Effects of cytokines on mycobacterial phagosome maturation

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Via, L. E.
	Articles by Deretic, V.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Via, L. E.
	Articles by Deretic, V.

Armstrong, J. A. and D'Arcy Hart, P (1971). Response of cultured macrophages to Mycobacterium tuberculosis , with observations on fusion of lysosomes with phagosomes. J. Exp. Med 134, 713-740.[Abstract]

Baca, O. G., Li, Y.-P. and Kumar, H (1994). Survival of the Q fever agent Coxiella burnetii in the phagosome. Trends Microbiol 2, 476-480.[Medline]

Barker, L. P., George, K. M., Falkow, S. and Small, P. L. C (1997). Differential trafficking of live and dead Mycobacterium marinum organisms in macrophages. Infect. Immun 65, 1497-1504.[Abstract]

Barnes, P. F., Chaterjee, D., Abrams, J. S., Lu, S., Wang, E., Yamamura, M., Brennan, P. J. and Modlin, R. L (1992). Cytokine production induced by Mycobacterium tuberculosis lipoarabinomannan. relationship to chemical structure. J. Immunol 149, 541-547.[Abstract]

Barnewall, R. E., Rikihisa, Y. and Lee, E. H (1997). Ehrlichia chaffeensis inclusions are early endosomes which selectively accumulate transferrin receptor. Infect. Immun 65, 1455-1461.[Abstract]

Bermudez, E. L. and Young, L. S (1988). Tumor necrosis factor, alone or in combination with IL-2, but not IFN-gamma, is associated with macrophage killing of Mycobacterium avium complex. J. Immunol 140, 3006-3013.[Abstract]

Bermudez, L. E. and Young, L. S (1990). Recombinant granulocyte-macrophage colony-stimulating factor activates human macrophages to inhibit growth or kill Mycobacterium avium complex. J. Leukocyte Biol 48, 67-73.[Abstract]

Bogdan, C., Vodovotz, Y. and Nathan, C (1991). Macrophage deactivation by interleukin 10. J. Exp. Med 174, 1209-1220.[Abstract/Free Full Text]

Byrd, T. F (1997). Tumor necrosis factor(TNF- ) promotes growth of virulent Mycobacterium tuberculosis in human macrophages. J. Clin. Invest 99, 2518-2529.[Medline]

Chan, J., Tanaka, K., Carroll, D., Flynn, J. and Bloom, B. R (1995). Effects of nitric oxide synthase inhibitors on murine infection with Mycobacterium tuberculosis. Infect. Immun 63, 736-740.[Abstract]

Chan, J., Xing, Y., Magliozzo, R. S. and Bloom, B. R (1992). Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages. J. Exp. Med 175, 1111-1122.[Abstract/Free Full Text]

Clemens, D. L (1996). Characterization of the Mycobacterium tuberculosis phagosome. Trends Microbiol 4, 133-117.

Clemens, D. L. and Horwitz, M. A (1995). Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. J. Exp. Med 181, 257-270.[Abstract/Free Full Text]

Cooper, A. M., Dalton, D. K., Stewart, T. A., Griffin, J. P., Russell, D. G. and Orme, I. M (1993). Disseminated tuberculosis in interferon-gamma gene-disrupted mice. J. Exp. Med 178, 2242-2248.

Crowle, A., Dahl, R., Ross, E. and May, M (1991). Evidence that vesicles containing living virulent M. tuberculosis or M. avium in cultured human macrophages are not acidic. Infect. Immun 59, 1823-1831.[Abstract/Free Full Text]

de Chastellier, C., Lang, T. and Thilo, L (1995). Phagocytic processing of the macrophage endoparasite, Mycobacterium avium in comparison to phagosomes which contain Bacillus subtilis or latex beads. Eur. J. Cell Biol 68, 167-182.[Medline]

de Chastellier, C. and Thilo, L (1997). Phagosome maturation and fusion with lysosomes in relation to surface property and size of the phagocytic particle. Eur. J. Cell Biol 74, 49-62.[Medline]

de Wall Malefyt, R., Haanen, J., Spits, H., Roncarolo, M.-G., te Velde, A., Figdor, C., Johnson, K., Kastelein, R., Yssel, H. and de Vries, J. E (1991). Interleukin 10 (IL-10) and viral IL-10 strongly reduce antigen-specific human T cell proliferation by diminishing the antigen-presenting capacity of monocytes via downregulation of class II major histocompatibility complex expression. J. Exp. Med 174, 915-924.[Abstract/Free Full Text]

Deretic, V., Via, L. E., Fratti, R. and Deretic, D (1997). Mycobacterial Phagosome Maturation, Rab Proteins and Intracellular Trafficking. Electrophoresis 18, 2542-2547.[Medline]

Desjardins, M., Celis, J. E., Van Meer, G., Dieplinger, H., Jahraus, A., Griffiths, G. and Huber, L. A (1994). Molecular characterization of phagosomes. J. Biol. Chem 269, 32194-32200.[Abstract/Free Full Text]

Desjardins, M., Huber, L. A., Parton, R. G. F. and Griffiths, G (1994). Biogenesis of phagolysosomes proceeds through a sequential series of interactions with endocytic apparatus. J. Cell Biol 124, 677-688.[Abstract/Free Full Text]

Desjardins, M., Nzala, N. N., Corsini, R. and Rondeau, C (1997). Maturation of phagosomes is accompanied by changes in their fusion properties and size-selective acquisition of solute materials from endosome. J. Cell Sci 110, 2303-2314.[Abstract]

Dhandayuthapani, S., Via, L. E., Thomas, C. A., Horowitz, P. M., Deretic, D. and Deretic, V (1995). Green fluorescent protein as a marker for gene expression and cell biology of mycobacterial interactions with macrophages. Mol. Microbiol 17, 901-912.[Medline]

Eisenberg, L. J., Goldman, W. E. and Schlesinger, P. H (1993). Histoplasma capsulatum modulates the acidification of phagolysosomes. J. Exp. Med 177, 1605-1611.[Abstract/Free Full Text]

Falkinham, J. O (1996). Epidemiology of infection by nontuberculous mycobacteria. Clin. Microbiol. Rev 9, 177-215.[Medline]

Fenton, M. J. and Vermeulen, M. W (1996). Immunopathology of tuberculosis: roles of macrophages and monocytes. Infect. Immun 64, 683-690.[Medline]

Finley, B. B. and Cossart, P (1997). Exploitation of mammalian host cell functions by bacterial pathogens. Science 276, 718-725.[Abstract/Free Full Text]

Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M. and O'Garra, A (1991). IL-10 inhibits cytokine production by activated macrophages. J. Immunol 147, 3815-3822.[Abstract]

Flesch, I. E. A. and Kaufmann, S. H. E (1990). Activation of tuberculostatic macrophage functions by gamma interferon, interleukin-4 and tumor necrosis factor. Infect. Immun 58, 2675-2677.[Abstract/Free Full Text]

Flesch, I. E. A. and Kaufmann, S. H. E (1991). Mechanisms involved in mycobacterial growth inhibition by gamma interferon-activated bone marrow macrophages: role of reactive nitrogen intermediates. Infect. Immun 59, 3121-3218.

Flynn, J. L., Chan, J., Triebold, K. J., Dalton, D. K., Steward, T. A. and Bloom, B. R (1993). An essential role for IFN-gamma in resistance to Mycobacterium tuberculosis infection. J. Exp. Med 178, 2249-2254.[Abstract/Free Full Text]

Flynn, J. L., Goldstein, M. M., Chan, J., Triebold, K. J., Pfeffer, K., Lowenstein, C. J., Schreiber, R., Mak, T. W. and Bloom, B. R (1995). Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2, 561-572.[Medline]

Flynn, J. L., Goldstein, M. M., Triebold, K. J., Koller, B. and Bloom, B. R (1992). Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection. Proc. Nat. Acad. Sci. USA 89, 12013-12017.[Abstract/Free Full Text]

Frehel, C., de Chastellier, C., Lang, T. and Rastogi, N (1986). Evidence for inhibition of lysosomal and prelysosomal compartments with phagosomes in macrophages infected with pathogenic Mycobacterium avium. Infect. Immun 52, 252-262.[Abstract/Free Full Text]

Frehel, C., Offredo, C. and de Chastellier, C (1997). The phagosomal environment protects virulent Mycobacterium avium from killing and destruction by clarithromycin. Infect. Immun 65, 2792-2802.[Abstract]

Fukuda, M (1991). Lysosomal membrane glycoproteins. J. Biol. Chem 266, 21327-21330.[Free Full Text]

Garcia-del Portillo, F. and Finlay, B. B (1995). The varied lifestyles of intracellular pathogens within eukaryotic vacuolar compartments. Trends Microbiol 3, 373-380.[Medline]

Gong, J.-H., Zhang, M., Modlin, R. L., Linsley, P. S., Iyer, D., Lin, Y. and Barnes, P. F (1996). Interleukin-10 downregulates Mycobcaterium tuberculosis -induced Th1 responses and CTLA-4 expression. Infect. Immun 64, 913-918.[Abstract]

Hackstadt, T., Scidmore, M. A. and Rockey, D. D (1995). Lipid metabolism in Chlamydia trachomatis- infected cells: directed trafficking of Golgi-derived sphingolipids to the chlamydial inclusion. Proc. Nat. Acad. Sci. USA 92, 4877-4881.[Abstract/Free Full Text]

Joiner, K. A., Fuhrman, S. A., Miettinen, H. M., Jasper, L. H. and Mellman, I (1990). Toxoplasma gondii : fusion competence of parasitophorous vacuole in Fc receptor transfected fibroblasts. Science 249, 641-646.[Abstract/Free Full Text]

MacMicking, J. D., North, R. J., LaCourse, R., Mudgett, J. S., Shah, S. K. and Nathan, C. F (1997). Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc. Nat. Acad. Sci. USA 94, 5243-5248.[Abstract/Free Full Text]

Magez, S., Geuskens, M., Beschin, del Favero, H., Verschueren, H., Lucas, R., Pays, E. and de Baetselier, P (1997). Specific uptake of tumor necrosis factor-alpha is involved in growth control of Trypanosoma brucei. J. Cell Biol 137, 715-727.[Abstract/Free Full Text]

McDonough, K. A., Kress, Y. and Bloom, B. R (1993). Pathogenesis of tuberculosis: interaction of M. tuberculosis with macrophages. Infect. Immun 61, 2763-2773.[Abstract/Free Full Text]

Molloy, A., Laochumroonvorapong, P. and Kaplan, G (1994). Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular Bacillus Calmette-Guerin. J. Exp. Med 180, 1499-1509.[Abstract/Free Full Text]

Molloy, A., Meyn, P. A., Smith, K. D. and Kaplan, G (1993). Recognition and destruction of Bacillus Calmette-Guerin-infected human monocytes. J. Exp. Med 177, 1691-1698.[Abstract/Free Full Text]

Ramakrishnan, L. and Falkow, S (1994). Mycobacterium marinum persists in cultured mammalian cells in a temperature-restricted fashion. Infect. Immun 62, 3222-3229.[Abstract/Free Full Text]

Stenger, S., Mazzaccaro, R. J., Uyemura, K., Cho, S., Barnes, P. F., Rosat, J.-P., Sette, A., Brenner, M. B., Porcelli, S. A., Bloom, B. R. and Modlin, R. L (1997). Differential effects of cytolytic T cell subsets on intracellular infection. Science 276, 1684-1687.[Abstract/Free Full Text]

Strugill-Koszycki, S., Schaible, U. E. and Russell, D. G (1996). Mycobacterium -containing phagosomes are accessible to early endosomes and reflect a transition state in normal phagosome biogenesis. EMBO J 15, 6960-6968.[Medline]

Strugill-Koszycki, S., Schlesinger, P. H., Chakraborty, P., Haddix, P. L., Collins, H. L., Fok, A. K., Allen, R. D., Gluck, S. L., Heuser, J. and Russell, D. G (1994). Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263, 678-681.[Abstract/Free Full Text]

Swanson, M. S. and Isberg, R. R (1995). Association of Legionella pneumophila with the macrophage endoplasmic reticulum. Infect. Immun 64, 2585-2594.[Abstract]

Tardieux, I., Webster, P., Ravesloot, J., Boron, W., Lunn, J. A., Heuser, J. E. and Andrews, N. W (1992). Lysosome recruitment and fusion are early events required for trypanosome invasion of mammalian cells. Cell 71, 1117-1130.[Medline]

Via, L. E., Deretic, D., Ulmer, R. J., Hibler, N. S., Huber, L. A. and Deretic, V (1997). Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by rab5 and rab7. J. Biol. Chem 272, 13326-13331.[Abstract/Free Full Text]

Via, L. E., Curcic, R., Mudd, M. H., Dhandayuthapani, S., Ulmer, R. J. and Deretic, V (1996). Elements of signal transduction in Mycobacterium tubeculosis : in vitro phopshorylation and in vivo expression of the response regulator MtrA. J. Bacteriol 178, 3314-3321.[Abstract/Free Full Text]

White, B. H. and Kaczmarek, L. K (1997). Identification of a vesicular pool of calcium channels in the bag cell neurons of Aplysia californica. J. Neurosci 17, 1582-1595.[Abstract/Free Full Text]

Wubbolts, R., Fernandez-Borja, M., Oomen, L., Verwoerd, D., Janssen, H., Calafat, J., Tulp, A., Dusseljee, S. and Heefjes, J (1996). Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface. J. Cell Biol 135, 611-622.[Abstract/Free Full Text]

Xu, S., Cooper, A., Sturgill-Koszycki, S., van Heyningen, T., Chaterjee, D., Orme, I., Allen, P. and Russell, D. G (1994). Intracellular trafficking in Mycobacterium tuberculosis and Mycobacterium avium-infected macrophages. J. Immunol 153, 2568-257.[Abstract]

Zhang, M., Lin, Y., Iyer, D. V., Gong, J., Abrams, J. S. and Barnes, P. F (1995). T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect. Immun 63, 3231-3234.[Abstract]

This article has been cited by other articles:

K. E. Van Zandt, F. B. Sow, W. C. Florence, B. S. Zwilling, A. R. Satoskar, L. S. Schlesinger, and W. P. Lafuse
The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome
J. Leukoc. Biol., September 1, 2008; 84(3): 689 - 700.
[Abstract] [Full Text] [PDF]

M. G. Gutierrez, B. B. Mishra, L. Jordao, E. Elliott, E. Anes, and G. Griffiths
NF-{kappa}B Activation Controls Phagolysosome Fusion-Mediated Killing of Mycobacteria by Macrophages
J. Immunol., August 15, 2008; 181(4): 2651 - 2663.
[Abstract] [Full Text] [PDF]

M.-A. Frese, S. Schulz, and T. Dierks
Arylsulfatase G, a Novel Lysosomal Sulfatase
J. Biol. Chem., April 25, 2008; 283(17): 11388 - 11395.
[Abstract] [Full Text] [PDF]

M. S. Saldias, J. Lamothe, R. Wu, and M. A. Valvano
Burkholderia cenocepacia Requires the RpoN Sigma Factor for Biofilm Formation and Intracellular Trafficking within Macrophages
Infect. Immun., March 1, 2008; 76(3): 1059 - 1067.
[Abstract] [Full Text] [PDF]

M. Alter-Koltunoff, S. Goren, J. Nousbeck, C. G. Feng, A. Sher, K. Ozato, A. Azriel, and B.-Z. Levi
Innate Immunity to Intraphagosomal Pathogens Is Mediated by Interferon Regulatory Factor 8 (IRF-8) That Stimulates the Expression of Macrophage-specific Nramp1 through Antagonizing Repression by c-Myc
J. Biol. Chem., February 1, 2008; 283(5): 2724 - 2733.
[Abstract] [Full Text] [PDF]

J. Sun, A.-E. Deghmane, H. Soualhine, T. Hong, C. Bucci, A. Solodkin, and Z. Hmama
Mycobacterium bovis BCG disrupts the interaction of Rab7 with RILP contributing to inhibition of phagosome maturation
J. Leukoc. Biol., December 1, 2007; 82(6): 1437 - 1445.
[Abstract] [Full Text] [PDF]

F. B. Sow, W. C. Florence, A. R. Satoskar, L. S. Schlesinger, B. S. Zwilling, and W. P. Lafuse
Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis
J. Leukoc. Biol., October 1, 2007; 82(4): 934 - 945.
[Abstract] [Full Text] [PDF]

K. K. Huynh and S. Grinstein
Regulation of Vacuolar pH and Its Modulation by Some Microbial Species
Microbiol. Mol. Biol. Rev., September 1, 2007; 71(3): 452 - 462.
[Abstract] [Full Text] [PDF]

A.-E. Deghmane, H. Soualhine, H. Bach, K. Sendide, S. Itoh, A. Tam, S. Noubir, A. Talal, R. Lo, S. Toyoshima, et al.
Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation
J. Cell Sci., August 15, 2007; 120(16): 2796 - 2806.
[Abstract] [Full Text] [PDF]

E. P. Williams, J.-H. Lee, W. R. Bishai, C. Colantuoni, and P. C. Karakousis
Mycobacterium tuberculosis SigF Regulates Genes Encoding Cell Wall-Associated Proteins and Directly Regulates the Transcriptional Regulatory Gene phoY1
J. Bacteriol., June 1, 2007; 189(11): 4234 - 4242.
[Abstract] [Full Text] [PDF]

L. Pompei, S. Jang, B. Zamlynny, S. Ravikumar, A. McBride, S. P. Hickman, and P. Salgame
Disparity in IL-12 Release in Dendritic Cells and Macrophages in Response to Mycobacterium tuberculosis Is Due to Use of Distinct TLRs
J. Immunol., April 15, 2007; 178(8): 5192 - 5199.
[Abstract] [Full Text] [PDF]

S. Alonso, K. Pethe, D. G. Russell, and G. E. Purdy
Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy
PNAS, April 3, 2007; 104(14): 6031 - 6036.
[Abstract] [Full Text] [PDF]

P. Bandyopadhyay, S. Liu, C. B. Gabbai, Z. Venitelli, and H. M. Steinman
Environmental Mimics and the Lvh Type IVA Secretion System Contribute to Virulence-Related Phenotypes of Legionella pneumophila
Infect. Immun., February 1, 2007; 75(2): 723 - 735.
[Abstract] [Full Text] [PDF]

C. R. Singh, R. A. Moulton, L. Y. Armitige, A. Bidani, M. Snuggs, S. Dhandayuthapani, R. L. Hunter, and C. Jagannath
Processing and Presentation of a Mycobacterial Antigen 85B Epitope by Murine Macrophages Is Dependent on the Phagosomal Acquisition of Vacuolar Proton ATPase and In Situ Activation of Cathepsin D.
J. Immunol., September 1, 2006; 177(5): 3250 - 3259.
[Abstract] [Full Text] [PDF]

R. Appelberg
Macrophage nutriprive antimicrobial mechanisms
J. Leukoc. Biol., June 1, 2006; 79(6): 1117 - 1128.
[Abstract] [Full Text] [PDF]

M. Torres, L. Ramachandra, R. E. Rojas, K. Bobadilla, J. Thomas, D. H. Canaday, C. V. Harding, and W. H. Boom
Role of Phagosomes and Major Histocompatibility Complex Class II (MHC-II) Compartment in MHC-II Antigen Processing of Mycobacterium tuberculosis in Human Macrophages
Infect. Immun., March 1, 2006; 74(3): 1621 - 1630.
[Abstract] [Full Text] [PDF]

M. J. Cayabyab, A.-H. Hovav, T. Hsu, G. R. Krivulka, M. A. Lifton, D. A. Gorgone, G. J. Fennelly, B. F. Haynes, W. R. Jacobs Jr., and N. L. Letvin
Generation of CD8+ T-Cell Responses by a Recombinant Nonpathogenic Mycobacterium smegmatis Vaccine Vector Expressing Human Immunodeficiency Virus Type 1 Env
J. Virol., February 15, 2006; 80(4): 1645 - 1652.
[Abstract] [Full Text] [PDF]

K. Toyooka, S. Takai, and T. Kirikae
Rhodococcus equi can survive a phagolysosomal environment in macrophages by suppressing acidification of the phagolysosome
J. Med. Microbiol., November 1, 2005; 54(11): 1007 - 1015.
[Abstract] [Full Text] [PDF]

M. A. Gordon, D. L. Jack, D. H. Dockrell, M. E. Lee, and R. C. Read
Gamma Interferon Enhances Internalization and Early Nonoxidative Killing of Salmonella enterica Serovar Typhimurium by Human Macrophages and Modifies Cytokine Responses
Infect. Immun., June 1, 2005; 73(6): 3445 - 3452.
[Abstract] [Full Text] [PDF]

J. Hostetter, E. Huffman, K. Byl, and E. Steadham
Inducible Nitric Oxide Synthase Immunoreactivity in the Granulomatous Intestinal Lesions of Naturally Occurring Bovine Johne's Disease
Vet. Pathol., May 1, 2005; 42(3): 241 - 249.
[Abstract] [Full Text] [PDF]

E. J. Cheadle, D. O'Donnell, P. J. Selby, and A. M. Jackson
Closely Related Mycobacterial Strains Demonstrate Contrasting Levels of Efficacy as Antitumor Vaccines and Are Processed for Major Histocompatibility Complex Class I Presentation by Multiple Routes in Dendritic Cells
Infect. Immun., February 1, 2005; 73(2): 784 - 794.
[Abstract] [Full Text] [PDF]

L. Ramachandra, J. L. Smialek, S. S. Shank, M. Convery, W. H. Boom, and C. V. Harding
Phagosomal Processing of Mycobacterium tuberculosis Antigen 85B Is Modulated Independently of Mycobacterial Viability and Phagosome Maturation
Infect. Immun., February 1, 2005; 73(2): 1097 - 1105.
[Abstract] [Full Text] [PDF]

K. Pethe, D. L. Swenson, S. Alonso, J. Anderson, C. Wang, and D. G. Russell
Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturation
PNAS, September 14, 2004; 101(37): 13642 - 13647.
[Abstract] [Full Text] [PDF]

J. M. Blander and R. Medzhitov
Regulation of Phagosome Maturation by Signals from Toll-Like Receptors
Science, May 14, 2004; 304(5673): 1014 - 1018.
[Abstract] [Full Text] [PDF]

B. H. Miller, R. A. Fratti, J. F. Poschet, G. S. Timmins, S. S. Master, M. Burgos, M. A. Marletta, and V. Deretic
Mycobacteria Inhibit Nitric Oxide Synthase Recruitment to Phagosomes during Macrophage Infection
Infect. Immun., May 1, 2004; 72(5): 2872 - 2878.
[Abstract] [Full Text] [PDF]

Z. Hmama, K. Sendide, A. Talal, R. Garcia, K. Dobos, and N. E. Reiner
Quantitative analysis of phagolysosome fusion in intact cells: inhibition by mycobacterial lipoarabinomannan and rescue by an 1{alpha},25-dihydroxyvitamin D3-phosphoinositide 3-kinase pathway
J. Cell Sci., April 15, 2004; 117(10): 2131 - 2140.
[Abstract] [Full Text] [PDF]

H. C. Mwandumba, D. G. Russell, M. H. Nyirenda, J. Anderson, S. A. White, M. E. Molyneux, and S. B. Squire
Mycobacterium tuberculosis Resides in Nonacidified Vacuoles in Endocytically Competent Alveolar Macrophages from Patients with Tuberculosis and HIV Infection
J. Immunol., April 1, 2004; 172(7): 4592 - 4598.
[Abstract] [Full Text] [PDF]

I. Vergne, R. A. Fratti, P. J. Hill, J. Chua, J. Belisle, and V. Deretic
Mycobacterium tuberculosis Phagosome Maturation Arrest: Mycobacterial Phosphatidylinositol Analog Phosphatidylinositol Mannoside Stimulates Early Endosomal Fusion
Mol. Biol. Cell, February 1, 2004; 15(2): 751 - 760.
[Abstract] [Full Text] [PDF]

R. A. Fratti, J. Chua, and V. Deretic
Induction of p38 Mitogen-activated Protein Kinase Reduces Early Endosome Autoantigen 1 (EEA1) Recruitment to Phagosomal Membranes
J. Biol. Chem., November 21, 2003; 278(47): 46961 - 46967.
[Abstract] [Full Text] [PDF]

P.-J. Cardona, S. Gordillo, J. Diaz, G. Tapia, I. Amat, A. Pallares, C. Vilaplana, A. Ariza, and V. Ausina
Widespread Bronchogenic Dissemination Makes DBA/2 Mice More Susceptible than C57BL/6 Mice to Experimental Aerosol Infection with Mycobacterium tuberculosis
Infect. Immun., October 1, 2003; 71(10): 5845 - 5854.
[Abstract] [Full Text] [PDF]

S. M. Townsend, H. A. Pollack, I. Gonzalez-Gomez, H. Shimada, and J. L. Badger
Citrobacter koseri Brain Abscess in the Neonatal Rat: Survival and Replication within Human and Rat Macrophages
Infect. Immun., October 1, 2003; 71(10): 5871 - 5880.
[Abstract] [Full Text] [PDF]

J. Indrigo, R. L. Hunter Jr, and J. K. Actor
Cord factor trehalose 6,6'-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages
Microbiology, August 1, 2003; 149(8): 2049 - 2059.
[Abstract] [Full Text] [PDF]

O. Ibrahim-Granet, B. Philippe, H. Boleti, E. Boisvieux-Ulrich, D. Grenet, M. Stern, and J. P. Latge
Phagocytosis and Intracellular Fate of Aspergillus fumigatus Conidia in Alveolar Macrophages
Infect. Immun., February 1, 2003; 71(2): 891 - 903.
[Abstract] [Full Text] [PDF]

E. Ghigo, C. Capo, C.-H. Tung, D. Raoult, J.-P. Gorvel, and J.-L. Mege
Coxiellaburnetii Survival in THP-1 Monocytes Involves the Impairment of Phagosome Maturation: IFN-{gamma} Mediates its Restoration and Bacterial Killing
J. Immunol., October 15, 2002; 169(8): 4488 - 4495.
[Abstract] [Full Text] [PDF]

T. R. M. da Silva, J. R. de Freitas, Q. C. Silva, C. P. Figueira, E. Roxo, S. C. Leao, L. A. R. de Freitas, and P. S. T. Veras
Virulent Mycobacterium fortuitum Restricts NO Production by a Gamma Interferon-Activated J774 Cell Line and Phagosome-Lysosome Fusion
Infect. Immun., October 1, 2002; 70(10): 5628 - 5634.
[Abstract] [Full Text] [PDF]

K. Mukherjee, S. Parashuraman, G. Krishnamurthy, J. Majumdar, A. Yadav, R. Kumar, S. K. Basu, and A. Mukhopadhyay
Diverting intracellular trafficking of Salmonella to the lysosome through activation of the late endocytic Rab7 by intracellular delivery of muramyl dipeptide
J. Cell Sci., September 15, 2002; 115(18): 3693 - 3701.
[Abstract] [Full Text] [PDF]

D. B Young and G. R Stewart
Tuberculosis vaccines
Br. Med. Bull., July 1, 2002; 62(1): 73 - 86.
[Abstract] [Full Text] [PDF]

R. A. Fratti, J. Chua, and V. Deretic
Cellubrevin Alterations and Mycobacterium tuberculosis Phagosome Maturation Arrest
J. Biol. Chem., May 3, 2002; 277(19): 17320 - 17326.
[Abstract] [Full Text] [PDF]

R. Lang, R. L. Rutschman, D. R. Greaves, and P. J. Murray
Autocrine Deactivation of Macrophages in Transgenic Mice Constitutively Overexpressing IL-10 Under Control of the Human CD68 Promoter
J. Immunol., April 1, 2002; 168(7): 3402 - 3411.
[Abstract] [Full Text] [PDF]

D. M. Bouley, N. Ghori, K. L. Mercer, S. Falkow, and L. Ramakrishnan
Dynamic Nature of Host-Pathogen Interactions in Mycobacterium marinum Granulomas
Infect. Immun., December 1, 2001; 69(12): 7820 - 7831.
[Abstract] [Full Text] [PDF]

L. Ramachandra, E. Noss, W. H. Boom, and C. V. Harding
Processing of Mycobacterium tuberculosis Antigen 85B Involves Intraphagosomal Formation of Peptide-Major Histocompatibility Complex II Complexes and Is Inhibited by Live Bacilli that Decrease Phagosome Maturation
J. Exp. Med., November 12, 2001; 194(10): 1421 - 1432.
[Abstract] [Full Text] [PDF]

T. C. Zahrt and V. Deretic
Mycobacterium tuberculosis signal transduction system required for persistent infections
PNAS, October 23, 2001; 98(22): 12706 - 12711.
[Abstract] [Full Text] [PDF]

B. Springer, S. Master, P. Sander, T. Zahrt, M. McFalone, J. Song, K. G. Papavinasasundaram, M. J. Colston, E. Boettger, and V. Deretic
Silencing of Oxidative Stress Response in Mycobacterium tuberculosis: Expression Patterns of ahpC in Virulent and Avirulent Strains and Effect of ahpC Inactivation
Infect. Immun., October 1, 2001; 69(10): 5967 - 5973.
[Abstract] [Full Text] [PDF]

D. J. Kusner and J. A. Barton
ATP Stimulates Human Macrophages to Kill Intracellular Virulent Mycobacterium tuberculosis Via Calcium-Dependent Phagosome-Lysosome Fusion
J. Immunol., September 15, 2001; 167(6): 3308 - 3315.
[Abstract] [Full Text] [PDF]

R. A. Fratti, J. M. Backer, J. Gruenberg, S. Corvera, and V. Deretic
Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
J. Cell Biol., August 6, 2001; 154(3): 631 - 644.
[Abstract] [Full Text] [PDF]

L.-G. Bekker, S. Freeman, P. J. Murray, B. Ryffel, and G. Kaplan
TNF-{{alpha}} Controls Intracellular Mycobacterial Growth by Both Inducible Nitric Oxide Synthase-Dependent and Inducible Nitric Oxide Synthase-Independent Pathways
J. Immunol., June 1, 2001; 166(11): 6728 - 6734.
[Abstract] [Full Text] [PDF]

E. Fiebiger, P. Meraner, E. Weber, I-F. Fang, G. Stingl, H. Ploegh, and D. Maurer
Cytokines Regulate Proteolysis in Major Histocompatibility Complex Class II-dependent Antigen Presentation by Dendritic Cells
J. Exp. Med., April 9, 2001; 193(8): 881 - 892.
[Abstract] [Full Text] [PDF]

Z. A. Malik, S. S. Iyer, and D. J. Kusner
Mycobacterium tuberculosis Phagosomes Exhibit Altered Calmodulin-Dependent Signal Transduction: Contribution to Inhibition of Phagosome-Lysosome Fusion and Intracellular Survival in Human Macrophages
J. Immunol., March 1, 2001; 166(5): 3392 - 3401.
[Abstract] [Full Text] [PDF]

O. Neyrolles, K. Gould, M.-P. Gares, S. Brett, R. Janssen, P. O'Gaora, J.-L. Herrmann, M.-C. Prevost, E. Perret, J. E. R. Thole, et al.
Lipoprotein Access to MHC Class I Presentation During Infection of Murine Macrophages with Live Mycobacteria
J. Immunol., January 1, 2001; 166(1): 447 - 457.
[Abstract] [Full Text] [PDF]

M. Groger, W. Holnthoner, D. Maurer, S. Lechleitner, K. Wolff, B. B. Mayr, W. Lubitz, and P. Petzelbauer
Dermal Microvascular Endothelial Cells Express the 180-kDa Macrophage Mannose Receptor In Situ and In Vitro
J. Immunol., November 15, 2000; 165(10): 5428 - 5434.
[Abstract] [Full Text] [PDF]

				M. G. Gutierrez, B. B. Mishra, L. Jordao, E. Elliott, E. Anes, and G. Griffiths NF-{kappa}B Activation Controls Phagolysosome Fusion-Mediated Killing of Mycobacteria by Macrophages J. Immunol., August 15, 2008; 181(4): 2651 - 2663. [Abstract] [Full Text] [PDF]

				M.-A. Frese, S. Schulz, and T. Dierks Arylsulfatase G, a Novel Lysosomal Sulfatase J. Biol. Chem., April 25, 2008; 283(17): 11388 - 11395. [Abstract] [Full Text] [PDF]

				M. S. Saldias, J. Lamothe, R. Wu, and M. A. Valvano Burkholderia cenocepacia Requires the RpoN Sigma Factor for Biofilm Formation and Intracellular Trafficking within Macrophages Infect. Immun., March 1, 2008; 76(3): 1059 - 1067. [Abstract] [Full Text] [PDF]

				M. Alter-Koltunoff, S. Goren, J. Nousbeck, C. G. Feng, A. Sher, K. Ozato, A. Azriel, and B.-Z. Levi Innate Immunity to Intraphagosomal Pathogens Is Mediated by Interferon Regulatory Factor 8 (IRF-8) That Stimulates the Expression of Macrophage-specific Nramp1 through Antagonizing Repression by c-Myc J. Biol. Chem., February 1, 2008; 283(5): 2724 - 2733. [Abstract] [Full Text] [PDF]

				J. Sun, A.-E. Deghmane, H. Soualhine, T. Hong, C. Bucci, A. Solodkin, and Z. Hmama Mycobacterium bovis BCG disrupts the interaction of Rab7 with RILP contributing to inhibition of phagosome maturation J. Leukoc. Biol., December 1, 2007; 82(6): 1437 - 1445. [Abstract] [Full Text] [PDF]

				F. B. Sow, W. C. Florence, A. R. Satoskar, L. S. Schlesinger, B. S. Zwilling, and W. P. Lafuse Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis J. Leukoc. Biol., October 1, 2007; 82(4): 934 - 945. [Abstract] [Full Text] [PDF]

				K. K. Huynh and S. Grinstein Regulation of Vacuolar pH and Its Modulation by Some Microbial Species Microbiol. Mol. Biol. Rev., September 1, 2007; 71(3): 452 - 462. [Abstract] [Full Text] [PDF]

				A.-E. Deghmane, H. Soualhine, H. Bach, K. Sendide, S. Itoh, A. Tam, S. Noubir, A. Talal, R. Lo, S. Toyoshima, et al. Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation J. Cell Sci., August 15, 2007; 120(16): 2796 - 2806. [Abstract] [Full Text] [PDF]

				E. P. Williams, J.-H. Lee, W. R. Bishai, C. Colantuoni, and P. C. Karakousis Mycobacterium tuberculosis SigF Regulates Genes Encoding Cell Wall-Associated Proteins and Directly Regulates the Transcriptional Regulatory Gene phoY1 J. Bacteriol., June 1, 2007; 189(11): 4234 - 4242. [Abstract] [Full Text] [PDF]

				L. Pompei, S. Jang, B. Zamlynny, S. Ravikumar, A. McBride, S. P. Hickman, and P. Salgame Disparity in IL-12 Release in Dendritic Cells and Macrophages in Response to Mycobacterium tuberculosis Is Due to Use of Distinct TLRs J. Immunol., April 15, 2007; 178(8): 5192 - 5199. [Abstract] [Full Text] [PDF]

				S. Alonso, K. Pethe, D. G. Russell, and G. E. Purdy Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy PNAS, April 3, 2007; 104(14): 6031 - 6036. [Abstract] [Full Text] [PDF]

				P. Bandyopadhyay, S. Liu, C. B. Gabbai, Z. Venitelli, and H. M. Steinman Environmental Mimics and the Lvh Type IVA Secretion System Contribute to Virulence-Related Phenotypes of Legionella pneumophila Infect. Immun., February 1, 2007; 75(2): 723 - 735. [Abstract] [Full Text] [PDF]

				C. R. Singh, R. A. Moulton, L. Y. Armitige, A. Bidani, M. Snuggs, S. Dhandayuthapani, R. L. Hunter, and C. Jagannath Processing and Presentation of a Mycobacterial Antigen 85B Epitope by Murine Macrophages Is Dependent on the Phagosomal Acquisition of Vacuolar Proton ATPase and In Situ Activation of Cathepsin D. J. Immunol., September 1, 2006; 177(5): 3250 - 3259. [Abstract] [Full Text] [PDF]

				R. Appelberg Macrophage nutriprive antimicrobial mechanisms J. Leukoc. Biol., June 1, 2006; 79(6): 1117 - 1128. [Abstract] [Full Text] [PDF]

				M. Torres, L. Ramachandra, R. E. Rojas, K. Bobadilla, J. Thomas, D. H. Canaday, C. V. Harding, and W. H. Boom Role of Phagosomes and Major Histocompatibility Complex Class II (MHC-II) Compartment in MHC-II Antigen Processing of Mycobacterium tuberculosis in Human Macrophages Infect. Immun., March 1, 2006; 74(3): 1621 - 1630. [Abstract] [Full Text] [PDF]

				M. J. Cayabyab, A.-H. Hovav, T. Hsu, G. R. Krivulka, M. A. Lifton, D. A. Gorgone, G. J. Fennelly, B. F. Haynes, W. R. Jacobs Jr., and N. L. Letvin Generation of CD8+ T-Cell Responses by a Recombinant Nonpathogenic Mycobacterium smegmatis Vaccine Vector Expressing Human Immunodeficiency Virus Type 1 Env J. Virol., February 15, 2006; 80(4): 1645 - 1652. [Abstract] [Full Text] [PDF]

				K. Toyooka, S. Takai, and T. Kirikae Rhodococcus equi can survive a phagolysosomal environment in macrophages by suppressing acidification of the phagolysosome J. Med. Microbiol., November 1, 2005; 54(11): 1007 - 1015. [Abstract] [Full Text] [PDF]

				M. A. Gordon, D. L. Jack, D. H. Dockrell, M. E. Lee, and R. C. Read Gamma Interferon Enhances Internalization and Early Nonoxidative Killing of Salmonella enterica Serovar Typhimurium by Human Macrophages and Modifies Cytokine Responses Infect. Immun., June 1, 2005; 73(6): 3445 - 3452. [Abstract] [Full Text] [PDF]

				J. Hostetter, E. Huffman, K. Byl, and E. Steadham Inducible Nitric Oxide Synthase Immunoreactivity in the Granulomatous Intestinal Lesions of Naturally Occurring Bovine Johne's Disease Vet. Pathol., May 1, 2005; 42(3): 241 - 249. [Abstract] [Full Text] [PDF]

				E. J. Cheadle, D. O'Donnell, P. J. Selby, and A. M. Jackson Closely Related Mycobacterial Strains Demonstrate Contrasting Levels of Efficacy as Antitumor Vaccines and Are Processed for Major Histocompatibility Complex Class I Presentation by Multiple Routes in Dendritic Cells Infect. Immun., February 1, 2005; 73(2): 784 - 794. [Abstract] [Full Text] [PDF]

				L. Ramachandra, J. L. Smialek, S. S. Shank, M. Convery, W. H. Boom, and C. V. Harding Phagosomal Processing of Mycobacterium tuberculosis Antigen 85B Is Modulated Independently of Mycobacterial Viability and Phagosome Maturation Infect. Immun., February 1, 2005; 73(2): 1097 - 1105. [Abstract] [Full Text] [PDF]

				K. Pethe, D. L. Swenson, S. Alonso, J. Anderson, C. Wang, and D. G. Russell Isolation of Mycobacterium tuberculosis mutants defective in the arrest of phagosome maturation PNAS, September 14, 2004; 101(37): 13642 - 13647. [Abstract] [Full Text] [PDF]

				J. M. Blander and R. Medzhitov Regulation of Phagosome Maturation by Signals from Toll-Like Receptors Science, May 14, 2004; 304(5673): 1014 - 1018. [Abstract] [Full Text] [PDF]

				B. H. Miller, R. A. Fratti, J. F. Poschet, G. S. Timmins, S. S. Master, M. Burgos, M. A. Marletta, and V. Deretic Mycobacteria Inhibit Nitric Oxide Synthase Recruitment to Phagosomes during Macrophage Infection Infect. Immun., May 1, 2004; 72(5): 2872 - 2878. [Abstract] [Full Text] [PDF]

				Z. Hmama, K. Sendide, A. Talal, R. Garcia, K. Dobos, and N. E. Reiner Quantitative analysis of phagolysosome fusion in intact cells: inhibition by mycobacterial lipoarabinomannan and rescue by an 1{alpha},25-dihydroxyvitamin D3-phosphoinositide 3-kinase pathway J. Cell Sci., April 15, 2004; 117(10): 2131 - 2140. [Abstract] [Full Text] [PDF]

				H. C. Mwandumba, D. G. Russell, M. H. Nyirenda, J. Anderson, S. A. White, M. E. Molyneux, and S. B. Squire Mycobacterium tuberculosis Resides in Nonacidified Vacuoles in Endocytically Competent Alveolar Macrophages from Patients with Tuberculosis and HIV Infection J. Immunol., April 1, 2004; 172(7): 4592 - 4598. [Abstract] [Full Text] [PDF]

				I. Vergne, R. A. Fratti, P. J. Hill, J. Chua, J. Belisle, and V. Deretic Mycobacterium tuberculosis Phagosome Maturation Arrest: Mycobacterial Phosphatidylinositol Analog Phosphatidylinositol Mannoside Stimulates Early Endosomal Fusion Mol. Biol. Cell, February 1, 2004; 15(2): 751 - 760. [Abstract] [Full Text] [PDF]

				R. A. Fratti, J. Chua, and V. Deretic Induction of p38 Mitogen-activated Protein Kinase Reduces Early Endosome Autoantigen 1 (EEA1) Recruitment to Phagosomal Membranes J. Biol. Chem., November 21, 2003; 278(47): 46961 - 46967. [Abstract] [Full Text] [PDF]

				P.-J. Cardona, S. Gordillo, J. Diaz, G. Tapia, I. Amat, A. Pallares, C. Vilaplana, A. Ariza, and V. Ausina Widespread Bronchogenic Dissemination Makes DBA/2 Mice More Susceptible than C57BL/6 Mice to Experimental Aerosol Infection with Mycobacterium tuberculosis Infect. Immun., October 1, 2003; 71(10): 5845 - 5854. [Abstract] [Full Text] [PDF]

				S. M. Townsend, H. A. Pollack, I. Gonzalez-Gomez, H. Shimada, and J. L. Badger Citrobacter koseri Brain Abscess in the Neonatal Rat: Survival and Replication within Human and Rat Macrophages Infect. Immun., October 1, 2003; 71(10): 5871 - 5880. [Abstract] [Full Text] [PDF]