Profilin is predominantly associated with monomeric actin in Acanthamoeba

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Almo, S. C., Pollard, T. D., Way, M. and Lattman, E. E (1994). Purification, characterization and crystallization of Acanthamoeba profilin expressed in Escherichia coli. J. Mol. Biol 236, 950-952.[Medline]

Alvarez-Martinez, M. T., Mani, J. C., Porte, F., Faivre-Sarrailh, C., Liautard, J. P. and Sri Widada, J (1996). Characterization of the interaction between annexin I and profilin. Eur. J. Biochem 238, 777-784.[Medline]

Archer, S. J., Vinson, V. K., Pollard, T. D. and Torchia, D. A (1994). Elucidation of the poly-L-proline binding site in Acanthamoeba profilin-I by NMR spectroscopy. FEBS Lett 337, 145-151.[Medline]

Balasubramanian, M. K., Hirani, B. R., Burke, J. D. and Gould, K. L (1994). The Schizosaccharomyces pombe cdc3+ gene encodes a profilin essential for cytokinesis. J. Cell Biol 125, 1289-1301.[Abstract/Free Full Text]

Bray, D. and Thomas, C (1976). Unpolymerized actin in fibroblasts and brain. J. Mol. Biol 105, 527-544.[Medline]

Bubb, M. R., Baines, I. C. and Korn, E. D (1998). Localization of actobindin, profilin I, profilin II and phosphatidylinositol-4, 5-bisphosphate (PIP2) in Acanthamoeba castellanii. Cell Motil. Cytoskel 39, 134-146.[Medline]

Buss, F., Temm-Grove, C., Henning, S. and Jockusch, B (1992). Distribution of profilin in fibroblasts correlates with the presence of highly dynamic actin filaments. Cell Motil. Cytoskel 22, 51-61.[Medline]

Carlsson, L., Nystrom, L. E., Sundkvisk, I., Markey, F. and Lindberg, U (1977). Actin polymerizability is influenced by profilin, a low molecular weight protein in non-muscle cells. J. Mol. Biol 115, 465-483.[Medline]

Castrillon, D. and Wasserman, D (1994). diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene. Development 120, 3367-3377.[Abstract]

Chang, F., Drubin, D. and Nurse, P (1997). cdc12p, a protein required for cytokinesis in fission yeast, is a component of the cell division ring and interacts with profilin. J. Cell Biol 137, 169-182.[Abstract/Free Full Text]

Clarke, M. S. and McNeil, P. L (1992). Syringe loading introduces macromolecules into living mammalian cell cytosol. J. Cell Sci 102, 533-541.[Abstract/Free Full Text]

Cooley, L., Verheyen, E. and Ayers, K (1992). Chickadee encodes a profilin required for intercellular cytoplasmic transport during Drosophila oogenesis. Cell 69, 173-184.[Medline]

Doberstein, S., Baines, I. C., Weigand, G., Korn, E. D. and Pollard, T. D (1993). Inhibition of contractile vacuole function in-vivo by antibodies against myosin-I. Nature 365, 841-843.[Medline]

Eads, J. C., Mahoney, N. M., Vorobiev, S., Bresnick, A. R., Wen, K. K., Rubenstein, P. A., Haarer, B. K. and Almo, S. C (1998). Structure determination and characterization of Saccharomyces cerevisea profilin. Biochemistry 37, 11171-11181.[Medline]

Eddy, R. J., Han, J. and Condeelis, J. S (1997). Capping protein terminates but does not initiate chemoattractant-induced actin assembly in Dictyostelium. J. Cell Biol 139, 1243-1253.[Abstract/Free Full Text]

Edmatsu, M., Hirono, M. and Watanabe, Y (1992). Tetrahymena profilin is localized in the division furrow. J. Biochem 112, 637-642.

Evangelista, M., Blundell, K., Longtine, M., Chow, C., Adames, N., Pringle, J., Peter, M. and Boone. C (1997). Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis. Science 276, 118-122.[Abstract/Free Full Text]

Faivre-Sarrailh, C., Lena, J. Y., Had, L., Vignes, M. and Lindberg, U (1993). Location of profilin at presynaptic sites in the cerebellar cortex; implication for the regulation of the actin-polymerization state during axonal elongation and synaptogenesis. J. Neurocytol 22, 1060-1072.[Medline]

Frazier, J. A. and Field, C. M (1997). Actin cytoskeleton: are FH proteins local organizers?. Curr. Biol 7, 414-.

Goldschmidt-Clermont, P. J., Kim, J. W., Machesky, L. M., Rhee, S. G. and Pollard, T. D (1991). Regulation of phospholipase C-1 by profilin and tyrosine phosphorylation. Science 251, 1231-1233.[Abstract/Free Full Text]

Gutsche-Perelroizen, I., Lepault, J., Ott, A. and Carlier, M.-F (1999). Filament assembly from profilin-actin. J. Biol. Chem 274, 6234-6243.[Abstract/Free Full Text]

Haarer, B. K., Petzold, A. S. and Brown, S. S (1993). Mutational analysis of yeast profilin. Mol. Cell. Biol 13, 7864-7873.[Abstract/Free Full Text]

Hajkova, L., Bjorkegren Sjogren, C., Korenbaum, E., Nordberg, P. and Karlsson, R (1997). Characterization of a mutant profilin with reduced actin-binding capacity: effects in vitro and in vivo. Exp. Cell Res 234, 66-77.[Medline]

Harris, S., Hamer, L., Sharpless, K. and Hamer, J (1997). The Aspergillus nidulans sepA gene encodes an FH1/2 protein involved in cytokinesis and the maintenance of cellular polarity. EMBO J 16, 3474-3483.[Medline]

Hartwig, J. H., Chambers, K. A., Hopcia, K. L. and Kwiatkowski, D. J (1989). Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation. J. Cell. Biol 109, 1571-1579.[Abstract/Free Full Text]

Haugwitz, M., Noegel, A. A., Karakesisoglou, J. and Schleicher, M (1994). Dictyostelium amebas that lack G-actin-sequestering profilins show defects in F-actin content, cytokinesis and development. Cell 79, 303-314.[Medline]

Janmey, P. A (1994). Phosphoinositides and calcium as regulators of cellular actin assembly and disassembly. Annu. Rev. Physiol 56, 169-191.[Medline]

Kaiser, D. A., Sato, M., Ebert, R. and Pollard, T. D (1986). Purification and characterization of two isoforms of Acanthamoeba profilin. J. Cell Biol 102, 221-226.[Abstract/Free Full Text]

Kaiser, D. A., Goldschmidt-Clermont, P. J., Levine, B. A. and Pollard, T. D (1989). Characterization of renatured profilin purified by urea elution from poly-L-proline agarose columns. Cell Motil. Cytoskel 14, 251-262.[Medline]

Kaiser, D. A. and Pollard, T. D (1996). Characterization of actin and poly-L-proline binding sites of Acanthamoeba profilin with monoclonal antibodies and by mutagenesis. J. Mol. Biol 255, 89-107.

Kiehart, D. P., Kaiser, D. A. and Pollard, T. D (1984). Monoclonal antibodies demonstrate limited structural homology between myosin isozymes from Acanthamoeba. J. Cell Biol 99, 1002-1014.[Abstract/Free Full Text]

Laemmli, U. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.[Medline]

Lassing, I. and Lindberg, U (1985). Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin. Nature 314, 472-474.[Medline]

Lessard, J. L (1988). 2 monoclonal antibodies to actin \320 one muscle selective and one generally reactive. Cell Motil. Cytoskel 10, 349-362.[Medline]

Ma, L., Rohatgi, R. and Kirschner, M. W (1998). , The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42. Proc. Nat. Acad. Sci. USA 95, 15362-15367.[Abstract/Free Full Text]

Machesky, L. M., Goldschmidt-Clermont, P. J. and Pollard, T. D (1990). The affinities of human platelet and Acanthamoeba profilin isoforms for polyphosphoinositides account for their relative abilities to inhibit phospholipase C. Cell Reg 1, 937-950.[Medline]

Machesky, L. M., Atkinson, S. J., Ampe, C., Vandekerckhove, J. and Pollard, T. D (1994). Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin agarose. J. Cell Biol 127, 107-115.[Abstract/Free Full Text]

Machesky, L. M., Mullins, R. D., Higgs, H. N., Kaiser, D. A., Blanchoin, L., May, R., Hall, M. and Pollard, T. D (1999). Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc. Nat. Acad. Sci. USA 96, 3739-3744.[Abstract/Free Full Text]

Magdolen, V., Oechsner, U., Muller, G. and Bandlow, W (1988). The intron-containing gene for yeast profilin (PFY) encodes a vital function. Mol. Cell Biol 8, 5108-5115.[Abstract/Free Full Text]

Mahoney, N. M., Janmey, P. A. and Almo, S. C (1997). Structure of the profilin-poly-L-proline complex involved in morphogenesis and cytoskeletal regulation. Nat. Struct. Biol 4, 953-960.[Medline]

Mayboroda, O., Schluter, K. and Jockusch, B (1997). Differentialcolocalization of profilin with microfilaments in PtK2cells. Cell Motil. Cytoskel 37, 166-177.[Medline]

Metzler, W. J., Bell, A. J., Ernst, E., Lavoie, T. B. and Mueller, L (1994). Identification of the poly-L-proline-binding site on human profilin. J. Biol. Chem 269, 4620-4625.[Abstract/Free Full Text]

Mullins, R. D., Heuser, J. A. and Pollard, T. D (1998). The interaction of Arp2/3 complex with actin: nucleation, high-affinity pointed end capping and formation of branching networks of filaments. Proc. Nat. Acad. Sci. USA 95, 6181-6186.[Abstract/Free Full Text]

Mullins, R. D., Kelleher, J. F., Xu, J. and Pollard, T. D (1998). Arp2/3 complex from Acanthamoeba binds profilin and crosslinks actin filaments. Mol. Biol. Cell 9, 841-852.[Abstract/Free Full Text]

Mullins, R. D. and Pollard, T. D (1999). Structure and function of the Arp2/3 complex. Curr. Opin. Struct. Biol 9, 244-249.[Medline]

Pantaloni, D. and Carlier, M.-F (1993). How profilin promotes actin filament assembly in the presence of thymosin4. Cell 75, 1007-1014.[Medline]

Perelroizen, I., Marchand, J. B., Blanchoin, L., Didry, D. and Carlier, M.-F (1994). Interaction of profilin with G-actin and poly(L-proline). Biochemistry 33, 8472-8478.[Medline]

Petrella, E. C., Machesky, L. M., Kaiser, D. A. and Pollard, T. D (1996). Structural requirements and thermodynamics of the interaction of proline peptides with profilin. Biochemistry 35, 16535-16543.[Medline]

Pollard, T. D (1984). Polymerization of ADP-actin. J. Cell Biol 99, 769-777.[Abstract/Free Full Text]

Pollard, T. D. and Cooper, J. A (1984). Quantitative analysis of the effect of Acanthamoeba profilin on actin filament nucleation and elongation. Biochemistry 23, 6631-6641.[Medline]

Pollard, T. D. and Cooper, J. A (1986). Actin and actin-binding proteins. A critical evaluation of mechanisms and functions. Annu. Rev. Biochem 55, 987-1035.[Medline]

Pring, M., Weber, A. and Bubb, M (1992). Profilin-actin complexes directly elongate actin filaments at the barbed end. Biochemistry 31, 1827-1836.[Medline]

Reichlin, M (1980). Use of glutaraldehyde as a coupling agent for proteins and peptides. Meth. Enzymol 70, 159-165.[Medline]

Reinhard, M., Giehl, K., Abel, K., Haffner, C., Jarchau, T., Hoppe, V., Jockusch, B. M. and Walter, U (1995). The proline-rich focal adhesion and microfilament protein VASP is a ligand for profilins. EMBO J 14, 1583-1589.[Medline]

Rohatgi, R., Ma, L., Miki, H., Lopez, M., Kirchhausen, T., Takenawa, T. and Kirschner, M. W (1999). The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97, 221-231.[Medline]

Rothkegel, M., Mayboroda, O., Rohde, M., Wucherpfennig, C., Valenta, R. and Jockusch, B. M (1996). Plant and animal profilins are functionally equivalent and stabilize microfilaments in living animal cells. J. Cell Sci 109, 83-90.[Abstract]

Schafer, D. A., Jennings, P. B. and Cooper, J. A (1996). Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J. Cell Biol 135, 169-179.[Abstract/Free Full Text]

Schluter, K., Jockusch, B. M. and Rothkegel, M (1997). Profilins as regulators of actin dynamics. Biochim. Biophys. Acta 1359, 97-109.[Medline]

Schutt, C., Myslik, J. C., Rozychi, M. D., Goonesekere, N. C. W. and Lindberg, U (1993). The structure of crystalline profilin--actin. Nature 365, 810-816.[Medline]

Sinard, J. H. and Pollard, T. D (1989). Microinjection into Acanthamoeba castellanii of monoclonal antibodies to myosin-II slows but does not stop cell locomotion. Cell Motil. Cytoskel 12, 42-53.[Medline]

Suetsugu, S., Miki, H. and Takenawa, T (1998). The essential role of profilin in the assembly of actin for microspike formation. EMBO J 17, 6516-6526.[Medline]

Svitkina, T. M., Verkhovsky, A. B., McQuade, K. M. and Borisy, G. G (1997). Analysis of the actin-myosin II system in fish epidermal keratocytes: mechanism of cell body translocation. J. Cell Biol 139, 397-415.[Abstract/Free Full Text]

Tanaka, M. and Shibata, H (1985). Poly (L-proline)-binding proteins from chick embryos are a profilin and profilactin. Eur. J. Biochem 151, 291-297.[Medline]

Tarachandani, A. and Wang, Y. L (1996). Site-directed mutagenesis enabled preparation of a functional fluorescent analog of profilin: biochemical characterization and localization in living cells. Cell Motil. Cytoskel 34, 313-323.[Medline]

Tseng, P. C. H., Runge, M. S., Cooper, J. A., Williams, Jr., R. C. and Pollard, T. D (1984). Physical, immunochemical and functional properties of Acanthamoeba profilin. J. Cell Biol 98, 214-221.[Abstract/Free Full Text]

Vandekerckhove, J., Kaiser, D. A. and Pollard, T. D (1989). Acanthamoeba actin and profilin can be crosslinked between glutamic acid 364 of actin and lysine 115 of profilin. J. Cell Biol 109, 619-626.[Abstract/Free Full Text]

Verheyen, E. M. and Cooley, L (1994). Profilin mutations disrupt multiple actin-dependent processes during Drosophila development. Development 120, 717-728.[Abstract]

Vidali, L. and Hepler, P. K (1997). Characterization and localization of profilin in pollen grains and tubes of Lilium longiflorum. Cell Motil. Cytoskel 36, 323-338.[Medline]

Vinson, V. K., De La Cruz, E. M., Higgs, H. N. and Pollard, T. D (1998). Interactions of Acanthamoeba profilin with actin and nucleotides bound to actin. Biochemistry 37, 10871-10880.[Medline]

Watanabe, N., Madaule, P., Reid, T., Ishizaki, T., Watanabe, G., Kakizuka, A., Saito, Y., Nakao, K., Jockusch, B. and Narumiya, S (1997). p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J 16, 3044-3056.[Medline]

Welch, M. D., DePace, A. H., Verma, S., Iwamatsu, A. and Mitchison, T. J (1997). The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J. Cell Biol 138, 375-384.[Abstract/Free Full Text]

Winter, D., Lechler, T. and Li, R (1999). Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. Curr. Biol 9, 501-504.[Medline]

Witke, W., Sharpe, A. H. and Kwiatkowski, D. J (1993). Profilin deficient mice are not viable. Mol. Biol. Cell 4, 149-.

Witke, W. A., Podtelejnikov, V., Di Nardo, A., Sutherland, J. D., Gurniak, C. B., Dotti, C. and Mann, M (1998). In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. EMBO J 17, 967-976.[Medline]

Yonemura, S. Y. and Pollard, T. D (1992). Localization of myosin-I and myosin-II in Acanthamoeba. J. Cell Sci 102, 629-642.[Abstract/Free Full Text]

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				D. R. Kovar, J. R. Kuhn, A. L. Tichy, and T. D. Pollard The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin J. Cell Biol., June 9, 2003; 161(5): 875 - 887. [Abstract] [Full Text] [PDF]

				H.-H. Kong and T. D. Pollard Intracellular localization and dynamics of myosin-II and myosin-IC in live Acanthamoeba by transient transfection of EGFP fusion proteins J. Cell Sci., March 14, 2003; 115(24): 4993 - 5002. [Abstract] [Full Text] [PDF]

				B. N. Snowman, D. R. Kovar, G. Shevchenko, V. E. Franklin-Tong, and C. J. Staiger Signal-Mediated Depolymerization of Actin in Pollen during the Self-Incompatibility Response PLANT CELL, October 1, 2002; 14(10): 2613 - 2626. [Abstract] [Full Text] [PDF]

				A Di Nardo, R Gareus, D Kwiatkowski, and W Witke Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms J. Cell Sci., January 11, 2000; 113(21): 3795 - 3803. [Abstract] [PDF]

				H. Mimuro, T. Suzuki, S. Suetsugu, H. Miki, T. Takenawa, and C. Sasakawa Profilin Is Required for Sustaining Efficient Intra- and Intercellular Spreading of Shigella flexneri J. Biol. Chem., September 8, 2000; 275(37): 28893 - 28901. [Abstract] [Full Text] [PDF]

				J. Zalevsky, I. Grigorova, and R. D. Mullins Activation of the Arp2/3 Complex by the Listeria ActA Protein. ActA BINDS TWO ACTIN MONOMERS AND THREE SUBUNITS OF THE Arp2/3 COMPLEX J. Biol. Chem., January 26, 2001; 276(5): 3468 - 3475. [Abstract] [Full Text] [PDF]

				W. Witke, J. D. Sutherland, A. Sharpe, M. Arai, and D. J. Kwiatkowski Profilin I is essential for cell survival and cell division in early mouse development PNAS, March 27, 2001; 98(7): 3832 - 3836. [Abstract] [Full Text] [PDF]