Homophilic PECAM-1(CD31) interactions prevent endothelial cell apoptosis but do not support cell spreading or migration

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Almendro, N., Bellon, T., Ruis, C., Lastres, P., Langa, C., Corbi, A. and Bernabeu, C (1996). Cloning of the human platelet endothelial cell adhesion molecule-1 promoter and its tissue specific expression. J. Immunol 157, 5411-5421.[Abstract]

Bird, I. N., Spragg, J. H., Ager, A. and Matthews, N (1993). Studies of lymphocyte transendothelial migration: analysis of migrated cell phenotypes with regard to CD31 (PECAM-1), CD45RA and CD45RO. Immunology 80, 553-560.[Medline]

Bischoff, J (1997). Cell adhesion and angiogenesis. J. Clin. Invest 99, 373-376.[Medline]

Brooks, P. C., Clark, R. A. F. and Cheresh, D. A (1994). Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science 264, 569-571.[Abstract/Free Full Text]

Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G. and Cheresh, D. A (1994). Integrinv 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.[Medline]

Buckley, C. D., Doyonnas, R., Newton, J. P., Blystone, S. D., Brown, E. J., Watt. S. M. and Simmons, D. L (1996). Identification ofv 3 as a heterotypic ligand for CD31/PECAM-1. J. Cell Sci 109, 437-445.[Abstract]

Bussolino, F., Mantovani, A. and Persico, G (1997). Molecular mechanisms of blood vessel formation. Trends Biochem. Sci 22, 251-256.[Medline]

Cao, M. Y., Huber, M., Beauchemin, N., Famiglietti, J., Albelda, S. M. and Veillette, A (1998). Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases. J. Biol. Chem 273, 15765-15772.[Abstract/Free Full Text]

Chen, W., Knapp, W., Majdic, O., Stockinger, H., Bohmig, G. A. and Zlabinger, G. J (1994). Co-ligation of CD31 and FcRII induces cytokine production in human monocytes. J. Immunol 152, 3991-3997.[Abstract]

DeLisser, H. M., Yan, C. Y., Newman, P. J., Muller, W. A., Buck, C. A. and Albelda, S. M (1993). PECAM-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. J. Biol. Chem 268, 16037-16046.[Abstract/Free Full Text]

Drake, C. J., Cheresh, D. A. and Little, C. D (1995). An antagonist of integrin alpha v beta 3 prevents maturation of blood vessels during embryonic neovascularization. J. Cell Sci 108, 2655-2661.[Abstract]

Famiglietti, J., Sun, J., DeLisser, H. M. and Albelda, S. M (1997). Tyrosine residue in exon 14 of the cytoplasmic domain of platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) regulates ligand binding specificity. J. Cell Biol 138, 1425-1435.[Abstract/Free Full Text]

Fawcett, J., Buckley, C. D., Holness, C. L., Bird, I. N., Spragg, J. H., Saunders, J., Harris, A. and Simmons, D. L (1995). Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts. J. Cell Biol 128, 1229-1241.[Abstract/Free Full Text]

Frielander, M., Theesfeld, C. L., Sugita, M., Fruttiger, M., Thomas, M. A., Chang, S. and Cheresh, D. A (1996). Involvement of integrins alpha(v)beta(3) and alpha(v)beta(3) in ocular neovascular disease. Proc. Nat. Acad. Sci. USA 93, 9764-9769.[Abstract/Free Full Text]

Goldberger, A., Middleton, K. A., Oliver, J. A., Paddock, C., Yan, H-C., Delisser, H. M., Albelda, S. M. and Newman, P. J (1994). Biosynthesis and processing of the cell adhesion molecule PECAM-1 includes production of a soluble form. J. Biol. Chem 269, 17183-17191.[Abstract/Free Full Text]

Horenstein, A. L., Stockinger, H., Imhof, B. A. and Malavasi, F (1998). CD38 binding to human myeloid cells is mediated by mouse and human CD31. Biochem. J 330, 1129-1135.

Imhof, B. A., Weerasinghe, D., Brown, E. J., Lindberg, F. P., Hammel, P., Piali, L., Dessing, M. and Gisler, R (1998). Cross talk betweenv 3 and4 1 integrins regulates lymphocyte migration on vascular cell adhesion molecule 1. Eur. J. Immunol 27, 3242-3252.

Jackson, D. E,, Ward, C. M., Wang, R. and Newman, P. J (1997). The protein-tyrosine phosphatase SHP-2 binds platelet/endothelial cell adhesion molecule-1 (PECAM-1) and forms a distinct signaling complex during platelet aggregation. J. Biol. Chem 272, 6986-6993.[Abstract/Free Full Text]

Jackson, D. E., Kupcho, K. R. and Newman, P. J (1997). Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation for the protein-tyrosine phosphatase, SHP-2. J. Biol. Chem 272, 24868-24875.[Abstract/Free Full Text]

Kim, C. S., Wang, T. and Madri J. A (1998). Platelet endothelial cell adhesion molecule-1 expression modulates endothelial cell migration in vivo. Lab Invest 78, 583-590.[Medline]

Kirschbaum, N. E., Gumina, R. J. and Newman, P. J (1994). Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain. Blood 84, 4028-4037.[Abstract/Free Full Text]

Korff, T. and Augustin, H. G (1998). Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J. Cell Biol 143, 1341-1352.[Abstract/Free Full Text]

Lampugnani, M. G., Resnati, M., Dejana, E. and Marchisio, P. C (1991). The role of integrins in the maintenance of endothelial monolayer integrity. J. Cell Biol 112, 479-490.[Abstract/Free Full Text]

Lampugnani, M. G., Corada, M., Caveda, L., Breviario, F., Ayalon, O., Geiger, B. and Dejana, E (1995). The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J. Cell Biol 129, 203-217.[Abstract/Free Full Text]

Leavesley, D. I., Schwartz, M. A., Rosenfeld, M. and Cheresh, D. A (1993). Integrin1-and 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. J. Cell Biol 121, 163-170.[Abstract/Free Full Text]

Litwin, M., Clark, K,. Noack, L., Furze, J., Berndt, M., Albelda, S. M., Vadas, M. and Gamble, J (1997). Novel cytokine-independent induction of endothelial cell adhesion molecules regulated by platelet/endothelial cell adhesion molecule (CD31). J. Cell Biol 139, 219-228.[Abstract/Free Full Text]

Lu, T. T., Yan, L. G. and Madri, J. A (1996). Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. Proc. Nat. Acad. Sci. USA 93, 11808-11813.[Abstract/Free Full Text]

Lu, T. T., Barreuther, M., Davies, S. and Madri, J. A (1997). Platelet endothelial cell adhesion molecule-1 is phosphorylatable by c-Src, binds src-src homology 2 domain, and exhibits immunoreceptor tyrosine-based activation motif-like properties. J. Biol. Chem 272, 14442-14446.[Abstract/Free Full Text]

Masuda, M., Osawa, M., Shigematsu, H., Harada, N. and Fujiwara, K (1997). Platelet endothelial cell adhesion molecule-1 is a major SH-PTP-2 binding protein in vascular endothelial cells. FEBS Lett 408, 331-336.[Medline]

Meredith, J. E., Fazeli, B. and Schwartz, M. A (1993). The extracellular matrix as a survival factor. Mol. Biol Cell 4, 953-961.[Abstract]

Muller, W. A., Berman, M. E., Newman, P. J., DeLisser, H. M. and Albelda, S. M (1992). A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31). J. Exp. Med 175, 1401-1404.[Abstract/Free Full Text]

Mutin, M., Dignat-George, F. and Sampol, J (1997). Immunologic phenotype of culture endothelial cells: quantitative analysis of cell surface molecules. Tissue Antigens 50, 449-458.[Medline]

Newman, P. J., Berndt, M. C., Gorski, J., White, G. C., Lyman, S., Paddock, C. and Muller, W. A (1990). PECAM-1(CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science 247, 1219-1222.[Abstract/Free Full Text]

Newman, P. J (1997). Cell adhesion in vascular biology. The biology of PECAM-1. J. Clin. Invest 99, 3-8.[Medline]

Newman, P. J (1999). Switched at birth: a new family for PECAM-1. J. Clin. Invest 103, 5-9.[Medline]

Newton, J. P., Buckley, C. D., Jones, E. Y. and Simmons, D. L (1997). Residues on both faces of the first immunoglobulin fold contribute to homophilic bindings sites of PECAM-1/CD31. J. Biol. Chem 272, 20555-20563.[Abstract/Free Full Text]

Osawa, M., Masuda, M., Harada, N., Lopes, R. B. and Fujiwara, K (1997). Tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1(PECAM-1, CD31) in mechanically stimulated vascular endothelial cells. Eur. J. Cell Biol 72, 229-237.[Medline]

Piali, L., Albelda, S. M., Baldwin, H. S., Hammel, P., Gisler, R. H. and Imhof, B. A (1993). Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates2 integrins on lymphokine-activated killer cells. Eur. J. Immunol 23, 2464-2471.[Medline]

Piali, L., Hammel, P., Uherek, C., Bachmann, F., Gisler, R. H., Dunon, D. and Imhof, B. A (1995). CD31/PECAM-1 is a ligand forv 3 integrin involved in adhesion of leukocytes to endothelium. J. Cell Biol 130, 451-460.[Abstract/Free Full Text]

Poggi, A., Panzeri, M. C., Moretta, L. and Zocchi, M. R (1996). CD31-triggered rearrangement of the actin cytoskeleton in human natural killer cells. Eur. J. Immunol 26, 817-824.[Medline]

Prager, E., Sunder-Plassmann, R., Koch, C., Holter, W., Knapp, W. and Stockinger, H (1996). Interaction of CD31 with a heterophilic counterreceptor involved in downregulation of human T cell responses. J. Exp. Med 184, 41-50.[Abstract/Free Full Text]

Re, F., Zanetti, A., Sironi, M., Polentarutti, N., Lanfrancone, L., Dejana, E. and Colotta, F (1994). Inhibition of anchorage dependent cell spreading triggers apoptosis in cultured endothelial cells. J. Cell Biol 127, 537-546.[Abstract/Free Full Text]

Risau, W (1997). Mechanisms of angiogenesis. Nature 386, 671-674.[Medline]

Romer, L. H., McLean, N. V., Yan, H. C., Daise, M., Sun, J. and DeLisser, H. M (1995). IFNand TNF induce redistribution of PECAM-1 (CD31) on human endothelial cells. J. Immunol 154, 6582-6592.[Abstract]

Sagawa, K., Swain, W., Zhang, J., Unsworth, E. and Siraganian, R. P (1997). Aggregation of the high affinity IgE receptor results in the tyrosine phosphorylation of the surface adhesion protein PECAM-1 (CD31). J. Biol. Chem 272, 13412-13418.[Abstract/Free Full Text]

Sagawa, K., Kimura, T., Swieter, M. and Siraganian, R. P (1997). Theprotein-tyrosine phosphatase SHP-2 associates with tyrosine-phosphorylated adhesion molecule PECAM-1 (CD31). J. Biol. Chem 272, 31086-31091.[Abstract/Free Full Text]

Scatena, M., Almeida, M., Chaisson, M. L., Fausto, N., Nicosia, R. F. and Giachelli, C. M (1998). NF-B mediates v3 integrin-induced endothelial cell survival. J. Cell Biol 141, 1083-1093.[Abstract/Free Full Text]

Shattil, S. J. and Ginsberg, M. H (1997). Integrin signaling in vascular biology. J. Clin. Invest 100, 1-5.[Medline]

Sheibani, N., Newman, P. J. and Frazier, W. A (1997). Thrombospondin-1, a natural inhibitor of angiogenesis regulates platelet-endothelial cell adhesion molecule-1 expression and endothelial cell morphogenesis. Mol. Biol. Cell 8, 1329-1341.[Abstract]

Simmons, D. L., Walker, C., Power, C. and Pigott, R (1990). Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen. J. Exp. Med 171, 2147-2152.[Abstract/Free Full Text]

Stromblad, S., Becker, J. C., Yebra, M., Brooks, P. C. and Cheresh, D. A (1996). Supression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphavbeta3 during angiogenesis. J. Clin. Invest 98, 426-433.[Medline]

Sun, J., Williams, J., Yan, H.-C., Amin K. M., Albelda, S. M. and DeLisser, H. M (1996). Platelet endothelial cell adhesion molecule-1 (PECAM-1) is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic tail and the level of surface expression. J. Biol. Chem 271, 18561-18570.[Abstract/Free Full Text]

Sun, Q. H., DeLisser, H. M., Zukowski, M. M., Paddock, C., Albelda, S. M. and Newman, P. J (1996). Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity. J. Biol. Chem 271, 11090-11098.[Abstract/Free Full Text]

Tanaka, Y., Albelda, S. M., Horgan, K. J., van Seventer, G. A., Shimuzu, Y., Newman, P. J., Buck, C. A. and Shaw, S (1992). CD31 expressed on distinctive T Cell subsets is a preferential amplifier of1 integrin-mediated adhesion. J. Exp. Med 176, 245-253.[Abstract/Free Full Text]

Varon, D., Jackson, D. E., Shenkman, B., Dardik, R., Tamarin, I. Savion, N. and Newman, P. J (1998). Platelet/endothelial cell adhesion molecule-1 serves as a costimulatory agonist receptor that modulates integrin-dependent adhesion and aggregation of human platelets. Blood 91, 500-507.[Abstract/Free Full Text]

Yang, C., Chang, J., Gorospe, M. and Passaniti, A (1996). Protein tyrosine phosphatase regulation of endothelial cell apoptosis and differentiation. Cell Growth Differ 7, 161-171.[Abstract]

Zehnder, J. L., Hirai, K., Shatsky, M., McGregor, J. L., Levitt, L. J. and Leung, L. L. K (1992). The cell adhesion molecule CD31 is phosphorylated after cell activation. J. Biol. Chem 267, 5243-5249.[Abstract/Free Full Text]

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				G. Cao, C. D. O'Brien, Z. Zhou, S. M. Sanders, J. N. Greenbaum, A. Makrigiannakis, and H. M. DeLisser Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration Am J Physiol Cell Physiol, May 1, 2002; 282(5): C1181 - C1190. [Abstract] [Full Text] [PDF]