Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Plemper, R. K.
	Articles by Wolf, D. H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Plemper, R. K.
	Articles by Wolf, D. H.

Abeijon, C., Orlean, P., Robbins, P. W. and Hirschberg, C. B (1989). Topography of glycosylation in yeast: characterization of GDPmannose transport and lumenal guanosine diphosphatase activities in Golgi-like vesicles. Proc. Nat. Acad. Sci. USA 86, 6935-6939.[Abstract/Free Full Text]

Baumeister, W., Walz, J., Zuhl, F. and Seemuller, E (1998). The proteasome: paradigm of a self-compartmentalizing protease. Cell 92, 367-380.[Medline]

Biederer, T., Volkwein, C. and Sommer, T (1996). Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway. EMBO J 15, 2069-2076.[Medline]

Biederer, T., Volkwein, C. and Sommer, T (1997). Role of Cue1p in ubiquitination and degradation at the ER surface. Science 278, 1806-1809.[Abstract/Free Full Text]

Bordallo, J., Plemper, R. K., Finger, A. and Wolf, D. H (1998). Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol. Biol. Cell 9, 209-222.[Abstract/Free Full Text]

Bordallo, J. and Wolf, D. H (1999). A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae. FEBS Lett 448, 244-248.[Medline]

Brodsky, J. L., Werner, E. D., Dubas, M. E., Goeckeler, J. L., Kruse, K. B. and McCracken, A. A (1999). The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct. J. Biol. Chem 274, 3453-3460.[Abstract/Free Full Text]

Ciechanover, A (1998). The ubiquitin-proteasome pathway: on protein death and cell life. EMBO J 17, 7151-7160.[Medline]

de Virgilio, M., Weninger, H. and Ivessa, N. E (1998). Ubiquitination is required for the retro-translocation of a short-lived luminal endoplasmic reticulum glycoprotein to the cytosol for degradation by the proteasome. J. Biol. Chem 273, 9734-9743.[Abstract/Free Full Text]

Egner, R., Rosenthal, F. E., Kralli, A., Sanglard, D. and Kuchler, K (1998). Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter. Mol. Biol. Cell 9, 523-543.[Abstract/Free Full Text]

Enenkel, C., Lehmann, A. and Kloetzel, P. M (1998). Subcellular distribution of proteasomes implicates a major location of proteindegradation in the nuclear envelope-ER network in yeast. EMBO J 17, 6144-6154.[Medline]

Hampton, R. Y., Gardner, R. G. and Rine, J (1996). Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol. Biol. Cell 7, 2029-2044.[Abstract]

Hampton, R. Y. and Bhakta, H (1997). Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. Proc. Nat. Acad. Sci. USA 94, 12944-12948.[Abstract/Free Full Text]

Hartl, F. U., Hlodan, R. and Langer, T (1994). Molecular chaperones in protein folding: the art of avoiding sticky situations. Trends Biochem. Sci 19, 20-25.[Medline]

Heinemeyer, W., Kleinschmidt, J. A., Saidowsky, J., Escher, C. and Wolf, D. H (1991). Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival. EMBO J 10, 555-562.[Medline]

Hiller, M. M., Finger, A., Schweiger, M. and Wolf, D. H (1996). ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway. Science 273, 1725-1728.[Abstract/Free Full Text]

Huppa, J. B. and Ploegh, H. L (1997). The alpha chain of the T cell antigen receptor is degraded in the cytosol. Immunity 7, 113-122.[Medline]

Jensen, T. J., Loo, M. A., Pind, S., Williams, D. B., Goldberg, A. L. and Riordan, J. R (1995). Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell 83, 129-135.[Medline]

Johnson, E. S., Gonda, D. K. and Varshavsky, A (1990). Cis-trans recognition and subunit-specific degradation of short-lived proteins. Nature 346, 287-291.[Medline]

Knop, M., Finger, A., Braun, T., Hellmuth, K. and Wolf, D. H (1996). Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast. EMBO J 15, 753-763.[Medline]

Kopito, R. R (1997). ER quality control: the cytoplasmic connection. Cell 88, 427-430.[Medline]

Mayer, T. U., Braun, T. and Jentsch, S (1998). Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein. EMBO J 17, 3251-3257.[Medline]

McCracken, A. A. and Brodsky, J. L (1996). Assembly of ER-associated protein degradation in vitro: dependence on cytosol, calnexin and ATP. J. Cell Biol 132, 291-298.[Abstract/Free Full Text]

Moriyama, T., Sather, S. K., McGee, T. P. and Simoni, R. D (1998). Degradation of HMG-CoA reductase in vitro. Cleavage in the membrane domain by a membrane-bound cysteine protease. J. Biol. Chem 273, 22037-22043.[Abstract/Free Full Text]

Opheim, D. J (1978). alpha-D-Mannosidase of Saccharomyces cerevisiae. Characterization and modulation of activity. Biochim. Biophys. Acta 524, 121-130.[Medline]

Peters, J. M (1998). SCF and APC: the Yin and Yang of cell cycle regulated proteolysis. Curr. Opin. Cell Biol 10, 759-768.[Medline]

Pilon, M., Schekman, R. and R\232misch, K (1997). Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation. EMBO J 16, 4540-4548.[Medline]

Plemper, R. K., B\232hmler, S., Bordallo, J., Sommer, T. and Wolf, D. H (1997). Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation. Nature 388, 891-895.[Medline]

Plemper, R. K., Egner, R., Kuchler, K. and Wolf, D. H (1998). Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome. J. Biol. Chem 273, 32848-32856.[Abstract/Free Full Text]

Plemper, R. K., Deak, P. M., Otto, R. T. and Wolf, D. H (1999). Re-entering the translocon from the lumenal side of the endoplasmic reticulum. Studies on mutated carboxypeptidase yscY species. FEBS Lett 443, 241-245.[Medline]

Plemper, R. K. and Wolf, D. H (1999). Retrograde protein translocation: ERADication of secretory proteins in health and disease. Trends Biochem. Sci 24, 266-270.[Medline]

Rapoport, T. A., Jungnickel, B. and Kutay, U (1996). Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes. Annu. Rev. Biochem 65, 271-303.[Medline]

Saito, Y., Yamanushi, T., Oka, T. and Nakano, A (1999). Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of ts mutants of Sar1 GTPase. J. Biochem. (Tokyo) 125, 130-137.[Abstract/Free Full Text]

Sikorski, R. S. and Hieter, P (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.[Abstract/Free Full Text]

Sommer, T. and Jentsch, S (1993). A protein translocation defect linked toubiquitin conjugation at the endoplasmic reticulum. Nature 365, 176-179.[Medline]

Sommer, T. and Wolf, D. H (1997). Endoplasmic reticulum degradation: reverse protein flow of no return. FASEB J 11, 1227-1233.[Abstract]

Stirling, C. J., Rothblatt, J., Hosobuchi, M., Deshaies, R. and Schekman, R (1992). Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum. Mol. Biol. Cell 3, 129-142.[Abstract]

Tyers, M. and Willems, A. R (1999). One ring to rule a superfamily of E3 ubiquitin ligases. Science 284, 601-604.[Free Full Text]

Ward, C. L., Omura, S. and Kopito, R. R (1995). Degradation of CFTR by the ubiquitin-proteasome pathway. Cell 83, 121-127.[Medline]

Wiertz, E. J., Tortorella, D., Bogyo, M., Yu, J., Mothes, W., Jones, T. R., Rapoport, T. A. and Ploegh, H. L (1996). Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature 384, 432-438.[Medline]

Wolf, D. H. and Fink, G. R (1975). Proteinase C (carboxypeptidase Y) mutant of yeast. J. Bacteriol 123, 1150-1156.[Abstract/Free Full Text]

Yu, H., Kaung, G., Kobayashi, S. and Kopito, R. R (1997). Cytosolic degradation of T-cell receptor alpha chains by the proteasome. J. Biol. Chem 272, 20800-20804.[Abstract/Free Full Text]

This article has been cited by other articles:

S. Kohlmann, A. Schafer, and D. H. Wolf
Ubiquitin Ligase Hul5 Is Required for Fragment-specific Substrate Degradation in Endoplasmic Reticulum-associated Degradation
J. Biol. Chem., June 13, 2008; 283(24): 16374 - 16383.
[Abstract] [Full Text] [PDF]

J. J. Yi and M. D. Ehlers
Emerging Roles for Ubiquitin and Protein Degradation in Neuronal Function
Pharmacol. Rev., March 1, 2007; 59(1): 14 - 39.
[Abstract] [Full Text] [PDF]

B. Mueller, B. N. Lilley, and H. L. Ploegh
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER
J. Cell Biol., October 23, 2006; 175(2): 261 - 270.
[Abstract] [Full Text] [PDF]

S. J. Marciniak and D. Ron
Endoplasmic reticulum stress signaling in disease.
Physiol Rev, October 1, 2006; 86(4): 1133 - 1149.
[Abstract] [Full Text] [PDF]

M. S. Mavinakere, C. D. Williamson, V. S. Goldmacher, and A. M. Colberg-Poley
Processing of Human Cytomegalovirus UL37 Mutant Glycoproteins in the Endoplasmic Reticulum Lumen prior to Mitochondrial Importation
J. Virol., July 15, 2006; 80(14): 6771 - 6783.
[Abstract] [Full Text] [PDF]

S. Katiyar, S. Joshi, and W. J. Lennarz
The Retrotranslocation Protein Derlin-1 Binds Peptide:N-Glycanase to the Endoplasmic Reticulum
Mol. Biol. Cell, October 1, 2005; 16(10): 4584 - 4594.
[Abstract] [Full Text] [PDF]

M. E. Kirst, D. J. Meyer, B. C. Gibbon, R. Jung, and R. S. Boston
Identification and Characterization of Endoplasmic Reticulum-Associated Degradation Proteins Differentially Affected by Endoplasmic Reticulum Stress
Plant Physiology, May 1, 2005; 138(1): 218 - 231.
[Abstract] [Full Text] [PDF]

E. D. Spear and D. T.W. Ng
Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation
J. Cell Biol., April 11, 2005; 169(1): 73 - 82.
[Abstract] [Full Text] [PDF]

G. Huyer, W. F. Piluek, Z. Fansler, S. G. Kreft, M. Hochstrasser, J. L. Brodsky, and S. Michaelis
Distinct Machinery Is Required in Saccharomyces cerevisiae for the Endoplasmic Reticulum-associated Degradation of a Multispanning Membrane Protein and a Soluble Luminal Protein
J. Biol. Chem., September 10, 2004; 279(37): 38369 - 38378.
[Abstract] [Full Text] [PDF]

A. Gnann, J. R. Riordan, and D. H. Wolf
Cystic Fibrosis Transmembrane Conductance Regulator Degradation Depends on the Lectins Htm1p/EDEM and the Cdc48 Protein Complex in Yeast
Mol. Biol. Cell, September 1, 2004; 15(9): 4125 - 4135.
[Abstract] [Full Text] [PDF]

C. Taxis, R. Hitt, S.-H. Park, P. M. Deak, Z. Kostova, and D. H. Wolf
Use of Modular Substrates Demonstrates Mechanistic Diversity and Reveals Differences in Chaperone Requirement of ERAD
J. Biol. Chem., September 19, 2003; 278(38): 35903 - 35913.
[Abstract] [Full Text] [PDF]

E. A. Palmer, K. B. Kruse, S. W. Fewell, S. M. Buchanan, J. L. Brodsky, and A. A. McCracken
Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation
J. Cell Sci., June 1, 2003; 116(11): 2361 - 2373.
[Abstract] [Full Text] [PDF]

T. Suzuki and W. J. Lennarz
Glycopeptide export from the endoplasmic reticulum into cytosol is mediated by a mechanism distinct from that for export of misfolded glycoprotein
Glycobiology, December 1, 2002; 12(12): 803 - 811.
[Abstract] [Full Text] [PDF]

S. McBratney and M. Winey
Mutant Membrane Protein of the Budding Yeast Spindle Pole Body Is Targeted to the Endoplasmic Reticulum Degradation Pathway
Genetics, October 1, 2002; 162(2): 567 - 578.
[Abstract] [Full Text] [PDF]

L. Monteoliva, M. Lopez Matas, C. Gil, C. Nombela, and J. Pla
Large-Scale Identification of Putative Exported Proteins in Candida albicans by Genetic Selection
Eukaryot. Cell, August 1, 2002; 1(4): 514 - 525.
[Abstract] [Full Text] [PDF]

C. Taxis, F. Vogel, and D. H. Wolf
ER-Golgi Traffic Is a Prerequisite for Efficient ER Degradation
Mol. Biol. Cell, June 1, 2002; 13(6): 1806 - 1818.
[Abstract] [Full Text] [PDF]

B. P. Murray, V. G. Zgoda, and M. A. Correia
Native CYP2C11: Heterologous Expression in Saccharomyces cerevisiae Reveals a Role for Vacuolar Proteases Rather Than the Proteasome System in the Degradation of This Endoplasmic Reticulum Protein
Mol. Pharmacol., May 1, 2002; 61(5): 1146 - 1153.
[Abstract] [Full Text] [PDF]

R. G. Gardner, A. G. Shearer, and R. Y. Hampton
In Vivo Action of the HRD Ubiquitin Ligase Complex: Mechanisms of Endoplasmic Reticulum Quality Control and Sterol Regulation
Mol. Cell. Biol., July 1, 2001; 21(13): 4276 - 4291.
[Abstract] [Full Text] [PDF]

R. G. Gardner, G. M. Swarbrick, N. W. Bays, S. R. Cronin, S. Wilhovsky, L. Seelig, C. Kim, and R. Y. Hampton
Endoplasmic Reticulum Degradation Requires Lumen to Cytosol Signaling: Transmembrane Control of Hrd1p by Hrd3p
J. Cell Biol., October 3, 2000; 151(1): 69 - 82.
[Abstract] [Full Text] [PDF]

S. Wilhovsky, R. Gardner, and R. Hampton
HRD Gene Dependence of Endoplasmic Reticulum-associated Degradation
Mol. Biol. Cell, May 1, 2000; 11(5): 1697 - 1708.
[Abstract] [Full Text]

T. Ravid, R. Doolman, R. Avner, D. Harats, and J. Roitelman
The Ubiquitin-Proteasome Pathway Mediates the Regulated Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase
J. Biol. Chem., November 10, 2000; 275(46): 35840 - 35847.
[Abstract] [Full Text] [PDF]

P. M. Deak and D. H. Wolf
Membrane Topology and Function of Der3/Hrd1p as a Ubiquitin-Protein Ligase (E3) Involved in Endoplasmic Reticulum Degradation
J. Biol. Chem., March 30, 2001; 276(14): 10663 - 10669.
[Abstract] [Full Text] [PDF]

K. Umebayashi, R. Fukuda, A. Hirata, H. Horiuchi, A. Nakano, A. Ohta, and M. Takagi
Activation of the Ras-cAMP Signal Transduction Pathway Inhibits the Proteasome-independent Degradation of Misfolded Protein Aggregates in the Endoplasmic Reticulum Lumen
J. Biol. Chem., October 26, 2001; 276(44): 41444 - 41454.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Plemper, R. K.

Articles by Wolf, D. H.

Search for Related Content

PubMed

PubMed Citation

Articles by Plemper, R. K.

Articles by Wolf, D. H.

				J. J. Yi and M. D. Ehlers Emerging Roles for Ubiquitin and Protein Degradation in Neuronal Function Pharmacol. Rev., March 1, 2007; 59(1): 14 - 39. [Abstract] [Full Text] [PDF]

				B. Mueller, B. N. Lilley, and H. L. Ploegh SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER J. Cell Biol., October 23, 2006; 175(2): 261 - 270. [Abstract] [Full Text] [PDF]

				S. J. Marciniak and D. Ron Endoplasmic reticulum stress signaling in disease. Physiol Rev, October 1, 2006; 86(4): 1133 - 1149. [Abstract] [Full Text] [PDF]

				M. S. Mavinakere, C. D. Williamson, V. S. Goldmacher, and A. M. Colberg-Poley Processing of Human Cytomegalovirus UL37 Mutant Glycoproteins in the Endoplasmic Reticulum Lumen prior to Mitochondrial Importation J. Virol., July 15, 2006; 80(14): 6771 - 6783. [Abstract] [Full Text] [PDF]

				S. Katiyar, S. Joshi, and W. J. Lennarz The Retrotranslocation Protein Derlin-1 Binds Peptide:N-Glycanase to the Endoplasmic Reticulum Mol. Biol. Cell, October 1, 2005; 16(10): 4584 - 4594. [Abstract] [Full Text] [PDF]

				M. E. Kirst, D. J. Meyer, B. C. Gibbon, R. Jung, and R. S. Boston Identification and Characterization of Endoplasmic Reticulum-Associated Degradation Proteins Differentially Affected by Endoplasmic Reticulum Stress Plant Physiology, May 1, 2005; 138(1): 218 - 231. [Abstract] [Full Text] [PDF]

				E. D. Spear and D. T.W. Ng Single, context-specific glycans can target misfolded glycoproteins for ER-associated degradation J. Cell Biol., April 11, 2005; 169(1): 73 - 82. [Abstract] [Full Text] [PDF]

				G. Huyer, W. F. Piluek, Z. Fansler, S. G. Kreft, M. Hochstrasser, J. L. Brodsky, and S. Michaelis Distinct Machinery Is Required in Saccharomyces cerevisiae for the Endoplasmic Reticulum-associated Degradation of a Multispanning Membrane Protein and a Soluble Luminal Protein J. Biol. Chem., September 10, 2004; 279(37): 38369 - 38378. [Abstract] [Full Text] [PDF]

				A. Gnann, J. R. Riordan, and D. H. Wolf Cystic Fibrosis Transmembrane Conductance Regulator Degradation Depends on the Lectins Htm1p/EDEM and the Cdc48 Protein Complex in Yeast Mol. Biol. Cell, September 1, 2004; 15(9): 4125 - 4135. [Abstract] [Full Text] [PDF]

				C. Taxis, R. Hitt, S.-H. Park, P. M. Deak, Z. Kostova, and D. H. Wolf Use of Modular Substrates Demonstrates Mechanistic Diversity and Reveals Differences in Chaperone Requirement of ERAD J. Biol. Chem., September 19, 2003; 278(38): 35903 - 35913. [Abstract] [Full Text] [PDF]

				E. A. Palmer, K. B. Kruse, S. W. Fewell, S. M. Buchanan, J. L. Brodsky, and A. A. McCracken Differential requirements of novel A1PiZ degradation deficient (ADD) genes in ER-associated protein degradation J. Cell Sci., June 1, 2003; 116(11): 2361 - 2373. [Abstract] [Full Text] [PDF]

				T. Suzuki and W. J. Lennarz Glycopeptide export from the endoplasmic reticulum into cytosol is mediated by a mechanism distinct from that for export of misfolded glycoprotein Glycobiology, December 1, 2002; 12(12): 803 - 811. [Abstract] [Full Text] [PDF]

				S. McBratney and M. Winey Mutant Membrane Protein of the Budding Yeast Spindle Pole Body Is Targeted to the Endoplasmic Reticulum Degradation Pathway Genetics, October 1, 2002; 162(2): 567 - 578. [Abstract] [Full Text] [PDF]

				L. Monteoliva, M. Lopez Matas, C. Gil, C. Nombela, and J. Pla Large-Scale Identification of Putative Exported Proteins in Candida albicans by Genetic Selection Eukaryot. Cell, August 1, 2002; 1(4): 514 - 525. [Abstract] [Full Text] [PDF]

				C. Taxis, F. Vogel, and D. H. Wolf ER-Golgi Traffic Is a Prerequisite for Efficient ER Degradation Mol. Biol. Cell, June 1, 2002; 13(6): 1806 - 1818. [Abstract] [Full Text] [PDF]

				B. P. Murray, V. G. Zgoda, and M. A. Correia Native CYP2C11: Heterologous Expression in Saccharomyces cerevisiae Reveals a Role for Vacuolar Proteases Rather Than the Proteasome System in the Degradation of This Endoplasmic Reticulum Protein Mol. Pharmacol., May 1, 2002; 61(5): 1146 - 1153. [Abstract] [Full Text] [PDF]

				R. G. Gardner, A. G. Shearer, and R. Y. Hampton In Vivo Action of the HRD Ubiquitin Ligase Complex: Mechanisms of Endoplasmic Reticulum Quality Control and Sterol Regulation Mol. Cell. Biol., July 1, 2001; 21(13): 4276 - 4291. [Abstract] [Full Text] [PDF]

				R. G. Gardner, G. M. Swarbrick, N. W. Bays, S. R. Cronin, S. Wilhovsky, L. Seelig, C. Kim, and R. Y. Hampton Endoplasmic Reticulum Degradation Requires Lumen to Cytosol Signaling: Transmembrane Control of Hrd1p by Hrd3p J. Cell Biol., October 3, 2000; 151(1): 69 - 82. [Abstract] [Full Text] [PDF]

				S. Wilhovsky, R. Gardner, and R. Hampton HRD Gene Dependence of Endoplasmic Reticulum-associated Degradation Mol. Biol. Cell, May 1, 2000; 11(5): 1697 - 1708. [Abstract] [Full Text]

				T. Ravid, R. Doolman, R. Avner, D. Harats, and J. Roitelman The Ubiquitin-Proteasome Pathway Mediates the Regulated Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase J. Biol. Chem., November 10, 2000; 275(46): 35840 - 35847. [Abstract] [Full Text] [PDF]

				P. M. Deak and D. H. Wolf Membrane Topology and Function of Der3/Hrd1p as a Ubiquitin-Protein Ligase (E3) Involved in Endoplasmic Reticulum Degradation J. Biol. Chem., March 30, 2001; 276(14): 10663 - 10669. [Abstract] [Full Text] [PDF]

				K. Umebayashi, R. Fukuda, A. Hirata, H. Horiuchi, A. Nakano, A. Ohta, and M. Takagi Activation of the Ras-cAMP Signal Transduction Pathway Inhibits the Proteasome-independent Degradation of Misfolded Protein Aggregates in the Endoplasmic Reticulum Lumen J. Biol. Chem., October 26, 2001; 276(44): 41444 - 41454. [Abstract] [Full Text] [PDF]