Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotion

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Wang, H. Q.
	Articles by Smart, R. C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Wang, H. Q.
	Articles by Smart, R. C.


Social Bookmarking

	What's this?

Ashendel, C. L., Staller, J. M. and Boutwell, R. K (1983). Protein kinase activity associated with a phorbol ester receptor purified from mouse brain. Cancer Res 43, 4333-4337.[Abstract/Free Full Text]

Baggiolini, M., Dewald, B. and Moser, B (1994). Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines. Adv. Immunol 55, 97-179.[Medline]

Barker, J. N., Jones, M. L., Mitra, R. S., Crockett-Torabe, E., Fantone, J. C., Kunkel, S. L., Warren, J. S., Dixit, V. M. and Nickoloff, B. J (1991). Modulation of keratinocyte-derived interleukin-8 which is chemotactic for neutrophils and T lymphocytes. Am. J. Pathol 139, 869-876.[Abstract]

Blessing, M., Nanney, L. B., King, L. E., Jones, C. M. and Hogan, B. L (1993). Transgenic mice as a model to study the role of TGF--related molecules in hair follicles. Genes Dev 7, 204-215.[Abstract/Free Full Text]

Blumberg, P. M (1988). Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture. Cancer Res 48, 1-8.[Free Full Text]

Bos, J. D. and Kapsenberg, M. L (1993). The skin immune system: progress in cutaneous biology. Immunol. Today 14, 75-78.[Medline]

Chomczynski, P. and Sacchi, N (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem 162, 156-159.[Medline]

Dlugosz, A. A., Mischak, H., Mushinski, J. F. and Yuspa, S. H (1992). Transcripts encoding protein kinase C-,- ,-,- , and-are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells. Mol. Carcinog 5, 286-292.[Medline]

Dlugosz, A. A. and Yuspa, S. H (1993). Coordinate changes in gene expression which mark the spinous to granular cell transition in epidermis are regulated by protein kinase C. J. Cell Biol 120, 217-225.[Abstract/Free Full Text]

Dlugosz, A. A., Cheng, C., Williams, E. K., Dharia, A. G., Denning, M. F. and Yuspa, S. H (1994). Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-. Cancer Res 54, 6413-6420.[Abstract/Free Full Text]

Enk, A. H. and Katz, S. I (1992). Early molecular events in the induction phase of contact sensitivity. Proc. Nat. Acad. Sci. USA 89, 1398-1402.[Abstract/Free Full Text]

Fisher, G. J., Tavakkol, A., Leach, K., Burns, D., Basta, P., Loomis, C., Griffiths, C. E., Cooper, K. D., Reynolds, N. J., Elder, J. T. et al (1993). Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin: reduced expression of protein kinase C-II in psoriasis. J. Invest. Dermatol 101, 553-559.[Medline]

Fuchs, E (1990). Epidermal differentiation: the bare essentials. J. Cell Biol 111, 2807-2814.[Free Full Text]

Godson, C., Bell, K. S. and Insel, P. A (1993). Inhibition of expression of protein kinase C-by antisense cDNA inhibits phorbol ester-mediated arachidonate release. J. Biol Chem 268, 11946-11950.[Abstract/Free Full Text]

Gschwendt, M., Leibersperger, H., Kittstein, W. and Marks, F (1992). Protein kinase C-and- in murine epidermis. TPA induces down-regulation of PKC-but not PKC-. FEBS Lett 307, 151-155.[Medline]

Hansen, L. A., Monteiro-Riviere, N. A. and Smart, R. C (1990). Differential down-regulation of epidermal protein kinase C by 12-O-tetradecanoylphorbol-13-acetate and diacylglycerol: association with epidermal hyperplasia and tumor promotion. Cancer Res 50, 5740-5745.[Abstract/Free Full Text]

Kulke, R., Todt-Pingel, I., Rademacher, D., Rowert, J., Schroder, J. M. and Christophers, E (1996). Co-localized overexpression of GRO-and IL-8 mRNA is restricted to the suprapapillary layers of psoriatic lesions. J. Invest. Dermatol 106, 526-530.[Medline]

Lee, Y. S., Dlugosz, A. A., McKay, R., Dean, N. M. and Yuspa, S. H (1997). Definition by specific antisense oligonucleotides of a role for protein kinase C-in expression of differentiation markers in normal and neoplastic mouse epidermal keratinocytes. Mol. Carcinog 18, 44-53.[Medline]

Leibersperger, H., Gschwendt, M., Gernold, M. and Marks, F (1991). Immunological demonstration of a calcium-unresponsive protein kinase C of the-type in different species and murine tissues. Predominance in epidermis. J. Biol. Chem 266, 14778-14784.[Abstract/Free Full Text]

Matsue, H., Cruz, P. D. Jr, Bergstresser, P. R. and Takashima, A (1992). Cytokine expression by epidermal cell subpopulations. J. Invest. Dermatol 99, 42-.

Mills, K. J., Bocckino, S. B., Burns, D. J., Loomis, C. R. and Smart, R. C (1992). Alterations in protein kinase C isozymesand II in activated Ha-ras containing papillomas in the absence of an increase in diacylglycerol. Carcinogenesis 13, 1113-1120.[Abstract/Free Full Text]

Niedel, J. E., Kuhn, L. J. and Vandenbark, G. R (1983). Phorbol diester receptor copurifies with protein kinase C. Proc Nat. Acad Sci USA 80, 36-40.[Abstract/Free Full Text]

Nishizuka, Y (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.[Abstract/Free Full Text]

Oberyszyn, T. M., Sabourin, C. L., Bijur, G. N., Oberyszyn, A. S., Boros,L. G. and Robertson, F. M (1993). Interleukin-1gene expression and localization of interleukin-1 protein during tumor promotion. Mol. Carcinog 7, 238-248.[Medline]

Oh, H. S. and Smart, R. C (1996). An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proc. Nat. Acad. Sci. USA 93, 12525-12530.[Abstract/Free Full Text]

Ohba, M., Ishino, K., Kashiwagi, M., Kawabe, S., Chida, K., Huh, N. H. and Kuroki, T (1998). Induction of differentiation in normal human keratinocytes by adenovirus-mediated introduction of theand isoforms of protein kinase C. Mol. Cell Biol 18, 5199-5207.[Abstract/Free Full Text]

Osada, S., Hashimoto, Y., Nomura, S., Kohno, Y., Chida, K., Tajima, O., Kubo, K., Akimoto, K., Koizumi, H., Kitamura, Y. et al (1993). Predominant expression of nPKC-, a Ca2+-independent isoform of protein kinase C in epithelial tissues, in association with epithelial differentiation. Cell Growth Differ 4, 167-175.[Abstract]

Rennecke, J., Rehberger, P. A., Furstenberger, G., Johannes, F. J., Stohr, M., Marks, F. and Richter, K. H (1999). Protein kinase C-expression correlates with enhanced keratinocyte proliferation in normal and neoplastic mouse epidermis and in cell culture. Int. J. Cancer 80, 98-103.[Medline]

Reynolds, N. J., Talwar, H. S., Baldassare, J. J., Henderson, P. A., Elder, J. T., Voorhees, J. J. and Fisher, G. J (1993). Differential induction of phosphatidylcholine hydrolysis, diacylglycerol formation and protein kinase C activation by epidermal growth factor and transforming growth factor-in normal human skin fibroblasts and keratinocytes [published erratum appears in Biochem J 1993 Nov 1;295(Pt 3):903]. Biochem. J 294, 535-544.

Scholz, K., Furstenberger, G., Muller-Decker, K. and Marks, F (1995). Differential expression of prostaglandin-H synthase isoenzymes in normal and activated keratinocytes in vivo and in vitro. Biochem. J 309, 263-269.

Smart, R. C., Huang, M. T., Monteiro-Riviere, N. A., Wong, C. Q., Mills, K. J. and Conney, A. H (1988). Comparison of the effect of sn-1, 2-didecanoylglycerol and 12-O-tetradecanoylphorbol-13-acetate on cutaneous morphology, inflammation and tumor promotion in CD-1 mice. Carcinogenesis 9, 2221-2226.[Abstract/Free Full Text]

Smart, R. C., Mills, K. J., Hansen, L. A. and Conney, A. H (1989). Synthetic lipid second messenger sn-1, 2-didecanoylglycerol: a complete tumor promoter in mouse skin. Cancer Res 49, 4455-4458.[Abstract/Free Full Text]

Tekamp-Olson, P., Gallegos, C., Bauer, D., McClain, J., Sherry, B., Fabre, M., van Deventer, S. and Cerami, A (1990). Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. J. Exp. Med 172, 911-919.[Abstract/Free Full Text]

Toftgard, R., Yuspa, S. H. and Roop, D. R (1985). Keratin gene expression in mouse skin treated with 12-O-tetradecanoyl phorbol 13-acetate. Cancer Res 45, 5845-5850.[Abstract/Free Full Text]

Vasunia, K. B., Miller, M. L., Puga, A. and Baxter, C. S (1994). Granulocyte-macrophage colony-stimulating factor (GM-CSF) is expressed in mouse skin in response to tumor-promoting agents and modulates dermal inflammation and epidermal dark cell numbers. Carcinogenesis 15, 653-660.[Abstract/Free Full Text]

Wang, X. J., Warren, B. S., Beltran, L. M., Fosmire, S. P. and DiGiovanni, J (1993). Further identification of protein kinase C isozymes in mouse epidermis. J. Cancer Res. Clin. Oncol 119, 279-287.[Medline]

Wang, X. J., Warren, B. S., Rupp, T., Beltran, L. M. and DiGiovanni, J (1994). Loss of mouse epidermal protein kinase C isozyme activities following treatment with phorbol ester and non-phorbol ester tumor promoters. Carcinogenesis 15, 2795-2803.[Abstract/Free Full Text]

Watt, F. M (1989). Terminal differentiation of epidermal keratinocytes. Curr. Opin. Cell Biol 1, 1107-1115.[Medline]

Wilmer, J. L., Burleson, F. G., Kayama, F., Kanno, J. and Luster, M. I (1994). Cytokine induction in human epidermal keratinocytes exposed to contact irritants and its relation to chemical-induced inflammation in mouse skin. J. Invest. Dermatol 102, 915-922.[Medline]

Wolpe, S. D., Sherry, B., Juers, D., Davatelis, G., Yurt, R. W. and Cerami, A (1989). Identification and characterization of macrophage inflammatory protein 2. Proc. Nat. Acad. Sci. USA 86, 612-616.[Abstract/Free Full Text]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

H. C. Chong, M. J. Tan, V. Philippe, S. H. Tan, C. K. Tan, C. W. Ku, Y. Y. Goh, W. Wahli, L. Michalik, and N. S. Tan
Regulation of epithelial-mesenchymal IL-1 signaling by PPAR{beta}/{delta} is essential for skin homeostasis and wound healing
J. Cell Biol., March 23, 2009; 184(6): 817 - 831.
[Abstract] [Full Text] [PDF]

C. Cataisson, R. Ohman, G. Patel, A. Pearson, M. Tsien, S. Jay, L. Wright, H. Hennings, and S. H. Yuspa
Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis
Cancer Res., January 1, 2009; 69(1): 319 - 328.
[Abstract] [Full Text] [PDF]

R. Garg, A. G. Ramchandani, and G. B. Maru
Curcumin decreases 12-O-tetradecanoylphorbol-13-acetate-induced protein kinase C translocation to modulate downstream targets in mouse skin
Carcinogenesis, June 1, 2008; 29(6): 1249 - 1257.
[Abstract] [Full Text] [PDF]

S. Ikuta, H. Edamatsu, M. Li, L. Hu, and T. Kataoka
Crucial Role of Phospholipase C{varepsilon} in Skin Inflammation Induced by Tumor-Promoting Phorbol Ester
Cancer Res., January 1, 2008; 68(1): 64 - 72.
[Abstract] [Full Text] [PDF]

Amended Final Report on the Safety Assessment of Glyceryl Dilaurate, Glyceryl Diarachidate, Glyceryl Dibehenate, Glyceryl Dierucate, Glyceryl Dihydroxystearate, Glyceryl Diisopalmitate, Glyceryl Diisostearate, Glyceryl Dilinoleate, Glyceryl Dimyristate, Glyceryl Dioleate, Glyceryl Diricinoleate, Glyceryl Dipalmitate, Glyceryl Dipalmitoleate, Glyceryl Distearate, Glyceryl Palmitate Lactate, Glyceryl Stearate Citrate, Glyceryl Stearate Lactate, and Glyceryl Stearate Succinate
International Journal of Toxicology, May 1, 2007; 26(3_suppl): 1 - 30.
[Abstract] [Full Text] [PDF]

C. E. Oki-Idouchi and P. S. Lorenzo
Transgenic Overexpression of RasGRP1 in Mouse Epidermis Results in Spontaneous Tumors of the Skin
Cancer Res., January 1, 2007; 67(1): 276 - 280.
[Abstract] [Full Text] [PDF]

C. Pfeifhofer, T. Gruber, T. Letschka, N. Thuille, C. Lutz-Nicoladoni, N. Hermann-Kleiter, U. Braun, M. Leitges, and G. Baier
Defective IgG2a/2b Class Switching in PKC{alpha}-/- Mice
J. Immunol., May 15, 2006; 176(10): 6004 - 6011.
[Abstract] [Full Text] [PDF]

M. H. Aziz, D. L. Wheeler, B. Bhamb, and A. K. Verma
Protein Kinase C {delta} Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation-Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2
Cancer Res., January 15, 2006; 66(2): 713 - 722.
[Abstract] [Full Text] [PDF]

T. Hara, Y. Saito, T. Hirai, K. Nakamura, K. Nakao, M. Katsuki, and K. Chida
Deficiency of Protein Kinase C{alpha} in Mice Results in Impairment of Epidermal Hyperplasia and Enhancement of Tumor Formation in Two-Stage Skin Carcinogenesis
Cancer Res., August 15, 2005; 65(16): 7356 - 7362.
[Abstract] [Full Text] [PDF]

D. J. Kim, I. A. Murray, A. M. Burns, F. J. Gonzalez, G. H. Perdew, and J. M. Peters
Peroxisome Proliferator-activated Receptor-{beta}/{delta} Inhibits Epidermal Cell Proliferation by Down-regulation of Kinase Activity
J. Biol. Chem., March 11, 2005; 280(10): 9519 - 9527.
[Abstract] [Full Text] [PDF]

D. L. Wheeler, P. J. Reddig, K. J. Ness, C. P. Leith, T. D. Oberley, and A. K. Verma
Overexpression of Protein Kinase C-{epsilon} in the Mouse Epidermis Leads to a Spontaneous Myeloproliferative-Like Disease
Am. J. Pathol., January 1, 2005; 166(1): 117 - 126.
[Abstract] [Full Text] [PDF]

N. Kedei, D. J. Lundberg, A. Toth, P. Welburn, S. H. Garfield, and P. M. Blumberg
Characterization of the Interaction of Ingenol 3-Angelate with Protein Kinase C
Cancer Res., May 1, 2004; 64(9): 3243 - 3255.
[Abstract] [Full Text] [PDF]

F. Chu, L. H. Chen, and C. A. O'Brian
Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides--implications of oxidative protein kinase C regulation to cancer prevention
Carcinogenesis, April 1, 2004; 25(4): 585 - 596.
[Abstract] [Full Text] [PDF]

N. Osakabe, A. Yasuda, M. Natsume, and T. Yoshikawa
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model
Carcinogenesis, April 1, 2004; 25(4): 549 - 557.
[Abstract] [Full Text] [PDF]

R. A. Rambaratsingh, J. C. Stone, P. M. Blumberg, and P. S. Lorenzo
RasGRP1 Represents a Novel Non-protein Kinase C Phorbol Ester Signaling Pathway in Mouse Epidermal Keratinocytes
J. Biol. Chem., December 26, 2003; 278(52): 52792 - 52801.
[Abstract] [Full Text] [PDF]

H. Q. Wang, T. Quan, T. He, T. F. Franke, J. J. Voorhees, and G. J. Fisher
Epidermal Growth Factor Receptor-dependent, NF-{kappa}B-independent Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway Inhibits Ultraviolet Irradiation-induced Caspases-3, -8, and -9 in Human Keratinocytes
J. Biol. Chem., November 14, 2003; 278(46): 45737 - 45745.
[Abstract] [Full Text] [PDF]

C. Cataisson, E. Joseloff, R. Murillas, A. Wang, C. Atwell, S. Torgerson, M. Gerdes, J. Subleski, J.-L. Gao, P. M. Murphy, et al.
Activation of Cutaneous Protein Kinase C{alpha} Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways
J. Immunol., September 1, 2003; 171(5): 2703 - 2713.
[Abstract] [Full Text] [PDF]

G. W. Neill, L. R Ghali, J. L. Green, M. S. Ikram, M. P. Philpott, and A. G. Quinn
Loss of Protein Kinase C{alpha} Expression May Enhance the Tumorigenic Potential of Gli1 in Basal Cell Carcinoma
Cancer Res., August 1, 2003; 63(15): 4692 - 4697.
[Abstract] [Full Text] [PDF]

D. L. Wheeler, K. J. Ness, T. D. Oberley, and A. K. Verma
Inhibition of the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase C {epsilon} Transgenic Mice by {alpha}-Difluoromethylornithine Accompanied by Marked Hair Follicle Degeneration and Hair Loss
Cancer Res., June 15, 2003; 63(12): 3037 - 3042.
[Abstract] [Full Text] [PDF]

R. T. M. Boudreau, R. Garduno, and T.-J. Lin
Protein Phosphatase 2A and Protein Kinase Calpha Are Physically Associated and Are Involved in Pseudomonas aeruginosa-induced Interleukin 6 Production by Mast Cells
J. Biol. Chem., February 8, 2002; 277(7): 5322 - 5329.
[Abstract] [Full Text] [PDF]

J. Yang, J. Luan, Y. Yu, C. Li, R. A. DePinho, L. Chin, and A. Richmond
Induction of Melanoma in Murine Macrophage Inflammatory Protein 2 Transgenic Mice Heterozygous for Inhibitor of Kinase/Alternate Reading Frame
Cancer Res., November 1, 2001; 61(22): 8150 - 8157.
[Abstract] [Full Text] [PDF]

T. Takano, A. V. Cybulsky, X. Yang, and L. Aoudjit
Complement C5b-9 induces cyclooxygenase-2 gene transcription in glomerular epithelial cells
Am J Physiol Renal Physiol, November 1, 2001; 281(5): F841 - F850.
[Abstract] [Full Text] [PDF]

F. Chu, N. E. Ward, and C. A. O'Brian
Potent inactivation of representative members of each PKC isozyme subfamily and PKD via S-thiolation by the tumor-promotion/progression antagonist glutathione but not by its precursor cysteine
Carcinogenesis, August 1, 2001; 22(8): 1221 - 1229.
[Abstract] [Full Text] [PDF]

H. Q. Wang, M. P. Kim, H. F. Tiano, R. Langenbach, and R. C. Smart
Protein Kinase C-{alpha} Coordinately Regulates Cytosolic Phospholipase A2 Activity and the Expression of Cyclooxygenase-2 through Different Mechanisms in Mouse Keratinocytes
Mol. Pharmacol., April 1, 2001; 59(4): 860 - 866.
[Abstract] [Full Text]

M. Giroux and A. Descoteaux
Cyclooxygenase-2 Expression in Macrophages: Modulation by Protein Kinase C-{alpha}
J. Immunol., October 1, 2000; 165(7): 3985 - 3991.
[Abstract] [Full Text] [PDF]

G. Neufang, G. Furstenberger, M. Heidt, F. Marks, and K. Muller-Decker
Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin
PNAS, June 19, 2001; 98(13): 7629 - 7634.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Wang, H. Q.

Articles by Smart, R. C.

Search for Related Content

PubMed

PubMed Citation

Articles by Wang, H. Q.

Articles by Smart, R. C.

Social Bookmarking

What's this?

				C. Cataisson, R. Ohman, G. Patel, A. Pearson, M. Tsien, S. Jay, L. Wright, H. Hennings, and S. H. Yuspa Inducible Cutaneous Inflammation Reveals a Protumorigenic Role for Keratinocyte CXCR2 in Skin Carcinogenesis Cancer Res., January 1, 2009; 69(1): 319 - 328. [Abstract] [Full Text] [PDF]

				R. Garg, A. G. Ramchandani, and G. B. Maru Curcumin decreases 12-O-tetradecanoylphorbol-13-acetate-induced protein kinase C translocation to modulate downstream targets in mouse skin Carcinogenesis, June 1, 2008; 29(6): 1249 - 1257. [Abstract] [Full Text] [PDF]

				S. Ikuta, H. Edamatsu, M. Li, L. Hu, and T. Kataoka Crucial Role of Phospholipase C{varepsilon} in Skin Inflammation Induced by Tumor-Promoting Phorbol Ester Cancer Res., January 1, 2008; 68(1): 64 - 72. [Abstract] [Full Text] [PDF]

				Amended Final Report on the Safety Assessment of Glyceryl Dilaurate, Glyceryl Diarachidate, Glyceryl Dibehenate, Glyceryl Dierucate, Glyceryl Dihydroxystearate, Glyceryl Diisopalmitate, Glyceryl Diisostearate, Glyceryl Dilinoleate, Glyceryl Dimyristate, Glyceryl Dioleate, Glyceryl Diricinoleate, Glyceryl Dipalmitate, Glyceryl Dipalmitoleate, Glyceryl Distearate, Glyceryl Palmitate Lactate, Glyceryl Stearate Citrate, Glyceryl Stearate Lactate, and Glyceryl Stearate Succinate International Journal of Toxicology, May 1, 2007; 26(3_suppl): 1 - 30. [Abstract] [Full Text] [PDF]

				C. E. Oki-Idouchi and P. S. Lorenzo Transgenic Overexpression of RasGRP1 in Mouse Epidermis Results in Spontaneous Tumors of the Skin Cancer Res., January 1, 2007; 67(1): 276 - 280. [Abstract] [Full Text] [PDF]

				C. Pfeifhofer, T. Gruber, T. Letschka, N. Thuille, C. Lutz-Nicoladoni, N. Hermann-Kleiter, U. Braun, M. Leitges, and G. Baier Defective IgG2a/2b Class Switching in PKC{alpha}-/- Mice J. Immunol., May 15, 2006; 176(10): 6004 - 6011. [Abstract] [Full Text] [PDF]

				M. H. Aziz, D. L. Wheeler, B. Bhamb, and A. K. Verma Protein Kinase C {delta} Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation-Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Res., January 15, 2006; 66(2): 713 - 722. [Abstract] [Full Text] [PDF]

				T. Hara, Y. Saito, T. Hirai, K. Nakamura, K. Nakao, M. Katsuki, and K. Chida Deficiency of Protein Kinase C{alpha} in Mice Results in Impairment of Epidermal Hyperplasia and Enhancement of Tumor Formation in Two-Stage Skin Carcinogenesis Cancer Res., August 15, 2005; 65(16): 7356 - 7362. [Abstract] [Full Text] [PDF]

				D. J. Kim, I. A. Murray, A. M. Burns, F. J. Gonzalez, G. H. Perdew, and J. M. Peters Peroxisome Proliferator-activated Receptor-{beta}/{delta} Inhibits Epidermal Cell Proliferation by Down-regulation of Kinase Activity J. Biol. Chem., March 11, 2005; 280(10): 9519 - 9527. [Abstract] [Full Text] [PDF]

				D. L. Wheeler, P. J. Reddig, K. J. Ness, C. P. Leith, T. D. Oberley, and A. K. Verma Overexpression of Protein Kinase C-{epsilon} in the Mouse Epidermis Leads to a Spontaneous Myeloproliferative-Like Disease Am. J. Pathol., January 1, 2005; 166(1): 117 - 126. [Abstract] [Full Text] [PDF]

				N. Kedei, D. J. Lundberg, A. Toth, P. Welburn, S. H. Garfield, and P. M. Blumberg Characterization of the Interaction of Ingenol 3-Angelate with Protein Kinase C Cancer Res., May 1, 2004; 64(9): 3243 - 3255. [Abstract] [Full Text] [PDF]

				F. Chu, L. H. Chen, and C. A. O'Brian Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides--implications of oxidative protein kinase C regulation to cancer prevention Carcinogenesis, April 1, 2004; 25(4): 585 - 596. [Abstract] [Full Text] [PDF]

				N. Osakabe, A. Yasuda, M. Natsume, and T. Yoshikawa Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model Carcinogenesis, April 1, 2004; 25(4): 549 - 557. [Abstract] [Full Text] [PDF]

				R. A. Rambaratsingh, J. C. Stone, P. M. Blumberg, and P. S. Lorenzo RasGRP1 Represents a Novel Non-protein Kinase C Phorbol Ester Signaling Pathway in Mouse Epidermal Keratinocytes J. Biol. Chem., December 26, 2003; 278(52): 52792 - 52801. [Abstract] [Full Text] [PDF]

				H. Q. Wang, T. Quan, T. He, T. F. Franke, J. J. Voorhees, and G. J. Fisher Epidermal Growth Factor Receptor-dependent, NF-{kappa}B-independent Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway Inhibits Ultraviolet Irradiation-induced Caspases-3, -8, and -9 in Human Keratinocytes J. Biol. Chem., November 14, 2003; 278(46): 45737 - 45745. [Abstract] [Full Text] [PDF]

				C. Cataisson, E. Joseloff, R. Murillas, A. Wang, C. Atwell, S. Torgerson, M. Gerdes, J. Subleski, J.-L. Gao, P. M. Murphy, et al. Activation of Cutaneous Protein Kinase C{alpha} Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways J. Immunol., September 1, 2003; 171(5): 2703 - 2713. [Abstract] [Full Text] [PDF]

				G. W. Neill, L. R Ghali, J. L. Green, M. S. Ikram, M. P. Philpott, and A. G. Quinn Loss of Protein Kinase C{alpha} Expression May Enhance the Tumorigenic Potential of Gli1 in Basal Cell Carcinoma Cancer Res., August 1, 2003; 63(15): 4692 - 4697. [Abstract] [Full Text] [PDF]

				D. L. Wheeler, K. J. Ness, T. D. Oberley, and A. K. Verma Inhibition of the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase C {epsilon} Transgenic Mice by {alpha}-Difluoromethylornithine Accompanied by Marked Hair Follicle Degeneration and Hair Loss Cancer Res., June 15, 2003; 63(12): 3037 - 3042. [Abstract] [Full Text] [PDF]

				R. T. M. Boudreau, R. Garduno, and T.-J. Lin Protein Phosphatase 2A and Protein Kinase Calpha Are Physically Associated and Are Involved in Pseudomonas aeruginosa-induced Interleukin 6 Production by Mast Cells J. Biol. Chem., February 8, 2002; 277(7): 5322 - 5329. [Abstract] [Full Text] [PDF]

				J. Yang, J. Luan, Y. Yu, C. Li, R. A. DePinho, L. Chin, and A. Richmond Induction of Melanoma in Murine Macrophage Inflammatory Protein 2 Transgenic Mice Heterozygous for Inhibitor of Kinase/Alternate Reading Frame Cancer Res., November 1, 2001; 61(22): 8150 - 8157. [Abstract] [Full Text] [PDF]

				T. Takano, A. V. Cybulsky, X. Yang, and L. Aoudjit Complement C5b-9 induces cyclooxygenase-2 gene transcription in glomerular epithelial cells Am J Physiol Renal Physiol, November 1, 2001; 281(5): F841 - F850. [Abstract] [Full Text] [PDF]

				F. Chu, N. E. Ward, and C. A. O'Brian Potent inactivation of representative members of each PKC isozyme subfamily and PKD via S-thiolation by the tumor-promotion/progression antagonist glutathione but not by its precursor cysteine Carcinogenesis, August 1, 2001; 22(8): 1221 - 1229. [Abstract] [Full Text] [PDF]

				H. Q. Wang, M. P. Kim, H. F. Tiano, R. Langenbach, and R. C. Smart Protein Kinase C-{alpha} Coordinately Regulates Cytosolic Phospholipase A2 Activity and the Expression of Cyclooxygenase-2 through Different Mechanisms in Mouse Keratinocytes Mol. Pharmacol., April 1, 2001; 59(4): 860 - 866. [Abstract] [Full Text]

				M. Giroux and A. Descoteaux Cyclooxygenase-2 Expression in Macrophages: Modulation by Protein Kinase C-{alpha} J. Immunol., October 1, 2000; 165(7): 3985 - 3991. [Abstract] [Full Text] [PDF]

				G. Neufang, G. Furstenberger, M. Heidt, F. Marks, and K. Muller-Decker Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin PNAS, June 19, 2001; 98(13): 7629 - 7634. [Abstract] [Full Text] [PDF]