Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Ebisawa, T.
	Articles by Imamura, T.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Ebisawa, T.
	Articles by Imamura, T.


Social Bookmarking

	What's this?

Attisano, L., C\207rcamo, J., Ventura, F., Weis, F. M. B., Massague, J. and Wrana, J. L (1993). Identification of human activin and TGFtype I receptors that form heteromeric kinase complexes with type II receptors. Cell 75, 671-680.[Medline]

Attisano, L. and Wrana, J. L (1998). Mads and Smads in TGFsignalling. Curr. Opin. Cell Biol 10, 188-194.[Medline]

Celeste, A. J., Iannazzi, J. A., Taylor, R. C., Hewick, R. M., Rosen, V., Wang, E. A. and Wozney, J. M (1990). Identification of transforming growth factor-family members present in bone-inductive protein purified from bovine bone. Proc. Nat. Acad. Sci. USA 86, 9843-9847.

Chen, Y., Bhushan, A. and Vale, W (1997). Smad8 mediates the signalingof the ALK-2 receptor serine kinase. Proc. Nat. Acad. Sci. USA 94, 12938-12943.[Abstract/Free Full Text]

Derynck, R., Zhang, T. and Feng, X.-H (1998). Smads: Transcriptional activators of TGF-responses. Cell 95, 737-740.[Medline]

Feng, X.-H. and Derynck, R (1997). A kinase subdomain of transforming growth factor-(TGF- ) type I receptor determines the TGF-intracellular signaling specificity. EMBO J 16, 3912-3923.[Medline]

Franzen, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C.-H. and Miyazono, K (1993). Cloning of a TGFtype I receptor that forms a heteromeric complex with the TGF type II receptor. Cell 75, 681-692.[Medline]

Gitelman, S. E., Kobrin, M. S., Ye, J.-Q., Lopez, A. R., Lee, A. and Derynck, R (1994). Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and enchondral bone formation in vivo. J. Cell Biol 126, 1595-1609.[Abstract/Free Full Text]

Gitelman, S. E., Kirk, M., Ye, J.-Q., Filvaroff, E. H., Kahn, A. J. and Derynck, R (1995). Vgr-1/BMP-6 induces osteoblast differentiation of pluripotential mesenchymal cells. Cell Growth Differ 6, 827-836.[Abstract]

Graff, J. M., Bansal, A. and Melton, D. A (1996). Xenopus Mad proteins transduce distinct subsets of signals for the TGF-superfamily. Cell 85, 479-487.[Medline]

Heldin, C.-H., Miyazono, K. and ten Dijke, P (1997). TGF-signalling from cell membrane to nucleus through SMAD proteins. Nature 390, 465-471.[Medline]

Hogan, B. L (1996). Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10, 1580-1594.[Free Full Text]

Hoodless, P. A., Haerry, T., Abdollah, S., Stapleton, N., O'Connor, M. B., Attisano, L. and Wrana, J. L (1996). MADR1, a MAD-related protein that functions in BMP-2 signaling pathways. Cell 85, 489-500.[Medline]

Ichijo, H., Yamashita, H., ten Dijke, P., Eto, Y., Heldin, C.-H. and Miyazono, K (1993). Characterization of in vivo phosphorylation of activin type II receptor. Biochem. Biophys. Res. Commun 194, 1508-1514.[Medline]

Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J.-i., Kawabata, M. and Miyazono, K (1997). Smad6 inhibits signalling by the TGF-superfamily. Nature 389, 622-626.[Medline]

Jones, C. M., Lyons, K. M. and Hogan, B. L. M (1991). Involvement of bone morphogenetic protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in mouse. Development 111, 531-542.[Abstract]

Katagiri, T., Yamaguchi, A., Komaki, M., Abe, E., Takahashi, N., Ikeda, T., Rosen, V., Wozney, J. M., Fujisawa-Sehara, A. and Suda, T (1994). Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol 127, 1755-1766.[Abstract/Free Full Text]

Kawabata, M., Chytil, A. and Moses, H. L (1995). Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-receptor. J. Biol. Chem 270, 5625-5630.[Abstract/Free Full Text]

Kawabata, M., Imamura, T. and Miyazono, K (1998). Signal transduction by bone morphogenetic proteins. Cytokine Growth Factor Rev 9, 49-61.[Medline]

Kawabata, M., Inoue, H., Hanyu, A., Imamura, T. and Miyazono, K (1998). Smad proteins exist as monomers in vivo and undergo homo-and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J 17, 4056-4065.[Medline]

Koening, B. B., Cook, J. S., Wolsing, D. H., Ting, J., Tiesman, J. P., Correa, P. E., Olson, C. A., Pecquet, A. L., Ventura, F., Grant, R. A., Chen, G.-X., Wrana, J. L., Massague, J. and Rosenbaum, J. S (1994). Characterization and cloning of a receptor for BMP-2 and BMP-4 from NIH 3T3 cells. Mol. Cell. Biol 14, 5961-5974.[Abstract/Free Full Text]

Liu, F., Ventura, F., Doody, J. and Massague, J (1995). Human type II receptor for bone morphogenetic proteins (BMPs): extension of two-kinase receptor model to the BMPs. Mol. Cell. Biol 15, 3479-3486.[Abstract]

Lyons, K. M., Pelton, R. W. and Hogan, B. L. M (1989). Patterns of expression of murine Vgr-1 and BMP-2 RNA suggest that transforming growth factor--like genes coordinately regulate aspects of embryonic development. Genes Dev 3, 1657-1668.[Abstract/Free Full Text]

Mac\222as-Silva, M., Hoodless, P. A., Tang, S. J., Buchwald, M. and Wrana, J. L (1998). Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J. Biol. Chem 273, 25628-25636.[Abstract/Free Full Text]

Massague, J (1998). TGF-signal transduction. Annu. Rev. Biochem 67, 753-791.[Medline]

Nohno, T., Ishikawa, T., Saitoh, T., Hosokawa, K., Noji, S., Wolsing, D. H. and Rosenbaum, J. S (1995). Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. J. Biol. Chem 270, 22522-22526.[Abstract/Free Full Text]

Nishimura, R., Kato, Y., Chen, D., Harris, S. E., Mundy, G. R. and Yoneda, T (1998). Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J. Biol. Chem 273, 1872-1879.[Abstract/Free Full Text]

Oeda, E., Oka, Y., Miyazono, K. and Kawabata, M (1998). Interaction of Drosophila inhibitors of apoptosis with thick veins, a type I serine/threonine kinase receptor for Decapentaplegic. J. Biol. Chem 273, 9353-9356.[Abstract/Free Full Text]

Paralkar, V. M., Weeks, B. S., Yu, Y. M., Kleinman, H. K. and Reddi, A. H (1992). Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: potentiation and binding to type IV collagen. J. Cell Biol 119, 1721-1728.[Abstract/Free Full Text]

Reddi, A. H (1994). Bone and cartilage differentiation. Curr. Opin. Genet. Dev 4, 737-744.[Medline]

Rosenzweig, B. L., Imamura, T., Okadome, T., Cox, G. N., Yamashita, H., ten Dijke, P., Heldin, C.-H. and Miyazono, K (1995). Cloning and characterization of a human type II receptor for bone morphogenetic proteins. Proc. Nat. Acad. Sci. USA 92, 7632-7636.[Abstract/Free Full Text]

Shukunami, C., Shigeno, C., Atsumi, T., Ishizeki, K., Suzuki, F. and Hiraki, Y (1996). Chondrogenic differentiation of clonal mouse embryonic cell line ATDC5 in vivo: differentiation-dependent gene expression of parathyroid hormone (PTH)/PTH-related peptide receptor. J. Cell Biol 133, 457-468.[Abstract/Free Full Text]

Suzuki, A., Chang, C., Yingling, J. M., Wang, X.-H. and Hemmati-Brivanlou, A (1997). Smad5 induces ventral fates in Xenopus embryo. Dev. Biol 184, 402-405.[Medline]

Tamaki, K., Souchelnytskyi, S., Itoh, S., Nakao, A., Sampath, K., Heldin, C.-H. and ten Dijke, P (1998). Intracellular signaling of osteogenic protein-1 through Smad5 activation. J. Cell. Physiol 177, 355-363.[Medline]

Takeda, K., Ichijo, H., Fujii, M., Mochida, Y., Saitoh, M., Nishitoh, H., Sampath, T. K. and Miyazono, K (1998). Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA. J. Biol. Chem 273, 17079-17085.[Abstract/Free Full Text]

ten Dijke, P., Yamashita, H., Ichijo, H., Franzen, P., Laiho, M., Miyazono, K. and Heldin, C.-H (1994). Characterization of type I receptors for transforming growth factor-and activin. Science 264, 101-104.[Abstract/Free Full Text]

ten Dijke, P., Yamashita, H., Sampath, T. K., Reddi, A. H., Estevez, M., Riddle, D. L., Ichijo, H., Heldin, C.-H. and Miyazono, K (1994). Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J. Biol. Chem 269, 16985-16988.[Abstract/Free Full Text]

Thomsen, G. H (1996). Xenopus mothers against decapentaplegic is an embryonic ventralization agent that acts downstream of BMP-2/4 receptor. Development 122, 2359-2366.[Abstract]

Yamaguchi, A., Ishizuya, T., Kintou, N., Wada, Y., Katagiri, T., Wozney, J. M., Rosen, V. and Yoshiki, S (1996). Effect of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem. Biophys. Res. Commun 220, 366-371.[Medline]

Yamamoto, N., Akiyama, S., Katagiri, T., Namiki, M., Kurokawa, T. and Suda, T (1997). Smad1 and Smad5 act downstream of intracellular signaling of BMP-2 that inhibits myogenic differentiation and induces osteoblast differentiation in C2C12 myoblasts. Biochem. Biophys. Res. Commun 238, 574-580.[Medline]

Yamashita, H., ten Dijke, P., Huylebroeck, D., Sampath, T. K., Andries, M., Smith, J. C., Heldin, C-. H. and Miyazono, K (1995). Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects. J. Cell Biol 130, 217-226.[Abstract/Free Full Text]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

N. Y. Lee, K. C. Kirkbride, R. D. Sheu, and G. C. Blobe
The Transforming Growth Factor-{beta} Type III Receptor Mediates Distinct Subcellular Trafficking and Downstream Signaling of Activin-like Kinase (ALK)3 and ALK6 Receptors
Mol. Biol. Cell, October 15, 2009; 20(20): 4362 - 4370.
[Abstract] [Full Text] [PDF]

P. D. Upton, R. J. Davies, R. C. Trembath, and N. W. Morrell
Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells
J. Biol. Chem., June 5, 2009; 284(23): 15794 - 15804.
[Abstract] [Full Text] [PDF]

K. Inagaki, F. Otsuka, T. Miyoshi, M. Yamashita, M. Takahashi, J. Goto, J. Suzuki, and H. Makino
p38-Mitogen-Activated Protein Kinase Stimulated Steroidogenesis in Granulosa Cell-Oocyte Cocultures: Role of Bone Morphogenetic Proteins 2 and 4
Endocrinology, April 1, 2009; 150(4): 1921 - 1930.
[Abstract] [Full Text] [PDF]

M. Takahata, Y. Inoue, H. Tsuda, I. Imoto, D. Koinuma, M. Hayashi, T. Ichikura, T. Yamori, K. Nagasaki, M. Yoshida, et al.
SKI and MEL1 Cooperate to Inhibit Transforming Growth Factor-{beta} Signal in Gastric Cancer Cells
J. Biol. Chem., January 30, 2009; 284(5): 3334 - 3344.
[Abstract] [Full Text] [PDF]

D. Koinuma, S. Tsutsumi, N. Kamimura, H. Taniguchi, K. Miyazawa, M. Sunamura, T. Imamura, K. Miyazono, and H. Aburatani
Chromatin Immunoprecipitation on Microarray Analysis of Smad2/3 Binding Sites Reveals Roles of ETS1 and TFAP2A in Transforming Growth Factor {beta} Signaling
Mol. Cell. Biol., January 1, 2009; 29(1): 172 - 186.
[Abstract] [Full Text] [PDF]

E. Fukunaga, Y. Inoue, S. Komiya, K. Horiguchi, K. Goto, M. Saitoh, K. Miyazawa, D. Koinuma, A. Hanyu, and T. Imamura
Smurf2 Induces Ubiquitin-dependent Degradation of Smurf1 to Prevent Migration of Breast Cancer Cells
J. Biol. Chem., December 19, 2008; 283(51): 35660 - 35667.
[Abstract] [Full Text] [PDF]

M. Takahashi, F. Otsuka, T. Miyoshi, H. Otani, J. Goto, M. Yamashita, T. Ogura, H. Makino, and H. Doihara
Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation
J. Endocrinol., December 1, 2008; 199(3): 445 - 455.
[Abstract] [Full Text] [PDF]

C. Gamell, N. Osses, R. Bartrons, T. Ruckle, M. Camps, J. L. Rosa, and F. Ventura
BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity
J. Cell Sci., December 1, 2008; 121(23): 3960 - 3970.
[Abstract] [Full Text] [PDF]

Y. Xia, J. L. Babitt, Y. Sidis, R. T. Chung, and H. Y. Lin
Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
Blood, May 15, 2008; 111(10): 5195 - 5204.
[Abstract] [Full Text] [PDF]

T. Miyoshi, F. Otsuka, H. Otani, K. Inagaki, J. Goto, M. Yamashita, T. Ogura, Y. Iwasaki, and H. Makino
Involvement of bone morphogenetic protein-4 in GH regulation by octreotide and bromocriptine in rat pituitary GH3 cells
J. Endocrinol., April 1, 2008; 197(1): 159 - 169.
[Abstract] [Full Text] [PDF]

L Nicol, M-O Faure, J R McNeilly, J Fontaine, C Taragnat, and A S McNeilly
Bone morphogenetic protein-4 interacts with activin and GnRH to modulate gonadotrophin secretion in L{beta}T2 gonadotrophs
J. Endocrinol., March 1, 2008; 196(3): 497 - 507.
[Abstract] [Full Text] [PDF]

M. Yamashita, F. Otsuka, T. Mukai, H. Otani, K. Inagaki, T. Miyoshi, J. Goto, M. Yamamura, and H. Makino
Simvastatin antagonizes tumor necrosis factor-{alpha} inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway
J. Endocrinol., March 1, 2008; 196(3): 601 - 613.
[Abstract] [Full Text] [PDF]

A. Kotzsch, J. Nickel, A. Seher, K. Heinecke, L. van Geersdaele, T. Herrmann, W. Sebald, and T. D. Mueller
Structure Analysis of Bone Morphogenetic Protein-2 Type I Receptor Complexes Reveals a Mechanism of Receptor Inactivation in Juvenile Polyposis Syndrome
J. Biol. Chem., February 29, 2008; 283(9): 5876 - 5887.
[Abstract] [Full Text] [PDF]

K. Goto, Y. Kamiya, T. Imamura, K. Miyazono, and K. Miyazawa
Selective Inhibitory Effects of Smad6 on Bone Morphogenetic Protein Type I Receptors
J. Biol. Chem., July 13, 2007; 282(28): 20603 - 20611.
[Abstract] [Full Text] [PDF]

O. Scherner, S. K. Meurer, L. Tihaa, A. M. Gressner, and R. Weiskirchen
Endoglin Differentially Modulates Antagonistic Transforming Growth Factor-beta1 and BMP-7 Signaling
J. Biol. Chem., May 11, 2007; 282(19): 13934 - 13943.
[Abstract] [Full Text] [PDF]

H. Otani, F. Otsuka, K. Inagaki, M. Takeda, T. Miyoshi, J. Suzuki, T. Mukai, T. Ogura, and H. Makino
Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation
Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1513 - F1525.
[Abstract] [Full Text] [PDF]

T. Miyoshi, F. Otsuka, K. Inagaki, H. Otani, M. Takeda, J. Suzuki, J. Goto, T. Ogura, and H. Makino
Differential Regulation of Steroidogenesis by Bone Morphogenetic Proteins in Granulosa Cells: Involvement of Extracellularly Regulated Kinase Signaling and Oocyte Actions in Follicle-Stimulating Hormone-Induced Estrogen Production
Endocrinology, January 1, 2007; 148(1): 337 - 345.
[Abstract] [Full Text] [PDF]

M. Nagata, K. Goto, S. Ehata, N. Kobayashi, M. Saitoh, H. Miyoshi, T. Imamura, K. Miyazawa, and K. Miyazono
Nuclear and cytoplasmic c-Ski differently modulate cellular functions
Genes Cells, November 1, 2006; 11(11): 1267 - 1280.
[Abstract] [Full Text] [PDF]

E. Bangi and K. Wharton
Dual function of the Drosophila Alk1/Alk2 ortholog Saxophone shapes the Bmp activity gradient in the wing imaginal disc
Development, September 1, 2006; 133(17): 3295 - 3303.
[Abstract] [Full Text] [PDF]

S. Mazerbourg and A. J.W. Hsueh
Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands
Hum. Reprod. Update, July 1, 2006; 12(4): 373 - 383.
[Abstract] [Full Text] [PDF]

K. Inagaki, F. Otsuka, J. Suzuki, Y. Kano, M. Takeda, T. Miyoshi, H. Otani, Y. Mimura, T. Ogura, and H. Makino
Involvement of Bone Morphogenetic Protein-6 in Differential Regulation of Aldosterone Production by Angiotensin II and Potassium in Human Adrenocortical Cells
Endocrinology, June 1, 2006; 147(6): 2681 - 2689.
[Abstract] [Full Text] [PDF]

T. Miyoshi, F. Otsuka, J. Suzuki, M. Takeda, K. Inagaki, Y. Kano, H. Otani, Y. Mimura, T. Ogura, and H. Makino
Mutual Regulation of Follicle-Stimulating Hormone Signaling and Bone Morphogenetic Protein System in Human Granulosa Cells
Biol Reprod, June 1, 2006; 74(6): 1073 - 1082.
[Abstract] [Full Text] [PDF]

Z. Wang, C. C. Clark, and C. T. Brighton
Up-Regulation of Bone Morphogenetic Proteins in Cultured Murine Bone Cells with Use of Specific Electric Fields
J. Bone Joint Surg. Am., May 1, 2006; 88(5): 1053 - 1065.
[Abstract] [Full Text] [PDF]

S. Mazerbourg, K. Sangkuhl, C.-W. Luo, S. Sudo, C. Klein, and A. J. W. Hsueh
Identification of Receptors and Signaling Pathways for Orphan Bone Morphogenetic Protein/Growth Differentiation Factor Ligands Based on Genomic Analyses
J. Biol. Chem., September 16, 2005; 280(37): 32122 - 32132.
[Abstract] [Full Text] [PDF]

J. Dai, J. Keller, J. Zhang, Y. Lu, Z. Yao, and E. T. Keller
Bone Morphogenetic Protein-6 Promotes Osteoblastic Prostate Cancer Bone Metastases through a Dual Mechanism
Cancer Res., September 15, 2005; 65(18): 8274 - 8285.
[Abstract] [Full Text] [PDF]

P. B. Yu, H. Beppu, N. Kawai, E. Li, and K. D. Bloch
Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells
J. Biol. Chem., July 1, 2005; 280(26): 24443 - 24450.
[Abstract] [Full Text] [PDF]

T. Satoh, K. Kimura, Y. Okano, M. Hirakata, Y. Kawakami, and M. Kuwana
Lack of circulating autoantibodies to bone morphogenetic protein receptor-II or activin receptor-like kinase 1 in mixed connective tissue disease patients with pulmonary arterial hypertension
Rheumatology, February 1, 2005; 44(2): 192 - 196.
[Abstract] [Full Text] [PDF]

M. Takeda, F. Otsuka, K. Nakamura, K. Inagaki, J. Suzuki, D. Miura, H. Fujio, H. Matsubara, H. Date, T. Ohe, et al.
Characterization of the Bone Morphogenetic Protein (BMP) System in Human Pulmonary Arterial Smooth Muscle Cells Isolated from a Sporadic Case of Primary Pulmonary Hypertension: Roles of BMP Type IB Receptor (Activin Receptor-Like Kinase-6) in the Mitotic Action
Endocrinology, September 1, 2004; 145(9): 4344 - 4354.
[Abstract] [Full Text] [PDF]

A. Brederlau, R. Faigle, M. Elmi, A. Zarebski, S. Sjoberg, M. Fujii, K. Miyazono, and K. Funa
The Bone Morphogenetic Protein Type Ib Receptor Is a Major Mediator of Glial Differentiation and Cell Survival in Adult Hippocampal Progenitor Cell Culture
Mol. Biol. Cell, August 1, 2004; 15(8): 3863 - 3875.
[Abstract] [Full Text] [PDF]

T. Akiyoshi, K. Uchida, and S. Tateyama
Expression of Bone Morphogenetic Protein-6 and Bone Morphogenetic Protein Receptors in Myoepithelial Cells of Canine Mammary Gland Tumors
Vet. Pathol., March 1, 2004; 41(2): 154 - 163.
[Abstract] [Full Text] [PDF]

S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson
The Bone Morphogenetic Protein System In Mammalian Reproduction
Endocr. Rev., February 1, 2004; 25(1): 72 - 101.
[Abstract] [Full Text] [PDF]

C. Glister, C F. Kemp, and P. G Knight
Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin
Reproduction, February 1, 2004; 127(2): 239 - 254.
[Abstract] [Full Text] [PDF]

J. Suzuki, F. Otsuka, K. Inagaki, M. Takeda, T. Ogura, and H. Makino
Novel Action of Activin and Bone Morphogenetic Protein in Regulating Aldosterone Production by Human Adrenocortical Cells
Endocrinology, February 1, 2004; 145(2): 639 - 649.
[Abstract] [Full Text] [PDF]

E. Hay, J. Lemonnier, O. Fromigue, H. Guenou, and P. J. Marie
Bone Morphogenetic Protein Receptor IB Signaling Mediates Apoptosis Independently of Differentiation in Osteoblastic Cells
J. Biol. Chem., January 16, 2004; 279(3): 1650 - 1658.
[Abstract] [Full Text] [PDF]

S. Matsuyama, M. Iwadate, M. Kondo, M. Saitoh, A. Hanyu, K. Shimizu, H. Aburatani, H. K. Mishima, T. Imamura, K. Miyazono, et al.
SB-431542 and Gleevec Inhibit Transforming Growth Factor-{beta}-Induced Proliferation of Human Osteosarcoma Cells
Cancer Res., November 15, 2003; 63(22): 7791 - 7798.
[Abstract] [Full Text] [PDF]

N. Kusu, J. Laurikkala, M. Imanishi, H. Usui, M. Konishi, A. Miyake, I. Thesleff, and N. Itoh
Sclerostin Is a Novel Secreted Osteoclast-derived Bone Morphogenetic Protein Antagonist with Unique Ligand Specificity
J. Biol. Chem., June 20, 2003; 278(26): 24113 - 24117.
[Abstract] [Full Text] [PDF]

Y. Tajima, K. Goto, M. Yoshida, K. Shinomiya, T. Sekimoto, Y. Yoneda, K. Miyazono, and T. Imamura
Chromosomal Region Maintenance 1 (CRM1)-dependent Nuclear Export of Smad Ubiquitin Regulatory Factor 1 (Smurf1) Is Essential for Negative Regulation of Transforming Growth Factor-beta Signaling by Smad7
J. Biol. Chem., March 14, 2003; 278(12): 10716 - 10721.
[Abstract] [Full Text] [PDF]

R. K. Moore, F. Otsuka, and S. Shimasaki
Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells
J. Biol. Chem., January 3, 2003; 278(1): 304 - 310.
[Abstract] [Full Text] [PDF]

C. Suzuki, G. Murakami, M. Fukuchi, T. Shimanuki, Y. Shikauchi, T. Imamura, and K. Miyazono
Smurf1 Regulates the Inhibitory Activity of Smad7 by Targeting Smad7 to the Plasma Membrane
J. Biol. Chem., October 11, 2002; 277(42): 39919 - 39925.
[Abstract] [Full Text] [PDF]

U. Valcourt, J. Gouttenoire, A. Moustakas, D. Herbage, and F. Mallein-Gerin
Functions of Transforming Growth Factor-beta Family Type I Receptors and Smad Proteins in the Hypertrophic Maturation and Osteoblastic Differentiation of Chondrocytes
J. Biol. Chem., September 6, 2002; 277(37): 33545 - 33558.
[Abstract] [Full Text] [PDF]

A. Nishihara, T. Watabe, T. Imamura, and K. Miyazono
Functional Heterogeneity of Bone Morphogenetic Protein Receptor-II Mutants Found in Patients with Primary Pulmonary Hypertension
Mol. Biol. Cell, September 1, 2002; 13(9): 3055 - 3063.
[Abstract] [Full Text] [PDF]

C. Shiels, S. A. Islam, R. Vatcheva, P. Sasieni, M. J. E. Sternberg, P. S. Freemont, and D. Sheer
PML bodies associate specifically with the MHC gene cluster in interphase nuclei
J. Cell Sci., March 12, 2002; 114(20): 3705 - 3716.
[Abstract] [Full Text] [PDF]

R. Jaatinen, J. Bondestam, T. Raivio, K. Hilden, L. Dunkel, N. Groome, and O. Ritvos
Activation of the Bone Morphogenetic Protein Signaling Pathway Induces Inhibin {beta}B-Subunit mRNA and Secreted Inhibin B Levels in Cultured Human Granulosa-Luteal Cells
J. Clin. Endocrinol. Metab., March 1, 2002; 87(3): 1254 - 1261.
[Abstract] [Full Text] [PDF]

Y. Wang, C.-F. Chang, M. Morales, J. Chou, H.-L. Chen, Y.-H. Chiang, S.-Z. Lin, J. L. Cadet, X. Deng, J.-Y. Wang, et al.
Bone Morphogenetic Protein-6 Reduces Ischemia-Induced Brain Damage in Rats
Stroke, September 1, 2001; 32(9): 2170 - 2178.
[Abstract] [Full Text] [PDF]

M. Furuhashi, K. Yagi, H. Yamamoto, Y. Furukawa, S. Shimada, Y. Nakamura, A. Kikuchi, K. Miyazono, and M. Kato
Axin Facilitates Smad3 Activation in the Transforming Growth Factor {beta} Signaling Pathway
Mol. Cell. Biol., August 1, 2001; 21(15): 5132 - 5141.
[Abstract] [Full Text] [PDF]

M. Fukuchi, T. Imamura, T. Chiba, T. Ebisawa, M. Kawabata, K. Tanaka, and K. Miyazono
Ligand-dependent Degradation of Smad3 by a Ubiquitin Ligase Complex of ROC1 and Associated Proteins
Mol. Biol. Cell, May 1, 2001; 12(5): 1431 - 1443.
[Abstract] [Full Text]

P. S. Leboy, G. Grasso-Knight, M. D'Angelo, S. W. Volk, J. B. Lian, H. Drissi, G. S. Stein, and S. L. Adams
Smad-Runx Interactions During Chondrocyte Maturation
J. Bone Joint Surg. Am., April 1, 2001; 83(90010): S15 - 22.
[Abstract] [Full Text] [PDF]

P. S. Leboy, G. Grasso-Knight, M. D'Angelo, S. W. Volk, J. B. Lian, H. Drissi, G. S. Stein, and S. L. Adams
Smad-Runx Interactions During Chondrocyte Maturation
J. Bone Joint Surg. Am., March 1, 2001; 83(1_suppl_1): S15 - S22.
[Abstract] [Full Text] [PDF]

H Aoki, M Fujii, T Imamura, K Yagi, K Takehara, M Kato, and K Miyazono
Synergistic effects of different bone morphogenetic protein type I receptors on alkaline phosphatase induction
J. Cell Sci., January 4, 2001; 114(8): 1483 - 1489.
[Abstract] [PDF]

T. Ebisawa, M. Fukuchi, G. Murakami, T. Chiba, K. Tanaka, T. Imamura, and K. Miyazono
Smurf1 Interacts with Transforming Growth Factor-beta Type I Receptor through Smad7 and Induces Receptor Degradation
J. Biol. Chem., April 13, 2001; 276(16): 12477 - 12480.
[Abstract] [Full Text] [PDF]

X. Gu, B.-H. Shin, Y. Akbarali, A. Weiss, J. Boltax, P. Oettgen, and T. A. Libermann
Tel-2 Is a Novel Transcriptional Repressor Related to the Ets Factor Tel/ETV-6
J. Biol. Chem., March 16, 2001; 276(12): 9421 - 9436.
[Abstract] [Full Text] [PDF]

F. Otsuka, R. K. Moore, and S. Shimasaki
Biological Function and Cellular Mechanism of Bone Morphogenetic Protein-6 in the Ovary
J. Biol. Chem., August 24, 2001; 276(35): 32889 - 32895.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Ebisawa, T.

Articles by Imamura, T.

Search for Related Content

PubMed

PubMed Citation

Articles by Ebisawa, T.

Articles by Imamura, T.

Social Bookmarking

What's this?

				P. D. Upton, R. J. Davies, R. C. Trembath, and N. W. Morrell Bone Morphogenetic Protein (BMP) and Activin Type II Receptors Balance BMP9 Signals Mediated by Activin Receptor-like Kinase-1 in Human Pulmonary Artery Endothelial Cells J. Biol. Chem., June 5, 2009; 284(23): 15794 - 15804. [Abstract] [Full Text] [PDF]

				K. Inagaki, F. Otsuka, T. Miyoshi, M. Yamashita, M. Takahashi, J. Goto, J. Suzuki, and H. Makino p38-Mitogen-Activated Protein Kinase Stimulated Steroidogenesis in Granulosa Cell-Oocyte Cocultures: Role of Bone Morphogenetic Proteins 2 and 4 Endocrinology, April 1, 2009; 150(4): 1921 - 1930. [Abstract] [Full Text] [PDF]

				M. Takahata, Y. Inoue, H. Tsuda, I. Imoto, D. Koinuma, M. Hayashi, T. Ichikura, T. Yamori, K. Nagasaki, M. Yoshida, et al. SKI and MEL1 Cooperate to Inhibit Transforming Growth Factor-{beta} Signal in Gastric Cancer Cells J. Biol. Chem., January 30, 2009; 284(5): 3334 - 3344. [Abstract] [Full Text] [PDF]

				D. Koinuma, S. Tsutsumi, N. Kamimura, H. Taniguchi, K. Miyazawa, M. Sunamura, T. Imamura, K. Miyazono, and H. Aburatani Chromatin Immunoprecipitation on Microarray Analysis of Smad2/3 Binding Sites Reveals Roles of ETS1 and TFAP2A in Transforming Growth Factor {beta} Signaling Mol. Cell. Biol., January 1, 2009; 29(1): 172 - 186. [Abstract] [Full Text] [PDF]

				E. Fukunaga, Y. Inoue, S. Komiya, K. Horiguchi, K. Goto, M. Saitoh, K. Miyazawa, D. Koinuma, A. Hanyu, and T. Imamura Smurf2 Induces Ubiquitin-dependent Degradation of Smurf1 to Prevent Migration of Breast Cancer Cells J. Biol. Chem., December 19, 2008; 283(51): 35660 - 35667. [Abstract] [Full Text] [PDF]

				M. Takahashi, F. Otsuka, T. Miyoshi, H. Otani, J. Goto, M. Yamashita, T. Ogura, H. Makino, and H. Doihara Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation J. Endocrinol., December 1, 2008; 199(3): 445 - 455. [Abstract] [Full Text] [PDF]

				C. Gamell, N. Osses, R. Bartrons, T. Ruckle, M. Camps, J. L. Rosa, and F. Ventura BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity J. Cell Sci., December 1, 2008; 121(23): 3960 - 3970. [Abstract] [Full Text] [PDF]

				Y. Xia, J. L. Babitt, Y. Sidis, R. T. Chung, and H. Y. Lin Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin Blood, May 15, 2008; 111(10): 5195 - 5204. [Abstract] [Full Text] [PDF]

				T. Miyoshi, F. Otsuka, H. Otani, K. Inagaki, J. Goto, M. Yamashita, T. Ogura, Y. Iwasaki, and H. Makino Involvement of bone morphogenetic protein-4 in GH regulation by octreotide and bromocriptine in rat pituitary GH3 cells J. Endocrinol., April 1, 2008; 197(1): 159 - 169. [Abstract] [Full Text] [PDF]

				L Nicol, M-O Faure, J R McNeilly, J Fontaine, C Taragnat, and A S McNeilly Bone morphogenetic protein-4 interacts with activin and GnRH to modulate gonadotrophin secretion in L{beta}T2 gonadotrophs J. Endocrinol., March 1, 2008; 196(3): 497 - 507. [Abstract] [Full Text] [PDF]

				M. Yamashita, F. Otsuka, T. Mukai, H. Otani, K. Inagaki, T. Miyoshi, J. Goto, M. Yamamura, and H. Makino Simvastatin antagonizes tumor necrosis factor-{alpha} inhibition of bone morphogenetic proteins-2-induced osteoblast differentiation by regulating Smad signaling and Ras/Rho-mitogen-activated protein kinase pathway J. Endocrinol., March 1, 2008; 196(3): 601 - 613. [Abstract] [Full Text] [PDF]

				A. Kotzsch, J. Nickel, A. Seher, K. Heinecke, L. van Geersdaele, T. Herrmann, W. Sebald, and T. D. Mueller Structure Analysis of Bone Morphogenetic Protein-2 Type I Receptor Complexes Reveals a Mechanism of Receptor Inactivation in Juvenile Polyposis Syndrome J. Biol. Chem., February 29, 2008; 283(9): 5876 - 5887. [Abstract] [Full Text] [PDF]

				K. Goto, Y. Kamiya, T. Imamura, K. Miyazono, and K. Miyazawa Selective Inhibitory Effects of Smad6 on Bone Morphogenetic Protein Type I Receptors J. Biol. Chem., July 13, 2007; 282(28): 20603 - 20611. [Abstract] [Full Text] [PDF]

				O. Scherner, S. K. Meurer, L. Tihaa, A. M. Gressner, and R. Weiskirchen Endoglin Differentially Modulates Antagonistic Transforming Growth Factor-beta1 and BMP-7 Signaling J. Biol. Chem., May 11, 2007; 282(19): 13934 - 13943. [Abstract] [Full Text] [PDF]

				H. Otani, F. Otsuka, K. Inagaki, M. Takeda, T. Miyoshi, J. Suzuki, T. Mukai, T. Ogura, and H. Makino Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation Am J Physiol Renal Physiol, May 1, 2007; 292(5): F1513 - F1525. [Abstract] [Full Text] [PDF]

				T. Miyoshi, F. Otsuka, K. Inagaki, H. Otani, M. Takeda, J. Suzuki, J. Goto, T. Ogura, and H. Makino Differential Regulation of Steroidogenesis by Bone Morphogenetic Proteins in Granulosa Cells: Involvement of Extracellularly Regulated Kinase Signaling and Oocyte Actions in Follicle-Stimulating Hormone-Induced Estrogen Production Endocrinology, January 1, 2007; 148(1): 337 - 345. [Abstract] [Full Text] [PDF]

				M. Nagata, K. Goto, S. Ehata, N. Kobayashi, M. Saitoh, H. Miyoshi, T. Imamura, K. Miyazawa, and K. Miyazono Nuclear and cytoplasmic c-Ski differently modulate cellular functions Genes Cells, November 1, 2006; 11(11): 1267 - 1280. [Abstract] [Full Text] [PDF]

				E. Bangi and K. Wharton Dual function of the Drosophila Alk1/Alk2 ortholog Saxophone shapes the Bmp activity gradient in the wing imaginal disc Development, September 1, 2006; 133(17): 3295 - 3303. [Abstract] [Full Text] [PDF]

				S. Mazerbourg and A. J.W. Hsueh Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands Hum. Reprod. Update, July 1, 2006; 12(4): 373 - 383. [Abstract] [Full Text] [PDF]

				K. Inagaki, F. Otsuka, J. Suzuki, Y. Kano, M. Takeda, T. Miyoshi, H. Otani, Y. Mimura, T. Ogura, and H. Makino Involvement of Bone Morphogenetic Protein-6 in Differential Regulation of Aldosterone Production by Angiotensin II and Potassium in Human Adrenocortical Cells Endocrinology, June 1, 2006; 147(6): 2681 - 2689. [Abstract] [Full Text] [PDF]

				T. Miyoshi, F. Otsuka, J. Suzuki, M. Takeda, K. Inagaki, Y. Kano, H. Otani, Y. Mimura, T. Ogura, and H. Makino Mutual Regulation of Follicle-Stimulating Hormone Signaling and Bone Morphogenetic Protein System in Human Granulosa Cells Biol Reprod, June 1, 2006; 74(6): 1073 - 1082. [Abstract] [Full Text] [PDF]

				Z. Wang, C. C. Clark, and C. T. Brighton Up-Regulation of Bone Morphogenetic Proteins in Cultured Murine Bone Cells with Use of Specific Electric Fields J. Bone Joint Surg. Am., May 1, 2006; 88(5): 1053 - 1065. [Abstract] [Full Text] [PDF]

				S. Mazerbourg, K. Sangkuhl, C.-W. Luo, S. Sudo, C. Klein, and A. J. W. Hsueh Identification of Receptors and Signaling Pathways for Orphan Bone Morphogenetic Protein/Growth Differentiation Factor Ligands Based on Genomic Analyses J. Biol. Chem., September 16, 2005; 280(37): 32122 - 32132. [Abstract] [Full Text] [PDF]

				J. Dai, J. Keller, J. Zhang, Y. Lu, Z. Yao, and E. T. Keller Bone Morphogenetic Protein-6 Promotes Osteoblastic Prostate Cancer Bone Metastases through a Dual Mechanism Cancer Res., September 15, 2005; 65(18): 8274 - 8285. [Abstract] [Full Text] [PDF]

				P. B. Yu, H. Beppu, N. Kawai, E. Li, and K. D. Bloch Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells J. Biol. Chem., July 1, 2005; 280(26): 24443 - 24450. [Abstract] [Full Text] [PDF]

				T. Satoh, K. Kimura, Y. Okano, M. Hirakata, Y. Kawakami, and M. Kuwana Lack of circulating autoantibodies to bone morphogenetic protein receptor-II or activin receptor-like kinase 1 in mixed connective tissue disease patients with pulmonary arterial hypertension Rheumatology, February 1, 2005; 44(2): 192 - 196. [Abstract] [Full Text] [PDF]

				M. Takeda, F. Otsuka, K. Nakamura, K. Inagaki, J. Suzuki, D. Miura, H. Fujio, H. Matsubara, H. Date, T. Ohe, et al. Characterization of the Bone Morphogenetic Protein (BMP) System in Human Pulmonary Arterial Smooth Muscle Cells Isolated from a Sporadic Case of Primary Pulmonary Hypertension: Roles of BMP Type IB Receptor (Activin Receptor-Like Kinase-6) in the Mitotic Action Endocrinology, September 1, 2004; 145(9): 4344 - 4354. [Abstract] [Full Text] [PDF]

				A. Brederlau, R. Faigle, M. Elmi, A. Zarebski, S. Sjoberg, M. Fujii, K. Miyazono, and K. Funa The Bone Morphogenetic Protein Type Ib Receptor Is a Major Mediator of Glial Differentiation and Cell Survival in Adult Hippocampal Progenitor Cell Culture Mol. Biol. Cell, August 1, 2004; 15(8): 3863 - 3875. [Abstract] [Full Text] [PDF]

				T. Akiyoshi, K. Uchida, and S. Tateyama Expression of Bone Morphogenetic Protein-6 and Bone Morphogenetic Protein Receptors in Myoepithelial Cells of Canine Mammary Gland Tumors Vet. Pathol., March 1, 2004; 41(2): 154 - 163. [Abstract] [Full Text] [PDF]

				S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson The Bone Morphogenetic Protein System In Mammalian Reproduction Endocr. Rev., February 1, 2004; 25(1): 72 - 101. [Abstract] [Full Text] [PDF]