Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Sieg, D. J.
	Articles by Schlaepfer, D. D.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Sieg, D. J.
	Articles by Schlaepfer, D. D.


Social Bookmarking

	What's this?

Anand-Apte, B., Zetter, B. R., Viswanathan, A., Qiu, R. G., Chen, J., Ruggieri, R. and Symons, M (1997). Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways. J. Biol. Chem 272, 30688-30692.[Abstract/Free Full Text]

Angers-Loustau, A., Cote, J.-F., Charest, A., Dowbenko, D., Spencer, S., Lasky, L. A. and Tremblay, M. L (1999). Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts. J. Cell Biol 144, 1019-1031.[Abstract/Free Full Text]

Calalb, M., Polte, T. and Hanks, S. K (1995). Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for the Src family kinases. Mol. Cell. Biol 15, 954-963.[Abstract]

Cary, L. A., Chang, J. F. and Guan, J.-L (1996). Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn. J. Cell Sci 108, 1787-1794.

Cary, L. A., Han, D. C., Polte, T. R., Hanks, S. K. and Guan, J.-L (1998). Identification of p130Casas a mediator of focal adhesion kinase-promoted cell migration. J. Cell Biol 140, 211-221.[Abstract/Free Full Text]

Chen, H. C., Appeddu, P. A., Isoda, H. and Guan, J. L (1996). Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase. J. Biol. Chem 271, 26329-26334.[Abstract/Free Full Text]

Chen, H. C., Appeddu, P. A., Parsons, J. T., Hildebrand, J. D., Schaller, M. D. and Guan, J. L (1995). Interaction of focal adhesion kinase with cytoskeletal protein talin. J. Biol. Chem 270, 16995-16999.[Abstract/Free Full Text]

Fincham, V. J. and Frame, M. C (1998). The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J 17, 81-92.[Medline]

Frisch, S. M., Vuori, K., Ruoslahti, E. and Chan-Hui, P. Y (1996). Control of adhesion-dependent cell survival by focal adhesion kinase. J. Cell Biol 134, 793-799.[Abstract/Free Full Text]

Furuta, Y., Ilic, D., Kanazawa, S., Takeda, N., Yamamoto, T. and Aizawa, S (1995). Mesodermal defect in late phase of gastrulation by a targeted mutation of focal adhesion kinase, FAK. Oncogene 11, 1989-1995.[Medline]

George, E. L., Georges-Labouesse, E. N., Patel-King, R. S., Rayburn, H. and Hynes, R. O (1993). Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119, 1079-1091.[Abstract]

Gilmore, A. P. and Romer, L. H (1996). Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation. Mol. Biol. Cell 7, 1209-1224.[Abstract]

Hanks, S. K. and Polte, T. R (1997). Signaling through focal adhesion kinase. BioEssays 19, 137-145.[Medline]

Hildebrand, J. D., Schaller, M. D. and Parsons, J. T (1995). Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Mol. Biol. Cell 6, 637-647.[Abstract]

Hildebrand, J. D., Taylor, J. M. and Parsons, J. T (1996). An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase. Mol. Cell. Biol 16, 3169-3178.[Abstract]

Honda, H., Oda, H., Nakamoto, T., Honda, Z., Sakai, R., Suzuki, T., Saito, T., Nakamura, K., Nakao, K., Ishikawa, T. et al (1998). Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nature Genet 19, 361-365.[Medline]

Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T. et al (1995). Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 377, 539-544.[Medline]

Ilic, D., Almeida, E. A., Schlaepfer, D. D., Dazin, P., Aizawa, S. and Damsky, C. H (1998). Extracellular matrix survival signals transduced by focal adheison kinase suppress p53-mediated apoptosis. J. Cell Biol 143, 547-560.[Abstract/Free Full Text]

Keely, P. J., Westwick, J. K., Whitehead, I. P., Der, C. J. and Parise, L. V (1997). Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390, 632-636.[Medline]

Klemke, R. L., Cai, S., Giannini, A. L., Gallagher, P. J., de Lanerolle, P. and Cheresh, D. A (1997). Regulation of cell motility by mitogen-activated protein kinase. J. Cell Biol 137, 481-492.[Abstract/Free Full Text]

Klemke, R. L., Leng, J., Molander, R., Brooks, P. C., Vuori, K. and Cheresh, D. A (1998). Cas/Crk coupling serves as a \324molecular switch' for induction of cell migration. J. Cell Biol 140, 961-972.[Abstract/Free Full Text]

Klinghoffer, R. A., Sachsenmaier, C., Cooper, J. A. and Soriano, P (1999). Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 18, 2459-2471.[Medline]

Owens, L. V., Xu, L. H., Craven, R. J., Dent, G. A., Weiner, T. M., Kornberg, L., Liu, E. T. and Cance, W. G (1995). Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55, 2752-2755.[Abstract/Free Full Text]

Polte, T. R. and Hanks, S. K (1995). Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc. Nat. Acad. Sci. USA 92, 10678-10682.[Abstract/Free Full Text]

Polte, T. R. and Hanks, S. K (1997). Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130Cas) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs. J. Biol. Chem 272, 5501-5509.[Abstract/Free Full Text]

Ren, X. D., Kiosses, W. B. and Schwartz, M. A (1999). Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J 18, 578-585.[Medline]

Richardson, A. and Parsons, J. T (1996). A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK. Nature 380, 538-540.[Medline]

Richardson, A., Malik, R. K., Hildebrand, J. D. and Parsons, J. T (1997). Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation. Mol. Cell Biol 17, 6906-6914.[Abstract]

Schaller, M. D., Borgman, C. A. and Parsons, J. T (1993). Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK. Mol. Cell. Biol 13, 785-791.[Abstract/Free Full Text]

Schaller, M. D., Otey, C. A., Hildebrand, J. D. and Parsons, J. T (1995). Focal adhesion kinase and paxillin bind peptides mimickingintegrin cytoplasmic domains. J. Cell Biol 130, 1181-1187.[Abstract/Free Full Text]

Schlaepfer, D. D., Hanks, S. K., Hunter, T. and van der Geer, P (1994). Integrin-mediated signal transduction linked to Ras pathway by Grb2 binding to focal adhesion kinase. Nature 372, 786-791.[Medline]

Schlaepfer, D. D. and Hunter, T (1996). Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol. Cell. Biol 16, 5623-5633.[Abstract]

Schlaepfer, D. D. and Hunter, T (1997). FAK overexpression enhances Ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src. J. Biol. Chem 272, 13189-13195.[Abstract/Free Full Text]

Schlaepfer, D. D., Broome, M. A. and Hunter, T (1997). Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130Cas, and Nck adaptor proteins. Mol. Cell. Biol 17, 1702-1713.[Abstract]

Schlaepfer, D. D., Jones, K. C. and Hunter, T (1998). Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: Summation of both c-Src and FAK-initiated tyrosine phosphorylation events. Mol. Cell. Biol 18, 2571-2585.[Abstract/Free Full Text]

Schlaepfer, D. D., Hauck, C. R. and Sieg, D. J (1999). Signaling through focal adhesion kinase. Prog. Biophys. Mol. Biol 71, 435-478.[Medline]

Sieg, D. J., Ilic, D., Jones, K. C., Damsky, C. H., Hunter, T. and Schlaepfer, D. D (1998). Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAKcell migration. EMBO J 17, 5933-5947.[Medline]

Stephens, L. E., Sutherland, A. E., Klimanskaya, I. V., Andrieux, A., Meneses, J., Pedersen, R. A. and Damsky, C. H (1995). Deletion of1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev 9, 1883-1895.[Abstract/Free Full Text]

Tachibana, K., Sato, T., D'Avirro, N. and Morimoto, C (1995). Direct association of pp125FAKwith paxillin, the focal adhesion-targeting mechanism of pp125FAK. J. Exp. Med 182, 1089-1100.[Abstract/Free Full Text]

Tachibana, K., Urano, T., Fujita, H., Ohashi, Y., Kamiguchi, K., Iwata, S., Hirai, H. and Morimoto, C (1997). Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates. J. Biol. Chem 272, 29083-29090.[Abstract/Free Full Text]

Tamura, M., Gu, J., Matsumoto, K., Aota, S., Parsons, R. and Yamada, K. M (1998). Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 280, 1614-1617.[Abstract/Free Full Text]

Tamura, M., Gu, J., Takino, T. and Yamada, K. M (1999). Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas. Cancer Res 59, 442-449.[Abstract/Free Full Text]

Taylor, J. M., Macklem, M. M. and Parsons, J. T (1999). Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho. J. Cell Sci 112, 231-242.[Abstract]

Vuori, K., Hirai, H., Aizawa, S. and Ruoslahti, E (1996). Induction of p130Cassignaling complex formation upon integrin-mediated cell adhesion: a role for the Src family kinases. Mol. Cell. Biol 16, 2606-2613.[Abstract]

Yu, D. H., Qu, C. K., Henegariu, O., Lu, X. and Feng, G. S (1998). Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesion. J. Biol. Chem 273, 21125-21131.[Abstract/Free Full Text]

Zhao, J.-H., Reiske, H. and Guan, J.-L (1998). Regulation of the cell cycle by focal adhesion kinase. J. Cell Biol 143, 1997-2008.[Abstract/Free Full Text]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

Y. E. Koshman, S. J. Engman, T. Kim, R. Iyengar, K. K. Henderson, and A. M. Samarel
Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration
Cardiovasc Res, October 24, 2009; (2009) cvp322v2.
[Abstract] [Full Text] [PDF]

P. A. Kiely, G. S. Baillie, R. Barrett, D. A. Buckley, D. R. Adams, M. D. Houslay, and R. O'Connor
Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase
J. Biol. Chem., July 24, 2009; 284(30): 20263 - 20274.
[Abstract] [Full Text] [PDF]

A. Kasorn, P. Alcaide, Y. Jia, K. K. Subramanian, B. Sarraj, Y. Li, F. Loison, H. Hattori, L. E. Silberstein, W. F. Luscinskas, et al.
Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating Both Adhesion-Dependent and -Independent Cellular Signals
J. Immunol., July 15, 2009; 183(2): 1032 - 1043.
[Abstract] [Full Text] [PDF]

E. M. Goldblatt, E. R. Gentry, M. J. Fox, S. M. Gryaznov, C. Shen, and B.-S. Herbert
The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel
Mol. Cancer Ther., July 1, 2009; 8(7): 2027 - 2035.
[Abstract] [Full Text] [PDF]

U. Schlomann, J. C. Schwamborn, M. Muller, R. Fassler, and A. W. Puschel
The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase
J. Cell Sci., June 15, 2009; 122(12): 2034 - 2042.
[Abstract] [Full Text] [PDF]

A. Tomar, S.-T. Lim, Y. Lim, and D. D. Schlaepfer
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells
J. Cell Sci., June 1, 2009; 122(11): 1852 - 1862.
[Abstract] [Full Text] [PDF]

K. E. Michael, D. W. Dumbauld, K. L. Burns, S. K. Hanks, and A. J. Garcia
Focal Adhesion Kinase Modulates Cell Adhesion Strengthening via Integrin Activation
Mol. Biol. Cell, May 1, 2009; 20(9): 2508 - 2519.
[Abstract] [Full Text] [PDF]

K. T. Chan, C. L. Cortesio, and A. Huttenlocher
FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion
J. Cell Biol., April 20, 2009; 185(2): 357 - 370.
[Abstract] [Full Text] [PDF]

J. M. Carvajal-Gonzalez, S. Mulero-Navarro, A. C. Roman, V. Sauzeau, J. M. Merino, X. R. Bustelo, and P. M. Fernandez-Salguero
The Dioxin Receptor Regulates the Constitutive Expression of the Vav3 Proto-Oncogene and Modulates Cell Shape and Adhesion
Mol. Biol. Cell, March 15, 2009; 20(6): 1715 - 1727.
[Abstract] [Full Text] [PDF]

E. Papusheva, F. M. de Queiroz, J. Dalous, Y. Han, A. Esposito, E. A. Jares-Erijmanxa, T. M. Jovin, and G. Bunt
Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility
J. Cell Sci., March 1, 2009; 122(5): 656 - 666.
[Abstract] [Full Text] [PDF]

A. M. Manso, S.-M. Kang, S. V. Plotnikov, I. Thievessen, J. Oh, H. E. Beggs, and R. S. Ross
Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration
Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H627 - H638.
[Abstract] [Full Text] [PDF]

Y. Wu, J. Zuo, G. Ji, H. Saiyin, X. Liu, F. Yin, N. Cao, Y. Wen, J. J. Li, and L. Yu
Proapoptotic Function of Integrin {beta}3 in Human Hepatocellular Carcinoma Cells
Clin. Cancer Res., January 1, 2009; 15(1): 60 - 69.
[Abstract] [Full Text] [PDF]

R. L. Sayers, L. J. Sundberg-Smith, M. Rojas, H. Hayasaka, J. T. Parsons, C. P. Mack, and J. M. Taylor
FRNK Expression Promotes Smooth Muscle Cell Maturation During Vascular Development and After Vascular Injury
Arterioscler Thromb Vasc Biol, December 1, 2008; 28(12): 2115 - 2122.
[Abstract] [Full Text] [PDF]

Q. Ding, C. L. Gladson, H. Wu, H. Hayasaka, and M. A. Olman
Focal Adhesion Kinase (FAK)-related Non-kinase Inhibits Myofibroblast Differentiation through Differential MAPK Activation in a FAK-dependent Manner
J. Biol. Chem., October 3, 2008; 283(40): 26839 - 26849.
[Abstract] [Full Text] [PDF]

M. F. Walsh, D. R. Ampasala, J. Hatfield, R. Vander Heide, S. Suer, A. K. Rishi, and M. D. Basson
Transforming Growth Factor-{beta} Stimulates Intestinal Epithelial Focal Adhesion Kinase Synthesis via Smad- and p38-Dependent Mechanisms
Am. J. Pathol., August 1, 2008; 173(2): 385 - 399.
[Abstract] [Full Text] [PDF]

S. Zhao, S. Ammanamanchi, M. Brattain, L. Cao, A. Thangasamy, J. Wang, and J. W. Freeman
Smad4-dependent TGF-{beta} Signaling Suppresses RON Receptor Tyrosine Kinase-dependent Motility and Invasion of Pancreatic Cancer Cells
J. Biol. Chem., April 25, 2008; 283(17): 11293 - 11301.
[Abstract] [Full Text] [PDF]

Y. Lim, S.-T. Lim, A. Tomar, M. Gardel, J. A. Bernard-Trifilo, X. L. Chen, S. A. Uryu, R. Canete-Soler, J. Zhai, H. Lin, et al.
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
J. Cell Biol., January 10, 2008; 180(1): 187 - 203.
[Abstract] [Full Text] [PDF]

H.-B. Guo, M. Randolph, and M. Pierce
Inhibition of a Specific N-Glycosylation Activity Results in Attenuation of Breast Carcinoma Cell Invasiveness-related Phenotypes: INHIBITION OF EPIDERMAL GROWTH FACTOR-INDUCED DEPHOSPHORYLATION OF FOCAL ADHESION KINASE
J. Biol. Chem., July 27, 2007; 282(30): 22150 - 22162.
[Abstract] [Full Text] [PDF]

M. Parri, F. Buricchi, E. Giannoni, G. Grimaldi, T. Mello, G. Raugei, G. Ramponi, and P. Chiarugi
EphrinA1 Activates a Src/Focal Adhesion Kinase-mediated Motility Response Leading to Rho-dependent Actino/Myosin Contractility
J. Biol. Chem., July 6, 2007; 282(27): 19619 - 19628.
[Abstract] [Full Text] [PDF]

Y. Shen, P. R. Khusial, X. Li, H. Ichikawa, A. P. Moreno, and G. S. Goldberg
Src Utilizes Cas to Block Gap Junctional Communication Mediated by Connexin43
J. Biol. Chem., June 29, 2007; 282(26): 18914 - 18921.
[Abstract] [Full Text] [PDF]

D. D. Schlaepfer, S. Hou, S.-T. Lim, A. Tomar, H. Yu, Y. Lim, D. A. Hanson, S. A. Uryu, J. Molina, and S. K. Mitra
Tumor Necrosis Factor-{alpha} Stimulates Focal Adhesion Kinase Activity Required for Mitogen-activated Kinase-associated Interleukin 6 Expression
J. Biol. Chem., June 15, 2007; 282(24): 17450 - 17459.
[Abstract] [Full Text] [PDF]

J. K. Slack-Davis, K. H. Martin, R. W. Tilghman, M. Iwanicki, E. J. Ung, C. Autry, M. J. Luzzio, B. Cooper, J. C. Kath, W. G. Roberts, et al.
Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor
J. Biol. Chem., May 18, 2007; 282(20): 14845 - 14852.
[Abstract] [Full Text] [PDF]

J. L. Walker, I. M. Wolff, L. Zhang, and A. S. Menko
Activation of Src Kinases Signals Induction of Posterior Capsule Opacification
Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2214 - 2223.
[Abstract] [Full Text] [PDF]

Z. Salah, M. Maoz, E. Pokroy, M. Lotem, R. Bar-Shavit, and B. Uziely
Protease-Activated Receptor-1 (hPar1), A Survival Factor Eliciting Tumor Progression
Mol. Cancer Res., March 1, 2007; 5(3): 229 - 240.
[Abstract] [Full Text] [PDF]

F Rieder, J Brenmoehl, S Leeb, J Scholmerich, and G Rogler
Wound healing and fibrosis in intestinal disease
Gut, January 1, 2007; 56(1): 130 - 139.
[Full Text] [PDF]

F. Chang, C. A. Lemmon, D. Park, and L. H. Romer
FAK Potentiates Rac1 Activation and Localization to Matrix Adhesion Sites: A Role for betaPIX
Mol. Biol. Cell, January 1, 2007; 18(1): 253 - 264.
[Abstract] [Full Text] [PDF]

Y. Zhao, S. Itoh, X. Wang, T. Isaji, E. Miyoshi, Y. Kariya, K. Miyazaki, N. Kawasaki, N. Taniguchi, and J. Gu
Deletion of Core Fucosylation on {alpha}3beta1 Integrin Down-regulates Its Functions
J. Biol. Chem., December 15, 2006; 281(50): 38343 - 38350.
[Abstract] [Full Text] [PDF]

A. Serrels, I. R.J. Macpherson, T.R. J. Evans, F. Y. Lee, E. A. Clark, O. J. Sansom, G. H. Ashton, M. C. Frame, and V. G. Brunton
Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib
Mol. Cancer Ther., December 1, 2006; 5(12): 3014 - 3022.
[Abstract] [Full Text] [PDF]

Z. Chaar, P. O'Reilly, I. Gelman, and L. A. Sabourin
v-Src-dependent Down-regulation of the Ste20-like Kinase SLK by Casein Kinase II
J. Biol. Chem., September 22, 2006; 281(38): 28193 - 28199.
[Abstract] [Full Text] [PDF]

G. Monami, E. M. Gonzalez, M. Hellman, L. G. Gomella, R. Baffa, R. V. Iozzo, and A. Morrione
Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex.
Cancer Res., July 15, 2006; 66(14): 7103 - 7110.
[Abstract] [Full Text] [PDF]

M. G. Yeo, M. A. Partridge, E. J. Ezratty, Q. Shen, G. G. Gundersen, and E. E. Marcantonio
Src SH2 Arginine 175 Is Required for Cell Motility: Specific Focal Adhesion Kinase Targeting and Focal Adhesion Assembly Function
Mol. Cell. Biol., June 15, 2006; 26(12): 4399 - 4409.
[Abstract] [Full Text] [PDF]

P. Bryant, Q. Zheng, and K. Pumiglia
Focal Adhesion Kinase Controls Cellular Levels of p27/Kip1 and p21/Cip1 through Skp2-Dependent and -Independent Mechanisms.
Mol. Cell. Biol., June 1, 2006; 26(11): 4201 - 4213.
[Abstract] [Full Text] [PDF]

P. M.F. Siesser and S. K. Hanks
The Signaling and Biological Implications of FAK Overexpression in Cancer.
Clin. Cancer Res., June 1, 2006; 12(11): 3233 - 3237.
[Full Text] [PDF]

R. S. Greenberg, A. M. Bernstein, M. Benezra, I. H. Gelman, L. Taliana, and S. K. Masur
FAK-dependent regulation of myofibroblast differentiation
FASEB J, May 1, 2006; 20(7): 1006 - 1008.
[Abstract] [Full Text] [PDF]

S. Meierjohann, E. Wende, A. Kraiss, C. Wellbrock, and M. Schartl
The oncogenic epidermal growth factor receptor variant xiphophorus melanoma receptor kinase induces motility in melanocytes by modulation of focal adhesions.
Cancer Res., March 15, 2006; 66(6): 3145 - 3152.
[Abstract] [Full Text] [PDF]

M. A. Partridge, F. S. David, and E. E. Marcantonio
Displacement of the {beta} cytoplasmic domain recovers focal adhesion formation, cytoskeletal organization and motility in swapped integrin chimeras
J. Cell Sci., March 15, 2006; 119(6): 1175 - 1183.
[Abstract] [Full Text] [PDF]

K. A. Kragtorp and J. R. Miller
Regulation of somitogenesis by Ena/VASP proteins and FAK during Xenopus development
Development, February 15, 2006; 133(4): 685 - 695.
[Abstract] [Full Text] [PDF]

Y. Shen, Z. Jia, R. G. Nagele, H. Ichikawa, and G. S. Goldberg
Src Uses Cas to Suppress Fhl1 in Order to Promote Nonanchored Growth and Migration of Tumor Cells
Cancer Res., February 1, 2006; 66(3): 1543 - 1552.
[Abstract] [Full Text] [PDF]

S. J. Wall, E. Werner, Z. Werb, and Y. A. DeClerck
Discoidin Domain Receptor 2 Mediates Tumor Cell Cycle Arrest Induced by Fibrillar Collagen
J. Biol. Chem., December 2, 2005; 280(48): 40187 - 40194.
[Abstract] [Full Text] [PDF]

D. A. Hsia, S.-T. Lim, J. A. Bernard-Trifilo, S. K. Mitra, S. Tanaka, J. den Hertog, D. N. Streblow, D. Ilic, M. H. Ginsberg, and D. D. Schlaepfer
Integrin {alpha}4{beta}1 Promotes Focal Adhesion Kinase-Independent Cell Motility via {alpha}4 Cytoplasmic Domain-Specific Activation of c-Src
Mol. Cell. Biol., November 1, 2005; 25(21): 9700 - 9712.
[Abstract] [Full Text] [PDF]

M. J. Riemenschneider, W. Mueller, R. A. Betensky, G. Mohapatra, and D. N. Louis
In Situ Analysis of Integrin and Growth Factor Receptor Signaling Pathways in Human Glioblastomas Suggests Overlapping Relationships with Focal Adhesion Kinase Activation
Am. J. Pathol., November 1, 2005; 167(5): 1379 - 1387.
[Abstract] [Full Text] [PDF]

A. Hamadi, M. Bouali, M. Dontenwill, H. Stoeckel, K. Takeda, and P. Ronde
Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397
J. Cell Sci., October 1, 2005; 118(19): 4415 - 4425.
[Abstract] [Full Text] [PDF]

C. Urbinati, A. Bugatti, M. Giacca, D. Schlaepfer, M. Presta, and M. Rusnati
{alpha}v{beta}3-integrin-dependent activation of focal adhesion kinase mediates NF-{kappa}B activation and motogenic activity by HIV-1 Tat in endothelial cells
J. Cell Sci., September 1, 2005; 118(17): 3949 - 3958.
[Abstract] [Full Text] [PDF]

V. M. Golubovskaya, R. Finch, and W. G. Cance
Direct Interaction of the N-terminal Domain of Focal Adhesion Kinase with the N-terminal Transactivation Domain of p53
J. Biol. Chem., July 1, 2005; 280(26): 25008 - 25021.
[Abstract] [Full Text] [PDF]

R. S. Fan, R. O. Jacamo, X. Jiang, J. Sinnett-Smith, and E. Rozengurt
G Protein-coupled Receptor Activation Rapidly Stimulates Focal Adhesion Kinase Phosphorylation at Ser-843: MEDIATION BY Ca2+, CALMODULIN, AND Ca2+/CALMODULIN-DEPENDENT KINASE II
J. Biol. Chem., June 24, 2005; 280(25): 24212 - 24220.
[Abstract] [Full Text] [PDF]

R. W. Tilghman, J. K. Slack-Davis, N. Sergina, K. H. Martin, M. Iwanicki, E. D. Hershey, H. E. Beggs, L. F. Reichardt, and J. T. Parsons
Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells
J. Cell Sci., June 15, 2005; 118(12): 2613 - 2623.
[Abstract] [Full Text] [PDF]

D. Humphrey, Z. Rajfur, M. E. Vazquez, D. Scheswohl, M. D. Schaller, K. Jacobson, and B. Imperiali
In Situ Photoactivation of a Caged Phosphotyrosine Peptide Derived from Focal Adhesion Kinase Temporarily Halts Lamellar Extension of Single Migrating Tumor Cells
J. Biol. Chem., June 10, 2005; 280(23): 22091 - 22101.
[Abstract] [Full Text] [PDF]

M. J. van Nimwegen, S. Verkoeijen, L. van Buren, D. Burg, and B. van de Water
Requirement for Focal Adhesion Kinase in the Early Phase of Mammary Adenocarcinoma Lung Metastasis Formation
Cancer Res., June 1, 2005; 65(11): 4698 - 4706.
[Abstract] [Full Text] [PDF]

F. Agerer, S. Lux, A. Michel, M. Rohde, K. Ohlsen, and C. R. Hauck
Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation
J. Cell Sci., May 15, 2005; 118(10): 2189 - 2200.
[Abstract] [Full Text] [PDF]

H.-B. Guo, I. Lee, B. T. Bryan, and M. Pierce
Deletion of Mouse Embryo Fibroblast N-Acetylglucosaminyltransferase V Stimulates {alpha}5{beta}1 Integrin Expression Mediated by the Protein Kinase C Signaling Pathway
J. Biol. Chem., March 4, 2005; 280(9): 8332 - 8342.
[Abstract] [Full Text] [PDF]

S. J. Pratt, H. Epple, M. Ward, Y. Feng, V. M. Braga, and G. D. Longmore
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration
J. Cell Biol., February 28, 2005; 168(5): 813 - 824.
[Abstract] [Full Text] [PDF]

V. G. Brunton, E. Avizienyte, V. J. Fincham, B. Serrels, C. A. Metcalf III, T. K. Sawyer, and M. C. Frame
Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior
Cancer Res., February 15, 2005; 65(4): 1335 - 1342.
[Abstract] [Full Text] [PDF]

D. Tvorogov, X.-J. Wang, R. Zent, and G. Carpenter
Integrin-dependent PLC-{gamma}1 phosphorylation mediates fibronectin-dependent adhesion
J. Cell Sci., February 1, 2005; 118(3): 601 - 610.
[Abstract] [Full Text] [PDF]

A. von Sengbusch, P. Gassmann, K. M. Fisch, A. Enns, G. L. Nicolson, and J. Haier
Focal Adhesion Kinase Regulates Metastatic Adhesion of Carcinoma Cells within Liver Sinusoids
Am. J. Pathol., February 1, 2005; 166(2): 585 - 596.
[Abstract] [Full Text] [PDF]

T. Iwahara, T. Akagi, Y. Fujitsuka, and H. Hanafusa
CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas
PNAS, December 21, 2004; 101(51): 17693 - 17698.
[Abstract] [Full Text] [PDF]

V. Budagian, E. Bulanova, Z. Orinska, T. Pohl, E. C. Borden, R. Silverman, and S. Bulfone-Paus
Reverse Signaling through Membrane-bound Interleukin-15
J. Biol. Chem., October 1, 2004; 279(40): 42192 - 42201.
[Abstract] [Full Text] [PDF]

K. A Cho, S. J. Ryu, Y. S. Oh, J. H. Park, J. W. Lee, H.-P. Kim, K. T. Kim, I. S. Jang, and S. C. Park
Morphological Adjustment of Senescent Cells by Modulating Caveolin-1 Status
J. Biol. Chem., October 1, 2004; 279(40): 42270 - 42278.
[Abstract] [Full Text] [PDF]

M. A. Westhoff, B. Serrels, V. J. Fincham, M. C. Frame, and N. O. Carragher
Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling
Mol. Cell. Biol., September 15, 2004; 24(18): 8113 - 8133.
[Abstract] [Full Text] [PDF]

N.-Y. Shin, R. S. Dise, J. Schneider-Mergener, M. D. Ritchie, D. M. Kilkenny, and S. K. Hanks
Subsets of the Major Tyrosine Phosphorylation Sites in Crk-associated Substrate (CAS) Are Sufficient to Promote Cell Migration
J. Biol. Chem., September 10, 2004; 279(37): 38331 - 38337.
[Abstract] [Full Text] [PDF]

G. Giannone, P. Ronde, M. Gaire, J. Beaudouin, J. Haiech, J. Ellenberg, and K. Takeda
Calcium Rises Locally Trigger Focal Adhesion Disassembly and Enhance Residency of Focal Adhesion Kinase at Focal Adhesions
J. Biol. Chem., July 2, 2004; 279(27): 28715 - 28723.
[Abstract] [Full Text] [PDF]

S.-Y. Lin, S. Raval, Z. Zhang, M. Deverill, K. A. Siminovitch, D. R. Branch, and B. Haimovich
The Protein-tyrosine Phosphatase SHP-1 Regulates the Phosphorylation of {alpha}-Actinin
J. Biol. Chem., June 11, 2004; 279(24): 25755 - 25764.
[Abstract] [Full Text] [PDF]

X. Wu, S. Suetsugu, L. A. Cooper, T. Takenawa, and J.-L. Guan
Focal Adhesion Kinase Regulation of N-WASP Subcellular Localization and Function
J. Biol. Chem., March 5, 2004; 279(10): 9565 - 9576.
[Abstract] [Full Text] [PDF]

A. F. Palazzo, C. H. Eng, D. D. Schlaepfer, E. E. Marcantonio, and G. G. Gundersen
Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling
Science, February 6, 2004; 303(5659): 836 - 839.
[Abstract] [Full Text] [PDF]

D. Ilic, B. Kovacic, K. Johkura, D. D. Schlaepfer, N. Tomasevic, Q. Han, J.-B. Kim, K. Howerton, C. Baumbusch, N. Ogiwara, et al.
FAK promotes organization of fibronectin matrix and fibrillar adhesions
J. Cell Sci., January 15, 2004; 117(2): 177 - 187.
[Abstract] [Full Text] [PDF]

D. Vial, C. Oliver, M. C. Jamur, M. V. D. Pastor, E. da Silva Trindade, E. Berenstein, J. Zhang, and R. P. Siraganian
Alterations in Granule Matrix and Cell Surface of Focal Adhesion Kinase-Deficient Mast Cells
J. Immunol., December 1, 2003; 171(11): 6178 - 6186.
[Abstract] [Full Text] [PDF]

G. Kadare, M. Toutant, E. Formstecher, J.-C. Corvol, M. Carnaud, M.-C. Boutterin, and J.-A. Girault
PIAS1-mediated Sumoylation of Focal Adhesion Kinase Activates Its Autophosphorylationn
J. Biol. Chem., November 28, 2003; 278(48): 47434 - 47440.
[Abstract] [Full Text] [PDF]

K. Moissoglu and I. H. Gelman
v-Src Rescues Actin-based Cytoskeletal Architecture and Cell Motility and Induces Enhanced Anchorage Independence during Oncogenic Transformation of Focal Adhesion Kinase-null Fibroblasts
J. Biol. Chem., November 28, 2003; 278(48): 47946 - 47959.
[Abstract] [Full Text] [PDF]

G. S. Goldberg, D. B. Alexander, P. Pellicena, Z.-Y. Zhang, H. Tsuda, and W. T. Miller
Src Phosphorylates Cas on Tyrosine 253 to Promote Migration of Transformed Cells
J. Biol. Chem., November 21, 2003; 278(47): 46533 - 46540.
[Abstract] [Full Text] [PDF]

Q. Ding, J. Stewart Jr., M. A. Olman, M. R. Klobe, and C. L. Gladson
The Pattern of Enhancement of Src Kinase Activity on Platelet-derived Growth Factor Stimulation of Glioblastoma Cells Is Affected by the Integrin Engaged
J. Biol. Chem., October 10, 2003; 278(41): 39882 - 39891.
[Abstract] [Full Text] [PDF]

O. I. Stenina, S. Y. Desai, I. Krukovets, K. Kight, D. Janigro, E. J. Topol, and E. F. Plow
Thrombospondin-4 and Its Variants: Expression and Differential Effects on Endothelial Cells
Circulation, September 23, 2003; 108(12): 1514 - 1519.
[Abstract] [Full Text] [PDF]

M. Okigaki, C. Davis, M. Falasca, S. Harroch, D. P. Felsenfeld, M. P. Sheetz, and J. Schlessinger
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration
PNAS, September 16, 2003; 100(19): 10740 - 10745.
[Abstract] [Full Text] [PDF]

Y. A. Abassi, M. Rehn, N. Ekman, K. Alitalo, and K. Vuori
p130Cas Couples the Tyrosine Kinase Bmx/Etk with Regulation of the Actin Cytoskeleton and Cell Migration
J. Biol. Chem., September 12, 2003; 278(37): 35636 - 35643.
[Abstract] [Full Text] [PDF]

M. Funakoshi-Tago, Y. Sonoda, S. Tanaka, K. Hashimoto, K. Tago, S.-i. Tominaga, and T. Kasahara
Tumor Necrosis Factor-induced Nuclear Factor {kappa}B Activation Is Impaired in Focal Adhesion Kinase-deficient Fibroblasts
J. Biol. Chem., August 1, 2003; 278(31): 29359 - 29365.
[Abstract] [Full Text] [PDF]

J. Zhai, H. Lin, Z. Nie, J. Wu, R. Canete-Soler, W. W. Schlaepfer, and D. D. Schlaepfer
Direct Interaction of Focal Adhesion Kinase with p190RhoGEF
J. Biol. Chem., June 27, 2003; 278(27): 24865 - 24873.
[Abstract] [Full Text] [PDF]

D. M. Rose, S. Liu, D. G. Woodside, J. Han, D. D. Schlaepfer, and M. H. Ginsberg
Paxillin Binding to the {alpha}4 Integrin Subunit Stimulates LFA-1 (Integrin {alpha}L{beta}2)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/Proline-Rich Tyrosine Kinase-2
J. Immunol., June 15, 2003; 170(12): 5912 - 5918.
[Abstract] [Full Text] [PDF]

H. Haskell, M. Natarajan, T. P. Hecker, Q. Ding, J. Stewart Jr., J. R. Grammer, and C. L. Gladson
Focal Adhesion Kinase Is Expressed in the Angiogenic Blood Vessels of Malignant Astrocytic Tumors in Vivo and Promotes Capillary Tube Formation of Brain Microvascular Endothelial Cells
Clin. Cancer Res., June 1, 2003; 9(6): 2157 - 2165.
[Abstract] [Full Text] [PDF]

D. M. McKean, L. Sisbarro, D. Ilic, N. Kaplan-Alburquerque, R. Nemenoff, M. Weiser-Evans, M. J. Kern, and P. L. Jones
FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration
J. Cell Biol., April 28, 2003; 161(2): 393 - 402.
[Abstract] [Full Text] [PDF]

L. Li, D. L. Guris, M. Okura, and A. Imamoto
Translocation of CrkL to Focal Adhesions Mediates Integrin-Induced Migration Downstream of Src Family Kinases
Mol. Cell. Biol., April 15, 2003; 23(8): 2883 - 2892.
[Abstract] [Full Text] [PDF]

J. T. Parsons
Focal adhesion kinase: the first ten years
J. Cell Sci., April 15, 2003; 116(8): 1409 - 1416.
[Abstract] [Full Text] [PDF]

Q. G. Medley, E. G. Buchbinder, K. Tachibana, H. Ngo, C. Serra-Pages, and M. Streuli
Signaling between Focal Adhesion Kinase and Trio
J. Biol. Chem., April 4, 2003; 278(15): 13265 - 13270.
[Abstract] [Full Text] [PDF]

D. A. Hsia, S. K. Mitra, C. R. Hauck, D. N. Streblow, J. A. Nelson, D. Ilic, S. Huang, E. Li, G. R. Nemerow, J. Leng, et al.
Differential regulation of cell motility and invasion by FAK
J. Cell Biol., March 3, 2003; 160(5): 753 - 767.
[Abstract] [Full Text] [PDF]

C. A. Lipinski, N. L. Tran, C. Bay, J. Kloss, W. S. McDonough, C. Beaudry, M. E. Berens, and J. C. Loftus
Differential Role of Proline-Rich Tyrosine Kinase 2 and Focal Adhesion Kinase in Determining Glioblastoma Migration and Proliferation
Mol. Cancer Res., March 1, 2003; 1(5): 323 - 332.
[Abstract] [Full Text] [PDF]

L. Kwong, M. A. Wozniak, A. S. Collins, S. D. Wilson, and P. J. Keely
R-Ras Promotes Focal Adhesion Formation through Focal Adhesion Kinase and p130Cas by a Novel Mechanism That Differs from Integrins
Mol. Cell. Biol., February 1, 2003; 23(3): 933 - 949.
[Abstract] [Full Text]

E. A. Cox, D. Bennin, A. T. Doan, T. O'Toole, and A. Huttenlocher
RACK1 Regulates Integrin-mediated Adhesion, Protrusion, and Chemotactic Cell Migration via Its Src-binding Site
Mol. Biol. Cell, February 1, 2003; 14(2): 658 - 669.
[Abstract] [Full Text] [PDF]

L. Zeng, X. Si, W.-P. Yu, H. T. Le, K. P. Ng, R. M.H. Teng, K. Ryan, D. Z.-M. Wang, S. Ponniah, and C. J. Pallen
PTP{alpha} regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration
J. Cell Biol., January 2, 2003; 160(1): 137 - 146.
[Abstract] [Full Text] [PDF]

S. Mochizuki, B. Brassart, and A. Hinek
Signaling Pathways Transduced through the Elastin Receptor Facilitate Proliferation of Arterial Smooth Muscle Cells
J. Biol. Chem., November 15, 2002; 277(47): 44854 - 44863.
[Abstract] [Full Text] [PDF]

V. Golubovskaya, L. Beviglia, L.-H. Xu, H. S. Earp III, R. Craven, and W. Cance
Dual Inhibition of Focal Adhesion Kinase and Epidermal Growth Factor Receptor Pathways Cooperatively Induces Death Receptor-mediated Apoptosis in Human Breast Cancer Cells
J. Biol. Chem., October 4, 2002; 277(41): 38978 - 38987.
[Abstract] [Full Text] [PDF]

S. Wagner, T. A. Flood, P. O'Reilly, K. Hume, and L. A. Sabourin
Association of the Ste20-like Kinase (SLK) with the Microtubule. ROLE IN Rac1-MEDIATED REGULATION OF ACTIN DYNAMICS DURING CELL ADHESION AND SPREADING
J. Biol. Chem., September 27, 2002; 277(40): 37685 - 37692.
[Abstract] [Full Text] [PDF]

S. Abbi, H. Ueda, C. Zheng, L. A. Cooper, J. Zhao, R. Christopher, and J.-L. Guan
Regulation of Focal Adhesion Kinase by a Novel Protein Inhibitor FIP200
Mol. Biol. Cell, September 1, 2002; 13(9): 3178 - 3191.
[Abstract] [Full Text] [PDF]

S. A. Wilcox-Adelman, F. Denhez, and P. F. Goetinck
Syndecan-4 Modulates Focal Adhesion Kinase Phosphorylation
J. Biol. Chem., August 30, 2002; 277(36): 32970 - 32977.
[Abstract] [Full Text] [PDF]

G. Giannone, P. Ronde, M. Gaire, J. Haiech, and K. Takeda
Calcium Oscillations Trigger Focal Adhesion Disassembly in Human U87 Astrocytoma Cells
J. Biol. Chem., July 12, 2002; 277(29): 26364 - 26371.
[Abstract] [Full Text] [PDF]

Y.-P. Jin, R. P. Singh, Z.-Y. Du, A. K. Rajasekaran, E. Rozengurt, and E. F. Reed
Ligation of HLA Class I Molecules on Endothelial Cells Induces Phosphorylation of Src, Paxillin, and Focal Adhesion Kinase in an Actin-Dependent Manner
J. Immunol., June 1, 2002; 168(11): 5415 - 5423.
[Abstract] [Full Text] [PDF]

L. A. Cary, R. A. Klinghoffer, C. Sachsenmaier, and J. A. Cooper
Src Catalytic but Not Scaffolding Function Is Needed for Integrin-Regulated Tyrosine Phosphorylation, Cell Migration, and Cell Spreading
Mol. Cell. Biol., April 15, 2002; 22(8): 2427 - 2440.
[Abstract] [Full Text] [PDF]

G. Schratt, U. Philippar, J. Berger, H. Schwarz, O. Heidenreich, and A. Nordheim
Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells
J. Cell Biol., February 18, 2002; 156(4): 737 - 750.
[Abstract] [Full Text] [PDF]

A. Bhatt, I. Kaverina, C. Otey, and A. Huttenlocher
Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain
J. Cell Sci., January 9, 2002; 115(17): 3415 - 3425.
[Abstract] [Full Text] [PDF]

P. J. Bruce-Staskal, C. L. Weidow, J. J. Gibson, and A. H. Bouton
Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake
J. Cell Sci., January 7, 2002; 115(13): 2689 - 2700.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Sieg, D. J.

Articles by Schlaepfer, D. D.

Search for Related Content

PubMed

PubMed Citation

Articles by Sieg, D. J.

Articles by Schlaepfer, D. D.

Social Bookmarking

What's this?

				P. A. Kiely, G. S. Baillie, R. Barrett, D. A. Buckley, D. R. Adams, M. D. Houslay, and R. O'Connor Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase J. Biol. Chem., July 24, 2009; 284(30): 20263 - 20274. [Abstract] [Full Text] [PDF]

				A. Kasorn, P. Alcaide, Y. Jia, K. K. Subramanian, B. Sarraj, Y. Li, F. Loison, H. Hattori, L. E. Silberstein, W. F. Luscinskas, et al. Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating Both Adhesion-Dependent and -Independent Cellular Signals J. Immunol., July 15, 2009; 183(2): 1032 - 1043. [Abstract] [Full Text] [PDF]

				E. M. Goldblatt, E. R. Gentry, M. J. Fox, S. M. Gryaznov, C. Shen, and B.-S. Herbert The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel Mol. Cancer Ther., July 1, 2009; 8(7): 2027 - 2035. [Abstract] [Full Text] [PDF]

				U. Schlomann, J. C. Schwamborn, M. Muller, R. Fassler, and A. W. Puschel The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase J. Cell Sci., June 15, 2009; 122(12): 2034 - 2042. [Abstract] [Full Text] [PDF]

				A. Tomar, S.-T. Lim, Y. Lim, and D. D. Schlaepfer A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells J. Cell Sci., June 1, 2009; 122(11): 1852 - 1862. [Abstract] [Full Text] [PDF]

				K. E. Michael, D. W. Dumbauld, K. L. Burns, S. K. Hanks, and A. J. Garcia Focal Adhesion Kinase Modulates Cell Adhesion Strengthening via Integrin Activation Mol. Biol. Cell, May 1, 2009; 20(9): 2508 - 2519. [Abstract] [Full Text] [PDF]

				K. T. Chan, C. L. Cortesio, and A. Huttenlocher FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion J. Cell Biol., April 20, 2009; 185(2): 357 - 370. [Abstract] [Full Text] [PDF]

				J. M. Carvajal-Gonzalez, S. Mulero-Navarro, A. C. Roman, V. Sauzeau, J. M. Merino, X. R. Bustelo, and P. M. Fernandez-Salguero The Dioxin Receptor Regulates the Constitutive Expression of the Vav3 Proto-Oncogene and Modulates Cell Shape and Adhesion Mol. Biol. Cell, March 15, 2009; 20(6): 1715 - 1727. [Abstract] [Full Text] [PDF]

				E. Papusheva, F. M. de Queiroz, J. Dalous, Y. Han, A. Esposito, E. A. Jares-Erijmanxa, T. M. Jovin, and G. Bunt Dynamic conformational changes in the FERM domain of FAK are involved in focal-adhesion behavior during cell spreading and motility J. Cell Sci., March 1, 2009; 122(5): 656 - 666. [Abstract] [Full Text] [PDF]

				A. M. Manso, S.-M. Kang, S. V. Plotnikov, I. Thievessen, J. Oh, H. E. Beggs, and R. S. Ross Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration Am J Physiol Heart Circ Physiol, March 1, 2009; 296(3): H627 - H638. [Abstract] [Full Text] [PDF]

				Y. Wu, J. Zuo, G. Ji, H. Saiyin, X. Liu, F. Yin, N. Cao, Y. Wen, J. J. Li, and L. Yu Proapoptotic Function of Integrin {beta}3 in Human Hepatocellular Carcinoma Cells Clin. Cancer Res., January 1, 2009; 15(1): 60 - 69. [Abstract] [Full Text] [PDF]

				R. L. Sayers, L. J. Sundberg-Smith, M. Rojas, H. Hayasaka, J. T. Parsons, C. P. Mack, and J. M. Taylor FRNK Expression Promotes Smooth Muscle Cell Maturation During Vascular Development and After Vascular Injury Arterioscler Thromb Vasc Biol, December 1, 2008; 28(12): 2115 - 2122. [Abstract] [Full Text] [PDF]

				Q. Ding, C. L. Gladson, H. Wu, H. Hayasaka, and M. A. Olman Focal Adhesion Kinase (FAK)-related Non-kinase Inhibits Myofibroblast Differentiation through Differential MAPK Activation in a FAK-dependent Manner J. Biol. Chem., October 3, 2008; 283(40): 26839 - 26849. [Abstract] [Full Text] [PDF]

				M. F. Walsh, D. R. Ampasala, J. Hatfield, R. Vander Heide, S. Suer, A. K. Rishi, and M. D. Basson Transforming Growth Factor-{beta} Stimulates Intestinal Epithelial Focal Adhesion Kinase Synthesis via Smad- and p38-Dependent Mechanisms Am. J. Pathol., August 1, 2008; 173(2): 385 - 399. [Abstract] [Full Text] [PDF]

				S. Zhao, S. Ammanamanchi, M. Brattain, L. Cao, A. Thangasamy, J. Wang, and J. W. Freeman Smad4-dependent TGF-{beta} Signaling Suppresses RON Receptor Tyrosine Kinase-dependent Motility and Invasion of Pancreatic Cancer Cells J. Biol. Chem., April 25, 2008; 283(17): 11293 - 11301. [Abstract] [Full Text] [PDF]

				Y. Lim, S.-T. Lim, A. Tomar, M. Gardel, J. A. Bernard-Trifilo, X. L. Chen, S. A. Uryu, R. Canete-Soler, J. Zhai, H. Lin, et al. PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility J. Cell Biol., January 10, 2008; 180(1): 187 - 203. [Abstract] [Full Text] [PDF]

				H.-B. Guo, M. Randolph, and M. Pierce Inhibition of a Specific N-Glycosylation Activity Results in Attenuation of Breast Carcinoma Cell Invasiveness-related Phenotypes: INHIBITION OF EPIDERMAL GROWTH FACTOR-INDUCED DEPHOSPHORYLATION OF FOCAL ADHESION KINASE J. Biol. Chem., July 27, 2007; 282(30): 22150 - 22162. [Abstract] [Full Text] [PDF]

				M. Parri, F. Buricchi, E. Giannoni, G. Grimaldi, T. Mello, G. Raugei, G. Ramponi, and P. Chiarugi EphrinA1 Activates a Src/Focal Adhesion Kinase-mediated Motility Response Leading to Rho-dependent Actino/Myosin Contractility J. Biol. Chem., July 6, 2007; 282(27): 19619 - 19628. [Abstract] [Full Text] [PDF]

				Y. Shen, P. R. Khusial, X. Li, H. Ichikawa, A. P. Moreno, and G. S. Goldberg Src Utilizes Cas to Block Gap Junctional Communication Mediated by Connexin43 J. Biol. Chem., June 29, 2007; 282(26): 18914 - 18921. [Abstract] [Full Text] [PDF]

				D. D. Schlaepfer, S. Hou, S.-T. Lim, A. Tomar, H. Yu, Y. Lim, D. A. Hanson, S. A. Uryu, J. Molina, and S. K. Mitra Tumor Necrosis Factor-{alpha} Stimulates Focal Adhesion Kinase Activity Required for Mitogen-activated Kinase-associated Interleukin 6 Expression J. Biol. Chem., June 15, 2007; 282(24): 17450 - 17459. [Abstract] [Full Text] [PDF]

				J. K. Slack-Davis, K. H. Martin, R. W. Tilghman, M. Iwanicki, E. J. Ung, C. Autry, M. J. Luzzio, B. Cooper, J. C. Kath, W. G. Roberts, et al. Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor J. Biol. Chem., May 18, 2007; 282(20): 14845 - 14852. [Abstract] [Full Text] [PDF]

				J. L. Walker, I. M. Wolff, L. Zhang, and A. S. Menko Activation of Src Kinases Signals Induction of Posterior Capsule Opacification Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2214 - 2223. [Abstract] [Full Text] [PDF]

				Z. Salah, M. Maoz, E. Pokroy, M. Lotem, R. Bar-Shavit, and B. Uziely Protease-Activated Receptor-1 (hPar1), A Survival Factor Eliciting Tumor Progression Mol. Cancer Res., March 1, 2007; 5(3): 229 - 240. [Abstract] [Full Text] [PDF]

				F Rieder, J Brenmoehl, S Leeb, J Scholmerich, and G Rogler Wound healing and fibrosis in intestinal disease Gut, January 1, 2007; 56(1): 130 - 139. [Full Text] [PDF]

				F. Chang, C. A. Lemmon, D. Park, and L. H. Romer FAK Potentiates Rac1 Activation and Localization to Matrix Adhesion Sites: A Role for betaPIX Mol. Biol. Cell, January 1, 2007; 18(1): 253 - 264. [Abstract] [Full Text] [PDF]

				Y. Zhao, S. Itoh, X. Wang, T. Isaji, E. Miyoshi, Y. Kariya, K. Miyazaki, N. Kawasaki, N. Taniguchi, and J. Gu Deletion of Core Fucosylation on {alpha}3beta1 Integrin Down-regulates Its Functions J. Biol. Chem., December 15, 2006; 281(50): 38343 - 38350. [Abstract] [Full Text] [PDF]

				A. Serrels, I. R.J. Macpherson, T.R. J. Evans, F. Y. Lee, E. A. Clark, O. J. Sansom, G. H. Ashton, M. C. Frame, and V. G. Brunton Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib Mol. Cancer Ther., December 1, 2006; 5(12): 3014 - 3022. [Abstract] [Full Text] [PDF]

				Z. Chaar, P. O'Reilly, I. Gelman, and L. A. Sabourin v-Src-dependent Down-regulation of the Ste20-like Kinase SLK by Casein Kinase II J. Biol. Chem., September 22, 2006; 281(38): 28193 - 28199. [Abstract] [Full Text] [PDF]

				G. Monami, E. M. Gonzalez, M. Hellman, L. G. Gomella, R. Baffa, R. V. Iozzo, and A. Morrione Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex. Cancer Res., July 15, 2006; 66(14): 7103 - 7110. [Abstract] [Full Text] [PDF]

				M. G. Yeo, M. A. Partridge, E. J. Ezratty, Q. Shen, G. G. Gundersen, and E. E. Marcantonio Src SH2 Arginine 175 Is Required for Cell Motility: Specific Focal Adhesion Kinase Targeting and Focal Adhesion Assembly Function Mol. Cell. Biol., June 15, 2006; 26(12): 4399 - 4409. [Abstract] [Full Text] [PDF]