The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Faix, J.
	Articles by Kuhlmann, J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Faix, J.
	Articles by Kuhlmann, J.


Social Bookmarking

	What's this?

Adachi, H., Takahashi, Y., Hasebe, T., Shirouzu, M., Yokoyama, S. and Sutoh, K (1997). Dictyostelium IQGAP-related protein specifically involved in the completion of cytokinesis. J. Cell Biol 137, 891-898.[Abstract/Free Full Text]

Ahmadian, M. R., Wiesmuller, L., Lautwein, A., Bischoff, F. R. and Wittinghofer, A (1996). Structural differences in the minimal catalytic domains of the GTPase-activating proteins p120GAPand neurofibromin. J. Biol. Chem 271, 16409-16415.[Abstract/Free Full Text]

Ahmadian, M. R., Mittal, R., Hall, A. and Wittinghofer, A (1997). Aluminum fluoride associates with the small guanine nucleotide binding proteins. FEBS Lett 408, 315-318.[Medline]

Ahmadian, M. R., Stege, P., Scheffzek, K. and Wittinghofer, A (1997). Confirmation of the argininie-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras. Nature Struct. Biol 4, 686-689.[Medline]

Amano, M., Mukai, H., Ono, Y., Chihara, K., Matsui, T., Hamajima, Y., Okawa, K., Iwamatsu, A. and Kaibuchi, K (1996). Identification of a putative target for Rho as serine-threonine kinase protein kinase N. Science 271, 648-650.[Abstract]

Bashour, A.-M., Fullerton, A. T., Hart, M. J. and Bloom, G. S (1997). IQGAP1, a Rac and Cdc42-binding protein, directly binds and cross-links microfilaments. J. Cell Biol 137, 1555-1566.[Abstract/Free Full Text]

Boguski, M. S. and McCormick, F (1993). Proteins regulating ras and its relatives. Nature 366, 643-654.[Medline]

Braga, V. M. M., Machesky, L. M., Hall, A. and Hotchin, N. A (1997). Thesmall GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol 137, 1421-1431.[Abstract/Free Full Text]

Brill, S., Li, S., Lyman, C. W., Church, D. M., Wasmuth, J. J., Weissbach, L., Bernards, A. and Snijders, A. J (1996). The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol. Cell. Biol 16, 4869-4878.[Abstract]

Burbelo, P. D., Drechsel, D. and Hall, A (1995). A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem 270, 29071-29074.[Abstract/Free Full Text]

Bush, J., Franek, K. and Cardelli, J (1993). Cloning and characterization of seven novel Dictyostelium discoideumrac -related genes belonging to the rho family of GTPases. Gene 136, 61-68.[Medline]

Chant, J. and Stowers, L (1995). GTPase cascades \320 Choreographic cellular behavior: movement, morphogenesis, and more. Cell 81, 1-4.[Medline]

Claviez, M., Pagh, K., Maruta, H., Baltes, W., Fisher, P. and Gerisch, G (1982). Electron microscopic mapping of monoclonal antibodies on the tail region of Dictyostelium myosin. EMBO J 1, 1017-1022.[Medline]

Cooper, J. A (1991). The role of actin polymerization in cell motility. Annu. Rev. Physiol 53, 585-606.[Medline]

Cunningham, C. C., Stossel, T. P. and Kwiatkowski, D. J (1991). Enhanced motility in NHI 3T3 fibroblasts that overexpress gelsolin. Science 251, 1233-1236.[Abstract/Free Full Text]

Diekmann, D., Abo, A., Johnston, C., Segall, W. A. and Hall, A (1994). Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity. Science 265, 531-533.[Abstract/Free Full Text]

Djinovic Carugo, K., Ba\226uelos, S. and Saraste, M (1997). Crystal structure of a calponin homology domain. Nature 4, 175-179.

Faix, J., Steinmetz, M., Boves, H., Kammerer, R. A., Lottspeich, F., Mintert, U., Murphy, J., Stock, A., Aebi, U. and Gerisch, G (1996). Cortexillins, major determinants of cell shape and size, are actin-bundling proteins with a parallel coiled-coil tail. Cell 86, 631-642.[Medline]

Fisher, P. R., Merkl, R. and Gerisch, G (1989). Quantitative analysis of cell motility and chemotaxis in Dictyostelium discoideum by using an image processing system and a novel chemotaxis chamber providing stationary chemical gradients. J. Cell Biol 104, 973-984.

Gerisch, G., Albrecht, R., Heizer, C., Hodgkinson, S. and Maniak, M (1995). Chemoattractant-controlled accumulation of coronin at the leading edge of Dictyostelium cells monotored using a green fluorescent protein-coronin fusion. Curr. Cell Biol 5, 1280-1285.

Hart, M. J., Callow, M. G., Souza, B. and Polakis, P (1996). IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for Cdc42Hs. EMBO J 15, 2997-3005.[Medline]

Hartwig, J. H. and Kwiatkowski, D. J (1991). Actin-binding proteins. Curr. Opin. Cell Biol 3, 87-97.[Medline]

Hartwig, J. H., Bokoch, G. M., Carpenter, C. L., Janmey, P. A., Taylor, L. A., Toker, A. and Stossel, T. P (1995). Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell 82, 643-653.[Medline]

Hug, C., Jay, P., Reddy, I., McNally, J., Bridgman, P., Eison, E. and Cooper, J (1995). Capping protein level influence actin assembly and cell motility in Dictyostelium. Cell 81, 591-600.[Medline]

Humbel, B. M. and Biegelman, E (1992). A preparation protocol for postembedding immunoelectron microscopy of Dictyostelium discoideum with monoclonal antibodies. Scanning Microsc 6, 817-825.

Imai, Y., Miyake, S., Hughes, D. A. and Yamamoto, M (1991). Identification of a GTPase-activating protein homolog in Schizosaccharomyces pombe. Mol. Cell. Biol 11, 3088-3094.[Abstract/Free Full Text]

John, J., Sohmen, R., Feuerstein, J., Linke, R., Wittinghofer, A. and Goody, R. S (1990). Kinetics of interaction of nucleotides with nucleotide-free H-ras p21. Biochemistry 29, 6058-6065.[Medline]

Khosla, M., Spiegelman, G. B. and Weeks, G (1996). Overexpression of anactivated rasG gene during growth blocks the initiation of Dictyostelium development. Mol. Cell. Biol 16, 4156-4162.[Abstract]

Kimura,K., Ito, M., Amano, M., Chihara, K., Fukata, M., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A. and Kaibuchi, K (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248.[Abstract]

Kozma, R., Ahmed, S., Best, A. and Lim, L (1995). The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts. Mol. Cell Biol 15, 1942-1952.[Abstract]

Kuroda, S., Fukata, M., Kobayashi, K., Nakafuku, M., Nomura, N., Iwamatsu, A. and Kaibuchi, K (1996). Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J. Biol. Chem 271, 23363-23367.[Abstract/Free Full Text]

Lancaster, C. A., Taylor-Harris, P. M., Self, A. J., Brill, S., van Erp, H. E. and Hall, A (1994). Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases. J. Biol. Chem 269, 1137-42.[Abstract/Free Full Text]

Larochelle, D. A., Vithalani, K. K. and De Lozanne, A (1996). A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis. J. Cell Biol 133, 1321-1329.[Abstract/Free Full Text]

Larochelle, D. A., Vithalani, K. K. and De Lozanne, A (1997). Role of Dictyostelium racE in cytokinesis: Mutational analysis and localization studies by use of green fluorescent protein. Mol. Biol. Cell 8, 935-944.[Abstract]

Lee, S., Escalante, R. and Firtel, R. A (1997). A RasGAP is essential for cytokinesis and spatial patterning in Dictyostelium. Development 124, 983-996.[Abstract]

Lenzen, C., Cool, R. H., Prinz, H., Kuhlmann, J. and Wittinghofer, A (1998). Kinetic analysis by fluorescence of the interaction between Ras and the catalytic domain of the guanine nucleotide exchange factor Cdc25(Mm). Biochemistry 37, 7420-7430.[Medline]

Luna, E. J. and Condeelis, J. S (1990). Actin-associated proteins in Dictyostelium discoideum. Dev. Gen 11, 328-332.[Medline]

Maniak, M., Rauchenberger, R., Albrecht, R., Murphy, J. and Gerisch, G (1995). Coronin involved in phagocytosis: Dynamics of particle-induced relocalization visualized by a green fluorescent protein tag. Cell 83, 915-924.[Medline]

Manser, E., Leung, T., Salihuddin, H., Tan, L. and Lim, L (1993). A non-receptor tyrosine kinase that inhibits the GTPase activity of p21Cdc42. Nature 363, 364-367.[Medline]

Manser, E., Chong, C., Zhao, Z.S., Leung, T., Michael, G., Hall, C. and Lim, L (1995). Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J. Biol. Chem 270, 25070-25078.[Abstract/Free Full Text]

Martin, G. A., Bollag, G., McCormick, F. and Abo, A (1995). A novel serine kinase activated by rac1/Cdc42Hs-dependent autophosphorylation is related to Pak65 and STE20. EMBO J 14, 1970-1978.[Medline]

Matsui, T., Amano, M., Yamamoto, T., Chihara, K., Nakafuku, M., Ito, M., Nakano, T., Okawa, K., Iwamatsu, A. and Kaibuchi, K (1996). Rho-associated kinase, a novel serine/threonine kinase, as putative target for small GTP-binding protein Rho. EMBO J 15, 2208-2216.[Medline]

McCallum, S. J., Wu, W. J. and Cerione, R. A (1996). Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2. J. Biol. Chem 271, 21732-21737.[Abstract/Free Full Text]

Nellen, W., Silan, C. and Firtel, R. A (1984). DNA-mediated transformation of Dictyostelium discoideum : Regulated expression of an actin gene fusion. Mol. Cell. Biol 4, 2890-2898.[Abstract/Free Full Text]

Nobes, C. D. and Hall, A (1995). Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.[Medline]

Pollard, T. D. and Cooper, J. A (1986). Actin and actin-binding proteins. A critical evaluation of mechanisms and functions. Annu. Rev. Biochem 55, 987-1035.[Medline]

Ridley, A. and Hall, A (1992). The small GTP-binding protein rho regulates assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.[Medline]

Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D. and Hall, A (1992). The small GTP-binding protein ras regulates growth factor-induced membrane ruffling. Cell 70, 401-410.[Medline]

Robbins, S. M., Williams, J. G., Spiegelman, G. B. and Weeks, G (1992). Cloning and characterization of the Dictyostelium discoideumrasG genomic sequence. Biochim. Biophys. Act 1130, 85-89.[Medline]

Schafer, D. A., Jennings, P. B. and Cooper, J. A (1996). Dynamics of capping protein and actin assembly in vitro: Uncapping of barbed ends by phosphoinositides. J. Cell Biol 135, 169-179.[Abstract/Free Full Text]

Scheffzek, K., Lautwein, A., Kabsch, W., Ahmadian, M. R. and Wittinghofer, A (1996). Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. Nature 384, 591-596.[Medline]

Scheffzek, K., Ahmadian, M. R., Lautwein, A., Scherer, A., Franken, S. and Wittinghofer, A (1997). Crystallization and preliminary x-ray crystallographic study of the ras-GTPase-activating domain of human p120gap. Proteins 27, 315-318.[Medline]

Scheffzek, K., Ahmadian, M. R., Kabsch, W., Wiesmuller, L., Lautwein, A., Schmitz, F. and Wittinghofer, A (1997). The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 277, 333-338.[Abstract/Free Full Text]

Schleicher, M., Noegel, A., Schwarz, T., Wallraff, E., Brink, M., Faix, J., Gerisch, G. and Isenberg, G (1988). A Dictyostelium mutant with severe defects in-actinin: its characterisation using cDNA probes and monoclonal antibodies. J. Cell. Sci 90, 59-71.[Abstract/Free Full Text]

Stossel, T. P (1993). On the crawling of animal cells. Science 260, 1086-.[Abstract/Free Full Text]

Symons, M., Derry, J. M. J., Karlak, B., Jiang, S., Lemahieu, V., McCormick, F., Franke, U. and Abo, A (1996). Wiskott-Aldrich Syndrome protein, a novel effector for the GTPase Cdc42Hs, is implicated in actin polymerization. Cell 84, 723-734.[Medline]

Tucker, J., Sczakiel, G., Feuerstein, J., John, J., Goody, R. S. and Wittinghofer, A (1986). Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site. EMBO J 5, 1351-1358.[Medline]

Van Aelst, L., Joneson, T. and Bar-Sagi, D (1996). Identification of a novel Rac1-interacting protein involved in membrane ruffling. EMBO J 15, 3778-3786.[Medline]

Van Aelst, L. and D'Souza, C (1997). Rho GTPases and signaling networks. Gen. Dev 11, 2295-2322.[Free Full Text]

Wang, Y., Boguski, M., Riggs, M., Rodgers, L. and Wigler, M (1991). Sar1 , a gene from Schizosaccharomyces pombe encoding a protein that regulates ras. Cell Regulation 2, 453-465.[Medline]

Watts, D. J. and Ashworth, J. M (1970). Metabolism of the cellular slime mould Dictyostelium discoideum. Biochem. J 119, 175-182.[Medline]

Weissbach, L., Settleman, J., Kalady, M. F., Snijders, A. J., Murthy, A. E., Yan, Y.-X. and Bernards, A (1994). Identification of a human RasGAP-related protein containing calmodulin-binding motifs. J. Biol. Chem 269, 20517-20521.[Abstract/Free Full Text]

Zigmond, S. H., Joyce, M., Borleis, J., Bokoch, G. M. and Devreotes, P. N (1997). Regulation of actin polimerization in a cell-free system by GTPS and Cdc42. J. Cell Biol 138, 363-374.[Abstract/Free Full Text]

Zheng, Y., Bagrodia, S. and Cerione, R. A (1994). Activation of phoshoinositide 3-kinase activity by Cdc42Hs binding to p85. J. Biol. Chem 269, 18727-18730.[Abstract/Free Full Text]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

R. J. W. Heath and R. H. Insall
Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles
J. Cell Sci., April 1, 2008; 121(7): 1054 - 1064.
[Abstract] [Full Text] [PDF]

M. Rehberg, J. Kleylein-Sohn, J. Faix, T.-H. Ho, I. Schulz, and R. Graf
Dictyostelium LIS1 Is a Centrosomal Protein Required for Microtubule/Cell Cortex Interactions, Nucleus/Centrosome Linkage, and Actin Dynamics
Mol. Biol. Cell, June 1, 2005; 16(6): 2759 - 2771.
[Abstract] [Full Text] [PDF]

D. N. Robinson, S. S. Ocon, R. S. Rock, and J. A. Spudich
Dynacortin Is a Novel Actin Bundling Protein That Localizes to Dynamic Actin Structures
J. Biol. Chem., March 8, 2002; 277(11): 9088 - 9095.
[Abstract] [Full Text] [PDF]

D. Davy, H. Campbell, S Fountain, D de Jong, and M. Crouch
The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases
J. Cell Sci., January 2, 2001; 114(3): 549 - 562.
[Abstract] [PDF]

M Dumontier, P Hocht, U Mintert, and J Faix
Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium
J. Cell Sci., January 6, 2000; 113(12): 2253 - 2265.
[Abstract] [PDF]

A. Noegel and M Schleicher
The actin cytoskeleton of Dictyostelium: a story told by mutants
J. Cell Sci., January 3, 2000; 113(5): 759 - 766.
[Abstract] [PDF]

J. Chubb, A Wilkins, G. Thomas, and R. Insall
The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement
J. Cell Sci., January 2, 2000; 113(4): 709 - 719.
[Abstract] [PDF]

C. Y. Chung and R. A. Firtel
Paka, a Putative Pak Family Member, Is Required for Cytokinesis and the Regulation of the Cytoskeleton in Dictyostelium discoideum Cells during Chemotaxis
J. Cell Biol., November 1, 1999; 147(3): 559 - 576.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Faix, J.

Articles by Kuhlmann, J.

Search for Related Content

PubMed

PubMed Citation

Articles by Faix, J.

Articles by Kuhlmann, J.

Social Bookmarking

What's this?

				M. Rehberg, J. Kleylein-Sohn, J. Faix, T.-H. Ho, I. Schulz, and R. Graf Dictyostelium LIS1 Is a Centrosomal Protein Required for Microtubule/Cell Cortex Interactions, Nucleus/Centrosome Linkage, and Actin Dynamics Mol. Biol. Cell, June 1, 2005; 16(6): 2759 - 2771. [Abstract] [Full Text] [PDF]

				D. N. Robinson, S. S. Ocon, R. S. Rock, and J. A. Spudich Dynacortin Is a Novel Actin Bundling Protein That Localizes to Dynamic Actin Structures J. Biol. Chem., March 8, 2002; 277(11): 9088 - 9095. [Abstract] [Full Text] [PDF]

				D. Davy, H. Campbell, S Fountain, D de Jong, and M. Crouch The flightless I protein colocalizes with actin- and microtubule-based structures in motile Swiss 3T3 fibroblasts: evidence for the involvement of PI 3-kinase and Ras-related small GTPases J. Cell Sci., January 2, 2001; 114(3): 549 - 562. [Abstract] [PDF]

				M Dumontier, P Hocht, U Mintert, and J Faix Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium J. Cell Sci., January 6, 2000; 113(12): 2253 - 2265. [Abstract] [PDF]

				A. Noegel and M Schleicher The actin cytoskeleton of Dictyostelium: a story told by mutants J. Cell Sci., January 3, 2000; 113(5): 759 - 766. [Abstract] [PDF]

				J. Chubb, A Wilkins, G. Thomas, and R. Insall The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement J. Cell Sci., January 2, 2000; 113(4): 709 - 719. [Abstract] [PDF]

				C. Y. Chung and R. A. Firtel Paka, a Putative Pak Family Member, Is Required for Cytokinesis and the Regulation of the Cytoskeleton in Dictyostelium discoideum Cells during Chemotaxis J. Cell Biol., November 1, 1999; 147(3): 559 - 576. [Abstract] [Full Text] [PDF]