Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition

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Aaku-Sarraste, E., Hellwig, A. and Huttner, W. B (1996). Loss of occludin and functional tight junctions, but not ZO-1, during neural tube closure-remodeling of the neuroepithelium prior to neurogenesis. Dev. Biol 180, 664-679.[Medline]

Abedi, H. and Zachary, I (1997). Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J. Biol. Chem 272, 15442-15451.[Abstract/Free Full Text]

Anderson, J. M (1996). Cell signalling: MAGUK magic. Curr. Biol 6, 382-384.[Medline]

Ando-Akatsuka, Y., Saitou, M., Hirase, T., Kishi, M., Sakakibara, A., Itoh, M., Yonemura, S., Furuse, M. and Tsukita, S (1996). Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J. Cell Biol 133, 43-47.[Abstract/Free Full Text]

Balda, M. S., Whitney, J. A., Flores, C., Gonz\207lez, S., Cereijido, M. and Matter, K (1996). Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J. Cell Biol 134, 1031-1049.[Abstract/Free Full Text]

Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., Nelson, N., Boiani, N., Schooley, K. A., Gerhart, M., Davis, R., Fitzner, J. N., Johnson, R. S., Paxton, R. J., March, C. J. and Cerretti, D. P (1997). A metalloproteinase disintegrin that releases tumour-necrosis factor-a from cells. Nature 385, 729-733.[Medline]

Blum, M. S., Toninelli, E., Anderson, J. M., Balda, M. S., Zhou, J., O'Donnell, L., Pardi, R. and Bender, J. R (1997). Cytoskeletal rearrangement mediates human microvascular endothelial tight junction modulation by cytokines. Am. J. Physiol 273, 286-.

Bolton, S. J., Anthony, D. C. and Perry, V. H (1998). Loss of tight junctionproteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience 86, 1245-1257.[Medline]

Campan, M., Yoshizumi, M., Seidah, N. G., Lee, M.-E., Bianchi, C. and Haber, E (1996). Increased proteolytic processing of protein tyrosine phosphatase mu in confluent vascular endothelial cells: the role of PC5, a member of the subtilisin family. Biochemistry 35, 3797-3802.[Medline]

Citi, S., Sabanay, H., Jakes, R., Geiger, B. and Kendrick-Jones, J (1988). Cingulin, a new peripheral component of tight junctions. Nature 333, 272-276.[Medline]

Esser, S., Lampugnani, M. G., Corada, M., Dejana, E. and Risau, W (1998). Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J. Cell Sci 111, 1853-1865.[Abstract]

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S. and Tsukita, S (1993). Occludin: a novel integral membrane protein localizing at tight junctions. J. Cell Biol 123, 1777-1788.[Abstract/Free Full Text]

Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K. and Tsukita, S (1998). Claudin-1 and-2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol 141, 1539-1550.[Abstract/Free Full Text]

Furuse, M., Sasaki, H., Fujimoto, K. and Tsukita, S (1998). A single gene product, claudin-1 or-2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J. Cell. Biol 143, 391-401.[Abstract/Free Full Text]

Gloor, S. M., Weber, A., Adachi, N. and Frei, K (1997). Interleukin-1 modulates protein tyrosine phosphatase activity and permeability in endothelial cells. Biochem. Biophys. Res. Commun 239, 804-809.[Medline]

Gumbiner, B., Lowenkopf, T. and Apatira, D (1991). Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1. Proc. Natl. Acad. Sci. USA 88, 3460-3464.[Abstract/Free Full Text]

Haskins, J., Gu, L., Wittchen, E. S., Hibbard, J. and Stevenson, B. R (1998). ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. J. Cell Biol 141, 199-208.[Abstract/Free Full Text]

Herren, B., Levkau, B., Raines, E. W. and Ross, R (1998). Cleavage of b-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases. Mol. Biol. Cell 9, 1589-1601.[Abstract/Free Full Text]

Hirase, T., Staddon, J. M., Saitou, M., Ando-Akatsuka, Y., Itoh, M., Furuse, M., Fujimoto, K., Tsukita, S. and Rubin, L. L (1997). Occludin as a possible determinant of tight junction permeability in endothelial cells. J. Cell Sci 110, 1603-1613.[Abstract]

Hooper, N. M., Karran, E. H. and Turner, A. J (1997). Membrane protein secretases. Biochem. J 321, 265-279.

Jesaitis, L. A. and Goodenough, D. A (1994). Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein. J. Cell Biol 124, 949-961.[Abstract/Free Full Text]

Jou, T.-S., Schneeberger, E. E. and Nelson, W. J (1998). Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases. J. Cell Biol 142, 101-115.[Abstract/Free Full Text]

Keon, B. H., Sch\212fer, S., Kuhn, C., Grund, C. and Franke, W. W (1996). Symplekin, a novel type of tight junction plaque protein. J. Cell Biol 134, 1003-1018.[Abstract/Free Full Text]

Laemmli, U. K (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.[Medline]

Larsen, K. S. and Auld, D. S. ( (1991). Characterization of an inhibitory metal binding site in carboxypeptidase A. Biochemistry 30, 2613-2618.[Medline]

Madara, J. L (1998). Regulation of the movement of solutes across tight junctions. Annu. Rev. Physiol 60, 143-159.[Medline]

Mart\223n-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., Simmons, D. and Dejana, E (1998). Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J. Cell Biol 142, 117-127.[Abstract/Free Full Text]

McCarthy, K. M., Skare, I. B., Stankewich, M. C., Furuse, M., Tsukita, S., Rogers, R. A., Lynch, R. D. and Schneeberger, E. E (1996). Occludin is a functional component of the tight junction. J. Cell Sci 109, 2287-2298.[Abstract]

Messerli, J. M., Eppenberger-Eberhardt, M. E., Rutishauser, B. M., Schwarb, P. von Arx, P., Koch-Schneidemann, S., Eppenberger, H. M. and Perriard, J. C (1993). Remodelling of cardiomyocyte cytoarchitecture visualized by three-dimensional (3D) confocal microscopy. Histochem 100, 193-202.

Mitic, L. L. and Anderson, J. M (1998). Molecular architecture of tight junctions. Annu. Rev. Physiol 60, 121-142.[Medline]

Moss, M. L., Jin, S.-L. C., Milla, M. E., Burkhart, W., Carter, H. L., Chen, W.-J., Clay, W. C., Didsbury, J. R., Hassler, D., Hoffman, C. R., Kost, T.A., Lambert, M. H., Leesnitzer, M. A., McCauley, P., McGeehan, G., Mitchell, J., Moyer, M., Pahel, G., Rocque, W., Overton, L. K., Schoenen, F., Seaton, T., Su, J.-L., Warner, J., Willard, D. and Becherer, J. D (1997). Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-a. Nature 385, 733-736.[Medline]

Nakahara, H., Howard, L., Thompson, E. W., Sato, H., Seiki, M., Yeh, Y. and Chen, W.-T (1997). Transmembrane/cytoplasmic domain-mediated membrane type 1-matrix metalloprotease docking to invadopodia is required for cell adhesion. Proc. Natl. Acad. Sci. USA 94, 7959-7964.[Abstract/Free Full Text]

Reiland, J., Ott, V. L., Lebakken, C. S., Yeaman, C., McCarthy, J. and Rapraeger, A. C (1996). Pervanadate activation of intracellular kinases leads to tyrosine phosphorylation and shedding of syndecan-1. Biochem. J 319, 39-47.

Ridley, A. J. and Hall, A (1994). Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase. EMBO J 13, 2600-2610.[Medline]

Saitou, M., Fujimoto, K., Doi, Y., Itoh, M., Fujimoto, T., Furuse, M., Takano, H., Noda, T. and Tsukita, S (1998). Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J. Cell Biol 141, 397-408.[Abstract/Free Full Text]

Sakakibara, A., Furuse, M., Saitou, M., Ando-Akatsuka, Y. and Tsukita, S (1997). Possible involvement of phosphorylation of occludin in tight junction formation. J. Cell Biol 137, 1393-1401.[Abstract/Free Full Text]

Singer, K. L., Stevenson, B. R., Woo, P. L. and Firestone, G. L (1994). Relationship of serine/threonine phosphorylation/dephosphorylation signaling to glucocorticoid regulation of tight junction permeability and ZO-1 distribution in nontransformed mammary epithelial cells. J. Biol. Chem 269, 16108-16115.[Abstract/Free Full Text]

Slack, B. E., Breu, J., Petryniak, M. A., Srivastava, K. and Wurtman, R. J (1995). Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor. J. Biol. Chem 270, 8337-8344.[Abstract/Free Full Text]

Soker, S., Fiddler, H., Neufeld, G. and Klagsbrun, M (1996). Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain. J. Biol. Chem 271, 5761-5767.[Abstract/Free Full Text]

Staddon, J. M., Herrenknecht, K., Smales, C. and Rubin, L. L (1995). Evidence that tyrosine phosphorylation may increase tight junction permeability. J. Cell Sci 108, 609-619.[Abstract]

Stevenson, B. R., Anderson, J. M., Braun, I. D. and Mooseker, M. S (1989). Phosphorylation of the tight junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transeithelial resistance. Biochem. J 263, 597-599.[Medline]

Stevenson, B. R. and Keon, B. H (1998). The tight junction: morphology to molecules. Annu. Rev. Cell Dev. Biol 14, 89-109.[Medline]

Stevenson, B. R., Siliciano, J. D., Mooseker, M. S. and Goodenough, D. A (1986). Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J. Cell Biol 103, 755-766.[Abstract/Free Full Text]

Van Itallie, C. M. and Anderson, J. M (1997). Occludin confers adhesiveness when expressed in fibroblasts. J. Cell Sci 110, 1113-1121.[Abstract]

van Meer, G. and Simons, K (1986). The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domain of MDCK cells. EMBO J 5, 1455-1466.[Medline]

Vecchi, M., Rudolph-Owen, L. A., Brown, C. L., Dempsey, P. J. and Carpenter, G (1998). Thyrosine phosphorylation and proteolysis: Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin. J. Biol. Chem 273, 20589-20595.[Abstract/Free Full Text]

Weskamp, G., Kr\212tzschmar, J., Reid, M. S. and Blobel, C. P (1996). MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains. J. Cell Biol 132, 717-726.[Abstract/Free Full Text]

Wolfsberg, T. G. and White, J. M (1996). ADAMs in fertilization and development. Dev. Biol 180, 389-401.[Medline]

Wong, V. and Gumbiner, B. M (1997). A synthetic peptide corresponding to the extracellular domain of occludin perturbs the tight junction permeability barrier. J. Cell Biol 136, 399-409.[Abstract/Free Full Text]

Wong, V., Ching, D., McCrea, P. D. and Firestone, G. L (1999). Glucocorticoid down-regulation of fascin protein expression is required for the steroid-induced formation of tight junctions and cell-cell interactions in rat mammary epithelial tumor cells. J. Biol. Chem 274, 5443-5453.[Abstract/Free Full Text]

Zhong, Y., Saitoh, T., Minase, T., Sawada, N., Enomoto, K. and Mori, M (1993). Monoclonal antibody 7H6 reacts with a novel tight junction-associated protein distinct from ZO-1, cingulin and ZO-2. J. Cell Biol 120, 477-483.[Abstract/Free Full Text]

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				J. L. Sallee and K. Burridge Density-enhanced Phosphatase 1 Regulates Phosphorylation of Tight Junction Proteins and Enhances Barrier Function of Epithelial Cells J. Biol. Chem., May 29, 2009; 284(22): 14997 - 15006. [Abstract] [Full Text] [PDF]

				J. D. Kawedia, M. Jiang, A. Kulkarni, H. E. Waechter, K. S. Matlin, G. M. Pauletti, and A. G. Menon The Protein Kinase A Pathway Contributes to Hg2+-Induced Alterations in Phosphorylation and Subcellular Distribution of Occludin Associated with Increased Tight Junction Permeability of Salivary Epithelial Cell Monolayers J. Pharmacol. Exp. Ther., September 1, 2008; 326(3): 829 - 837. [Abstract] [Full Text] [PDF]

				D. Navaratna, G. Menicucci, J. Maestas, R. Srinivasan, P. McGuire, and A. Das A peptide inhibitor of the urokinase/urokinase receptor system inhibits alteration of the blood-retinal barrier in diabetes FASEB J, September 1, 2008; 22(9): 3310 - 3317. [Abstract] [Full Text] [PDF]

				R. Amstutz, M. Wachtel, H. Troxler, P. Kleinert, M. Ebauer, T. Haneke, C. Oehler-Janne, D. Fabbro, F. K. Niggli, and B. W. Schafer Phosphorylation Regulates Transcriptional Activity of PAX3/FKHR and Reveals Novel Therapeutic Possibilities Cancer Res., May 15, 2008; 68(10): 3767 - 3776. [Abstract] [Full Text] [PDF]

				M. Yamamoto, S. H. Ramirez, S. Sato, T. Kiyota, R. L. Cerny, K. Kaibuchi, Y. Persidsky, and T. Ikezu Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells Am. J. Pathol., February 1, 2008; 172(2): 521 - 533. [Abstract] [Full Text] [PDF]

				K. Wosik, R. Cayrol, A. Dodelet-Devillers, F. Berthelet, M. Bernard, R. Moumdjian, A. Bouthillier, T. L. Reudelhuber, and A. Prat Angiotensin II Controls Occludin Function and Is Required for Blood Brain Barrier Maintenance: Relevance to Multiple Sclerosis J. Neurosci., August 22, 2007; 27(34): 9032 - 9042. [Abstract] [Full Text] [PDF]

				A. Reijerkerk, G. Kooij, S. M. A. van der Pol, S. Khazen, C. D. Dijkstra, and H. E. de Vries Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells FASEB J, December 1, 2006; 20(14): 2550 - 2552. [Abstract] [Full Text] [PDF]

				L. DeMaio, M. Rouhanizadeh, S. Reddy, A. Sevanian, J. Hwang, and T. K. Hsiai Oxidized phospholipids mediate occludin expression and phosphorylation in vascular endothelial cells Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H674 - H683. [Abstract] [Full Text] [PDF]

				N. T. Collins, P. M. Cummins, O. C. Colgan, G. Ferguson, Y. A. Birney, R. P. Murphy, G. Meade, and P. A. Cahill Cyclic Strain-Mediated Regulation of Vascular Endothelial Occludin and ZO-1: Influence on Intercellular Tight Junction Assembly and Function Arterioscler Thromb Vasc Biol, January 1, 2006; 26(1): 62 - 68. [Abstract] [Full Text] [PDF]

				B. T. Hawkins and T. P. Davis The Blood-Brain Barrier/Neurovascular Unit in Health and Disease Pharmacol. Rev., June 1, 2005; 57(2): 173 - 185. [Abstract] [Full Text] [PDF]

				S. C. Pflugfelder, W. Farley, L. Luo, L. Z. Chen, C. S. de Paiva, L. C. Olmos, D.-Q. Li, and M. E. Fini Matrix Metalloproteinase-9 Knockout Confers Resistance to Corneal Epithelial Barrier Disruption in Experimental Dry Eye Am. J. Pathol., January 1, 2005; 166(1): 61 - 71. [Abstract] [Full Text] [PDF]

				C. Bojarski, J. Weiske, T. Schoneberg, W. Schroder, J. Mankertz, J.-D. Schulzke, P. Florian, M. Fromm, R. Tauber, and O. Huber The specific fates of tight junction proteins in apoptotic epithelial cells J. Cell Sci., April 15, 2004; 117(10): 2097 - 2107. [Abstract] [Full Text] [PDF]

				K. A. Witt, K. S. Mark, S. Hom, and T. P. Davis Effects of hypoxia-reoxygenation on rat blood-brain barrier permeability and tight junctional protein expression Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2820 - H2831. [Abstract] [Full Text] [PDF]

				S. H. M. Chen, M. F. Stins, S.-H. Huang, Y. H. Chen, K. J. Kwon-Chung, Y. Chang, K. S. Kim, K. Suzuki, and A. Y. Jong Cryptococcus neoformans induces alterations in the cytoskeleton of human brain microvascular endothelial cells J. Med. Microbiol., November 1, 2003; 52(11): 961 - 970. [Abstract] [Full Text] [PDF]

				R. H. Adamson, M. Zeng, G. N. Adamson, J. F. Lenz, and F. E. Curry PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction Am J Physiol Heart Circ Physiol, June 5, 2003; 285(1): H406 - H417. [Abstract] [Full Text] [PDF]

				J. D. Huber, V. S. Hau, L. Borg, C. R. Campos, R. D. Egleton, and T. P. Davis Blood-brain barrier tight junctions are altered during a 72-h exposure to lambda -carrageenan-induced inflammatory pain Am J Physiol Heart Circ Physiol, October 1, 2002; 283(4): H1531 - H1537. [Abstract] [Full Text] [PDF]

				M. Asahi, X. Wang, T. Mori, T. Sumii, J.-C. Jung, M. A. Moskowitz, M. E. Fini, and E. H. Lo Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood-Brain Barrier and White Matter Components after Cerebral Ischemia J. Neurosci., October 1, 2001; 21(19): 7724 - 7732. [Abstract] [Full Text] [PDF]

				H. Lum and K. A. Roebuck Oxidant stress and endothelial cell dysfunction Am J Physiol Cell Physiol, April 1, 2001; 280(4): C719 - C741. [Abstract] [Full Text] [PDF]

				J. D. Huber, K. A. Witt, S. Hom, R. D. Egleton, K. S. Mark, and T. P. Davis Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1241 - H1248. [Abstract] [Full Text] [PDF]

				J. Longin, P. Guillaumot, M.-A. Chauvin, A.-M. Morera, and B. Le Magueresse-Battistoni MT1-MMP in rat testicular development and the control of Sertoli cell proMMP-2 activation J. Cell Sci., January 6, 2001; 114(11): 2125 - 2134. [Abstract] [Full Text] [PDF]