Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets

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				M. C. Larocca, L. R. Soria, M. V. Espelt, G. L. Lehmann, and R. A. Marinelli Knockdown of hepatocyte aquaporin-8 by RNA interference induces defective bile canalicular water transport Am J Physiol Gastrointest Liver Physiol, January 1, 2009; 296(1): G93 - G100. [Abstract] [Full Text] [PDF]

				S. Sekine, K. Ito, and T. Horie Canalicular Mrp2 localization is reversibly regulated by the intracellular redox status Am J Physiol Gastrointest Liver Physiol, November 1, 2008; 295(5): G1035 - G1041. [Abstract] [Full Text] [PDF]

				D. A. J. Bow, J. L. Perry, D. S. Miller, J. B. Pritchard, and K. L. R. Brouwer Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in Freshly Isolated Rat Hepatocytes Drug Metab. Dispos., January 1, 2008; 36(1): 198 - 202. [Abstract] [Full Text] [PDF]

				Y. Wakabayashi, H. Kipp, and I. M. Arias Transporters on Demand: Intracellular Reservoirs and Cycling of Bile Canalicular ABC Transporters J. Biol. Chem., September 22, 2006; 281(38): 27669 - 27673. [Full Text] [PDF]

				S. Notenboom, A. C. Wouterse, B. Peters, L. H. Kuik, S. Heemskerk, F. G. M. Russel, and R. Masereeuw Increased Apical Insertion of the Multidrug Resistance Protein 2 (MRP2/ABCC2) in Renal Proximal Tubules following Gentamicin Exposure J. Pharmacol. Exp. Ther., September 1, 2006; 318(3): 1194 - 1202. [Abstract] [Full Text] [PDF]

				K. A. Wojtal, E. de Vries, D. Hoekstra, and S. C.D. van IJzendoorn Efficient Trafficking of MDR1/P-Glycoprotein to Apical Canalicular Plasma Membranes in HepG2 Cells Requires PKA-RII{alpha} Anchoring and Glucosylceramide Mol. Biol. Cell, August 1, 2006; 17(8): 3638 - 3650. [Abstract] [Full Text] [PDF]

				H. Herrema, D. Czajkowska, D. Theard, J. M. van der Wouden, D. Kalicharan, B. Zolghadr, D. Hoekstra, and S. C.D. van IJzendoorn Rho Kinase, Myosin-II, and p42/44 MAPK Control Extracellular Matrix-mediated Apical Bile Canalicular Lumen Morphogenesis in HepG2 Cells Mol. Biol. Cell, July 1, 2006; 17(7): 3291 - 3303. [Abstract] [Full Text] [PDF]

				S. Notenboom, D. S. Miller, L. H. Kuik, P. Smits, F. G. M. Russel, and R. Masereeuw Short-Term Exposure of Renal Proximal Tubules to Gentamicin Increases Long-Term Multidrug Resistance Protein 2 (Abcc2) Transport Function and Reduces Nephrotoxicant Sensitivity J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 912 - 920. [Abstract] [Full Text] [PDF]

				P. Chandra, B. M. Johnson, P. Zhang, G. M. Pollack, and K. L. R. Brouwer MODULATION OF HEPATIC CANALICULAR OR BASOLATERAL TRANSPORT PROTEINS ALTERS HEPATOBILIARY DISPOSITION OF A MODEL ORGANIC ANION IN THE ISOLATED PERFUSED RAT LIVER Drug Metab. Dispos., August 1, 2005; 33(8): 1238 - 1243. [Abstract] [Full Text] [PDF]

				P. Tietz, J. Jefferson, R. Pagano, and N. F. LaRusso Membrane microdomains in hepatocytes: potential target areas for proteins involved in canalicular bile secretion J. Lipid Res., July 1, 2005; 46(7): 1426 - 1432. [Abstract] [Full Text] [PDF]

				P. Chandra, P. Zhang, and K. L. R. Brouwer Short-term regulation of multidrug resistance-associated protein 3 in rat and human hepatocytes Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1252 - G1258. [Abstract] [Full Text] [PDF]

				A. D. Mottino, F. A. Crocenzi, E. J. S. Pozzi, L. M. Veggi, M. G. Roma, and M. Vore Role of microtubules in estradiol-17{beta}-D-glucuronide-induced alteration of canalicular Mrp2 localization and activity Am J Physiol Gastrointest Liver Physiol, February 1, 2005; 288(2): G327 - G336. [Abstract] [Full Text] [PDF]

				H. E.U. Meyer zu Schwabedissen, M. Grube, B. Heydrich, K. Linnemann, C. Fusch, H. K. Kroemer, and G. Jedlitschky Expression, Localization, and Function of MRP5 (ABCC5), a Transporter for Cyclic Nucleotides, in Human Placenta and Cultured Human Trophoblasts: Effects of Gestational Age and Cellular Differentiation Am. J. Pathol., January 1, 2005; 166(1): 39 - 48. [Abstract] [Full Text] [PDF]

				S. C.D. van IJzendoorn, J. M. van der Wouden, G. Liebisch, G. Schmitz, and D. Hoekstra Polarized Membrane Traffic and Cell Polarity Development Is Dependent on Dihydroceramide Synthase-Regulated Sphinganine Turnover Mol. Biol. Cell, September 1, 2004; 15(9): 4115 - 4124. [Abstract] [Full Text] [PDF]

				N. Mizuno, T. Niwa, Y. Yotsumoto, and Y. Sugiyama Impact of Drug Transporter Studies on Drug Discovery and Development Pharmacol. Rev., September 1, 2003; 55(3): 425 - 461. [Abstract] [Full Text] [PDF]

				F A Crocenzi, A D Mottino, E J Sanchez Pozzi, J M Pellegrino, E A Rodriguez Garay, P Milkiewicz, M Vore, R Coleman, and M G Roma Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat Gut, August 1, 2003; 52(8): 1170 - 1177. [Abstract] [Full Text] [PDF]

				F. A. Crocenzi, A. D. Mottino, J. Cao, L. M. Veggi, E. J. S. Pozzi, M. Vore, R. Coleman, and M. G. Roma Estradiol-17{beta}-D-glucuronide induces endocytic internalization of Bsep in rats Am J Physiol Gastrointest Liver Physiol, July 7, 2003; 285(2): G449 - G459. [Abstract] [Full Text] [PDF]

				M. Trauner and J. L. Boyer Bile Salt Transporters: Molecular Characterization, Function, and Regulation Physiol Rev, April 1, 2003; 83(2): 633 - 671. [Abstract] [Full Text] [PDF]

				V. Keitel, A. T. Nies, M. Brom, J. Hummel-Eisenbeiss, H. Spring, and D. Keppler A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2) Am J Physiol Gastrointest Liver Physiol, January 1, 2003; 284(1): G165 - G174. [Abstract] [Full Text] [PDF]

				P. M. Gerk and M. Vore Regulation of Expression of the Multidrug Resistance-Associated Protein 2 (MRP2) and Its Role in Drug Disposition J. Pharmacol. Exp. Ther., August 1, 2002; 302(2): 407 - 415. [Abstract] [Full Text] [PDF]

				P Milkiewicz, M G Roma, E Elias, and R Coleman Hepatoprotection with tauroursodeoxycholate and {beta} muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways Gut, July 1, 2002; 51(1): 113 - 119. [Abstract] [Full Text] [PDF]

				R. C. Huebert, P. L. Splinter, F. Garcia, R. A. Marinelli, and N. F. LaRusso Expression and Localization of Aquaporin Water Channels in Rat Hepatocytes. EVIDENCE FOR A ROLE IN CANALICULAR BILE SECRETION J. Biol. Chem., June 14, 2002; 277(25): 22710 - 22717. [Abstract] [Full Text] [PDF]

				J. F. Rebbeor, G. C. Connolly, J. H. Henson, J. L. Boyer, and N. Ballatori ATP-dependent GSH and glutathione S-conjugate transport in skate liver: role of an Mrp functional homologue Am J Physiol Gastrointest Liver Physiol, August 1, 2000; 279(2): G417 - G425. [Abstract] [Full Text] [PDF]

				R. A. M. H. Van Aubel, R. Masereeuw, and F. G. M. Russel Molecular pharmacology of renal organic anion transporters Am J Physiol Renal Physiol, August 1, 2000; 279(2): F216 - F232. [Abstract] [Full Text] [PDF]

				P. J. Meier and B. Stieger Molecular Mechanisms in Bile Formation Physiology, April 1, 2000; 15(2): 89 - 93. [Abstract] [Full Text] [PDF]

				T. Cantz, A. T. Nies, M. Brom, A. F. Hofmann, and D. Keppler MRP2, a human conjugate export pump, is present and transports fluo 3 into apical vacuoles of Hep G2 cells Am J Physiol Gastrointest Liver Physiol, April 1, 2000; 278(4): G522 - G531. [Abstract] [Full Text] [PDF]

				C. J. Soroka, M. K. Pate, and J. L. Boyer Canalicular Export Pumps Traffic with Polymeric Immunoglobulin A Receptor on the Same Microtubule-associated Vesicle in Rat Liver J. Biol. Chem., September 10, 1999; 274(37): 26416 - 26424. [Abstract] [Full Text] [PDF]

				H Roelofsen, G. Hooiveld, H Koning, R Havinga, P. Jansen, and M Muller Glutathione S-conjugate transport in hepatocytes entering the cell cycle is preserved by a switch in expression from the apical MRP2 to the basolateral MRP1 transporting protein J. Cell Sci., January 5, 1999; 112(9): 1395 - 1404. [Abstract] [PDF]

				S. Ryu, T. Kawabe, S. Nada, and A. Yamaguchi Identification of Basic Residues Involved in Drug Export Function of Human Multidrug Resistance-associated Protein 2 J. Biol. Chem., December 8, 2000; 275(50): 39617 - 39624. [Abstract] [Full Text] [PDF]

				F. Garcia, A. Kierbel, M. C. Larocca, S. A. Gradilone, P. Splinter, N. F. LaRusso, and R. A. Marinelli The Water Channel Aquaporin-8 Is Mainly Intracellular in Rat Hepatocytes, and Its Plasma Membrane Insertion Is Stimulated by Cyclic AMP J. Biol. Chem., April 6, 2001; 276(15): 12147 - 12152. [Abstract] [Full Text] [PDF]