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Ashikari, S., Habuchi, H. and Kimata, K (1995). Characterisation of heparan sulphate oligosaccharides that bind to hepatocyte growth factor. J. Biol. Chem 49, 29586-29593.

Bardelli, A., Maina, F., Gout, I., Fry, M. J., Waterfield, M. D., Comoglio, P. M. and Ponzetto, C (1992). Autophosphorylation promotes complex formation of recombinant hepatocyte growth factor receptor with cytoplasmic effectors containing SH2 domains. Oncogene 7, 1973-1978.[Medline]

Baeuerle, P. A. and Huttner, W. B (1986). Chlorate- a potent inhibitor of protein sulphation in intact cells. Biochem. Biophys. Res. Commun 141, 870-877.[Medline]

Chirgadze, D. Y., Hepple, J., Byrd, R. A., Sowdhamini, R., Blundell, T. L. and Gherardi, E (1998). Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation. FEBS Lett 430, 126-129.[Medline]

Davies, J., Lyon, M., Gallagher, J. T. and Garrod, D (1995). Sulphated proteoglycan is required for collecting duct growth and branching but not nephron formation during kidney development. Development 121, 1507-1517.[Abstract]

Farley, J. R., Nakayama, G., Cryns, D. and Sagel, I. H (1978). Adenosine triphosphate sulphurylase from Penicillium chrysogencium : equilibrium binding, substrate hydrolysis and isotope exchange studies. Arch. Biochem. Biophys 185, 376-390.[Medline]

Fournier, T. M., Kamikura, D., Teng, K. and Park, M (1996). Branching tubulogenesis but not scatter of Madin-Darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase. J. Biol. Chem 271, 22211-22217.[Abstract/Free Full Text]

Gallagher, J. T (1998). The interaction and regulation of basic and acidic fibroblast growth factors by heparan sulphate. Trends Genet 10, 137-144.

Hardingham, T. E (1979). The role of link protein in the structure of cartilage proteoglycan aggregates. Biochem. J 177, 237-247.[Medline]

Hartmann, G., Naldini, L., Weidner, K. M., Sachs, M., Vigna, E., Comoglio, P. M. and Birchmeier, W (1992). A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc. Natl. Acad. Sci. USA 89, 11574-11578.[Abstract/Free Full Text]

Jeffers, M., Rong, S. and Vande Woude, G. F (1996). Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis. J. Mol. Med 74, 505-513.[Medline]

Khwaja, A., Lehmann, K., Marte, B. M. and Downward, J (1998). Phosphoinositide 3-kinase induces scattering and tubulogenesis in epithelial cells through a novel pathway. J. Biol. Chem 30, 18793-18801.

Kinosaki, M., Yamaguchi, K., Murakami, A., Ueda, M., Morinaga, T. and Higashio, K (1998). Identification of heparin-binding stretches of a naturally occurring deleted variant of hepatocyte growth factor (dHGF). Biochim. Biophys. Acta 1384, 93-102.[Medline]

Lokker, N. A., Mark, M. R., Luis, E. A., Bennett, G. L., Robbins, K. A., Baker, J. B. and Godowski, P. J. ( (1992). Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding. EMBO J 11, 2503-2510.[Medline]

Lokker, N. A., Presta, L. G. and Godowski, P. J (1994). Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Met receptor. Protein Engineering 7, 895-903.[Abstract/Free Full Text]

Lyon, M. and Gallagher, J. T (1991). Purification and partial characterization of the major cell-associated heparan sulphate proteoglycan of rat liver. Biochem. J 273, 415-422.

Lyon, M., Deakin, J. A., Mizuno, K., Nakamura, T. and Gallagher, J. T (1994). Interaction of hepatocyte growth factor with heparan sulphate. J. Biol. Chem 269, 11216-11223.[Abstract/Free Full Text]

Lyon, M., Deakin, J. A. and Gallagher, J. T (1994). Liver heparan sulphate structure: a novel molecular design. J. Biol. Chem 269, 11208-11215.[Abstract/Free Full Text]

Lyon, M., Deakin, J. A., Rahmoune, H., Fernig, D. G. and Gallagher, J. T.( (1998). Hepatocyte growth factor/scatter factor binds with high affinity to dermatan sulphate. J. Biol. Chem 273, 271-278.[Abstract/Free Full Text]

Mark, M. R., Lokker, N. A., Zioncheck, T. F., Luis, E. A. and Godowski, P. J (1992). Expression and characterisation of hepatocyte growth factor receptor-IgG Fusion Proteins: effects of mutations in the potential proteolytic cleavage site on processing and ligand binding. J. Biol. Chem 267, 26166-26171.[Abstract/Free Full Text]

Matsumoto, K. and Nakamura, T (1996). Emerging multipotent aspects of hepatocyte growth factor. J. Biochem 119, 591-600.

Matsumoto, K., Kataoka, H., Date, K. and Nakamura, T (1998). Cooperative interaction between-and -chains of hepatocyte growth factor on c-Met receptor confers ligand-induced receptor tyrosine phosphorylation and multiple biological responses. J. Biol. Chem 273, 22913-22920.[Abstract/Free Full Text]

Miller, M. and Leonard, E. J (1998). Mode of receptor binding and activation by plasminogen-related growth factors. FEBS Lett 429, 1-3.[Medline]

Mizuno, K., Inoue, H., Hagiya, M., Shimizu, S., Nose, T., Shimohigashi, Y. and Nakamura, T (1994). Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor. J. Biol. Chem 269, 1131-1136.[Abstract/Free Full Text]

Naka, D., Ishii, T., Shimomura, T., Hishida, T. and Hara, H (1993). Heparin modulates the receptor-binding and mitogenic activity of hepatocyte growth factor on hepatocytes. Exp. Cell. Res 209, 317-324.[Medline]

Naldini, L., Weidner, K. M., Vigna, E., Gaudino, G., Bardelli, A., Ponzetto, C., Narsimhan, R. P., Hartmann, G., Zarnegar, R., Michalopoulos, G. K., Birchmeier, W. and Comoglio, P. M (1991). Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO. J 10, 2867-2878.[Medline]

Okigaki, M., Komada, M., Uehara, Y., Miyazawa, K. and Kitamura, N (1992). Functional characterization of human hepatocyte growth factor mutants obtained by deletion of structural domains. Biochemistry 31, 9555-9561.[Medline]

Pearson, C. H., Winterbottom, N., Fackre, D. S., Scott, P. G. and Carpenter, M. R (1983). The NH2-terminal amino acid sequence of bovine skin proteodermatan sulphate. J. Biol. Chem 258, 15101-15104.[Abstract/Free Full Text]

Pierce, A., Lyon, M., Hampson, I., Cowling, G. J. and Gallagher, J. T (1992). Molecular cloning of the major cell surface heparan sulphate proteoglycan from rat liver. J. Biol. Chem 267, 3894-3900.[Abstract/Free Full Text]

Ponzetto, C., Bardelli, A., Zhen, Z., Maina, F., dalla Zonca, P., Giordano, S., Graziani, A., Panayotou, G. and Comoglio, P. M (1994). A multifunctional docking site mediates signalling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 77, 261-271.[Medline]

Ponzetto, C., Zhen, Z., Audero, E., Maina, F., Bardelli, A., Basile, M. L., Giordano, S., Narsinham, R. and Comoglio, P (1996). Specific uncoupling of Grb2 from the Met receptor: differential effects on transformation and motility. J. Biol. Chem 271, 14119-14123.[Abstract/Free Full Text]

Prat, M., Crepaldi, T., Pennacchietti, S., Bussolino, F. and Comoglio, P. M (1998). Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF. J. Cell. Sci 111, 237-247.[Abstract]

Rahmoune, H., Chen, H.-L., Gallagher, J. T., Rudland, P. S. and Fernig, D. G (1998). Interaction of heparan sulfate from mammary cells with aFGF and bFGF: regulation of the activity of bFGF by high and low affinity binding sites in heparan sulphate. J. Biol. Chem 273, 7303-7310.[Abstract/Free Full Text]

Rahmoune, H., Rudland, P. S., Gallagher, J. T. and Fernig, D. G (1998). Hepatocyte growth factor/scatter factor has three classes of binding site in heparan sulphate from mammary cells. Biochemistry 37, 6003-6008.[Medline]

Rapraeger, A. C., Krufka, A. and Olwin, B. B (1991). Requirement of heparan sulphate for bFGF-mediated fibroblast growth and myoblast differentiation. Science 252, 1705-1708.[Abstract/Free Full Text]

Rosen, E. M., Goldberg, I. D., Kacinski, B. M., Buckholz, T. and Vinter, D. W (1989). Smooth muscle releases an epithelial cell scatter factor which binds to heparin. In Vitro 25, 163-173.

Rosen, E. M., Meromsky, L., Goldberg, I., Bhargava, M. and Setter, E (1990). Studies on the mechanism of scatter factor: effects of agents that modulate intracellular signal transduction, macromolecule synthesis and cytoskeleton assembly. J. Cell. Sci 96, 639-649.[Abstract/Free Full Text]

Rubin, J. S., Chan, A. M.-L., Bottaro, D. P., Burgess, W. H., Taylor, W. G., Cech, A. C., Hirschfield, D. W., Wong, J., Miki, T., Finch, P. W. and Aaronson, S. A (1991). A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc. Natl. Acad. Sci. USA 88, 415-419.[Abstract/Free Full Text]

Sakata, H., Stahl, S. J., Taylor, W. G., Rosenberg, J. M., Sakaguchi, K., Wingfield, P. T. and Rubin, J. S (1997). Heparin binding and oligomerization of hepatocyte growth factor/scatter factor isoforms: heparan sulphate glycosaminoglycan requirement for Met binding and signaling. J. Biol. Chem 272, 9457-9463.[Abstract/Free Full Text]

Schwall, R. H., Chang, L. Y., Godowski, P. J., Kahn, D. W., Hillan, K. J., Bauer, K. D. and Zioncheck, T. F (1996). Heparin induces dimerisation and confers proliferative activity onto the hepatocyte growth factor antagonists NK1 and NK2. J. Cell. Biol 133, 709-718.[Abstract/Free Full Text]

Stoker, M., Gherardi, E., Perryman, M. and Gray, J (1987). Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327, 239-242.[Medline]

Stoker, M (1989). Effect of scatter factor on motility of epithelial cells and fibroblasts. J. Cell. Physiol 139, 565-569.[Medline]

Svennevig, K., Prydz, K. and Kolset, S. O (1995). Proteoglycans in polarized epithelial Madin-Darby canine kidney cells. Biochem. J 311, 881-888.

Tajima, H., Matsumoto, K. and Nakamura, T (1992). Regulation of cell growth and motility by hepatocyte growth factor and receptor expression in various cell species. Exp. Cell. Res 202, 423-431.[Medline]

Tamagnone, L. and Comoglio, P. M (1997). Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors. Cytokine & Growth Factor Reviews 8, 129-142.[Medline]

Tanimura, S., Chatani, Y., Hoshino, R., Sato, M., Watanabe, S.-I., Kataoka, T., Nakamura, T. and Kohno, M (1998). Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering. Oncogene 17, 57-65.[Medline]

Trusolino, L., Pugliese, L. and Comoglio, P. M (1998). Interactions between scatter factors and their receptors: hints for therapeutic applications. FASEB J 12, 1267-1280.[Abstract/Free Full Text]

Weidner, K. M., Sachs, M. and Birchmeier, W (1993). The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J. Cell. Biol 121, 145-154.[Abstract/Free Full Text]

Zarnegar, R. and Michalopoulos, G (1989). Purification and biological characterisation of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res 49, 3314-3320.[Abstract/Free Full Text]

Zarnegar, R., DeFrances, M. C., Oliver, L. and Michalopoulos, G (1990). Identification and partial characterization of receptor binding sites for HGF on rat hepatocytes. Biochem. Biophys Res. Comm 173, 1179-1185.[Medline]

Zioncheck, T. F., Richardson, L., Liu, J., Chang, L., King, K. L., Bennett, G. L., Fugedi, P., Chamow, S. M., Schwall, R. H. and Stack, R. J (1995). Sulphated oligosaccharides promote hepatocyte growth factor association and govern its mitogenic activity. J. Biol. Chem 270, 16871-16878.[Abstract/Free Full Text]


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