Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Villa, P. G.
	Articles by Pettmann, B.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Villa, P. G.
	Articles by Pettmann, B.

Allsopp, T. E., Wyatt, S., Paterson, H. F. and Davies, A. M (1993). The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73, 295-307.[Medline]

Alnemri, E. S., Livingston, D. J., Nicholson, D. W., Salvesen, G., Thornberry, N. A., Wong W. W. andYuan, J (1996). Human ICE/CED-3 protease nomenclature. Cell 87, 171-.[Medline]

Bloch-Gallego, E., Huchet, M., El M'HamdiS, H., Xie, F. K., Tanaka, H. and Henderson, C. E (1991). Survival in vitro of motoneurons identified or purified by novel antibody-based methods is selectively enhanced by muscle-derived factors. Development 111, 221-232.[Abstract]

Brancolini, C., Benedetti, M. and Schneider, C (1995). Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases. EMBO J 14, 5179-5190.[Medline]

Brown, S. B., Bailey K. and Savill, J (1997). Actin is cleaved during constitutive apoptosis. Biochem. J 323, 233-237.

Casciola-Rosen, L. A., Anhalt, G. J. and Rosen, A (1995). DNA-dependant protein kinase is one of the subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med 182, 1625-1634.[Abstract/Free Full Text]

Cowan, W. M., Fawcett, J. W., O'Leary, D. D. and Stanfield B. B (1984). Regressive events in neurogenesis. Science 225, 1258-1265.[Abstract/Free Full Text]

Deshmukh, M., Vasilakos, J., Deckwerth, T. L., Lampe, P. A., Shivers, B. D. and Johnson, E. M. Jr (1996). Genetic and metabolic status of NGF-deprived sympathetic neurons saved by an inhibitor of ICE family proteases. J. Cell Biol 135, 1341-1354.[Abstract/Free Full Text]

Drexler, H. C (1997). Activation of the cell death program by inhibition of proteasome function. Proc. Nat. Acad. Sci. USA 94, 855-860.[Abstract/Free Full Text]

Ellis, H. M. and Horvitz, H. R (1986). Genetic control of programmed cell death in the nematode C. elegans. Cell 44, 817-829.[Medline]

Ellis, R. E., Yuan, J. Y. and Horvitz, H. R (1991). Mechanisms and functions of cell death. Annu. Rev. Cell Biol 7, 663-698.

Garrels, J. I (1979). Two dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines. J. Biol. Chem 254, 7961-7977.[Abstract/Free Full Text]

Gu, Y., Sarnecki, C., Aldape, R. A., Livingston, D. J. and Su, M. S (1995). Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2. J. Biol. Chem 270, 18715-18718.[Abstract/Free Full Text]

Henderson, C. E (1996). Programmed cell death in the developing nervous system. Neuron 17, 579-585.[Medline]

Hengartner, M. O., Ellis, R. E. and Horvitz, H. R (1992). Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature 356, 494-499.[Medline]

Humblet, C., Deman, J., Franzen, R., Greimers, R., Boniver, J. and Defresne, M. P (1995). Spontaneous and induced apoptosis after whole body radiation exposure: experimental approaches. Observations in radio-induced thymic lymphomagenesis. Stem Cells 1, 129-135.

Kabsch, W., Mannherz, H. G., Suck, D., Pai, E. F. and Holmes, K. C (1990). Atomic structure of the actin:DNase I complex [see comments]. Nature 347, 37-44.[Medline]

Kayalar, C., Ord, T., Testa, M. P., Zhong, L. T. and Bredesen, D. E (1996). Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition. Proc. Nat. Acad. Sci. USA 93, 2234-2238.[Abstract/Free Full Text]

Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. and Flavell, R. A (1995). Altered cytokine export and apoptosis in mice deficient in interleukin-1-beta converting-enzyme. Science 267, 2000-2003.[Abstract/Free Full Text]

Kuida, K., Zheng, T. S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P. and Flavell, R. A (1996). Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368-372.[Medline]

Lazarides, E. and Lindberg, U (1974). Actin is the naturally occurring inhibitor of deoxyribonuclease I. Proc. Nat. Acad. Sci. USA 71, 4742-4746.[Abstract/Free Full Text]

Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G. and Earnshaw, W. C (1994). Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 371, 346-347.[Medline]

Lazebnik, Y. A., Takahashi, A., Moir, R. D., Goldman, R. D., Poirier, G. G., Kaufmann, S. H. and Earnshaw, W. C (1995). Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc. Nat. Acad. Sci. USA 92, 9042-906.[Abstract/Free Full Text]

Levi-Montalcini, R (1964). Events in the developing nervous system. Prog. Brain Res 4, 1-29.

Li, P., Allen, H., Banerjee, S., Franklin, S., Herzog, L., Johnston, C., Mcdowell, J., Paskind, M., Rodman, L., Salfeld, J. Towne, E., Tracey, D. Wardwell, S., Wei, F. Y., Wong, W., Kamen, R. and Seshadri, T (1995). Mice deficient in IL-1-beta-converting enzyme are defective in production of mature IL-1-beta and resistant to endotoxic-shock. Cell 80, 401-411.[Medline]

Loret, C., Sensenbrenner, M. and Labourdette, G (1988). Maturation-related gene expression of rat astroblasts in vitro studied by two-dimensional polyacrylamide gel electrophoresis. Cell Differ Dev 25, 37-45.[Medline]

MacCarthy, N. J., Whyte, M. K. B., Gilbert C. S. and Evan, G (1997). Inhibition of Ced-3/ICE proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J. Cell Biol 136, 215-227.[Abstract/Free Full Text]

Manthorpe, M., Fagnani, R., Skaper, S. D. and Varon, S (1986). An automated colorimetric microassay for neuronotrophic factors. Brain Res 390, 191-198.[Medline]

Martin, S. J. and Green, D. R (1995). Protease activation during apoptosis: death by a thousand cuts?. Cell 82, 349-352.[Medline]

Martin, S. J., O'Brien, G. A., Nishioka, W. K., McGahon, A. J., Mahboubi, A., Saido T. C. and Green, D. R (1995). Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J. Biol. Chem 270, 6425-6428.[Abstract/Free Full Text]

Marwitt, R., Pilar, G. and Weakly, J. N (1971). Characterization of two ganglion cell populations in avian ciliary ganglia. Brain Res 25, 317-334.[Medline]

Mashima, T., Naito, M., Fujita, N., Noguchi, K. and Tsuruo, T (1995). Identification of actin as a substrate of ICE and an ICE-like protease and involvement of an ICE-like protease but not ICE in VP-16-induced U937 apoptosis. Biochem. Biophys. Res. Commun 217, 1185-1192.[Medline]

Mashima, T., Naito, M., Noguchi, K., Miller, D. K., Nicholson, D. W. and Tsuruo, T (1997). Actin cleavage by CPP-32/apopain during the development of apoptosis. Oncogene 14, 1007-1012.[Medline]

Merril, C. R., Goldman, D., Sedman, S. A. and Ebert, M. H (1981). Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. Science 211, 1437-1438.[Abstract/Free Full Text]

Milankov, K. and De, B. U (1993). Cytochemical localization of actin and myosin aggregates in interphase nuclei in situ. Exp. Cell Res 209, 189-199.[Medline]

Milligan, C. E., Prevette, D., Yaginuma, H., Homma, S., Cardwell, C., Fritz, L. C., Tomaselli, K. J., Oppenheim, R. W. and Schwartz, L. M (1995). Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro. Neuron 15, 385-393.[Medline]

Miura, M., Zhu, H., Rotello, R., Hartwieg, E. A. and Yuan, J (1993). Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75, 653-660.[Medline]

O'Farrell, P. H (1975). High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem 250, 4007-4021.[Abstract/Free Full Text]

Oppenheim, R. W (1985). Naturally occurring cell death during neural development. Trends Neurosci 8, 487-493.

Oppenheim, R. W (1991). Cell death during development of the nervous system. Annu. Rev. Neurosci 14, 453-501.[Medline]

Peitsch, M. C., Polzar, B., Stephan, H., Crompton, T., MacDonald, H. R., Mannherz, H. G. and Tschopp, J (1993). Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J 12, 371-377.[Medline]

Polverino, A. J. and Patterson, S. D (1997). Selective activation of caspases during apoptotic induction in HL-60 cells. J. Biol. Chem 272, 7013-7021.[Abstract/Free Full Text]

Polzar, B., Nowak, E., Goody, R. S. and Mannherz, H. G (1989). The complex of actin and deoxyribonuclease I as a model system to study the interactions of nucleotides, cations and cytochalasin D with monomeric actin. Eur. J. Biochem 182, 267-275.[Medline]

Roberts-Lewis, J. M., Savage, M. J., Marcy, V. R., Pinsker, L. R. and Siman, R (1994). Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain. J. Neurosci 14, 3934-3944.[Abstract]

Sadoul, R., Fernandez, P. A., Quiquerez, A. L., Martinou, I., Malki, M., Schroter, M., Becherer, J. D., Irmler, M., Tschopp, J. and Martinou, J. C (1996). Involvement of the proteasome in the programmed cell death of NGF-deprived sympathetic neurons. EMBO J 15, 3845-3852.[Medline]

Shiokawa, D., Ohyama, H., Yamada, T. and Tanuma, Si (1997). Purification and properties of DNase gamma from apoptotic rat thymocytes. Biochem. J 326, 675-681.

Sleath, P. R., Hendrickson, R. C., Kronheim, S. R., March, C. J. and Black, R. A (1990). Substrate specificity of the protease that processes human interleukin-1 beta. J. Biol. Chem 265, 14526-14528.[Abstract/Free Full Text]

Song, Q., Lees-Miller, S. P., Kumar, S., Zhang, Z., Chan, D. W., Smith, G. C., Jackson, S. P., Alnemri, E. S., Litwack, G., Khanna, K. K. and Lavin, M. F (1996). DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J 15, 3238-3246.[Medline]

Song, Q., Wei, T., Lees-Miler, S., Alnemri, E., Watters, D. and Lavin, M. F (1997). Resistance of actin to cleavage during apoptosis. Proc. Nat. Acad. Sci. USA 94, 157-162.[Abstract/Free Full Text]

Squier, M. K., Miller, A. C., Malkinson, A. M. and Cohen, J. J (1994). Calpain activation in apoptosis. J. Cell. Physiol 159, 229-237.[Medline]

Stabach, P. R., Cianci, C. D., Glantz, S. B., Zhang, Z. and Morrow, J. S (1997). Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility. Biochemistry 36, 57-65.[Medline]

Takahashi, A. and Earnshaw, W. C (1996). ICE-related proteases in apoptosis. Curr. Opin. Genet. Dev 6, 50-55.[Medline]

Torriglia, A., Chaudun, E., Chanyfournier, F., Jeanny, J. C., Courtois, Y. and Counis, M. F (1995). Involvement of DNase II in nuclear degeneration during lens cell differentiation. J. Biol. Chem 270, 28579-28585.[Abstract/Free Full Text]

Troy, C. M., Derossi, D., Prochiantz, A., Greene, L. A. and Shelanski, M. L (1996). Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway. J. Neurosci 16, 253-261.[Abstract/Free Full Text]

Troy, C. M., Stefanis, L., Prochiantz, A., Greene, L. A. and Shelanski, M. L (1996). The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation. Proc. Nat. Acad. Sci. USA 93, 5635-5640.[Abstract/Free Full Text]

Vandekerckhove, J. and Weber, K (1979). The complete amino-acid sequence of actins from bovine aorta, bovine heart, bovine fast skeletal muscle and rabbit slow skeletal muscle. Differentiation 14, 123-133.[Medline]

Villa, P., Miehe, M., Sensenbrenner, M. and Pettmann, B (1994). Synthesis of specific proteins in trophic factor-deprived neurons undergoing apoptosis. J. Neurochem 62, 1468-1475.[Medline]

Villa, P., Kaufmann, S. H. and Earnshaw, W. C (1997). Caspases and caspase inhibitors. Trends Biochem. Sci 22, 388-393.[Medline]

Zimmer, D. B. and Goldstein, M. A (1987). DNase I interactions with filaments of skeletal muscles. J. Muscle Res. Cell Motil 8, 30-38.[Medline]

This article has been cited by other articles:

A. Haacke, F. U. Hartl, and P. Breuer
Calpain Inhibition Is Sufficient to Suppress Aggregation of Polyglutamine-expanded Ataxin-3
J. Biol. Chem., June 29, 2007; 282(26): 18851 - 18856.
[Abstract] [Full Text] [PDF]

T. R. Van Vleet, T. L. Watterson, P. J. Klein, and R. A. Coulombe Jr.
Aflatoxin B1 Alters the Expression of p53 in Cytochrome P450-Expressing Human Lung Cells
Toxicol. Sci., February 1, 2006; 89(2): 399 - 407.
[Abstract] [Full Text] [PDF]

A. Jurewicz, M. Matysiak, K. Tybor, L. Kilianek, C. S. Raine, and K. Selmaj
Tumour necrosis factor-induced death of adult human oligodendrocytes is mediated by apoptosis inducing factor
Brain, November 1, 2005; 128(11): 2675 - 2688.
[Abstract] [Full Text] [PDF]

H. Weber, L. Jonas, S. Huhns, and P. Schuff-Werner
Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat
Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G932 - G941.
[Abstract] [Full Text] [PDF]

P. Tompa, P. Buzder-Lantos, A. Tantos, A. Farkas, A. Szilagyi, Z. Banoczi, F. Hudecz, and P. Friedrich
On the Sequential Determinants of Calpain Cleavage
J. Biol. Chem., May 14, 2004; 279(20): 20775 - 20785.
[Abstract] [Full Text] [PDF]

J.-P. Levraud, M. Adam, M.-F. Luciani, C. de Chastellier, R. L. Blanton, and P. Golstein
Dictyostelium cell death: early emergence and demise of highly polarized paddle cells
J. Cell Biol., March 31, 2003; 160(7): 1105 - 1114.
[Abstract] [Full Text] [PDF]

I. S. Mathiasen, I. N. Sergeev, L. Bastholm, F. Elling, A. W. Norman, and M. Jaattela
Calcium and Calpain as Key Mediators of Apoptosis-like Death Induced by Vitamin D Compounds in Breast Cancer Cells
J. Biol. Chem., August 16, 2002; 277(34): 30738 - 30745.
[Abstract] [Full Text] [PDF]

A. Robert, M.-J. Miron, C. Champagne, M.-C. Gingras, P. E. Branton, and J. N. Lavoie
Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein
J. Cell Biol., August 5, 2002; 158(3): 519 - 528.
[Abstract] [Full Text] [PDF]

S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman
Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia
J. Neurosci., January 15, 2002; 22(2): 455 - 463.
[Abstract] [Full Text] [PDF]

K. Shiraishi, K. Naito, and K.-i. Yoshida
Inhibition of Calpain but Not Caspase Protects the Testis Against Injury after Experimental Testicular Torsion of Rat
Biol Reprod, November 1, 2000; 63(5): 1538 - 1548.
[Abstract] [Full Text]

G. C. Fletcher, L. Xue, S. K. Passingham, and A. M. Tolkovsky
Death Commitment Point Is Advanced by Axotomy in Sympathetic Neurons
J. Cell Biol., August 21, 2000; 150(4): 741 - 754.
[Abstract] [Full Text] [PDF]

D.-M. Zhu and F. M. Uckun
Calpain Inhibitor II Induces Caspase-dependent Apoptosis in Human Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma Cells as Well as Some Solid Tumor Cells
Clin. Cancer Res., June 1, 2000; 6(6): 2456 - 2463.
[Abstract] [Full Text]

G. Tezel and M. B. Wax
The Mechanisms of hsp27 Antibody-Mediated Apoptosis in Retinal Neuronal Cells
J. Neurosci., May 15, 2000; 20(10): 3552 - 3562.
[Abstract] [Full Text] [PDF]

L. A. Sabourin, P. Seale, J. Wagner, and M. A. Rudnicki
Caspase 3 Cleavage of the Ste20-Related Kinase SLK Releases and Activates an Apoptosis-Inducing Kinase Domain and an Actin-Disassembling Region
Mol. Cell. Biol., January 15, 2000; 20(2): 684 - 696.
[Abstract] [Full Text]

S. E. Lewis, R. J. Mannion, F. A. White, R. E. Coggeshall, S. Beggs, M. Costigan, J. L. Martin, W. H. Dillmann, and C. J. Woolf
A Role for HSP27 in Sensory Neuron Survival
J. Neurosci., October 15, 1999; 19(20): 8945 - 8953.
[Abstract] [Full Text] [PDF]

P. Lipton
Ischemic Cell Death in Brain Neurons
Physiol Rev, October 1, 1999; 79(4): 1431 - 1568.
[Abstract] [Full Text] [PDF]

B. B. Wolf, J. C. Goldstein, H. R. Stennicke, H. Beere, G. P. Amarante-Mendes, G. S. Salvesen, and D. R. Green
Calpain Functions in a Caspase-Independent Manner to Promote Apoptosis-Like Events During Platelet Activation
Blood, September 1, 1999; 94(5): 1683 - 1692.
[Abstract] [Full Text] [PDF]

D. Dinsdale, J. Zhuang, and G. M. Cohen
Redistribution of Cytochrome c Precedes the Caspase-Dependent Formation of Ultracondensed Mitochondria, with a Reduced Inner Membrane Potential, in Apoptotic Monocytes
Am. J. Pathol., August 1, 1999; 155(2): 607 - 618.
[Abstract] [Full Text] [PDF]

B Buendia, A Santa-Maria, and J. Courvalin
Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis
J. Cell Sci., January 6, 1999; 112(11): 1743 - 1753.
[Abstract] [PDF]

Y.-Y. Kong, K.-D. Fischer, M. F. Bachmann, S. Mariathasan, I. Kozieradzki, M. P. Nghiem, D. Bouchard, A. Bernstein, P. S. Ohashi, and J. M. Penninger
Vav Regulates Peptide-specific Apoptosis in Thymocytes
J. Exp. Med., December 7, 1998; 188(11): 2099 - 2111.
[Abstract] [Full Text] [PDF]

M. R. Pulera, L. M. Adams, H. Liu, D. G. Santos, R. N. Nishimura, F. Yang, G. M. Cole, C. G. Wasterlain, and G. J. del Zoppo
Apoptosis in a Neonatal Rat Model of Cerebral Hypoxia-Ischemia � Editorial Comment
Stroke, December 1, 1998; 29(12): 2622 - 2630.
[Abstract] [Full Text] [PDF]

B. Knepper-Nicolai, J. Savill, and S. B. Brown
Constitutive Apoptosis in Human Neutrophils Requires Synergy between Calpains and the Proteasome Downstream of Caspases
J. Biol. Chem., November 13, 1998; 273(46): 30530 - 30536.
[Abstract] [Full Text] [PDF]

N. Canu, L. Dus, C. Barbato, M. T. Ciotti, C. Brancolini, A. M. Rinaldi, M. Novak, A. Cattaneo, A. Bradbury, and P. Calissano
Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis
J. Neurosci., September 15, 1998; 18(18): 7061 - 7074.
[Abstract] [Full Text] [PDF]

K. Blomgren, C. Zhu, X. Wang, J.-O. Karlsson, A.-L. Leverin, B. A. Bahr, C. Mallard, and H. Hagberg
Synergistic Activation of Caspase-3 by m-Calpain after Neonatal Hypoxia-Ischemia. A MECHANISM OF "PATHOLOGICAL APOPTOSIS"?
J. Biol. Chem., March 23, 2001; 276(13): 10191 - 10198.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Villa, P. G.

Articles by Pettmann, B.

Search for Related Content

PubMed

PubMed Citation

Articles by Villa, P. G.

Articles by Pettmann, B.

				T. R. Van Vleet, T. L. Watterson, P. J. Klein, and R. A. Coulombe Jr. Aflatoxin B1 Alters the Expression of p53 in Cytochrome P450-Expressing Human Lung Cells Toxicol. Sci., February 1, 2006; 89(2): 399 - 407. [Abstract] [Full Text] [PDF]

				A. Jurewicz, M. Matysiak, K. Tybor, L. Kilianek, C. S. Raine, and K. Selmaj Tumour necrosis factor-induced death of adult human oligodendrocytes is mediated by apoptosis inducing factor Brain, November 1, 2005; 128(11): 2675 - 2688. [Abstract] [Full Text] [PDF]

				H. Weber, L. Jonas, S. Huhns, and P. Schuff-Werner Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G932 - G941. [Abstract] [Full Text] [PDF]

				P. Tompa, P. Buzder-Lantos, A. Tantos, A. Farkas, A. Szilagyi, Z. Banoczi, F. Hudecz, and P. Friedrich On the Sequential Determinants of Calpain Cleavage J. Biol. Chem., May 14, 2004; 279(20): 20775 - 20785. [Abstract] [Full Text] [PDF]

				J.-P. Levraud, M. Adam, M.-F. Luciani, C. de Chastellier, R. L. Blanton, and P. Golstein Dictyostelium cell death: early emergence and demise of highly polarized paddle cells J. Cell Biol., March 31, 2003; 160(7): 1105 - 1114. [Abstract] [Full Text] [PDF]

				I. S. Mathiasen, I. N. Sergeev, L. Bastholm, F. Elling, A. W. Norman, and M. Jaattela Calcium and Calpain as Key Mediators of Apoptosis-like Death Induced by Vitamin D Compounds in Breast Cancer Cells J. Biol. Chem., August 16, 2002; 277(34): 30738 - 30745. [Abstract] [Full Text] [PDF]

				A. Robert, M.-J. Miron, C. Champagne, M.-C. Gingras, P. E. Branton, and J. N. Lavoie Distinct cell death pathways triggered by the adenovirus early region 4 ORF 4 protein J. Cell Biol., August 5, 2002; 158(3): 519 - 528. [Abstract] [Full Text] [PDF]

				S. A. Back, B. H. Han, N. L. Luo, C. A. Chricton, S. Xanthoudakis, J. Tam, K. L. Arvin, and D. M. Holtzman Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia-Ischemia J. Neurosci., January 15, 2002; 22(2): 455 - 463. [Abstract] [Full Text] [PDF]

				K. Shiraishi, K. Naito, and K.-i. Yoshida Inhibition of Calpain but Not Caspase Protects the Testis Against Injury after Experimental Testicular Torsion of Rat Biol Reprod, November 1, 2000; 63(5): 1538 - 1548. [Abstract] [Full Text]

				G. C. Fletcher, L. Xue, S. K. Passingham, and A. M. Tolkovsky Death Commitment Point Is Advanced by Axotomy in Sympathetic Neurons J. Cell Biol., August 21, 2000; 150(4): 741 - 754. [Abstract] [Full Text] [PDF]

				D.-M. Zhu and F. M. Uckun Calpain Inhibitor II Induces Caspase-dependent Apoptosis in Human Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma Cells as Well as Some Solid Tumor Cells Clin. Cancer Res., June 1, 2000; 6(6): 2456 - 2463. [Abstract] [Full Text]

				G. Tezel and M. B. Wax The Mechanisms of hsp27 Antibody-Mediated Apoptosis in Retinal Neuronal Cells J. Neurosci., May 15, 2000; 20(10): 3552 - 3562. [Abstract] [Full Text] [PDF]

				L. A. Sabourin, P. Seale, J. Wagner, and M. A. Rudnicki Caspase 3 Cleavage of the Ste20-Related Kinase SLK Releases and Activates an Apoptosis-Inducing Kinase Domain and an Actin-Disassembling Region Mol. Cell. Biol., January 15, 2000; 20(2): 684 - 696. [Abstract] [Full Text]

				S. E. Lewis, R. J. Mannion, F. A. White, R. E. Coggeshall, S. Beggs, M. Costigan, J. L. Martin, W. H. Dillmann, and C. J. Woolf A Role for HSP27 in Sensory Neuron Survival J. Neurosci., October 15, 1999; 19(20): 8945 - 8953. [Abstract] [Full Text] [PDF]

				P. Lipton Ischemic Cell Death in Brain Neurons Physiol Rev, October 1, 1999; 79(4): 1431 - 1568. [Abstract] [Full Text] [PDF]

				B. B. Wolf, J. C. Goldstein, H. R. Stennicke, H. Beere, G. P. Amarante-Mendes, G. S. Salvesen, and D. R. Green Calpain Functions in a Caspase-Independent Manner to Promote Apoptosis-Like Events During Platelet Activation Blood, September 1, 1999; 94(5): 1683 - 1692. [Abstract] [Full Text] [PDF]

				D. Dinsdale, J. Zhuang, and G. M. Cohen Redistribution of Cytochrome c Precedes the Caspase-Dependent Formation of Ultracondensed Mitochondria, with a Reduced Inner Membrane Potential, in Apoptotic Monocytes Am. J. Pathol., August 1, 1999; 155(2): 607 - 618. [Abstract] [Full Text] [PDF]

				B Buendia, A Santa-Maria, and J. Courvalin Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis J. Cell Sci., January 6, 1999; 112(11): 1743 - 1753. [Abstract] [PDF]

				Y.-Y. Kong, K.-D. Fischer, M. F. Bachmann, S. Mariathasan, I. Kozieradzki, M. P. Nghiem, D. Bouchard, A. Bernstein, P. S. Ohashi, and J. M. Penninger Vav Regulates Peptide-specific Apoptosis in Thymocytes J. Exp. Med., December 7, 1998; 188(11): 2099 - 2111. [Abstract] [Full Text] [PDF]

				M. R. Pulera, L. M. Adams, H. Liu, D. G. Santos, R. N. Nishimura, F. Yang, G. M. Cole, C. G. Wasterlain, and G. J. del Zoppo Apoptosis in a Neonatal Rat Model of Cerebral Hypoxia-Ischemia � Editorial Comment Stroke, December 1, 1998; 29(12): 2622 - 2630. [Abstract] [Full Text] [PDF]

				B. Knepper-Nicolai, J. Savill, and S. B. Brown Constitutive Apoptosis in Human Neutrophils Requires Synergy between Calpains and the Proteasome Downstream of Caspases J. Biol. Chem., November 13, 1998; 273(46): 30530 - 30536. [Abstract] [Full Text] [PDF]

				N. Canu, L. Dus, C. Barbato, M. T. Ciotti, C. Brancolini, A. M. Rinaldi, M. Novak, A. Cattaneo, A. Bradbury, and P. Calissano Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis J. Neurosci., September 15, 1998; 18(18): 7061 - 7074. [Abstract] [Full Text] [PDF]

				K. Blomgren, C. Zhu, X. Wang, J.-O. Karlsson, A.-L. Leverin, B. A. Bahr, C. Mallard, and H. Hagberg Synergistic Activation of Caspase-3 by m-Calpain after Neonatal Hypoxia-Ischemia. A MECHANISM OF "PATHOLOGICAL APOPTOSIS"? J. Biol. Chem., March 23, 2001; 276(13): 10191 - 10198. [Abstract] [Full Text] [PDF]