Cell. Biol 11, 3960-3971.[Abstract/Free Full Text]

Moolenaar, W. H (1991). Mitogenic action of lysophosphatidic acid. Advan. Can. Res 57, 87-102.[Medline]

Ohmstede, C. A., Bland, M. M., Merrill, B. M. and Sahyoun, N (1991). Relationship of genes encoding Ca2+/calmodulin-dependent protein kinase Gr and calspermin: A gene within a gene. Proc. Nat. Acad. Sci. USA 88, 5784-5788.[Abstract/Free Full Text]

Parsons, J. T (1996). Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins. Curr. Opin. Cell Biol 8, 146-152.[Medline]

Qian, D., Lev, S., van Oers, N. S. C., Dikic, I., Schlessinger, J. and Weiss, A (1997). Tyrosine phosphorylation of PYK2 is selectively regulated by Fyn during TCR signaling. J. Exp. Med 185, 1253-1259.[Abstract/Free Full Text]

Rankin, S. and Rozengurt, E (1994). Platelet-derived growth factor modulation of focal adhesion kinase and paxillin tyrosine phosphorylation in Swiss 3T3 cells: Bell-shaped dose response and cross-talk with bombesin. J. Biol. Chem 269, 704-710.[Abstract/Free Full Text]

Richardson, A., Malik, R. K., Hildebrand, J. D. and Parsons, J. T (1997). Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation. Mol. Cell. Biol 17, 6906-6914.[Abstract]

Richardson, A. and Parsons, J. T (1996). A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK. Nature 380, 538-540.[Medline]

Roussou, I., Thireos, G. and Hauge, B. M (1988). Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase. Mol. Cell. Biol 8, 2132-2139.[Abstract/Free Full Text]

Rozengurt, E (1991). Neuropeptides as cellular growth factors: role of multiple signaling pathways. Eur. J. Clin. Invest 21, 123-134.[Medline]

Salgia, R., Avraham, S., Pisick, E., Li, J.-L., Raja, S., Greenfield, E. A., Sattler, M., Avraham, H. and Griffin, J. D (1996). The related adhesion focal tyrosine kinase forms a complex with paxillin in hematopoietic cells. J. Biol. Chem 271, 31222-31226.[Abstract/Free Full Text]

Sasaki, H., Nagura, K., Ishino, M., Tobioka, H., Kotani, K. and Sasaki, T (1995). Cloning and characterization of cell adhesion kinase, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily. J. Biol. Chem 270, 21206-21219.[Abstract/Free Full Text]

Schaller, M. D., Borgman, C. A., Cobb, B. S., Vines, R. R., Reynolds, A. B. and Parsons, J. T (1992). pp125FAK, a structurally distinctive protein-tyrosine kinase associated with focal adhesions. Proc. Nat. Acad. Sci. USA 89, 5192-5196.[Abstract/Free Full Text]

Schaller, M. D., Borgman, C. A. and Parsons, J. T (1993). Autonomousexpression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. Mol. Cell. Biol 13, 785-791.[Abstract/Free Full Text]

Schaller, M. D., Hildebrand, J. D., Shannon, J. D., Fox, J. W., Vines, R. R. and Parsons, J. T (1994). Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src. Mol. Cell Biol 14, 1680-1688.[Abstract/Free Full Text]

Schaller, M. D. and Sasaki, T (1997). Differential signaling by the focal adhesion kinase and cell adhesion kinase. J. Biol. Chem 272, 25319-25325.[Abstract/Free Full Text]

Schlaepfer, D. D., Hanks, S. K., Hunter, T. and van der Geer, P (1994). Integrin-mediated signal transduction linked to Ras pathway by Grb2 binding to focal adhesion kinase. Nature 372, 786-791.[Medline]

Tachibana, K., Sato, T., D'Avirro, N. and Morimoto, C. J (1995). Direct association of pp125FAKwith paxillin, the focal adhesion targeting mechanism of pp125FAK. J. Exp. Med 182, 1089-1099.[Abstract/Free Full Text]

Talley, E. M., Negar, N. S. and Bayliss, D. A (1997). Postnatal development of serotonergic innervation, 5-HT1A receptor expression and 5-HT responses in rat motoneurons. J. Neurosci 17, 4473-4485.[Abstract/Free Full Text]

Tzamarias, D., Alexandraki, D. and Thireos, G (1986). Multiple cis-actingelements modulate the translational efficiency of GCN4 mRNA in yeast. Proc. Nat. Acad. Sci. USA 83, 4849-4853.[Abstract/Free Full Text]

Xiong, W. C. and Montell, C (1993). Tramtrack is a transcriptional repressor required for cell fate determination in the drosophila eye. Genes Dev 7, 1085-1096.[Abstract/Free Full Text]

Xiong, W. C. and Parsons, J. T (1997). Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase. J. Cell Biol 139, 529-539.[Abstract/Free Full Text]

Xu, L. H., Iwens, L. V., Sturge, G. C., Yang, X., Liu, E. T., Craven, R. J. and Cance, W. G (1996). Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Diff 7, 413-418.[Abstract]

Yu, H., Li, X., Marchetto, G. S., Dy, R., Hunter, D., Calvo, B., Dawson, T. L., Wilm, M., Anderegg, R. J., Graves, L. M. and Earp, H. S (1996). Activation of a novel calcium-dependent protein-tyrosine kinase. J. Biol. Chem 271, 29993-29998.[Abstract/Free Full Text]

Zachary, I., Sinnett-Smith, J. and Rozengurt, E (1992). Bombesin, vasapressin and endothelin rapidly stimulation of tyrosine phosphorylation in Swiss 3T3 cells. J. Biol. Chem 267, 19031-19034.[Abstract/Free Full Text]

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