Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration

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S.-Y. Lin, S. Raval, Z. Zhang, M. Deverill, K. A. Siminovitch, D. R. Branch, and B. Haimovich
The Protein-tyrosine Phosphatase SHP-1 Regulates the Phosphorylation of {alpha}-Actinin
J. Biol. Chem., June 11, 2004; 279(24): 25755 - 25764.
[Abstract] [Full Text] [PDF]

X. Wu, S. Suetsugu, L. A. Cooper, T. Takenawa, and J.-L. Guan
Focal Adhesion Kinase Regulation of N-WASP Subcellular Localization and Function
J. Biol. Chem., March 5, 2004; 279(10): 9565 - 9576.
[Abstract] [Full Text] [PDF]

A. F. Palazzo, C. H. Eng, D. D. Schlaepfer, E. E. Marcantonio, and G. G. Gundersen
Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling
Science, February 6, 2004; 303(5659): 836 - 839.
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D. Ilic, B. Kovacic, K. Johkura, D. D. Schlaepfer, N. Tomasevic, Q. Han, J.-B. Kim, K. Howerton, C. Baumbusch, N. Ogiwara, et al.
FAK promotes organization of fibronectin matrix and fibrillar adhesions
J. Cell Sci., January 15, 2004; 117(2): 177 - 187.
[Abstract] [Full Text] [PDF]

D. Vial, C. Oliver, M. C. Jamur, M. V. D. Pastor, E. da Silva Trindade, E. Berenstein, J. Zhang, and R. P. Siraganian
Alterations in Granule Matrix and Cell Surface of Focal Adhesion Kinase-Deficient Mast Cells
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G. Kadare, M. Toutant, E. Formstecher, J.-C. Corvol, M. Carnaud, M.-C. Boutterin, and J.-A. Girault
PIAS1-mediated Sumoylation of Focal Adhesion Kinase Activates Its Autophosphorylationn
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[Abstract] [Full Text] [PDF]

K. Moissoglu and I. H. Gelman
v-Src Rescues Actin-based Cytoskeletal Architecture and Cell Motility and Induces Enhanced Anchorage Independence during Oncogenic Transformation of Focal Adhesion Kinase-null Fibroblasts
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				Y. Lim, S.-T. Lim, A. Tomar, M. Gardel, J. A. Bernard-Trifilo, X. L. Chen, S. A. Uryu, R. Canete-Soler, J. Zhai, H. Lin, et al. PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility J. Cell Biol., January 10, 2008; 180(1): 187 - 203. [Abstract] [Full Text] [PDF]

				H.-B. Guo, M. Randolph, and M. Pierce Inhibition of a Specific N-Glycosylation Activity Results in Attenuation of Breast Carcinoma Cell Invasiveness-related Phenotypes: INHIBITION OF EPIDERMAL GROWTH FACTOR-INDUCED DEPHOSPHORYLATION OF FOCAL ADHESION KINASE J. Biol. Chem., July 27, 2007; 282(30): 22150 - 22162. [Abstract] [Full Text] [PDF]

				M. Parri, F. Buricchi, E. Giannoni, G. Grimaldi, T. Mello, G. Raugei, G. Ramponi, and P. Chiarugi EphrinA1 Activates a Src/Focal Adhesion Kinase-mediated Motility Response Leading to Rho-dependent Actino/Myosin Contractility J. Biol. Chem., July 6, 2007; 282(27): 19619 - 19628. [Abstract] [Full Text] [PDF]

				Y. Shen, P. R. Khusial, X. Li, H. Ichikawa, A. P. Moreno, and G. S. Goldberg Src Utilizes Cas to Block Gap Junctional Communication Mediated by Connexin43 J. Biol. Chem., June 29, 2007; 282(26): 18914 - 18921. [Abstract] [Full Text] [PDF]

				D. D. Schlaepfer, S. Hou, S.-T. Lim, A. Tomar, H. Yu, Y. Lim, D. A. Hanson, S. A. Uryu, J. Molina, and S. K. Mitra Tumor Necrosis Factor-{alpha} Stimulates Focal Adhesion Kinase Activity Required for Mitogen-activated Kinase-associated Interleukin 6 Expression J. Biol. Chem., June 15, 2007; 282(24): 17450 - 17459. [Abstract] [Full Text] [PDF]

				J. K. Slack-Davis, K. H. Martin, R. W. Tilghman, M. Iwanicki, E. J. Ung, C. Autry, M. J. Luzzio, B. Cooper, J. C. Kath, W. G. Roberts, et al. Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor J. Biol. Chem., May 18, 2007; 282(20): 14845 - 14852. [Abstract] [Full Text] [PDF]

				J. L. Walker, I. M. Wolff, L. Zhang, and A. S. Menko Activation of Src Kinases Signals Induction of Posterior Capsule Opacification Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2214 - 2223. [Abstract] [Full Text] [PDF]

				Z. Salah, M. Maoz, E. Pokroy, M. Lotem, R. Bar-Shavit, and B. Uziely Protease-Activated Receptor-1 (hPar1), A Survival Factor Eliciting Tumor Progression Mol. Cancer Res., March 1, 2007; 5(3): 229 - 240. [Abstract] [Full Text] [PDF]

				F Rieder, J Brenmoehl, S Leeb, J Scholmerich, and G Rogler Wound healing and fibrosis in intestinal disease Gut, January 1, 2007; 56(1): 130 - 139. [Full Text] [PDF]

				F. Chang, C. A. Lemmon, D. Park, and L. H. Romer FAK Potentiates Rac1 Activation and Localization to Matrix Adhesion Sites: A Role for betaPIX Mol. Biol. Cell, January 1, 2007; 18(1): 253 - 264. [Abstract] [Full Text] [PDF]

				Y. Zhao, S. Itoh, X. Wang, T. Isaji, E. Miyoshi, Y. Kariya, K. Miyazaki, N. Kawasaki, N. Taniguchi, and J. Gu Deletion of Core Fucosylation on {alpha}3beta1 Integrin Down-regulates Its Functions J. Biol. Chem., December 15, 2006; 281(50): 38343 - 38350. [Abstract] [Full Text] [PDF]

				A. Serrels, I. R.J. Macpherson, T.R. J. Evans, F. Y. Lee, E. A. Clark, O. J. Sansom, G. H. Ashton, M. C. Frame, and V. G. Brunton Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib Mol. Cancer Ther., December 1, 2006; 5(12): 3014 - 3022. [Abstract] [Full Text] [PDF]

				Z. Chaar, P. O'Reilly, I. Gelman, and L. A. Sabourin v-Src-dependent Down-regulation of the Ste20-like Kinase SLK by Casein Kinase II J. Biol. Chem., September 22, 2006; 281(38): 28193 - 28199. [Abstract] [Full Text] [PDF]

				G. Monami, E. M. Gonzalez, M. Hellman, L. G. Gomella, R. Baffa, R. V. Iozzo, and A. Morrione Proepithelin Promotes Migration and Invasion of 5637 Bladder Cancer Cells through the Activation of ERK1/2 and the Formation of a Paxillin/FAK/ERK Complex. Cancer Res., July 15, 2006; 66(14): 7103 - 7110. [Abstract] [Full Text] [PDF]

				M. G. Yeo, M. A. Partridge, E. J. Ezratty, Q. Shen, G. G. Gundersen, and E. E. Marcantonio Src SH2 Arginine 175 Is Required for Cell Motility: Specific Focal Adhesion Kinase Targeting and Focal Adhesion Assembly Function Mol. Cell. Biol., June 15, 2006; 26(12): 4399 - 4409. [Abstract] [Full Text] [PDF]

				P. Bryant, Q. Zheng, and K. Pumiglia Focal Adhesion Kinase Controls Cellular Levels of p27/Kip1 and p21/Cip1 through Skp2-Dependent and -Independent Mechanisms. Mol. Cell. Biol., June 1, 2006; 26(11): 4201 - 4213. [Abstract] [Full Text] [PDF]

				P. M.F. Siesser and S. K. Hanks The Signaling and Biological Implications of FAK Overexpression in Cancer. Clin. Cancer Res., June 1, 2006; 12(11): 3233 - 3237. [Full Text] [PDF]

				R. S. Greenberg, A. M. Bernstein, M. Benezra, I. H. Gelman, L. Taliana, and S. K. Masur FAK-dependent regulation of myofibroblast differentiation FASEB J, May 1, 2006; 20(7): 1006 - 1008. [Abstract] [Full Text] [PDF]

				S. Meierjohann, E. Wende, A. Kraiss, C. Wellbrock, and M. Schartl The oncogenic epidermal growth factor receptor variant xiphophorus melanoma receptor kinase induces motility in melanocytes by modulation of focal adhesions. Cancer Res., March 15, 2006; 66(6): 3145 - 3152. [Abstract] [Full Text] [PDF]

				M. A. Partridge, F. S. David, and E. E. Marcantonio Displacement of the {beta} cytoplasmic domain recovers focal adhesion formation, cytoskeletal organization and motility in swapped integrin chimeras J. Cell Sci., March 15, 2006; 119(6): 1175 - 1183. [Abstract] [Full Text] [PDF]

				K. A. Kragtorp and J. R. Miller Regulation of somitogenesis by Ena/VASP proteins and FAK during Xenopus development Development, February 15, 2006; 133(4): 685 - 695. [Abstract] [Full Text] [PDF]

				Y. Shen, Z. Jia, R. G. Nagele, H. Ichikawa, and G. S. Goldberg Src Uses Cas to Suppress Fhl1 in Order to Promote Nonanchored Growth and Migration of Tumor Cells Cancer Res., February 1, 2006; 66(3): 1543 - 1552. [Abstract] [Full Text] [PDF]

				S. J. Wall, E. Werner, Z. Werb, and Y. A. DeClerck Discoidin Domain Receptor 2 Mediates Tumor Cell Cycle Arrest Induced by Fibrillar Collagen J. Biol. Chem., December 2, 2005; 280(48): 40187 - 40194. [Abstract] [Full Text] [PDF]

				D. A. Hsia, S.-T. Lim, J. A. Bernard-Trifilo, S. K. Mitra, S. Tanaka, J. den Hertog, D. N. Streblow, D. Ilic, M. H. Ginsberg, and D. D. Schlaepfer Integrin {alpha}4{beta}1 Promotes Focal Adhesion Kinase-Independent Cell Motility via {alpha}4 Cytoplasmic Domain-Specific Activation of c-Src Mol. Cell. Biol., November 1, 2005; 25(21): 9700 - 9712. [Abstract] [Full Text] [PDF]

				M. J. Riemenschneider, W. Mueller, R. A. Betensky, G. Mohapatra, and D. N. Louis In Situ Analysis of Integrin and Growth Factor Receptor Signaling Pathways in Human Glioblastomas Suggests Overlapping Relationships with Focal Adhesion Kinase Activation Am. J. Pathol., November 1, 2005; 167(5): 1379 - 1387. [Abstract] [Full Text] [PDF]

				A. Hamadi, M. Bouali, M. Dontenwill, H. Stoeckel, K. Takeda, and P. Ronde Regulation of focal adhesion dynamics and disassembly by phosphorylation of FAK at tyrosine 397 J. Cell Sci., October 1, 2005; 118(19): 4415 - 4425. [Abstract] [Full Text] [PDF]

				C. Urbinati, A. Bugatti, M. Giacca, D. Schlaepfer, M. Presta, and M. Rusnati {alpha}v{beta}3-integrin-dependent activation of focal adhesion kinase mediates NF-{kappa}B activation and motogenic activity by HIV-1 Tat in endothelial cells J. Cell Sci., September 1, 2005; 118(17): 3949 - 3958. [Abstract] [Full Text] [PDF]

				V. M. Golubovskaya, R. Finch, and W. G. Cance Direct Interaction of the N-terminal Domain of Focal Adhesion Kinase with the N-terminal Transactivation Domain of p53 J. Biol. Chem., July 1, 2005; 280(26): 25008 - 25021. [Abstract] [Full Text] [PDF]

				R. S. Fan, R. O. Jacamo, X. Jiang, J. Sinnett-Smith, and E. Rozengurt G Protein-coupled Receptor Activation Rapidly Stimulates Focal Adhesion Kinase Phosphorylation at Ser-843: MEDIATION BY Ca2+, CALMODULIN, AND Ca2+/CALMODULIN-DEPENDENT KINASE II J. Biol. Chem., June 24, 2005; 280(25): 24212 - 24220. [Abstract] [Full Text] [PDF]

				R. W. Tilghman, J. K. Slack-Davis, N. Sergina, K. H. Martin, M. Iwanicki, E. D. Hershey, H. E. Beggs, L. F. Reichardt, and J. T. Parsons Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells J. Cell Sci., June 15, 2005; 118(12): 2613 - 2623. [Abstract] [Full Text] [PDF]