The ubiquitin-proteasome system and endocytosis

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Aberle, H., Bauer, A., Stappert, J., Kispert, A. and Kemler, R (1997). -catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16, 3797-3804.[Medline]

Baeuerle, P. A. and Baltimore, D (1996). NF-B: ten years after. Cell 87, 13-20.[Medline]

Cahoreau, C., Garnier, L., Djiane, J., Devauchelle, G. and Cerutti, M (1994). Evidence for N-glycosylation and ubiquitination of the prolactin receptor expressed in a baculovirus-insect cell system. FEBS Lett 350, 230-234.[Medline]

Carbone, R., Fre, S., Iannolo, G., Belleudi, F., Mancini, P., Pelicci, P. G., Torrisi, M. R. and Di Fiore, P. P (1997). Eps15 and Eps15R are essential components of the endocytic pathway. Cancer Res 57, 5498-5504.[Abstract/Free Full Text]

Cenciarelli, C., Hou, D., Hsu, K. C., Rellahan, B. L., Wiest, D. L., Smith, H. T., Fried, V. A. and Weissman, A. M (1992). Activation-induced ubiquitination of the T cell antigen receptor. Science 257, 795-797.[Abstract/Free Full Text]

Chau, V., Tobias, J. W., Bachmair, A., Marriott, D., Ecker, D. J., Gonda, D. K. and Varshavsky, A (1989). A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 243, 1576-1583.[Abstract/Free Full Text]

Chen, W.-J., Goldstein, J. L. and Brown, M. S (1990). NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the LDL receptor. J. Biol. Chem 265, 3116-3123.[Abstract/Free Full Text]

Collawn, J. F., Stangel, M., Kuhn, L. A., Esekogwu, V., Jing, S. Q., Trowbridge, I. S. and Tainer, J. A (1990). Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis. Cell 63, 1061-1072.[Medline]

DeLorey, T. M., Handforth, A., Anagnostaras, S. G., Homanics, G. E., Minassian, B. A., Asatourian, A., Fanselow, M. S., Delgado-Escueta, A., Ellison, G. D. and Olsen, R. W (1998). Mice lacking the3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome. J. Neurosci 18, 8505-8514.[Abstract/Free Full Text]

Dietrich, J., Hou, X. H., Wegener, A. M. K., Pedersen, L. O., Odum, N. and Geisler, C (1996). Molecular characterization of the di-leucine-based internalization motif of the T cell receptor. J. Biol. Chem 271, 11441-11448.[Abstract/Free Full Text]

Dittrich, E., Haft, C. R., Muys, L., Heinrich, P. C. and Graeve, L (1996). A di-leucine motif and an upstream serine in the interleukin-6 (IL-6) signal transducer gp130 mediate ligand-induced endocytosis and down-regulation of the il-6 receptor. J. Biol. Chem 271, 5487-5494.[Abstract/Free Full Text]

Doherty, F. J., Osborn, N. U., Wassell, J. A., Heggie, P. E., Laszlo, L. and Mayer, R. J (1989). Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors. Biochem. J 263, 47-55.[Medline]

Egner, R. and Kuchler, K (1996). The yeast multidrug transporter pdr5 ofthe plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole. FEBS Lett 378, 177-181.[Medline]

Fazioli, F., Minichiello, L., Matoskova, B., Wong, W. T. and Di Fiore, P. P (1993). Eps15, a novel tyrosine kinase substrate, exhibits transforming activity. Mol. Cell. Biol 13, 5814-5828.[Abstract/Free Full Text]

Foti, M., Mangasarian, A., Piguet, V., Lew, D. P., Krause, K. H., Trono, D. and Carpentier, J. L (1997). Nef-mediated clathrin-coated pit formation. J. Cell Biol 139, 37-47.[Abstract/Free Full Text]

Galan, J. M., Volland, C., Urban-Grimal, D. and Haguenauer-Tsapis, R (1994). The yeast plasma membrane uracil permease is stabilized against stress induced degradation by a point mutation in a cyclin-like destruction box. Biochem. Biophys. Res. Commun 201, 769-775.[Medline]

Galan, J. M., Moreau, V. andre, B., Volland, C. and Haguenauer-Tsapis, R (1996). Ubiquitination mediated by the npi1p/rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease. J. Biol. Chem 271, 10946-10952.[Abstract/Free Full Text]

Galan, J. M. and Haguenauer-Tsapis, R (1997). Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J 16, 5847-5854.[Medline]

Galcheva-Gargova, Z., Theroux, S. J. and Davis, R. J (1995). The epidermal growth factor receptor is covalently linked to ubiquitin. Oncogene 11, 2649-2655.[Medline]

Garippa, R. J., Judge, T. W., James, D. E. and McGraw, T. E (1994). The amino terminus of GLUT4 functions as an internalization motif but not an intracellular retention signal when substituted for the transferrin receptor cytoplasmic domain. J. Cell Biol 124, 705-715.[Abstract/Free Full Text]

Garippa, R. J., Johnson, A., Park, J., Petrush, R. L. and McGraw, T. E (1996). The carboxyl terminus of Glut4 contains a serine-leucine-leucine sequence that functions as a potent internalization motif in Chinese hamster ovary cells. J. Biol. Chem 271, 20660-20668.[Abstract/Free Full Text]

Goodman, O. B., Krupnick, J. G., Santini, F., Gurevich, V. V., Penn, R. B., Gagnon, A. W., Keen, J. and Benovic, J. L (1996). -arrestin acts as a clathrin adaptor in endocytosis of the 2-adrenergic receptor. Nature 383, 447-450.[Medline]

Govers, R., van Kerkhof, P., Schwartz, A. L. and Strous, G. J (1997). Linkage of the ubiquitin-conjugating system and the endocytic pathway in ligand-induced internalization of the growth hormone receptor. EMBO J 16, 4851-4858.[Medline]

Govers, R., van Kerkhof, P., Schwartz, A. L. and Strous, G. J (1998). Di-leucine-mediated internalization of ligand by a truncated growth hormone receptor is independent of the ubiquitin conjugation system. J. Biol. Chem 273, 16426-16433.[Abstract/Free Full Text]

Govers, R., ten Broeke, T., van Kerkhof, P., Schwartz, A. L. and Strous, G. J (1999). Identification of a novel conjugation motif, required for ligand-induced internalization of the growth hormone receptor. EMBO J 18, 28-36.[Medline]

Haft, C. R., Sierra, N. D. L., Hamer, I., Carpentier, J. L. and Taylor, I (1998). Analysis of the juxtamembrane dileucine motif in the insulin receptor. Endocrinology 139, 1618-1629.[Abstract/Free Full Text]

Hein, C., Springael, J. Y., Volland, C., Haguenauer-Tsapis, R. and Andre, B (1995). Npi1, an essential yeast gene involved in induced degradation of gap1 and fur4 permeases, encodes the rsp5 ubiquitin-protein ligase. Mol. Microbiol 18, 77-87.[Medline]

Hein, W. R., Dudler, L., Marston, W. L., Landsverk, T., Young, A. J. and Avila, D (1998). Ubiquitination and dimerization of complement receptor type 2 on sheep B cells. J. Immunol 161, 458-466.[Abstract/Free Full Text]

Hershko, A. and Ciechanover, A (1998). The ubiquitin system. Annu. Rev. Biochem 67, 425-479.[Medline]

Hicke, L (1997). Ubiquitin-dependent internalization and down-regulation of plasma membrane proteins. FASEB J 11, 1215-1226.[Abstract]

Hicke, L. and Riezman, H (1996). Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 84, 277-287.[Medline]

Horak, J. and Wolf, D. H (1997). Catabolite inactivation of the galactose transporter in the yeast Saccharomyces cerevisiae: Ubiquitination, endocytosis and degradation in the vacuole. J. Bacteriol 179, 1541-1549.[Abstract/Free Full Text]

Jeffers, M., Taylor, G. A., Weidner, K. M., Omura, S. and Vandewoude, G. F (1997). Degradation of the met tyrosine kinase receptor by the ubiquitin-proteasome pathway. Mol. Cell Biol 17, 799-808.[Abstract]

Klotzbucher, A., Stewart, E., Harrison, D. and Hunt, T (1996). The \324destruction box' of cyclin A allows B-type cyclins to be ubiquitinated, but not efficiently destroyed. EMBO J 15, 3053-3064.[Medline]

K\232lling, R. and Hollenberg, C. P (1994). The ABC-transpporter Ste6accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants. EMBO J 13, 3261-3271.[Medline]

K\232lling, R. and Losko, S (1997). The linker region of this ABC-transporter ste6 mediates ubiquitination and fast turnover of the protein. EMBO J 16, 2251-2261.[Medline]

Laszlo, L., Doherty, F. J., Osborn, N. U. and Mayer, R. J (1990). Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts. FEBS Lett 261, 365-368.[Medline]

Lenk, S. E., Dunn, W. A., Trausch, J. S., Ciechanover, A. and Schwartz, A. L (1992). Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles. J. Cell Biol 118, 301-308.[Abstract/Free Full Text]

Leung, D. W., Spencer, S. A., Cachianes, G., Hammonds, R. G., Collins, C., Henzel, W. J., Barnard, L., Waters, M. J and Wood, W. I (1987). Growth hormone receptor and serum binding protein purification, cloning and expression. Nature 330, 537-544.[Medline]

Lucero, P. and Lagunas, R (1997). Catabolite inactivation of the yeast maltose transporter requires ubiquitin-ligase npi1/rsp5 and ubiquitin-hydrolase npi2/doa4. FEMS Microbiol. Lett 147, 273-277.[Medline]

Marchal, C., Haguenauer-Tsapis, R. and Urbangrimal, D (1998). A PEST-like sequence mediates phosphorylation and efficient ubiquitination of yeast uracil permease. Mol. Cell Biol 18, 314-321.[Abstract/Free Full Text]

Mellman, I (1996). Endocytosis and molecular sorting. Annu. Rev. Cell Dev. Biol 12, 575-625.[Medline]

Mimnaugh, E. G., Chavany, C. and Neckers, L (1996). Polyubiquitination and proteasomal degradation of the p185(c-erbB-2) receptor protein-tyrosine kinase induced by geldanamycin. J. Biol. Chem 271, 22796-22801.[Abstract/Free Full Text]

Miyake, S., Lupher, M. L., Druker, B. and Band, H (1998). The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor. Proc. Nat. Acad. Sci. USA 95, 7927-7932.[Abstract/Free Full Text]

Miyazawa, K., Toyama, K., Gotoh, A., Hendrie, P. C., Mantel, C. and Broxmeyer, H. E (1994). Ligand-dependent polyubiquitination of c-kit gene product: a possible mechanism of receptor down regulation in M107e cells. Blood 83, 137-145.[Abstract/Free Full Text]

Moreau, V., Galan, J. M., Devilliers, G., Haguenauer-Tsapis, R. and Winsor, B (1997). The yeast actin-related protein Arp2p is required for the internalization step of endocytosis. Mol. Biol. Cell 8, 1361-1375.[Abstract]

Mori, S., Heldin, C. H. and Claesson-Welsh, L (1992). Ligand-induced polyubiquitination of the platelet-derived growth factor-receptor. J. Biol. Chem 267, 6429-6434.[Abstract/Free Full Text]

Mori, S., Ronnstrand, L., Claesson-Welsh, L. and Heldin, C. H (1994). A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor-receptor is critical for ligand-mediated endocytosis. J. Biol. Chem 269, 4917-4921.[Abstract/Free Full Text]

Mori, S., Claesson-Welsh, L., Okuyama, Y. and Saito, Y (1995). Ligand-induced polyubiquitination of receptor tyrosine kinases. Biochem. Biophys. Res. Commun 213, 32-39.[Medline]

Mori, S., Tanaka, K., Omura, S. and Saito, Y (1995). Degradation process of ligand-stimulated platelet-derived growth factor-receptor involves ubiquitin-proteasome proteolytic pathway. J. Biol. Chem 270, 29447-29452.[Abstract/Free Full Text]

Murakami, M., Narazaki, M., Hibi, M., Yawata, H., Yasukawa, K., Hamaguchi, M., Taga, T. and Kishimoto, T (1991). Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc. Nat. Acad. Sci. USA 88, 11349-11353.[Abstract/Free Full Text]

Murphy, L. J. and Lazarus, L (1984). The mouse fibroblast growth hormone receptor: ligand processing and receptor modulation and turnover. Endocrinology 115, 1625-1632.[Abstract]

Nicholls, R. D (1998). Strange bedfellows? Protein degradation and neurological dysfunction. Neuron 21, 647-649.[Medline]

Obin, M. S., Jahngenhodge, J., Nowell, T. and Taylor, A (1996). Ubiquitinylation and ubiquitin-dependent proteolysis in vertebrate photoreceptors (rod outer segments) \320 evidence for ubiquitinylation of g(t) and rhodopsin. J. Biol. Chem 271, 14473-14484.[Abstract/Free Full Text]

Owen, D. and Evans, P. R (1998). A structural explanation for the recognition of tyrosine-based endocytotic signals. Science 282, 1327-1332.[Abstract/Free Full Text]

Paolini, R. and Kinet, J. P (1993). Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors. EMBO J 12, 779-786.[Medline]

Piper, R. C., Tai, C., Kulesza, P., Pang, S., Warnock, D., Baenziger, J., Slot, J. W., Geuze, H. J., Puri, C. and James, D. E (1993). GLUT-4 NH2terminus contains a phenylalanine-based targeting motif that regulates intracellular sequestration. J. Cell Biol 121, 1221-1232.[Abstract/Free Full Text]

Pond, L., Kuhn, L. A., Teyton, L., Schutze, M. P., Tainer, J. A., Jackson, M. R. and Peterson, P. A (1995). A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway. J. Biol. Chem 270, 19989-19997.[Abstract/Free Full Text]

Roth, A. F. and Davis, N. G (1996). Ubiquitination of the yeast a-factor receptor. J. Cell Biol 134, 661-674.[Abstract/Free Full Text]

Roth, A. F., Sullivan, D. M. and Davis, N. G (1998). A large PEST-like sequence directs the ubiquitination, endocytosis and vacuolar degradation of the yeast a-factor receptor. J. Cell Biol 142, 949-961.[Abstract/Free Full Text]

Schild, L., Lu, Y., Gautschi, I., Schneeberger, E., Lifton, R. P. and Rossier, B. C (1996). Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J 15, 2381-2387.[Medline]

Schmid, S. L (1997). Clathrin-coated vesicle formation and protein sorting: An integrated process. Annu. Rev. Biochem 66, 511-548.[Medline]

Shimkets, R. A., Lifton, R. P. and Canessa, C. M (1997). The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis. J. Biol.Chem 272, 25537-25541.[Abstract/Free Full Text]

Shin, J., Dunbrack, R. L., Lee, J. S. and Strominger, J. L (1991). Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4. J. Biol. Chem 266, 10658-10665.[Abstract/Free Full Text]

Siegelman, M., Bond, M. W., Gallatin, W. M., St. John, T., Smith, H. T., Fried, V. A. and Weissman, I. L (1986). Cell surface molecule associated with lymphocyte homing is a ubiquitinated branched-chain glycoprotein. Science 231, 823-829.[Abstract/Free Full Text]

Spiess, M (1990). The asialoglycoprotein receptor: a model for endocytic transport receptors. Biochemistry 29, 10009-10018.[Medline]

Staub, O., Dho, S., Henry, P. C., Correa, J., Ishikawa, T., McGlade, J. and Torin, D (1996). WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na channel deleted in Liddle's syndrome. EMBO J 15, 2371-2380.[Medline]

Staub, O., Gautschi, I., Ishikawa, T., Breitschopf, K., Ciechanover, A.,Schild, L. and Rotin, D (1997). Regulation of stability and function of the epithelial Na-channel (ENaC) by ubiquitination. EMBO J 16, 6325-6336.[Medline]

Strous, G. J., van Kerkhof, P., Govers, R., Ciechanover, A. and Schwartz, A. L (1996). The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J 15, 3806-3812.[Medline]

Tanner, J. W., Chen, W., Young, R. L., Longmore, G. D. and Shaw, A. S (1995). The conserved box 1 motif of cytokine receptors is required for association with jak kinases. J. Biol. Chem 270, 6523-6530.[Abstract/Free Full Text]

Terrell, J., Shih, S., Dunn, R. and Hicke, L (1998). A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol. Cell 1, 193-202.

Trowbridge, I. S (1991). Endocytosis and signals for internalization. Curr. Opin. Cell Biol 3, 634-641.[Medline]

van Delft, S., Schumacher, C., Hage, W., Verkleij, A. J. and Henegouwen, P. M (1997). Association and colocalization of eps15 with adaptor protein-2 and clathrin. J. Cell Biol 136, 811-821.[Abstract/Free Full Text]

van Delft, S., Govers, R., Strous, G. J., Verkleij, A. J. and van Bergen en Henegouwen, P. M (1997). Epidermal growth factor induces ubiquitination of Eps15. J. Biol. Chem 272, 14013-14016.[Abstract/Free Full Text]

Wang, Y., Yeung, Y.-G., Langdon, W. Y. and Stanley, E. R (1996). c-Cbl is transiently tyrosine-phosphorylated, ubiquitinated and membrane-targeted following CSF-1 stimulation of macrophages. J. Biol. Chem 271, 17-20.[Abstract/Free Full Text]

Wilks, A. F. and Harpur, A. G (1994). Cytokine signal transduction and the JAK family of protein tyrosine kinases. BioEssays 16, 313-320.[Medline]

Yamada, K., Lipson, K. E. and Donner, D. B (1987). Structure and proteolysis of the growth hormone receptor on rat hepatocytes. Biochemistry 26, 4438-4443.[Medline]

Yarden, Y., Escobedo, J. A., Kuang, W. J., Yang-Fent, T., Daniel, T. O., Tremble, P. M., Chen, E. Y., Ando, M. E., Harkins, R. N., Francke, U., Fried, V. A., Ullrich, A. and Williams, L. T (1986). Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323, 226-231.[Medline]

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Z. Yan, R. Zak, G. W. G. Luxton, T. C. Ritchie, U. Bantel-Schaal, and J. F. Engelhardt
Ubiquitination of both Adeno-Associated Virus Type 2 and 5 Capsid Proteins Affects the Transduction Efficiency of Recombinant Vectors
J. Virol., March 1, 2002; 76(5): 2043 - 2053.
[Abstract] [Full Text] [PDF]

S. F. Hamm-Alvarez
Focus on "EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain"
Am J Physiol Cell Physiol, March 1, 2002; 282(3): C417 - C419.
[Full Text] [PDF]

D. G. Demirov, J. M. Orenstein, and E. O. Freed
The Late Domain of Human Immunodeficiency Virus Type 1 p6 Promotes Virus Release in a Cell Type-Dependent Manner
J. Virol., January 1, 2002; 76(1): 105 - 117.
[Abstract] [Full Text] [PDF]

M. E. Cavet, S. Akhter, R. Murtazina, F. Sanchez de Medina, C.-M. Tse, and M. Donowitz
Half-lives of plasma membrane Na+/H+ exchangers NHE1-3: plasma membrane NHE2 has a rapid rate of degradation
Am J Physiol Cell Physiol, December 1, 2001; 281(6): C2039 - C2048.
[Abstract] [Full Text] [PDF]

G. J. Strous and J. A. Schantl
{beta}-Arrestin and Mdm2, Unsuspected Partners in Signaling from the Cell Surface
Sci. Signal., November 27, 2001; 2001(110): pe41 - pe41.
[Abstract] [Full Text] [PDF]

C. Buttner, S. Sadtler, A. Leyendecker, B. Laube, N. Griffon, H. Betz, and G. Schmalzing
Ubiquitination Precedes Internalization and Proteolytic Cleavage of Plasma Membrane-bound Glycine Receptors
J. Biol. Chem., November 9, 2001; 276(46): 42978 - 42985.
[Abstract] [Full Text] [PDF]

P. J. Skinner, C. A. Vierra-Green, H. B. Clark, H. Y. Zoghbi, and H. T. Orr
Altered Trafficking of Membrane Proteins in Purkinje Cells of SCA1 Transgenic Mice
Am. J. Pathol., September 1, 2001; 159(3): 905 - 913.
[Abstract] [Full Text] [PDF]

R. Paolini, R. Molfetta, M. Piccoli, L. Frati, and A. Santoni
Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement
PNAS, August 1, 2001; (2001) 161298098.
[Abstract] [Full Text] [PDF]

P. van Kerkhof, C. M. A. dos Santos, M. Sachse, J. Klumperman, G. Bu, and G. J. Strous
Proteasome Inhibitors Block a Late Step in Lysosomal Transport of Selected Membrane but not Soluble Proteins
Mol. Biol. Cell, August 1, 2001; 12(8): 2556 - 2566.
[Abstract] [Full Text] [PDF]

S. Dupre and R. Haguenauer-Tsapis
Deubiquitination Step in the Endocytic Pathway of Yeast Plasma Membrane Proteins: Crucial Role of Doa4p Ubiquitin Isopeptidase
Mol. Cell. Biol., July 15, 2001; 21(14): 4482 - 4494.
[Abstract] [Full Text] [PDF]

M. Benharouga, M. Haardt, N. Kartner, and G. L. Lukacs
COOH-terminal Truncations Promote Proteasome-dependent Degradation of Mature Cystic Fibrosis Transmembrane Conductance Regulator from Post-Golgi Compartments
J. Cell Biol., May 21, 2001; 153(5): 957 - 970.
[Abstract] [Full Text] [PDF]

A. Rocca, C. Lamaze, A. Subtil, and A. Dautry-Varsat
Involvement of the Ubiquitin/Proteasome System in Sorting of the Interleukin 2 Receptor {beta} Chain to Late Endocytic Compartments
Mol. Biol. Cell, May 1, 2001; 12(5): 1293 - 1301.
[Abstract] [Full Text]

R. Dunn and L. Hicke
Domains of the Rsp5 Ubiquitin-Protein Ligase Required for Receptor-mediated and Fluid-Phase Endocytosis
Mol. Biol. Cell, February 1, 2001; 12(2): 421 - 435.
[Abstract] [Full Text]

M. Sachse, P. van Kerkhof, G. J. Strous, and J. Klumperman
The ubiquitin-dependent endocytosis motif is required for efficient incorporation of growth hormone receptor in clathrin-coated pits, but not clathrin-coated lattices
J. Cell Sci., January 11, 2001; 114(21): 3943 - 3952.
[Abstract] [Full Text] [PDF]

P Sutovsky, R Moreno, J Ramalho-Santos, T Dominko, W. Thompson, and G Schatten
A putative, ubiquitin-dependent mechanism for the recognition and elimination of defective spermatozoa in the mammalian epididymis
J. Cell Sci., January 5, 2001; 114(9): 1665 - 1675.
[Abstract] [PDF]

X. Chen and J. A. Fischer
In Vivo Structure/Function Analysis of the Drosophila fat facets Deubiquitinating Enzyme Gene
Genetics, December 1, 2000; 156(4): 1829 - 1836.
[Abstract] [Full Text]

C.-H. Yen, Y.-C. Yang, S. K. Ruscetti, R. A. Kirken, R. M. Dai, and C.-C. H. Li
Involvement of the Ubiquitin-Proteasome Pathway in the Degradation of Nontyrosine Kinase-Type Cytokine Receptors of IL-9, IL-2, and Erythropoietin
J. Immunol., December 1, 2000; 165(11): 6372 - 6380.
[Abstract] [Full Text] [PDF]

B. Strack, A. Calistri, M. A. Accola, G. Palu, and H. G. Gottlinger
A role for ubiquitin ligase recruitment in retrovirus release
PNAS, November 21, 2000; 97(24): 13063 - 13068.
[Abstract] [Full Text] [PDF]

P. Sutovsky, R. D. Moreno, J. Ramalho-Santos, T. Dominko, C. Simerly, and G. Schatten
Ubiquitinated Sperm Mitochondria, Selective Proteolysis, and the Regulation of Mitochondrial Inheritance in Mammalian Embryos
Biol Reprod, August 1, 2000; 63(2): 582 - 590.
[Abstract] [Full Text]

				P. Sutovsky, W. Plummer, K. Baska, K. Peterman, J. R. Diehl, and M. Sutovsky Relative Levels of Semen Platelet Activating Factor-Receptor (PAFr) and Ubiquitin in Yearling Bulls With High Content of Semen White Blood Cells: Implications for Breeding Soundness Evaluation J Androl, January 1, 2007; 28(1): 92 - 108. [Abstract] [Full Text] [PDF]

				M. D. Lopez-Avalos, V. F. Duvivier-Kali, G. Xu, S. Bonner-Weir, A. Sharma, and G. C. Weir Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. Diabetes, May 1, 2006; 55(5): 1223 - 1231. [Abstract] [Full Text] [PDF]

				R. Molfetta, F. Belleudi, G. Peruzzi, S. Morrone, L. Leone, I. Dikic, M. Piccoli, L. Frati, M. R. Torrisi, A. Santoni, et al. CIN85 Regulates the Ligand-Dependent Endocytosis of the IgE Receptor: A New Molecular Mechanism to Dampen Mast Cell Function J. Immunol., October 1, 2005; 175(7): 4208 - 4216. [Abstract] [Full Text] [PDF]

				J. Kwon, K. Mochida, Y.-L. Wang, S. Sekiguchi, T. Sankai, S. Aoki, A. Ogura, Y. Yoshikawa, and K. Wada Ubiquitin C-Terminal Hydrolase L-1 Is Essential for the Early Apoptotic Wave of Germinal Cells and for Sperm Quality Control During Spermatogenesis Biol Reprod, July 1, 2005; 73(1): 29 - 35. [Abstract] [Full Text] [PDF]

				J.-L. Hao, K. Suzuki, Y. Lu, S. Hirano, K. Fukuda, N. Kumagai, K. Kimura, and T. Nishida Inhibition of Gap Junction-Mediated Intercellular Communication by TNF-{alpha} in Cultured Human Corneal Fibroblasts Invest. Ophthalmol. Vis. Sci., April 1, 2005; 46(4): 1195 - 1200. [Abstract] [Full Text] [PDF]

				G.-Y. Yu and M. M. C. Lai The Ubiquitin-Proteasome System Facilitates the Transfer of Murine Coronavirus from Endosome to Cytoplasm during Virus Entry J. Virol., January 1, 2005; 79(1): 644 - 648. [Abstract] [Full Text] [PDF]

				G. A. Parker and C. A. Picut Liver Immunobiology Toxicol Pathol, January 1, 2005; 33(1): 52 - 62. [Abstract] [Full Text] [PDF]

				E. Leithe and E. Rivedal Ubiquitination and Down-regulation of Gap Junction Protein Connexin-43 in Response to 12-O-Tetradecanoylphorbol 13-Acetate Treatment J. Biol. Chem., November 26, 2004; 279(48): 50089 - 50096. [Abstract] [Full Text] [PDF]

				B. Q. Vuong, T. L. Arenzana, B. M. Showalter, J. Losman, X. P. Chen, J. Mostecki, A. S. Banks, A. Limnander, N. Fernandez, and P. B. Rothman SOCS-1 Localizes to the Microtubule Organizing Complex-Associated 20S Proteasome Mol. Cell. Biol., October 15, 2004; 24(20): 9092 - 9101. [Abstract] [Full Text] [PDF]

				Y. Li, W. Lu, A. L. Schwartz, and G. Bu Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway J. Lipid Res., June 1, 2004; 45(6): 1084 - 1091. [Abstract] [Full Text] [PDF]

				J. N. Hislop, A. Marley, and M. von Zastrow Role of Mammalian Vacuolar Protein-sorting Proteins in Endocytic Trafficking of a Non-ubiquitinated G Protein-coupled Receptor to Lysosomes J. Biol. Chem., May 21, 2004; 279(21): 22522 - 22531. [Abstract] [Full Text] [PDF]

				E. Leithe and E. Rivedal Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43 J. Cell Sci., March 1, 2004; 117(7): 1211 - 1220. [Abstract] [Full Text] [PDF]

				S. Polo, S. Confalonieri, A. E. Salcini, and P. P. Di Fiore EH and UIM: Endocytosis and More Sci. Signal., December 16, 2003; 2003(213): re17 - re17. [Abstract] [Full Text] [PDF]

				B. D. Cohen, J. T. Bariteau, L. M. Magenis, and J. A. Dias Regulation of Follitropin Receptor Cell Surface Residency by the Ubiquitin-Proteasome Pathway Endocrinology, October 1, 2003; 144(10): 4393 - 4402. [Abstract] [Full Text] [PDF]

				P. Sutovsky, T. C. McCauley, M. Sutovsky, and B. N. Day Early Degradation of Paternal Mitochondria in Domestic Pig (Sus scrofa) Is Prevented by Selective Proteasomal Inhibitors Lactacystin and MG132 Biol Reprod, May 1, 2003; 68(5): 1793 - 1800. [Abstract] [Full Text] [PDF]

				A. Lyakhovich and M. P. V. Shekhar Supramolecular Complex Formation between Rad6 and Proteins of the p53 Pathway during DNA Damage-Induced Response Mol. Cell. Biol., April 1, 2003; 23(7): 2463 - 2475. [Abstract] [Full Text] [PDF]

				C. V. Clevenger, P. A. Furth, S. E. Hankinson, and L. A. Schuler The Role of Prolactin in Mammary Carcinoma Endocr. Rev., February 1, 2003; 24(1): 1 - 27. [Abstract] [Full Text] [PDF]

				J. C. Badciong and A. L. Haas MdmX Is a RING Finger Ubiquitin Ligase Capable of Synergistically Enhancing Mdm2 Ubiquitination J. Biol. Chem., December 13, 2002; 277(51): 49668 - 49675. [Abstract] [Full Text] [PDF]

				J.-C. Lu, P. Scott, G. J. Strous, and L. A. Schuler Multiple Internalization Motifs Differentially Used by Prolactin Receptor Isoforms Mediate Similar Endocytic Pathways Mol. Endocrinol., November 1, 2002; 16(11): 2515 - 2527. [Abstract] [Full Text] [PDF]

				S. C. Bunnell, D. I. Hong, J. R. Kardon, T. Yamazaki, C. J. McGlade, V. A. Barr, and L. E. Samelson T cell receptor ligation induces the formation of dynamically regulated signaling assemblies J. Cell Biol., September 29, 2002; 158(7): 1263 - 1275. [Abstract] [Full Text] [PDF]

				L. Melman, H. J. Geuze, Y. Li, L. M. McCormick, P. van Kerkhof, G. J. Strous, A. L. Schwartz, and G. Bu Proteasome Regulates the Delivery of LDL Receptor-related Protein into the Degradation Pathway Mol. Biol. Cell, September 1, 2002; 13(9): 3325 - 3335. [Abstract] [Full Text] [PDF]

				J. Gent, P. van Kerkhof, M. Roza, G. Bu, and G. J. Strous Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis PNAS, July 23, 2002; 99(15): 9858 - 9863. [Abstract] [Full Text] [PDF]

				P. van Kerkhof, M. Smeets, and G. J. Strous The Ubiquitin-Proteasome Pathway Regulates the Availability of the GH Receptor Endocrinology, April 1, 2002; 143(4): 1243 - 1252. [Abstract] [Full Text] [PDF]

				M. H. Glickman and A. Ciechanover The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction Physiol Rev, April 1, 2002; 82(2): 373 - 428. [Abstract] [Full Text] [PDF]

				C. A. Worby, N. Simonson-Leff, J. C. Clemens, D. Huddler Jr., M. Muda, and J. E. Dixon Drosophila Ack Targets Its Substrate, the Sorting Nexin DSH3PX1, to a Protein Complex Involved in Axonal Guidance J. Biol. Chem., March 8, 2002; 277(11): 9422 - 9428. [Abstract] [Full Text] [PDF]

				K. E. Longva, F. D. Blystad, E. Stang, A. M. Larsen, L. E. Johannessen, and I. H. Madshus Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies J. Cell Biol., March 4, 2002; 156(5): 843 - 854. [Abstract] [Full Text] [PDF]

				Z. Yan, R. Zak, G. W. G. Luxton, T. C. Ritchie, U. Bantel-Schaal, and J. F. Engelhardt Ubiquitination of both Adeno-Associated Virus Type 2 and 5 Capsid Proteins Affects the Transduction Efficiency of Recombinant Vectors J. Virol., March 1, 2002; 76(5): 2043 - 2053. [Abstract] [Full Text] [PDF]

				S. F. Hamm-Alvarez Focus on "EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain" Am J Physiol Cell Physiol, March 1, 2002; 282(3): C417 - C419. [Full Text] [PDF]

				D. G. Demirov, J. M. Orenstein, and E. O. Freed The Late Domain of Human Immunodeficiency Virus Type 1 p6 Promotes Virus Release in a Cell Type-Dependent Manner J. Virol., January 1, 2002; 76(1): 105 - 117. [Abstract] [Full Text] [PDF]

				M. E. Cavet, S. Akhter, R. Murtazina, F. Sanchez de Medina, C.-M. Tse, and M. Donowitz Half-lives of plasma membrane Na+/H+ exchangers NHE1-3: plasma membrane NHE2 has a rapid rate of degradation Am J Physiol Cell Physiol, December 1, 2001; 281(6): C2039 - C2048. [Abstract] [Full Text] [PDF]