Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity

QUICK SEARCH:

[advanced]

	Author:		Keyword(s):

Home Help Feedback Subscriptions Archive Search Table of Contents

This Article

	Summary
	Full Text (PDF)
	Alert me when this article is cited
	Alert me if a correction is posted

Services

	Email this article to a friend
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new issues of the journal
	Download to citation manager


Citing Articles

	Citing Articles via HighWire
	Citing Articles via Google Scholar

Google Scholar

	Articles by Williams, K. P.
	Articles by Pepinsky, R. B.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Williams, K. P.
	Articles by Pepinsky, R. B.

Alcedo, J., Ayzenzon, M., Von Ohlen, T., Noll, M. and Hooper, J. E (1996). The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 86, 221-232.[Medline]

Alexandre, C., Jacinto, A. and Ingham, P. W (1996). Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 10, 2003-2013.[Abstract/Free Full Text]

Bumcrot, D. A., Takada, R. and McMahon, A. P (1995). Proteolytic processing yields two secreted forms of sonic hedgehog. Mol. Cell. Biol 15, 2294-2303.[Abstract]

Capdevila, J., Pariente, F., Sampedro, J., Alonso, J. L. and Guerrero, I (1994). Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos. Development 120, 987-998.[Abstract]

Carpenter, D., Stone, D. M., Brush, J., Ryan, A., Armanini, M., Frantz, G., Rosenthal, A. and de Sauvage, F. J (1998). Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc. Nat. Acad. Sci. USA 95, 13630-13634.[Abstract/Free Full Text]

Chen, Y. and Struhl, G (1998). In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex. Development 125, 4943-4948.[Abstract]

Chi-Rosso, G., Gotwals, P. J., Yang, J., Ling, L., Jiang, K., Chao, B., Baker, D. P., Burkly, L. C., Fawell, S. E. and Koteliansky, V. E (1997). Fibronectin type III repeats mediate RGD-independent adhesion and signaling through activated beta1 integrins. J. Biol. Chem 272, 31447-31452.[Abstract/Free Full Text]

Chuang, P. T. and McMahon, A. P (1999). Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 397, 617-621.[Medline]

Dominguez, M., Brunner, M., Hafen, E. and Basler, K (1996). Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus. Science 272, 1621-5.[Abstract]

Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J. A. and McMahon, A. P (1993). Sonic Hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.[Medline]

Eichele, G., Tickle, C. and Alberts, B. M (1985). Studies on the mechanism of retinoid-induced pattern duplications in the early chick limb bud: temporal and spatial aspects. J. Cell Biol 101, 1913-1920.[Abstract/Free Full Text]

Ericson, J., Morton, S., Kawakami, A., Roelink, H. and Jessell, T. L (1996). Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87, 661-673.[Medline]

Fan, C.-M., Porter, J. A., Chiang, C., Chang, D. T., Beachy, P. A. and Tessier-Lavigne, M (1995). Long-range sclerotome induction by Sonic Hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell 81, 457-465.[Medline]

Goodrich, L. V., Milenkovic, L., Higgins, K. M. and Scott, M. P (1997). Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 277, 1109-1113.[Abstract/Free Full Text]

Gotwals, P. J., Chi-Rosso, G., Lindner, V., Yang, J., Ling, L., Fawell, S. E. and Koteliansky, V. E (1996). The alpha1beta1 integrin is expressed during neointima formation in rat arteries and mediates collagen matrix reorganization. J. Clin. Invest 97, 2469-2477.[Medline]

Hammerschmidt, M., Bitgood, M. J. and McMahon, A. P (1996). Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo. Genes Dev 10, 647-658.[Abstract/Free Full Text]

Hammerschmidt, M., Brook, A. and McMahon, A. P (1997). The world according to Hedgehog. Trends Genet 13, 14-21.[Medline]

Ibric, L. L., Benedict, W. F. and Peterson, A. R (1988). Simultaneous determination of ascorbic acid and dehydroascorbic acid in cultures of C3H/10T1/2 cells. In Vitro Cell Dev. Biol 24, 669-676.[Medline]

Ingham, P. W (1998). Transducing Hedgehog: the story so far. EMBO J 17, 3505-3511.[Medline]

Katagiri, T., Yamaguchi, A., Ikeda, T., Yoshiki, S., Wozney, J. M., Rosen, V., Wang, E. A., Tanaka, H., Omura, S. and Suda, T (1990). The non-osteogenic mouse pluripotent cell line, C3H10T1/2, is induced to differentiate into osteoblastic cells by recombinant human bone morphogenetic protein-2. Biochem. Biophys. Res. Commun 172, 295-299.[Medline]

Kinto, N., Iwamoto, M., Enomoto-Iwamoto, M., Noji, S., Ohuchi, H., Yoshioka, H., Kataoka, H., Wada, Y., Yuhao, G., Takahashi, H. E (1997). Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation. FEBS Lett 404, 319-23.[Medline]

Kumar, S., Balczarek, K. A. and Lai, Z. C (1996). Evolution of the hedgehog gene family. Genetics 142, 965-72.[Abstract]

Lee, J. J., Ekker, S. C., von Kessler, D. P., Porter, J. A., Sun, B. I. and Beachy, P. A (1994). Autoproteolysis in Hedgehog protein biogenesis. Science 266, 1528-1537.[Abstract/Free Full Text]

Lopez-Martinez, A., Chang, D. T., Chiang, C., Porter, J. A., Ros, M. A., Simandl, B. K., Beachy, P. A. and Fallon, J. F (1995). Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage. Curr. Biol 5, 791-796.[Medline]

Marigo, V., Roberts, D. J., Scott, M. K. L., Tsukurov, O., Levi, T., Gastier, J. M., Epstein, D. J., Gilbert, D. J., Copeland, N. G., Seidman, C. E. et al (1995). Cloning, expression, and chromosomal location of SHH and IHH: two Hhuman homologues of the Drosophila segment polarity gene Hedgehog. Genomics 28, 44-51.[Medline]

Marigo, V., Davey, R. A., Zuo, Y., Cunningham, J. M. and Tabin, C. J (1996). Biochemical evidence that patched is the Hedgehog receptor. Nature 384, 176-179.[Medline]

Marti, E., Bumcrot, D. A., Takada, R. and McMahon, A. P (1995). Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants. Nature 375, 322-325.[Medline]

Motoyama, J., Takabatake, T., Takeshima, K. and Hui, C (1998). Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nature Genet 18, 104-106.[Medline]

Nakamura, T., Aikawa, T., Iwamoto-Enomoto, M., Iwamoto, M., Higuchi, Y., Maurizio, P., Kinto, N., Yamaguchi, A., Noji, S., Kurisu, K. et al (1997). Induction of osteogenic differentiation by hedgehog proteins. Biochem. Biophys. Res. Commun 237, 465-469.[Medline]

Ng, K. W., Hudson, P. J., Power, B. E., Manji, S. S., Gummer, P. R. and Martin, T. J (1989). Retinoic acid and tumour necrosis factor-alpha act in concert to control the level of alkaline phosphatase mRNA. J. Mol. Endocrinol 3, 57-64.[Abstract]

Pepinsky, R. B., Zeng, C., Wen, D., Rayhorn, P., Baker, D. P., Williams, K. P., Bixler, S. A., Ambrose, C. M., Garber, E. A., Miatkowski, K. et al (1998). Identification of a palmitic acid-modified form of human Sonic Hedhehog. J. Biol. Chem 273, 14037-14045.[Abstract/Free Full Text]

Porter, J. A., von Kessler, D. P., Ekker, S. C., Young, K. E., Lee, J. J., Moses, K. and Beachy, P. A (1995). The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature 374, 363-366.[Medline]

Porter, J. A., Ekker, S. C., Park, W. J., von Kessler, D. P., Young, K. E., Chen, C. H., Ma, Y., Woods, A. S., Cotter, R. J., Koonin, E. V. et al (1996). Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell 86, 21-34.[Medline]

Porter, J. A., Young, K. E. and Beachy, P. A (1996). Cholesterol modification of hedgehog signaling proteins in animal development. Science 274, 255-259.[Abstract/Free Full Text]

Reznikoff, C. A., Brankow, D. W. and Heidelberger, C (1973). Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. Cancer Res 33, 3231-3238.[Abstract/Free Full Text]

Riddle, R. D., Johnson, R. L., Laufer, E. and Tabin, C (1993). Sonic Hedgehog mediates the polarising activity of the ZPA. Cell 75, 1401-1416.[Medline]

Roelink, H., Augsburger, A., Heemskerk, J., Korzh, V., Norlin, S., Ruizi Altaba, A., Tanabe, Y., Placzek, M., Edlund, T., Jessell, T. M. et al (1994). Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord. Cell 76, 761-775.[Medline]

Roelink, H., Porter, J. A., Chiang, C., Tanabe, Y., Chang, D. T., Beachy, P. A. and Jessell, T. M (1995). Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of Sonic Hedgehog autoproteolysis. Cell 81, 445-455.[Medline]

Stone, D. M., Hynes, M., Armanini, M., Swanson, T. A., Gu, Q., Johnson, R. L., Scott, M. P., Pennica, D., Goddard, A., Phillips, H. et al (1996). The tumour-suppressor gne product Patched encodes a candidate receptor for Sonic Hedgehog. Nature 384, 129-134.[Medline]

Takabatake, T., Ogawa, M., Takahashi, T. C., Mizuno, M., Okamoto, M. and Takeshima, K (1997). Hedgehog and patched gene expression in adult ocular tissues. FEBS Lett 410, 485-489.[Medline]

Tanabe, Y., Roelink, H. and Jessell, T. M (1995). Induction of motor neurons by Sonic Hedgehog is independent of floor plate differentiation. Curr. Biol 5, 651-658.[Medline]

Taylor, S. M. and Jones, P. A (1979). Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell 17, 771-779.[Medline]

Thaller, C. and Eichele, G (1987). Identification and spatial distribution of retinoids in the developing chick limb bud. Nature 327, 625-628.[Medline]

Therond, P. P., Knight, J. D., Kornberg, T. B. and Bishop, J. M (1996). Phosphorylation of the fused protein kinase in response to signaling from hedgehog. Proc. Nat. Acad. Sci. USA 93, 4224-4228.[Abstract/Free Full Text]

Wang, E. A., Israel, D. I., Kelly, S. and Luxenberg, D. P (1993). Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells. Growth Factors 9, 57-71.[Medline]

Wechsler-Reya, R. J. and Scott, M. P (1999). Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron 22, 103-114.[Medline]

Weed, M., Mundlos, S. and Olsen, B. R (1997). The role of sonic hedgehog in vertebrate development. Matrix Biol 16, 53-58.[Medline]

Yang, Y., Drossopoulou, G., Chiang, P.-T., Duprez, D., Marti, E., Bumcrot, D., Clarke, J., Niswander, L., McMahon, A. and Tickle, C (1997). Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb. Development 124, 4393-4404.[Abstract]

Zhou, H., Manji, S. S., Findlay, D. M., Martin, T. J., Heath, J. K. and Ng, K. W (1994). Novel action of retinoic acid. Stabilization of newly synthesized alkaline phosphatase transcripts. J. Biol. Chem 269, 22433-22439.[Abstract/Free Full Text]

This article has been cited by other articles:

S. F. Farzan, S. Singh, N. S. Schilling, and D. J. Robbins
The Adventures of Sonic Hedgehog in Development and Repair. III. Hedgehog processing and biological activity
Am J Physiol Gastrointest Liver Physiol, April 1, 2008; 294(4): G844 - G849.
[Abstract] [Full Text] [PDF]

C. R. Morales, J. Zeng, M. El Alfy, J. L. Barth, M. R. Chintalapudi, R. A. McCarthy, J. P. Incardona, and W. S. Argraves
Epithelial Trafficking of Sonic Hedgehog By Megalin
J. Histochem. Cytochem., October 1, 2006; 54(10): 1115 - 1127.
[Abstract] [Full Text] [PDF]

A. Gallet, L. Ruel, L. Staccini-Lavenant, and P. P. Therond
Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia
Development, February 1, 2006; 133(3): 407 - 418.
[Abstract] [Full Text] [PDF]

T. Maity, N. Fuse, and P. A. Beachy
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly
PNAS, November 22, 2005; 102(47): 17026 - 17031.
[Abstract] [Full Text] [PDF]

J. Feng, B. White, O. V. Tyurina, B. Guner, T. Larson, H. Y. Lee, R. O. Karlstrom, and J. D. Kohtz
Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids
Development, September 1, 2004; 131(17): 4357 - 4370.
[Abstract] [Full Text] [PDF]

S. Couve-Privat, M. Le Bret, E. Traiffort, S. Queille, J. Coulombe, B. Bouadjar, M. F. Avril, M. Ruat, A. Sarasin, and L. Daya-Grosjean
Functional Analysis of Novel Sonic Hedgehog Gene Mutations Identified in Basal Cell Carcinomas from Xeroderma Pigmentosum Patients
Cancer Res., May 15, 2004; 64(10): 3559 - 3565.
[Abstract] [Full Text] [PDF]

C. Torroja, N. Gorfinkiel, and I. Guerrero
Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction
Development, May 15, 2004; 131(10): 2395 - 2408.
[Abstract] [Full Text] [PDF]

R. Dillon, C. Gadgil, and H. G. Othmer
Short- and long-range effects of Sonic hedgehog in limb development
PNAS, September 2, 2003; 100(18): 10152 - 10157.
[Abstract] [Full Text] [PDF]

G. A. Stewart, J. A. Lowrey, S. J. Wakelin, P. M. Fitch, S. Lindey, M. J. Dallman, J. R. Lamb, and S. E. M. Howie
Sonic Hedgehog Signaling Modulates Activation of and Cytokine Production by Human Peripheral CD4+ T Cells
J. Immunol., November 15, 2002; 169(10): 5451 - 5457.
[Abstract] [Full Text] [PDF]

M.-T. Teh, S.-T. Wong, G. W. Neill, L. R. Ghali, M. P. Philpott, and A. G. Quinn
FOXM1 Is a Downstream Target of Gli1 in Basal Cell Carcinomas
Cancer Res., August 15, 2002; 62(16): 4773 - 4780.
[Abstract] [Full Text] [PDF]

J. A. Lowrey, G. A. Stewart, S. Lindey, G. F. Hoyne, M. J. Dallman, S. E. M. Howie, and J. R. Lamb
Sonic Hedgehog Promotes Cell Cycle Progression in Activated Peripheral CD4+ T Lymphocytes
J. Immunol., August 15, 2002; 169(4): 1869 - 1875.
[Abstract] [Full Text] [PDF]

R. A. McCarthy, J. L. Barth, M. R. Chintalapudi, C. Knaak, and W. S. Argraves
Megalin Functions as an Endocytic Sonic Hedgehog Receptor
J. Biol. Chem., July 5, 2002; 277(28): 25660 - 25667.
[Abstract] [Full Text] [PDF]

S. Testaz, A. Jarov, K. P. Williams, L. E. Ling, V. E. Koteliansky, C. Fournier-Thibault, and J.-L. Duband
Sonic hedgehog restricts adhesion and migration of neural crest cells independently of the Patched- Smoothened-Gli signaling pathway
PNAS, October 5, 2001; (2001) 221108698.
[Abstract] [Full Text] [PDF]

M. van den Heuvel
Fat Hedgehogs, Slower or Richer?
Sci. Signal., September 18, 2001; 2001(100): pe31 - pe31.
[Abstract] [Full Text] [PDF]

M. Dyer, S. Farrington, D Mohn, J. Munday, and M. Baron
Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo
Development, January 5, 2001; 128(10): 1717 - 1730.
[Abstract] [PDF]

R. B. Pepinsky, P. Rayhorn, E. S. Day, A. Dergay, K. P. Williams, A. Galdes, F. R. Taylor, P. A. Boriack-Sjodin, and E. A. Garber
Mapping Sonic Hedgehog-Receptor Interactions by Steric Interference
J. Biol. Chem., April 6, 2000; 275(15): 10995 - 11001.
[Abstract] [Full Text] [PDF]

S. Testaz, A. Jarov, K. P. Williams, L. E. Ling, V. E. Koteliansky, C. Fournier-Thibault, and J.-L. Duband
Sonic hedgehog restricts adhesion and migration of neural crest cells independently of the Patched- Smoothened-Gli signaling pathway
PNAS, October 23, 2001; 98(22): 12521 - 12526.
[Abstract] [Full Text] [PDF]

This Article

Summary

Full Text (PDF)

Alert me when this article is cited

Alert me if a correction is posted

Services

Email this article to a friend

Similar articles in this journal

Similar articles in PubMed

Alert me to new issues of the journal

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via Google Scholar

Google Scholar

Articles by Williams, K. P.

Articles by Pepinsky, R. B.

Search for Related Content

PubMed

PubMed Citation

Articles by Williams, K. P.

Articles by Pepinsky, R. B.

				C. R. Morales, J. Zeng, M. El Alfy, J. L. Barth, M. R. Chintalapudi, R. A. McCarthy, J. P. Incardona, and W. S. Argraves Epithelial Trafficking of Sonic Hedgehog By Megalin J. Histochem. Cytochem., October 1, 2006; 54(10): 1115 - 1127. [Abstract] [Full Text] [PDF]

				A. Gallet, L. Ruel, L. Staccini-Lavenant, and P. P. Therond Cholesterol modification is necessary for controlled planar long-range activity of Hedgehog in Drosophila epithelia Development, February 1, 2006; 133(3): 407 - 418. [Abstract] [Full Text] [PDF]

				T. Maity, N. Fuse, and P. A. Beachy Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly PNAS, November 22, 2005; 102(47): 17026 - 17031. [Abstract] [Full Text] [PDF]

				J. Feng, B. White, O. V. Tyurina, B. Guner, T. Larson, H. Y. Lee, R. O. Karlstrom, and J. D. Kohtz Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids Development, September 1, 2004; 131(17): 4357 - 4370. [Abstract] [Full Text] [PDF]

				S. Couve-Privat, M. Le Bret, E. Traiffort, S. Queille, J. Coulombe, B. Bouadjar, M. F. Avril, M. Ruat, A. Sarasin, and L. Daya-Grosjean Functional Analysis of Novel Sonic Hedgehog Gene Mutations Identified in Basal Cell Carcinomas from Xeroderma Pigmentosum Patients Cancer Res., May 15, 2004; 64(10): 3559 - 3565. [Abstract] [Full Text] [PDF]

				C. Torroja, N. Gorfinkiel, and I. Guerrero Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction Development, May 15, 2004; 131(10): 2395 - 2408. [Abstract] [Full Text] [PDF]

				R. Dillon, C. Gadgil, and H. G. Othmer Short- and long-range effects of Sonic hedgehog in limb development PNAS, September 2, 2003; 100(18): 10152 - 10157. [Abstract] [Full Text] [PDF]

				G. A. Stewart, J. A. Lowrey, S. J. Wakelin, P. M. Fitch, S. Lindey, M. J. Dallman, J. R. Lamb, and S. E. M. Howie Sonic Hedgehog Signaling Modulates Activation of and Cytokine Production by Human Peripheral CD4+ T Cells J. Immunol., November 15, 2002; 169(10): 5451 - 5457. [Abstract] [Full Text] [PDF]

				M.-T. Teh, S.-T. Wong, G. W. Neill, L. R. Ghali, M. P. Philpott, and A. G. Quinn FOXM1 Is a Downstream Target of Gli1 in Basal Cell Carcinomas Cancer Res., August 15, 2002; 62(16): 4773 - 4780. [Abstract] [Full Text] [PDF]

				J. A. Lowrey, G. A. Stewart, S. Lindey, G. F. Hoyne, M. J. Dallman, S. E. M. Howie, and J. R. Lamb Sonic Hedgehog Promotes Cell Cycle Progression in Activated Peripheral CD4+ T Lymphocytes J. Immunol., August 15, 2002; 169(4): 1869 - 1875. [Abstract] [Full Text] [PDF]

				R. A. McCarthy, J. L. Barth, M. R. Chintalapudi, C. Knaak, and W. S. Argraves Megalin Functions as an Endocytic Sonic Hedgehog Receptor J. Biol. Chem., July 5, 2002; 277(28): 25660 - 25667. [Abstract] [Full Text] [PDF]

				S. Testaz, A. Jarov, K. P. Williams, L. E. Ling, V. E. Koteliansky, C. Fournier-Thibault, and J.-L. Duband Sonic hedgehog restricts adhesion and migration of neural crest cells independently of the Patched- Smoothened-Gli signaling pathway PNAS, October 5, 2001; (2001) 221108698. [Abstract] [Full Text] [PDF]

				M. van den Heuvel Fat Hedgehogs, Slower or Richer? Sci. Signal., September 18, 2001; 2001(100): pe31 - pe31. [Abstract] [Full Text] [PDF]

				M. Dyer, S. Farrington, D Mohn, J. Munday, and M. Baron Indian hedgehog activates hematopoiesis and vasculogenesis and can respecify prospective neurectodermal cell fate in the mouse embryo Development, January 5, 2001; 128(10): 1717 - 1730. [Abstract] [PDF]

				R. B. Pepinsky, P. Rayhorn, E. S. Day, A. Dergay, K. P. Williams, A. Galdes, F. R. Taylor, P. A. Boriack-Sjodin, and E. A. Garber Mapping Sonic Hedgehog-Receptor Interactions by Steric Interference J. Biol. Chem., April 6, 2000; 275(15): 10995 - 11001. [Abstract] [Full Text] [PDF]