HIV-induced T-cell syncytia release a two component T-helper cell chemoattractant composed of Nef and Tat

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Shutt, D. C.
	Articles by Soll, D. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Shutt, D. C.
	Articles by Soll, D. R.


Social Bookmarking

	What's this?

Aiken, C., Konner, J., Landau, N. R., Lenburg, M. E. and Trono, D (1994). Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell 76, 853-864.[Medline]

Albini, A., Errini, S., Benelli, R., Sforzini, S., Giunciuglio, D., Aluigi, M. G., Proudfoot, A. E., Alouani, S., Wells, T. N., Mariani, G., Rabin, R. L., Farber, J. M. and Noonan, D. M (1998). HIV-1 Tat protein mimicry of chemokines. Proc. Nat. Acad. Sci. USA 95, 13151-13158.

Arthos, J., Deen, K. C., Chaikin, M. A., Fornwald, J. A., Sathe, G., Sattentau, Q. J., Clapham, P. R., Weiss, R. A., McDougal, J. S., Pietropaolo, C., Axel, R., Truneh, A., Maddon, P. J. and Sweet, R. W (1989). Identification of the residues in human CD4 critical for the binding of HIV. Cell 57, 469-481.[Medline]

Attanasio, R. J. S., Allan, J. S., Anderson, S. A., Chanh, T. C. and Kennedy, R. C (1991). Anti-idiotypic antibody response to monoclonal anti-CD4 preparations in nonhuman primate species. J. Immunol 146, 507-514.[Abstract]

Benelli, R., Mortarini, R., Anichini, A., Giunciuglio, D., Noonan, D. M., Montalti, S., Tacchetti, C. and Albini, A (1998). Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides. AIDS 12, 261-268.[Medline]

Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark-Lewis, I., Sodroski, J. and Springer, T. A (1996). The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382, 829-833.[Medline]

Bohan, C. A, Kashanchi, F., Ensoli, B., Buonaguro, L., Boris-Lawrie, K. and Brady, J. N (1992). Analysis of Tat transactivation of human immunodeficiency virus transcription in vitro. Gene Expr 2, 391-407.[Medline]

Boyden, S. V (1962). The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J. Exp. Med 115, 453-466.[Abstract]

Campbell, J. J., Qin, S., Bacon, K. B., Mackay, C. R. and Butcher, E. C (1996). Biology of chemokine and classical chemoattractant receptors: differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells. J. Cell Biol 134, 255-266.[Abstract/Free Full Text]

Campioni, D., Corallini, A., Zauli, G., Possati, L., Altavilla, G. and Barbanti-Brodano, G (1995). HIV type I extracellular Tat protein stimulates growth and protects cells of BK virus/tat transgenic mice from apoptosis. AIDS Res Hum Retroviruses 11, 1039-1048.[Medline]

Cruikshank, W. W., Greenstein, J. L., Theodore, A. C. and Center, D. M (1991). Lymphocyte chemoattractant factor induces CD4-dependent intracytoplasmic signaling in lymphocytes. J. Immunol 146, 2928-2934.[Abstract]

Dorfman, T., Bukovsky, A., Ohagen, A., Hoglund, S. and Gottlinger, H. G (1994). Functional domains of the capsid protein of human immunodeficiency virus type 1. J. Virol 68, 8180-8187.[Abstract/Free Full Text]

Foxman, E. F., Campbell, J. J. and Butcher, E. C (1997). Multistep navigation and the combinatorial control of leukocyte chemotaxis. J. Cell Biol 139, 1349-1360.[Abstract/Free Full Text]

Garcia, J. V. and Miller, A. D (1991). Serine phosphorylation-independent downregulation of cell-surface CD4 by Nef. Nature 350, 508-511.[Medline]

Gelderblom, H. R., Reupke, H. J. and Pauli, G (1985). Loss of envelope antigens of HTLV-III/LAV, a factor in AIDS pathogenesis?. Lancet 2, 1016-1017.[Medline]

Graziani, A., Galimi, F., Medico, E., Cottone, E., Gramaglia, D., Boccoccio, C. and Comoglio, P. M (1996). The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation. J. Biol. Chem 271, 6590-6593.[Abstract/Free Full Text]

Inoue, M., Koga, Y., Djordjijevic, D., Fukuma, T., Reddy, E. P., Yokayama, M. M and Sagawa, K (1993). Down-regulation of CD-4 molecules by the expression of Nef: a quantitative analysis of CD4 antigens on the cell surface. Int. Immunol 5, 1067-1073.[Abstract/Free Full Text]

Janossy, G., Pinching, A. J., Bofill, M., Weber, J., McLaughlin, E., Ornstein, M., Ivory, K., Harris, J. R., Favrot, M. and Macdonald-Burns, D. C (1985). An immunohistological approach to persistentlymphadenopathy and its relevance to AIDS. Clin. Exp. Immunol 59, 257-266.[Medline]

Kim, S. Y., Byrn, R., Groopman, J. and Baltimore, D (1989). Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression. J. Virol 63, 3708-3713.[Abstract/Free Full Text]

Klotman, M. E., Kim, S., Buchbinder, A., DeRossi, A., Baltimore, D. and Wong-Staal, F (1991). Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes. Proc. Nat. Acad. Sci. USA 88, 5011-5015.[Abstract/Free Full Text]

Kornfeld, H., W. W. Cruikshank, S. W. Pyle, J. S. Berman and Center, D. M (1988). Lymphocyte activation by HIV-1 envelope glycoprotein. Nature 335, 445-448.[Medline]

Kowolski, M. Potz, J., Basiropour, L., Dorfman, T., Goh, W. C., Terwiliger, E., Dayton, A., Rosen, C., Haseltine, W. and Sodroski, J (1987). Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1. Science 237, 1351-1355.[Abstract/Free Full Text]

Lafrenie, R. M., Wahl, L. M., Epstein, J. S., Hewlett, I. K., Yamada, K. M. and Dhawan, S (1996). HIV-1 Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. A mechanism of HIV pathogenesis. J. Immunol 156, 1638-1645.[Abstract]

Lafrenie, R. M., Wahl, L. M., Epstein, J. S., Hewlett, I. K., Yamada, K. M. and Dhawan, S (1996). HIV-1 Tat protein promotes chemotaxis and invasive behavior by monocytes. J. Immunol 157, 974-977.[Abstract]

Lauffenberger, D. A., Tranquillo, R. T. and Zigmond, S. H (1988). Concentration gradients of chemotactic factors in chemotaxis assays. Meth. Enzymol 162, 84-101.

Lifson, J. D., Feinberg, M. B., Reyes, G. R., Rabin, L. Banapour, B., Chakrabarti, S., Moss, B., Wong-Staal, F., Steimer, K. and Engleman, E. G (1986). Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein. Nature 323, 725-728.[Medline]

Lifson, J. D., Reyes, G. R., McGrath, M. S., Stein, B. S. and Engleman, E. G (1986). AIDS retrovirus induced cytopathology: Giant cell formation and involvement of CD4 antigen. Science 232, 1123-1127.[Abstract/Free Full Text]

Loetscher, M., Gerber, B., Loetscher, P, Jones, S. A., Piali, L., Clark-Lewis, I., Baggiolini, M. and Moser, B (1996). Chemokine receptor specific for IP-10 and mig: structure, function and expression in activated T-lymphocytes. J. Exp. Med 184, 799-802.[Free Full Text]

McDougal, J. S., Kennedy, M. S., Sligh, J. M., Cort, S. P., Mawle, A. and Nicholson, J. K (1986). Binding of HTLV-III/LAV to T4+ cells by a complex of the 110K viral protein and the T4 molecule. Science 231, 382-385.[Abstract/Free Full Text]

Mitola, S., Sozzani, S., Luini, W., Primo, L., Borsatti, A., Weich, H. and Bussolino, F (1997). Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1. Blood 90, 1365-1372.[Abstract/Free Full Text]

Modesti, N., Garcia, J., DeBouck, C., Peterlin, M. and Gaynor, R (1991). Transdominant tat mutants with altercations in the basic domain inhibit HIV-1 gene expression. New Biol 3, 759-768.[Medline]

Murphy, S., Sylwester, A., Kennedy, R. and Soll, D. R (1995). Phagocytosis of individual CD4+cells by HIV-induced T cell syncytia. AIDS Res. Hum. Retroviruses 11, 433-442.[Medline]

O'Neill, G. J. and Parrott, D. M. V (1977). Locomotion of human lymphoid cells. Effect of culture and ConA on T and non-T lymphocytes. Cell. Immunol 33, 257-267.[Medline]

Orsini, M. J., Debouck, C. M., Webb, C. L. and Lysko, P. G (1996). Extracellular human immunodeficiency virus type 1 Tat protein promotes aggregation and adhesion of cerebellar neurons. J. Neurosci 16, 2546-2552.[Abstract/Free Full Text]

Pomerantz, R. J., Seshamma, T. and Trono, D (1992). Efficient replication of human immunodeficiency virus type 1 requires a threshold level of Rev: potential implications for latency. J. Virol 66, 1809-1813.[Abstract/Free Full Text]

Romero, I. A., Teixeira, A., Strosberg, A. D., Cazaubon, S. and Couraud, P. O (1998). The HIV-1 Nef protein inhibits extracellular signal-regulated kinase-dependent DNA synthesis in a human astocytic cell line. J. Neurochem 70, 778-785.[Medline]

Rosenberg, Y. J., Zack, P. M., White, B. D., Papermaster, S. F., Elkins, W. R., Eddy, G. A. and Lewis, M. G (1993). Decline in the CD4+ lymphocyte population in the blood of SIV-infected macaques is not reflected in lymph nodes. AIDS Res. Hum. Retroviruses 9, 639-646.[Medline]

Sawai, E. T., Baur, A., Struble, H., Peterlin, B. M., Levy, J. A. and Cheng-Mayer, C (1994). Human immunodeficiency virus type 1 Nef associateswith a cellular serine kinase in T lymphocytes. Proc. Nat. Acad. Sci. USA 91, 1539-1543.[Abstract/Free Full Text]

Schneider, J., Kaaden, O., Copeland, T. D., Orozslan, S. and Hunsmann, G (1986). Shedding and interspecies type seroreactivity of the envelope glycoprotein gp120 of the human immunodeficiency virus. J. Gen. Virol 67, 2533-2538.[Abstract/Free Full Text]

Selby, M. J. and Peterlin, B. M (1990). Trans-activation by HIV-1 Tat via a heterologous RNA binding protein. Cell 62, 769-776.[Medline]

Shutt, D., Wessels, D., Wagenknecht, K., Chandrasekhar, A., Hitt, A., Luna, E. and Soll, D. R (1995). Ponticulin plays a role in the positional stabilization of pseudopods. J. Cell Biol 131, 1495-1506.[Abstract/Free Full Text]

Shutt, D. C., Stapleton, J. T., Kennedy, R. C. and Soll, D. R (1995). HIV-induced syncytia in peripheral blood cell cultures crawl by extending giant pseudopods. Cell. Immunol 166, 261-274.[Medline]

Shutt, D. C., Jenkins, L. M., Carolan, E. J., Stapleton, J., Daniels, K. J., Kennedy, R. C. and Soll, D. R (1998). T cell syncytia induced by HIV release T cell chemoattractants: demonstration with a newly developed single cell chemotaxis chamber. J. Cell Sci 111, 99-109.[Abstract]

Smith, S. D., Shatsky, M., Cohen, P. S., Warake, R., Link, M. P. and Glader, B. E (1984). Monoclonal antibody and enzymatic profiles of human malignant T lymphoid cells and derived lines. Cancer Res 44, 5657-5660.[Abstract/Free Full Text]

Soll, D. R. and Kennedy, R. C (1994). The role of T cell motility and cytoskeletal reorganization in HIV-induced syncytium formation: a perspectus. AIDS Res. Hum. Retroviruses 10, 325-327.[Medline]

Soll, D. R (1995). The use of computers in understanding how cells crawl. Int. Rev. Cytol 163, 43-104.[Medline]

Soll, D. R (1997). Researchers in cell motility and the cytoskeleton can play major roles in understanding AIDS. Cell Motil. Cytoskel 37, 91-97.[Medline]

Soll, D. R (1999). Computer-assisted three-dimensional reconstruction and motion analysis of living, crawling cells. Comput. Med. Imag. Graph 23, 3-14.[Medline]

Steimer, K. S., Puma, J. P., Powers, M. A., George-Nascimento, C., Stephans, J. C., Levy, J. A., Sanchez-Pescador, R., Luciw, P. A., Barr, P. J. and Hallewell, R. A (1986). Differential antibody responses of individuals infected with AIDS-associated retroviruses surveyed using theviral core antigen p25 gag expressed in bacteria. Virology 150, 283-290.[Medline]

Sylwester, A., Wessels, D., Anderson, S. A., Warren, R. Q., Shutt, D., Kennedy, R. and Soll, D. R (1993). HIV-induced syncytia of a T cell line form single giant pseudopods and are motile. J. Cell Sci 106, 941-953.[Abstract]

Sylwester, A., Shutt, D. C., Wessels, D., Stapleton, J. T., Stites, J., Kennedy, R. C. and Soll, D. R (1995). T cells and HIV-induced T cell syncytia exhibit the same motility cycle. J. Leuk. Biol 57, 643-650.[Abstract]

Sylwester, A., Murphy, S., Shutt, D. and Soll, D. R (1997). HIV-induced syncytia are self-perpetuating and the primary cause of T cell death in culture. J. Immunol 158, 3996-4007.[Abstract]

Sylwester, A., Daniels, K. and Soll, D. R (1998). The invasive and destructive behavior of HIV-induced T cell syncytia on collagen and endothelium. J. Leuk. Biol 63, 233-244.[Abstract]

Taub, D. D., Anver, M., Oppenheim, J. J., Longo, D. L. and Murphy, W. J (1996). T lymphocyte recruitment by interleukin-8 (IL-8); IL-8 induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vivo and in vitro. J. Clin. Invest 97, 1931-1941.[Medline]

Varnum, B., Edwards, K. and Soll, D. R (1985). Dictyostelium amoebae alter motility differently in response to increasing versus decreasing temporal gradients of cAMP. J. Cell Biol 101, 1-5.[Abstract/Free Full Text]

Varnum-Finney, B., Edwards, K., Voss, E. and Soll, D. R (1987). Amoebae of Dictyostelium discoideum respond to an increasing temporal gradient of the chemoattractant cAMP with a reduced frequency of turning: evidence for a temporal mechanism in amoeboid chemotaxis. Cell Motil. Cytoskel 8, 7-17.[Medline]

von Poblotzki, A., Wagner, R., Niedrig, M., Wanner, G., Wolf, H. and Modrow, S (1993). Identification of a region in the Pr55gag-polyprotein essential for HIV-1 particle formation. Virology 193, 981-985.[Medline]

Wang, L., Chen, J. J. Y., Gelman, B. B., Konig, R. and Cloyd, M. W (1999). A novel mechanism of CD4 lymphocyte depletion involves effects of HIV on resting lymphocytes: induction of lymph node homing and apoptosis upon secondary signaling through homing receptors. J. Immunol 162, 268-276.[Abstract/Free Full Text]

Weissman, D., R. L. Rabin, J. Arthos, A. Ruppert, M. Dybul, R. Swofford, S. Venkatesan, J. M. Farber and Fauci, A. S (1997). Macrophage-trophic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor. Nature 389, 981-985.[Medline]

Wessels, D., Murray, J. and Soll, D. R (1992). The complex behavior cycle of chemotaxing Dictyostelium amoebae is regulated primarily by the temporal dynamics of the natural wave. Cell Motil. Cytoskel 23, 145-156.[Medline]

Wilkinson, P. C (1988). Micropore filter methods for measuring leukocyte chemotaxis. Meth. Enzymol 162, 38-50.[Medline]

Zigmond, S. H. and Hirsch, J. G (1973). Leukocyte locomotion and chemotaxis. New method for evaluation, and demonstration of a cell-derived chemotactic factor. J. Exp. Med 137, 387-410.[Abstract]

Zigmond, S. H (1977). The ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. J. Cell Biol 75, 606-616.[Abstract/Free Full Text]

Zigmond, S. H. and Sullivan, S. J (1979). Sensory adaptation of leukocytes to chemotactic peptides. J. Cell. Biol 82, 517-527.[Abstract/Free Full Text]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

Technorati

Twitter What's this?

This article has been cited by other articles:

M.-B. Huang, L. L. Jin, C. O. James, M. Khan, M. D. Powell, and V. C. Bond
Characterization of Nef-CXCR4 Interactions Important for Apoptosis Induction
J. Virol., October 15, 2004; 78(20): 11084 - 11096.
[Abstract] [Full Text] [PDF]

C. Pujol, K. J. Daniels, S. R. Lockhart, T. Srikantha, J. B. Radke, J. Geiger, and D. R. Soll
The Closely Related Species Candida albicans and Candida dubliniensis Can Mate
Eukaryot. Cell, August 1, 2004; 3(4): 1015 - 1027.
[Abstract] [Full Text] [PDF]

D. Wessels, R. Brincks, S. Kuhl, V. Stepanovic, K. J. Daniels, G. Weeks, C. J. Lim, G. Spiegelman, D. Fuller, N. Iranfar, et al.
RasC Plays a Role in Transduction of Temporal Gradient Information in the Cyclic-AMP Wave of Dictyostelium discoideum
Eukaryot. Cell, June 1, 2004; 3(3): 646 - 662.
[Abstract] [Full Text] [PDF]

J. Geiger, D. Wessels, S. R. Lockhart, and D. R. Soll
Release of a Potent Polymorphonuclear Leukocyte Chemoattractant Is Regulated by White-Opaque Switching in Candida albicans
Infect. Immun., February 1, 2004; 72(2): 667 - 677.
[Abstract] [Full Text] [PDF]

D. J. Wessels, H. Zhang, J. Reynolds, K. Daniels, P. Heid, S. Lu, A. Kuspa, G. Shaulsky, W. F. Loomis, and D. R. Soll
The Internal Phosphodiesterase RegA Is Essential for the Suppression of Lateral Pseudopods during Dictyostelium Chemotaxis
Mol. Biol. Cell, August 1, 2000; 11(8): 2803 - 2820.
[Abstract] [Full Text]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Shutt, D. C.

Articles by Soll, D. R.

Search for Related Content

PubMed

PubMed Citation

Articles by Shutt, D. C.

Articles by Soll, D. R.

Social Bookmarking

What's this?

				C. Pujol, K. J. Daniels, S. R. Lockhart, T. Srikantha, J. B. Radke, J. Geiger, and D. R. Soll The Closely Related Species Candida albicans and Candida dubliniensis Can Mate Eukaryot. Cell, August 1, 2004; 3(4): 1015 - 1027. [Abstract] [Full Text] [PDF]

				D. Wessels, R. Brincks, S. Kuhl, V. Stepanovic, K. J. Daniels, G. Weeks, C. J. Lim, G. Spiegelman, D. Fuller, N. Iranfar, et al. RasC Plays a Role in Transduction of Temporal Gradient Information in the Cyclic-AMP Wave of Dictyostelium discoideum Eukaryot. Cell, June 1, 2004; 3(3): 646 - 662. [Abstract] [Full Text] [PDF]

				J. Geiger, D. Wessels, S. R. Lockhart, and D. R. Soll Release of a Potent Polymorphonuclear Leukocyte Chemoattractant Is Regulated by White-Opaque Switching in Candida albicans Infect. Immun., February 1, 2004; 72(2): 667 - 677. [Abstract] [Full Text] [PDF]

				D. J. Wessels, H. Zhang, J. Reynolds, K. Daniels, P. Heid, S. Lu, A. Kuspa, G. Shaulsky, W. F. Loomis, and D. R. Soll The Internal Phosphodiesterase RegA Is Essential for the Suppression of Lateral Pseudopods during Dictyostelium Chemotaxis Mol. Biol. Cell, August 1, 2000; 11(8): 2803 - 2820. [Abstract] [Full Text]